PL95259B1 - Sposob wytwarzania nowych soli dwuguanidu - Google Patents

Sposob wytwarzania nowych soli dwuguanidu Download PDF

Info

Publication number
PL95259B1
PL95259B1 PL1975183923A PL18392375A PL95259B1 PL 95259 B1 PL95259 B1 PL 95259B1 PL 1975183923 A PL1975183923 A PL 1975183923A PL 18392375 A PL18392375 A PL 18392375A PL 95259 B1 PL95259 B1 PL 95259B1
Authority
PL
Poland
Prior art keywords
diguanide
salts
dichloroacetate
bis
hydrochloride
Prior art date
Application number
PL1975183923A
Other languages
English (en)
Polish (pl)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of PL95259B1 publication Critical patent/PL95259B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/24—Y being a hetero atom
    • C07C279/26—X and Y being nitrogen atoms, i.e. biguanides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PL1975183923A 1974-10-11 1975-10-10 Sposob wytwarzania nowych soli dwuguanidu PL95259B1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1369774A CH602612A5 (,) 1974-10-11 1974-10-11

Publications (1)

Publication Number Publication Date
PL95259B1 true PL95259B1 (pl) 1977-10-31

Family

ID=4394567

Family Applications (1)

Application Number Title Priority Date Filing Date
PL1975183923A PL95259B1 (pl) 1974-10-11 1975-10-10 Sposob wytwarzania nowych soli dwuguanidu

Country Status (26)

Country Link
US (1) US4028402A (,)
JP (1) JPS51125718A (,)
AR (1) AR209457A1 (,)
AT (1) AT343676B (,)
BE (1) BE834369A (,)
BR (1) BR7506595A (,)
CA (1) CA1053258A (,)
CH (1) CH602612A5 (,)
CU (1) CU34371A (,)
DD (1) DD123322A5 (,)
DE (1) DE2542598A1 (,)
DK (1) DK140834B (,)
ES (1) ES441673A1 (,)
FI (1) FI752626A7 (,)
FR (1) FR2287221A1 (,)
GB (1) GB1473256A (,)
IE (1) IE41807B1 (,)
IL (1) IL48116A (,)
LU (1) LU73557A1 (,)
NL (1) NL7511890A (,)
NO (1) NO753447L (,)
PH (1) PH12279A (,)
PL (1) PL95259B1 (,)
SE (1) SE7511357L (,)
SU (1) SU572200A3 (,)
ZA (1) ZA755861B (,)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2401898A1 (fr) * 1977-09-05 1979-03-30 Aec Chim Organ Biolog Nouveau sel de l'acide patoique
DE19616486C5 (de) 1996-04-25 2016-06-30 Royalty Pharma Collection Trust Verfahren zur Senkung des Blutglukosespiegels in Säugern
US20020006899A1 (en) * 1998-10-06 2002-01-17 Pospisilik Andrew J. Use of dipeptidyl peptidase IV effectors for lowering blood pressure in mammals
WO1998027982A1 (en) 1996-12-24 1998-07-02 Sumitomo Pharmaceuticals Co., Ltd. Composition containing ascorbic acid
DE19823831A1 (de) 1998-05-28 1999-12-02 Probiodrug Ges Fuer Arzneim Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen
DE19828113A1 (de) 1998-06-24 2000-01-05 Probiodrug Ges Fuer Arzneim Prodrugs von Inhibitoren der Dipeptidyl Peptidase IV
DE19828114A1 (de) 1998-06-24 2000-01-27 Probiodrug Ges Fuer Arzneim Produgs instabiler Inhibitoren der Dipeptidyl Peptidase IV
DE19834591A1 (de) 1998-07-31 2000-02-03 Probiodrug Ges Fuer Arzneim Verfahren zur Steigerung des Blutglukosespiegels in Säugern
US20030176357A1 (en) * 1998-10-06 2003-09-18 Pospisilik Andrew J. Dipeptidyl peptidase IV inhibitors and their uses for lowering blood pressure levels
DE19926233C1 (de) 1999-06-10 2000-10-19 Probiodrug Ges Fuer Arzneim Verfahren zur Herstellung von Thiazolidin
DE19940130A1 (de) * 1999-08-24 2001-03-01 Probiodrug Ges Fuer Arzneim Neue Effektoren der Dipeptidyl Peptidase IV zur topischen Anwendung
JP4719393B2 (ja) 1999-10-06 2011-07-06 敏男 宮田 カルボニルストレス改善剤
US20080076811A1 (en) * 2000-01-21 2008-03-27 Bork Balkan Combinations comprising depeptidypeptidase-iv inhibitors and antidiabetic agents
HU229042B1 (en) * 2000-03-31 2013-07-29 Prosidion Ltd Method for the improvement of islet signaling in diabetes mellitus and for its prevention
FR2809310B1 (fr) 2000-05-26 2004-02-13 Centre Nat Rech Scient Utilisation de derives de biguanide pour fabriquer un medicament ayant un effet cicatrisant
JP2005097117A (ja) * 2000-06-30 2005-04-14 Chugai Pharmaceut Co Ltd 糖尿病治療剤
US7132104B1 (en) 2000-10-27 2006-11-07 Probiodrug Ag Modulation of central nervous system (CNS) dipeptidyl peptidase IV (DPIV) -like activity for the treatment of neurological and neuropsychological disorders
KR20030096227A (ko) * 2000-10-27 2003-12-24 프로비오드룩 아게 신경 및 신경정신 질환의 치료방법
US6890905B2 (en) 2001-04-02 2005-05-10 Prosidion Limited Methods for improving islet signaling in diabetes mellitus and for its prevention
DE10150203A1 (de) 2001-10-12 2003-04-17 Probiodrug Ag Peptidylketone als Inhibitoren der DPIV
US7368421B2 (en) 2001-06-27 2008-05-06 Probiodrug Ag Use of dipeptidyl peptidase IV inhibitors in the treatment of multiple sclerosis
US20030130199A1 (en) 2001-06-27 2003-07-10 Von Hoersten Stephan Dipeptidyl peptidase IV inhibitors and their uses as anti-cancer agents
EP1492525A2 (en) * 2001-08-16 2005-01-05 Probiodrug AG Use of inhibitors of proline endopeptidase to modulate inositol (1,4,5) triphosphate concentration dependent on intracellular signal cascades
US6844316B2 (en) 2001-09-06 2005-01-18 Probiodrug Ag Inhibitors of dipeptidyl peptidase I
JP2005527504A (ja) 2002-02-28 2005-09-15 プロシディオン・リミテッド グルタミニルを基礎するｄｐｉｖ阻害剤
US20030232761A1 (en) * 2002-03-28 2003-12-18 Hinke Simon A. Novel analogues of glucose-dependent insulinotropic polypeptide
US20040033051A1 (en) * 2002-08-16 2004-02-19 Ip Kiril Kun Wan Method and system for producing and displaying visual presentations which inhibit off-screen duplication
US20040058876A1 (en) * 2002-09-18 2004-03-25 Torsten Hoffmann Secondary binding site of dipeptidyl peptidase IV (DP IV)
WO2004031374A2 (en) * 2002-09-18 2004-04-15 Prosidion Ltd. Secondary binding site of dipeptidyl peptidase iv (dp iv)
JP4806628B2 (ja) 2003-05-05 2011-11-02 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤
KR20110059664A (ko) 2003-05-05 2011-06-02 프로비오드룩 아게 글루타미닐 및 글루타메이트 사이클라제의 이펙터의 용도
BRPI0415409A (pt) * 2003-10-15 2006-12-05 Probiodrug Ag uso de efetuadores de ciclases de glutaminila e glutamato
US20050171112A1 (en) * 2003-11-03 2005-08-04 Probiodrug Ag Combinations useful for the treatment of neuronal disorders
US20100099721A1 (en) * 2003-11-03 2010-04-22 Probiodrug Ag Novel compounds for the treatment of neurological disorders
US7304086B2 (en) 2004-02-05 2007-12-04 Probiodrug Ag Inhibitors of glutaminyl cyclase
CN105152983A (zh) 2007-01-29 2015-12-16 韩诺生物制药株式会社 N,n-二甲基亚氨基二碳亚氨酸二酰胺乙酸盐、其制备方法和包含其的药物组合物
WO2008097861A2 (en) * 2007-02-02 2008-08-14 Braincells, Inc. MODULATION OF NEUROGENESIS WITH BIGUANIDES AND GSK3-ß AGENTS
CN101855204B (zh) * 2007-09-21 2013-09-11 韩兀生物制药株式会社 N,n-二甲基亚氨二羰酸二酰胺二羧酸盐、其制备方法及其药物组合物
WO2009088220A2 (ko) * 2008-01-08 2009-07-16 Hanall Pharmaceutical Company. Ltd Ｎ,ｎ-디메틸 이미도디카르본이미딕 디아미드의 니코틴산염, 그의 제조방법 및 그를 포함하는 약제학적 조성물
CN102159539B (zh) * 2008-06-26 2014-04-16 矽烷实验室股份公司 用于血糖控制的新型二甲双胍甘氨酸盐
WO2010146604A2 (en) 2009-06-18 2010-12-23 Exemed Pharmaceuticals Processes for preparing metformin hydrochloride
WO2011049400A2 (ko) * 2009-10-23 2011-04-28 한올바이오파마주식회사 N,n-디메틸 이미도디카르본이미딕 디아미드의 산 부가염을 포함하는 항암용 약제학적 조성물
KR101324283B1 (ko) 2010-04-27 2013-11-01 한올바이오파마주식회사 바이구아나이드 화합물의 신규 염, 그의 제조방법, 그를 포함하는 약제학적 조성물
WO2018060962A2 (en) 2016-09-30 2018-04-05 Laboratorios Silanes S.A. De C.V. Metformin amino acid compounds and methods of using the same
BR112019006401A2 (pt) 2016-09-30 2019-06-25 Laboratorios Silanes S A De C V glicinato de metformina, composições farmacêuticas que compreendem o mesmo e métodos de uso do mesmo
CN107118130A (zh) * 2017-05-11 2017-09-01 杜剑平 一类治疗肿瘤的药物化合物及其应用
CN106986791A (zh) * 2017-05-11 2017-07-28 杜剑平 一种治疗肿瘤的药物化合物及其制备方法和应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3179562A (en) * 1961-08-23 1965-04-20 Du Pont Treatment of diabetes with alpha, alpha substituted acetic acid derivatives

Also Published As

Publication number Publication date
ATA776375A (de) 1977-10-15
PH12279A (en) 1978-12-12
DD123322A5 (,) 1976-12-12
IE41807L (en) 1976-04-11
LU73557A1 (,) 1977-05-24
DK140834C (,) 1980-04-28
IE41807B1 (en) 1980-03-26
AR209457A1 (es) 1977-04-29
DK140834B (da) 1979-11-26
DE2542598A1 (de) 1976-04-22
IL48116A0 (en) 1975-11-25
BE834369A (fr) 1976-04-12
AU8497775A (en) 1977-03-24
SU572200A3 (ru) 1977-09-05
US4028402A (en) 1977-06-07
DK457475A (,) 1976-04-12
FR2287221A1 (fr) 1976-05-07
GB1473256A (en) 1977-05-11
ZA755861B (en) 1976-08-25
CU34371A (es) 1979-06-01
IL48116A (en) 1979-07-25
BR7506595A (pt) 1976-08-17
NL7511890A (nl) 1976-04-13
AT343676B (de) 1978-06-12
CH602612A5 (,) 1978-07-31
CA1053258A (en) 1979-04-24
SE7511357L (sv) 1976-04-12
ES441673A1 (es) 1977-04-01
JPS51125718A (en) 1976-11-02
NO753447L (,) 1976-04-13
FI752626A7 (,) 1976-04-12

Similar Documents

Publication Publication Date Title
PL95259B1 (pl) Sposob wytwarzania nowych soli dwuguanidu
WO2020010068A1 (en) Solid forms of 2-(3,5-dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile
HU201955B (en) Process for producing new ribofuranuronic acid derivatives and pharmaceutical compositions comprising such compounds
EP0346882B1 (en) Hydroxyalkylcysteine derivative and expectorant containing the same
NO762661L (,)
EP3100735B1 (en) Crystalline fosaprepitant dicyclohexylamine salt and its preparation
US4087526A (en) (3-Amino-5-substituted-6-fluoropyrazinoyl or pyrazamido)-guanidines and their derivatives bearing substituents on the guanidino nitrogens
NZ210945A (en) Methylenediphosphonic acid derivatives and pharmaceutical compositions
FI86431B (fi) Foerfarande foer framstaellning av -d-ribofuranuronsyratioamider.
KR20230141899A (ko) [(1S)-1-[(2S,4R,5R)-5-(5-아미노-2-옥소-티아졸로[4,5-d]피리미딘-3-일)-4-하이드록시-테트라하이드로퓨란-2-일]프로필]아세테이트의 고체 형태
JPS6136516B2 (,)
SU1384202A3 (ru) Способ получени замещенных тиазолидиниловых эфиров фосфорной кислоты
GB2078715A (en) N-(diethylaminoethyl)-2-alkoxybenzamide derivatives
JPS6344577A (ja) ピリミジン誘導体
US3718655A (en) Certain diisoniazid methane sulfonate complexes
US3076830A (en) Vanadium compounds
EP2542560B1 (en) Arylfluorophosphate inhibitors of intestinal apical membrane sodium/phosphate co-transport
EP0198508B1 (en) L-phosphoserine salts, a process for the preparation thereof and pharmaceutical compositions containing them
JPH0154326B2 (,)
MXPA01012328A (es) Polimorfos de un citrato de (2-benzhidril- 1-azabiciclo(2.2.2) oct-3-il- (5-iso- propil-2- metoxibencil) -amina como antagonistas del receptor de nk-1.
US3804835A (en) Pyrido(2,3-d)pyrimidin-4-(3h)-ones
US3094541A (en) 3-substituted ethers of the androstane series
US4226865A (en) Method of treating depression
US2440708A (en) d-chondocurarine halides and process for making same
US2582587A (en) N-alkylaminopropiophenones