PT1021553E - Cassette de expressao eucariotica de genes e suas utilizacoes - Google Patents

Cassette de expressao eucariotica de genes e suas utilizacoes

Info

Publication number
PT1021553E
PT1021553E PT98900570T PT98900570T PT1021553E PT 1021553 E PT1021553 E PT 1021553E PT 98900570 T PT98900570 T PT 98900570T PT 98900570 T PT98900570 T PT 98900570T PT 1021553 E PT1021553 E PT 1021553E
Authority
PT
Portugal
Prior art keywords
expression
genes
cassette
eucariotica
herpes simplex
Prior art date
Application number
PT98900570T
Other languages
English (en)
Portuguese (pt)
Inventor
Robert S Coffin
David S Latchman
Original Assignee
Biovex Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biovex Ltd filed Critical Biovex Ltd
Publication of PT1021553E publication Critical patent/PT1021553E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16641—Use of virus, viral particle or viral elements as a vector
    • C12N2710/16643—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
PT98900570T 1997-01-10 1998-01-12 Cassette de expressao eucariotica de genes e suas utilizacoes PT1021553E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9700411.3A GB9700411D0 (en) 1997-01-10 1997-01-10 Eukaryotic gene expression cassette and uses thereof

Publications (1)

Publication Number Publication Date
PT1021553E true PT1021553E (pt) 2004-09-30

Family

ID=10805768

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98900570T PT1021553E (pt) 1997-01-10 1998-01-12 Cassette de expressao eucariotica de genes e suas utilizacoes

Country Status (15)

Country Link
EP (2) EP1021553B1 (enExample)
JP (1) JP2001508294A (enExample)
KR (1) KR100507399B1 (enExample)
CN (1) CN1231589C (enExample)
AT (1) ATE267263T1 (enExample)
AU (1) AU749064B2 (enExample)
BR (1) BR9806866A (enExample)
CA (1) CA2278326A1 (enExample)
DE (1) DE69824027T2 (enExample)
DK (1) DK1021553T3 (enExample)
ES (1) ES2221980T3 (enExample)
GB (1) GB9700411D0 (enExample)
IL (2) IL130876A0 (enExample)
PT (1) PT1021553E (enExample)
WO (1) WO1998030707A2 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9801930D0 (en) 1998-01-29 1998-03-25 Univ London Mutant herpes simplex viruses and uses thereof
GB9807865D0 (en) * 1998-04-09 1998-06-10 Univ London Herpes simplex virus latency associated transcript polypeptides
US6713067B2 (en) 1998-07-31 2004-03-30 Biovex Limited Herpes viruses for immune modulation
WO2000008193A2 (en) * 1998-07-31 2000-02-17 Cambridge University Technical Services Limited Latency-active regulatory sequences of herpesviruses and latency-inactive herpesvirus for gene transfer
GB9930418D0 (en) 1999-12-22 2000-02-16 Neurovex Ltd Replication incompetent herpes virus vectors
US7063851B2 (en) 2000-04-12 2006-06-20 Biovex Limited Herpes viruses for immune modulation
CZ2003798A3 (cs) 2000-09-21 2003-08-13 Dsm N. V. Polypeptid s aktivitou xylanázy, sekvence nukleové kyseliny kódující polypeptid, způsob přípravy a použití polypeptidu
AUPR518501A0 (en) 2001-05-22 2001-06-14 Unisearch Limited Yin yang-1
TWI328612B (en) 2002-07-25 2010-08-11 Dsm Ip Assets Bv Genes and their encoded polypeptides involved in the biosynthetic pathway of vitamin b12, vectors and host cells comprising the genes, and process for producing vitamin b12
GB2409681B (en) * 2002-09-27 2007-03-28 Powderject Res Ltd Nucleic acid constructs for gene expression
GB0317511D0 (en) 2003-07-25 2003-08-27 Biovex Ltd Viral vectors
WO2005080581A2 (en) * 2004-02-17 2005-09-01 University Of Florida Research Foundation, Inc. Insulated herpesvirus-derived gene expression cassettes for sustained and regulatable gene expression
US9593347B2 (en) 2010-04-16 2017-03-14 University of Pittsburgh—of the Commonwealth System of Higher Education Identification of mutations in herpes simplex virus envelope glycoproteins that enable or enhance vector retargeting to novel non-HSV receptors
EP3022307A4 (en) 2013-07-17 2017-04-19 University of Pittsburgh - Of the Commonwealth System of Higher Education Non-toxic hsv vectors for efficient gene delivery applications and complementing cells for their production
EP3184641B1 (en) 2013-10-28 2020-07-08 University of Pittsburgh - Of the Commonwealth System of Higher Education Oncolytic hsv vector
CN109312309B (zh) 2016-01-08 2024-04-02 雷普利穆内有限公司 工程化的病毒
SG11201806134SA (en) 2016-01-27 2018-08-30 Oncorus Inc Oncolytic viral vectors and uses thereof
GB201700350D0 (en) * 2017-01-09 2017-02-22 Replimune Ltd Altered virus
US11612625B2 (en) 2017-07-26 2023-03-28 Oncorus, Inc. Oncolytic viral vectors and uses thereof
EP3976806A1 (en) * 2019-05-30 2022-04-06 Solidus Biosciences, Inc. Recombinant herpesvirales vector

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849571A (en) * 1990-10-10 1998-12-15 University Of Pittsburgh Of The Commonwealth System Of Higher Education Latency active herpes virus promoters and their use
JPH067174A (ja) * 1992-03-13 1994-01-18 Monsanto Co ヘルペスウイルスプロモーターとｖｐ１６トランスアクチベータを用いる組換え蛋白の産生

Also Published As

Publication number Publication date
DE69824027D1 (de) 2004-06-24
AU5566998A (en) 1998-08-03
ES2221980T3 (es) 2005-01-16
DE69824027T2 (de) 2004-10-28
AU749064B2 (en) 2002-06-20
IL130876A0 (en) 2001-01-28
JP2001508294A (ja) 2001-06-26
CA2278326A1 (en) 1998-07-16
KR100507399B1 (ko) 2005-08-10
EP1441033A2 (en) 2004-07-28
EP1021553B1 (en) 2004-05-19
ATE267263T1 (de) 2004-06-15
WO1998030707A3 (en) 1998-09-11
IL130876A (en) 2006-08-20
EP1021553A2 (en) 2000-07-26
EP1441033A3 (en) 2004-12-01
KR20000070037A (ko) 2000-11-25
CN1250480A (zh) 2000-04-12
GB9700411D0 (en) 1997-02-26
CN1231589C (zh) 2005-12-14
BR9806866A (pt) 2000-04-18
DK1021553T3 (da) 2004-09-27
WO1998030707A2 (en) 1998-07-16

Similar Documents

Publication Publication Date Title
PT1021553E (pt) Cassette de expressao eucariotica de genes e suas utilizacoes
ES2150894T1 (es) Vector de baculovirus modificado por proteinas de envoltura para terapia genica.
DE3586520D1 (de) Herpes simplex-virus als vektor.
DE69634752D1 (de) Adenovirale vektoren beinhaltend ein prostata spezifisches antigen (psa) "response element"
MX9800719A (es) Proteinas de transporte y sus usos.
NO303831B1 (no) Isolert DNA-sekvens, vektor, vertscelle, polypeptid og anvendelse in vitro av polypeptidet ved en fremgangsmÕte for transfeksjon av hematopoeseceller med eksogen DNA
ZA942778B (en) Recombinant viruses, and their preparation and use in gene therapy.
AU6149596A (en) Tumor- or cell-specific herpes simplex virus replication
WO1993024641A3 (en) Adeno-associated virus with inverted terminal repeat sequences as promoter
FI935459A0 (fi) Deletionsmutanter av noetkreaturens herpesvirus typ 1, vaccin baserade daerpao; diagnostiska redskap foer upptaeckande av deletionsmutanter av noetkreaturens herpesvirus typ 1
GB8718779D0 (en) Dna sequence & expression vector
ATE244311T1 (de) Expressionssystem von antikörpern bei homologischer rekombinierung in murinezellen
DK0566554T3 (da) Fremstilling af rekombinante proteiner ved anvendelse af herpesviruspromotorer og VP16-transaktivatorer
WO1999023216A3 (en) Hyperthermic inducible expression vectors for gene therapy and methods of use thereof
NZ502450A (en) Recombinant expression of multimeric polypeptide comprising multiple copies of insulin c-peptide
EP0837931A4 (en) PROCESS FOR THE EXPRESSION AND ISOLATION OF BIOLOGICALLY ACTIVE MOLECULES IN URINE
ZA200202413B (en) Cell-specific and/or tumor-specific promoter retargeting of herpes gamma 34.5 gene expression.
DK0453969T3 (enExample)
AU2085195A (en) Gene coding for igg-fc-binding protein
AU6568386A (en) Vector and method for achieving high level expression in eukaryotic cells
WO1994006919A3 (en) Stably-transformed mammalian cells expressing a regulated, inflammatory cyclooxygenase
AU692395B2 (en) Recombinant herpesvirus with the use of gB gene promoter
WO1997014808A3 (en) Herpesvirus vectors and their uses
AU2233297A (en) Promoter
CA2301874A1 (en) Suppression of malignancy utilizing ribonucleotide reductase r1