GB9700411D0 - Eukaryotic gene expression cassette and uses thereof - Google Patents

Eukaryotic gene expression cassette and uses thereof

Info

Publication number
GB9700411D0
GB9700411D0 GBGB9700411.3A GB9700411A GB9700411D0 GB 9700411 D0 GB9700411 D0 GB 9700411D0 GB 9700411 A GB9700411 A GB 9700411A GB 9700411 D0 GB9700411 D0 GB 9700411D0
Authority
GB
United Kingdom
Prior art keywords
expression cassette
gene expression
eukaryotic gene
herpes simplex
simplex virus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
GBGB9700411.3A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University College London
Original Assignee
University College London
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University College London filed Critical University College London
Priority to GBGB9700411.3A priority Critical patent/GB9700411D0/en
Publication of GB9700411D0 publication Critical patent/GB9700411D0/en
Priority to IL13087698A priority patent/IL130876A0/xx
Priority to ES98900570T priority patent/ES2221980T3/es
Priority to KR10-1999-7006256A priority patent/KR100507399B1/ko
Priority to EP98900570A priority patent/EP1021553B1/en
Priority to CA002278326A priority patent/CA2278326A1/en
Priority to AT98900570T priority patent/ATE267263T1/de
Priority to PCT/GB1998/000074 priority patent/WO1998030707A2/en
Priority to JP53066398A priority patent/JP2001508294A/ja
Priority to CNB988032147A priority patent/CN1231589C/zh
Priority to AU55669/98A priority patent/AU749064B2/en
Priority to PT98900570T priority patent/PT1021553E/pt
Priority to DE69824027T priority patent/DE69824027T2/de
Priority to EP04008341A priority patent/EP1441033A3/en
Priority to BR9806866-0A priority patent/BR9806866A/pt
Priority to DK98900570T priority patent/DK1021553T3/da
Priority to IL130876A priority patent/IL130876A/en
Priority to US10/355,248 priority patent/US20030219409A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16641—Use of virus, viral particle or viral elements as a vector
    • C12N2710/16643—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
GBGB9700411.3A 1997-01-10 1997-01-10 Eukaryotic gene expression cassette and uses thereof Pending GB9700411D0 (en)

Priority Applications (18)

Application Number Priority Date Filing Date Title
GBGB9700411.3A GB9700411D0 (en) 1997-01-10 1997-01-10 Eukaryotic gene expression cassette and uses thereof
DK98900570T DK1021553T3 (da) 1997-01-10 1998-01-12 Eukaryotisk genekspressionskassette og anvendelser deraf
JP53066398A JP2001508294A (ja) 1997-01-10 1998-01-12 真核細胞遺伝子発現カセットおよびその使用
AU55669/98A AU749064B2 (en) 1997-01-10 1998-01-12 Eukaryotic gene expression cassette and uses thereof
KR10-1999-7006256A KR100507399B1 (ko) 1997-01-10 1998-01-12 진핵생물의 유전자 발현 카세트 및 그의 용도
EP98900570A EP1021553B1 (en) 1997-01-10 1998-01-12 Eukaryotic gene expression cassette and uses thereof
CA002278326A CA2278326A1 (en) 1997-01-10 1998-01-12 Eukaryotic gene expression cassette and uses thereof
AT98900570T ATE267263T1 (de) 1997-01-10 1998-01-12 Eukaryotische genexpressionskassette und deren verwendungen
PCT/GB1998/000074 WO1998030707A2 (en) 1997-01-10 1998-01-12 Eukaryotic gene expression cassette and uses thereof
IL13087698A IL130876A0 (en) 1997-01-10 1998-01-12 Eukaryotic gene expression cassette and uses thereof
CNB988032147A CN1231589C (zh) 1997-01-10 1998-01-12 真核基因表达盒和其用途
ES98900570T ES2221980T3 (es) 1997-01-10 1998-01-12 Cassette de expresion de genes eucariotas y sus utilizaciones.
PT98900570T PT1021553E (pt) 1997-01-10 1998-01-12 Cassette de expressao eucariotica de genes e suas utilizacoes
DE69824027T DE69824027T2 (de) 1997-01-10 1998-01-12 Eukaryotische genexpressionskassette und deren verwendungen
EP04008341A EP1441033A3 (en) 1997-01-10 1998-01-12 Eukaryotic gene expression cassette based on Herpes simplex virus
BR9806866-0A BR9806866A (pt) 1997-01-10 1998-01-12 Cassete de expressão e uso do mesmo, cepa do cassete de expressão, vetor de ácido nucleico, cepa viral, composição farmacêutica, e, processos para estudar a função de um ou mais genes heterólogos em uma célula eucariótica, para produzir uma cepa de hsv, para tratamento do corpo humano ou animal e para realizar terapia genética em um humano ou animal, e, vacina.
IL130876A IL130876A (en) 1997-01-10 1999-07-09 A cassette for expressing genes in eukaryotes and its use
US10/355,248 US20030219409A1 (en) 1997-01-10 2003-01-31 Eukaryotic gene expression cassette and uses thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9700411.3A GB9700411D0 (en) 1997-01-10 1997-01-10 Eukaryotic gene expression cassette and uses thereof

Publications (1)

Publication Number Publication Date
GB9700411D0 true GB9700411D0 (en) 1997-02-26

Family

ID=10805768

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB9700411.3A Pending GB9700411D0 (en) 1997-01-10 1997-01-10 Eukaryotic gene expression cassette and uses thereof

Country Status (15)

Country Link
EP (2) EP1021553B1 (enExample)
JP (1) JP2001508294A (enExample)
KR (1) KR100507399B1 (enExample)
CN (1) CN1231589C (enExample)
AT (1) ATE267263T1 (enExample)
AU (1) AU749064B2 (enExample)
BR (1) BR9806866A (enExample)
CA (1) CA2278326A1 (enExample)
DE (1) DE69824027T2 (enExample)
DK (1) DK1021553T3 (enExample)
ES (1) ES2221980T3 (enExample)
GB (1) GB9700411D0 (enExample)
IL (2) IL130876A0 (enExample)
PT (1) PT1021553E (enExample)
WO (1) WO1998030707A2 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9801930D0 (en) 1998-01-29 1998-03-25 Univ London Mutant herpes simplex viruses and uses thereof
GB9807865D0 (en) * 1998-04-09 1998-06-10 Univ London Herpes simplex virus latency associated transcript polypeptides
US6713067B2 (en) 1998-07-31 2004-03-30 Biovex Limited Herpes viruses for immune modulation
WO2000008193A2 (en) * 1998-07-31 2000-02-17 Cambridge University Technical Services Limited Latency-active regulatory sequences of herpesviruses and latency-inactive herpesvirus for gene transfer
GB9930418D0 (en) 1999-12-22 2000-02-16 Neurovex Ltd Replication incompetent herpes virus vectors
US7063851B2 (en) 2000-04-12 2006-06-20 Biovex Limited Herpes viruses for immune modulation
CZ2003798A3 (cs) 2000-09-21 2003-08-13 Dsm N. V. Polypeptid s aktivitou xylanázy, sekvence nukleové kyseliny kódující polypeptid, způsob přípravy a použití polypeptidu
AUPR518501A0 (en) 2001-05-22 2001-06-14 Unisearch Limited Yin yang-1
TWI328612B (en) 2002-07-25 2010-08-11 Dsm Ip Assets Bv Genes and their encoded polypeptides involved in the biosynthetic pathway of vitamin b12, vectors and host cells comprising the genes, and process for producing vitamin b12
GB2409681B (en) * 2002-09-27 2007-03-28 Powderject Res Ltd Nucleic acid constructs for gene expression
GB0317511D0 (en) 2003-07-25 2003-08-27 Biovex Ltd Viral vectors
WO2005080581A2 (en) * 2004-02-17 2005-09-01 University Of Florida Research Foundation, Inc. Insulated herpesvirus-derived gene expression cassettes for sustained and regulatable gene expression
US9593347B2 (en) 2010-04-16 2017-03-14 University of Pittsburgh—of the Commonwealth System of Higher Education Identification of mutations in herpes simplex virus envelope glycoproteins that enable or enhance vector retargeting to novel non-HSV receptors
EP3022307A4 (en) 2013-07-17 2017-04-19 University of Pittsburgh - Of the Commonwealth System of Higher Education Non-toxic hsv vectors for efficient gene delivery applications and complementing cells for their production
EP3184641B1 (en) 2013-10-28 2020-07-08 University of Pittsburgh - Of the Commonwealth System of Higher Education Oncolytic hsv vector
CN109312309B (zh) 2016-01-08 2024-04-02 雷普利穆内有限公司 工程化的病毒
SG11201806134SA (en) 2016-01-27 2018-08-30 Oncorus Inc Oncolytic viral vectors and uses thereof
GB201700350D0 (en) * 2017-01-09 2017-02-22 Replimune Ltd Altered virus
US11612625B2 (en) 2017-07-26 2023-03-28 Oncorus, Inc. Oncolytic viral vectors and uses thereof
EP3976806A1 (en) * 2019-05-30 2022-04-06 Solidus Biosciences, Inc. Recombinant herpesvirales vector

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849571A (en) * 1990-10-10 1998-12-15 University Of Pittsburgh Of The Commonwealth System Of Higher Education Latency active herpes virus promoters and their use
JPH067174A (ja) * 1992-03-13 1994-01-18 Monsanto Co ヘルペスウイルスプロモーターとｖｐ１６トランスアクチベータを用いる組換え蛋白の産生

Also Published As

Publication number Publication date
DE69824027D1 (de) 2004-06-24
AU5566998A (en) 1998-08-03
ES2221980T3 (es) 2005-01-16
DE69824027T2 (de) 2004-10-28
AU749064B2 (en) 2002-06-20
IL130876A0 (en) 2001-01-28
JP2001508294A (ja) 2001-06-26
CA2278326A1 (en) 1998-07-16
KR100507399B1 (ko) 2005-08-10
EP1441033A2 (en) 2004-07-28
EP1021553B1 (en) 2004-05-19
ATE267263T1 (de) 2004-06-15
WO1998030707A3 (en) 1998-09-11
IL130876A (en) 2006-08-20
EP1021553A2 (en) 2000-07-26
EP1441033A3 (en) 2004-12-01
KR20000070037A (ko) 2000-11-25
CN1250480A (zh) 2000-04-12
CN1231589C (zh) 2005-12-14
BR9806866A (pt) 2000-04-18
PT1021553E (pt) 2004-09-30
DK1021553T3 (da) 2004-09-27
WO1998030707A2 (en) 1998-07-16

Similar Documents

Publication Publication Date Title
GB9700411D0 (en) Eukaryotic gene expression cassette and uses thereof
AU6663096A (en) Viral vectors and line for gene therapy
AU6149596A (en) Tumor- or cell-specific herpes simplex virus replication
DE3586520D1 (de) Herpes simplex-virus als vektor.
WO1998027204A3 (en) AAV split-packaging genes and cell lines comprising such genes for use in the production of recombinant AAV vectors
NO303831B1 (no) Isolert DNA-sekvens, vektor, vertscelle, polypeptid og anvendelse in vitro av polypeptidet ved en fremgangsmÕte for transfeksjon av hematopoeseceller med eksogen DNA
IE842210L (en) Vaccine
AU3675095A (en) Use of a non-mammalian dna virus to express an exogenous gene in a mammalian cell
GR3021426T3 (en) Transfer and expression of gene sequences into central nervous system cells using herpes simplex virus mutants with deletions in genes for viral replication
EP0260148A3 (en) Improved recombinant expression method, vector and transformed cells
AU7097494A (en) Envelope fusion vectors for use in gene delivery
GB8718779D0 (en) Dna sequence & expression vector
EP0564539A4 (en) Sustained and continuous production of high titers of recombinant viral vectors and transduced target cells for use in gene therapy
HUT74844A (en) Homologous recombination antibody expression system for murine cells
AU3868197A (en) Yeast vectors and process for producing proteins with the use of the same
AU5254496A (en) Delivery and expression of heterologous genes using upstream enhancer regions of mammalian gene promoters
AU5318496A (en) Adenovirus vectors for gene therapy
ZA200202413B (en) Cell-specific and/or tumor-specific promoter retargeting of herpes gamma 34.5 gene expression.
AU6568386A (en) Vector and method for achieving high level expression in eukaryotic cells
WO1996009399A3 (en) Chimeric adenovirus for gene delivery
WO1994006919A3 (en) Stably-transformed mammalian cells expressing a regulated, inflammatory cyclooxygenase
AU692395B2 (en) Recombinant herpesvirus with the use of gB gene promoter
CA2058971A1 (en) Efficient method for identifiable expression of non-selectable genes
WO1997014808A3 (en) Herpesvirus vectors and their uses
AU2233297A (en) Promoter