|
US4522811A
(en)
|
1982-07-08 |
1985-06-11 |
Syntex (U.S.A.) Inc. |
Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
|
|
DE4134467A1
(de)
|
1991-10-18 |
1993-04-22 |
Thomae Gmbh Dr K |
Heterobiarylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
|
|
JPH07501063A
(ja)
|
1991-11-14 |
1995-02-02 |
グラクソ、グループ、リミテッド |
フィブリノーゲン依存性血小板凝集阻害剤としてのピペリジン酢酸誘導体
|
|
AU3351293A
(en)
|
1992-01-21 |
1993-08-03 |
Glaxo Group Limited |
Piperidineacetic acid derivatives as inhibitors of fibrinogen-dependent blood platelet aggregation
|
|
ATE181735T1
(de)
|
1993-05-01 |
1999-07-15 |
Merck Patent Gmbh |
Substituierte 1-phenyl-oxazolidin-2-on derivate, deren herstellung und deren verwendung als adhäsionsrezeptor-antagonisten
|
|
US6069143A
(en)
|
1994-12-20 |
2000-05-30 |
Smithkline Beecham Corporation |
Fibrinogen receptor antagonists
|
|
US20010034445A1
(en)
|
1995-12-29 |
2001-10-25 |
Smithkline Beecham Corporation |
Vitronectin receptor antagonists
|
|
EP0895475A4
(en)
|
1995-12-29 |
2000-08-23 |
Smithkline Beecham Corp |
VITRONECTIN RECEPTOR ANTAGONISTS
|
|
JP2000502704A
(ja)
|
1995-12-29 |
2000-03-07 |
スミスクライン・ビーチャム・コーポレイション |
ビトロネクチン受容体拮抗物質
|
|
JP2000516197A
(ja)
|
1996-01-16 |
2000-12-05 |
メルク エンド カンパニー インコーポレーテッド |
インテグリンレセプターアンタゴニスト
|
|
EP0796855B1
(de)
|
1996-03-20 |
2002-02-06 |
Hoechst Aktiengesellschaft |
Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten
|
|
PT891332E
(pt)
|
1996-03-29 |
2004-07-30 |
Pfizer |
Derivados de 6-fenilpiridil-2-amina
|
|
WO1998008840A1
(en)
|
1996-08-29 |
1998-03-05 |
Merck & Co., Inc. |
Integrin antagonists
|
|
EP0946165B1
(en)
|
1996-10-30 |
2003-04-09 |
Merck & Co., Inc. |
Integrin antagonists
|
|
US5952341A
(en)
|
1996-10-30 |
1999-09-14 |
Merck & Co., Inc. |
Integrin antagonists
|
|
AU724216B2
(en)
|
1997-04-07 |
2000-09-14 |
Merck & Co., Inc. |
A method of treating cancer
|
|
AU7105498A
(en)
|
1997-04-14 |
1998-11-11 |
Merck & Co., Inc. |
Combination therapy for the prevention and treatment of osteoporosis
|
|
EP1049693A1
(en)
|
1997-11-26 |
2000-11-08 |
Du Pont Pharmaceuticals Company |
1,3,4-THIADIAZOLES AND 1,3,4-OXADIAZOLES AS $g(a) v?$g(b) 3? ANTAGONISTS
|
|
TR200001752T2
(tr)
|
1997-12-17 |
2000-12-21 |
Merck & Co., Inc. |
Entegrin reseptör antagonistleri
|
|
US6017926A
(en)
*
|
1997-12-17 |
2000-01-25 |
Merck & Co., Inc. |
Integrin receptor antagonists
|
|
US6048861A
(en)
|
1997-12-17 |
2000-04-11 |
Merck & Co., Inc. |
Integrin receptor antagonists
|
|
CA2315232A1
(en)
|
1997-12-17 |
1999-06-24 |
Merck & Co., Inc. |
Integrin receptor antagonists
|
|
ES2241192T3
(es)
*
|
1997-12-17 |
2005-10-16 |
MERCK & CO., INC. (A NEW JERSEY CORP.) |
Antagonistas del receptor de integrina.
|
|
WO1999030709A1
(en)
|
1997-12-17 |
1999-06-24 |
Merck & Co., Inc. |
Integrin receptor antagonists
|
|
US6329372B1
(en)
|
1998-01-27 |
2001-12-11 |
Celltech Therapeutics Limited |
Phenylalanine derivatives
|
|
AU747784B2
(en)
|
1998-07-29 |
2002-05-23 |
Merck & Co., Inc. |
Integrin receptor antagonists
|
|
GB9825652D0
(en)
|
1998-11-23 |
1999-01-13 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
EP1140989A1
(de)
|
1998-12-19 |
2001-10-10 |
MERCK PATENT GmbH |
Inhibitoren des integrins alpha(v) beta(6)
|
|
CA2358855A1
(en)
|
1999-02-03 |
2000-08-10 |
Merck & Co., Inc. |
Benzazepine derivatives as alpha-v integrin receptor antagonists
|
|
US6723711B2
(en)
|
1999-05-07 |
2004-04-20 |
Texas Biotechnology Corporation |
Propanoic acid derivatives that inhibit the binding of integrins to their receptors
|
|
US6518283B1
(en)
|
1999-05-28 |
2003-02-11 |
Celltech R&D Limited |
Squaric acid derivatives
|
|
PT1187592E
(pt)
|
1999-06-02 |
2007-10-19 |
Merck & Co Inc |
Antagonistas dos receptores de integrina alfa v
|
|
JP2003502373A
(ja)
*
|
1999-06-23 |
2003-01-21 |
メルク エンド カムパニー インコーポレーテッド |
インテグリン受容体アンタゴニスト
|
|
DE19933173A1
(de)
|
1999-07-15 |
2001-01-18 |
Merck Patent Gmbh |
Cyclische Peptidderivate als Inhibitoren des Integrins alpha¶v¶beta¶6¶
|
|
US6514964B1
(en)
|
1999-09-27 |
2003-02-04 |
Amgen Inc. |
Fused cycloheptane and fused azacycloheptane compounds and their methods of use
|
|
GB9929988D0
(en)
|
1999-12-17 |
2000-02-09 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
CA2397194C
(en)
|
2000-01-20 |
2011-05-17 |
Mark E. Duggan |
Alpha v integrin receptor antagonists
|
|
EP1254116A4
(en)
|
2000-01-24 |
2003-04-23 |
Merck & Co Inc |
ALPHA V INTEGRIN RECEPTOR ANTAGONISTS
|
|
JP2004511434A
(ja)
|
2000-06-15 |
2004-04-15 |
ファルマシア・コーポレーション |
インテグリン受容体アンタゴニストとしてのヘテロアリールアルカン酸
|
|
DE10041423A1
(de)
|
2000-08-23 |
2002-03-07 |
Merck Patent Gmbh |
Biphenylderivate
|
|
AU2001292598B2
(en)
|
2000-09-14 |
2006-06-29 |
Merck & Co., Inc. |
Alpha V integrin receptor antagonists
|
|
AU2001290772A1
(en)
|
2000-09-14 |
2002-03-26 |
Merck And Co., Inc. |
Alpha v integrin receptor antagonists
|
|
JP2004508401A
(ja)
|
2000-09-18 |
2004-03-18 |
メルク エンド カムパニー インコーポレーテッド |
シクロオキシゲナーゼ−2阻害剤およびインテグリンアルファ−vアンタゴニストの組合せを用いる炎症の治療
|
|
NZ539682A
(en)
|
2001-01-29 |
2006-03-31 |
Dimensional Pharm Inc |
Substituted indoles and their use as integrin antagonists
|
|
DE10112771A1
(de)
|
2001-03-16 |
2002-09-26 |
Merck Patent Gmbh |
Inhibitoren des Integrins alpha¶v¶beta¶6¶
|
|
WO2002090325A2
(en)
|
2001-05-03 |
2002-11-14 |
Merck & Co., Inc. |
Benzazepinone alpha v integrin receptor antagonists
|
|
US20040043988A1
(en)
|
2001-06-15 |
2004-03-04 |
Khanna Ish Kurmar |
Cycloalkyl alkanoic acids as intergrin receptor antagonists
|
|
DE10204789A1
(de)
|
2002-02-06 |
2003-08-14 |
Merck Patent Gmbh |
Inhibitoren des Integrins alpha¶v¶beta6
|
|
DK1539739T3
(da)
|
2002-08-16 |
2011-03-07 |
Janssen Pharmaceutica Nv |
Piperidinylforbindelser, der selektivt binder integriner
|
|
FI20041129A0
(fi)
|
2004-08-30 |
2004-08-30 |
Ctt Cancer Targeting Tech Oy |
Tioksotiatsolidinoniyhdisteitä lääkkeinä käytettäviksi
|
|
AR059224A1
(es)
|
2006-01-31 |
2008-03-19 |
Jerini Ag |
Compuestos para la inhibicion de integrinas y uso de estas
|
|
EP2049490A1
(en)
|
2006-06-09 |
2009-04-22 |
Astra Zeneca AB |
N-(benzoyl)-o- [2- (pyridin- 2 -ylamino) ethyl]-l-tyrosine derivatives and related compounds as a5b1 antagonists for the treatment of solid tumors
|
|
AR067329A1
(es)
|
2007-06-13 |
2009-10-07 |
Bristol Myers Squibb Co |
Analogos dipeptidos como inhibidores del factor de coagulacion
|
|
AU2008321770B2
(en)
|
2007-11-16 |
2012-09-06 |
Ube Industries, Ltd. |
Benzazepinone compound
|
|
US20120289481A1
(en)
|
2011-05-13 |
2012-11-15 |
O'neil Jennifer |
Compositions and methods for treating cancer
|
|
US8716226B2
(en)
|
2012-07-18 |
2014-05-06 |
Saint Louis University |
3,5 phenyl-substituted beta amino acid derivatives as integrin antagonists
|
|
WO2014015054A1
(en)
|
2012-07-18 |
2014-01-23 |
Saint Louis University |
Beta amino acid derivatives as integrin antagonists
|
|
EP2784511A1
(en)
|
2013-03-27 |
2014-10-01 |
Universität Zürich |
Integrin alpha-v-beta6 for diagnosis/prognosis of colorectal carcinoma
|
|
GB201305668D0
(en)
|
2013-03-28 |
2013-05-15 |
Glaxosmithkline Ip Dev Ltd |
Avs6 Integrin Antagonists
|
|
WO2015103643A2
(en)
|
2014-01-06 |
2015-07-09 |
The General Hospital Corporation |
Integrin antagonists
|
|
MA39823A
(fr)
|
2014-04-03 |
2018-01-09 |
Janssen Pharmaceutica Nv |
Dérivés de pyridine macrocyclique
|
|
WO2015179823A2
(en)
|
2014-05-23 |
2015-11-26 |
The California Institute For Biomedical Research |
Lung localized inhibitors of alpha(v)beta 6
|
|
WO2016022851A1
(en)
|
2014-08-06 |
2016-02-11 |
Children's Medical Center Corporation |
Modified integrin polypeptides, modified integrin polypeptide dimers, and uses thereof
|
|
GB201417002D0
(en)
*
|
2014-09-26 |
2014-11-12 |
Glaxosmithkline Ip Dev Ltd |
Novel compound
|
|
GB201417094D0
(en)
*
|
2014-09-26 |
2014-11-12 |
Glaxosmithkline Ip Dev Ltd |
Novel compounds
|
|
GB201417018D0
(en)
|
2014-09-26 |
2014-11-12 |
Glaxosmithkline Ip Dev Ltd |
Novel compounds
|
|
GB201417011D0
(en)
|
2014-09-26 |
2014-11-12 |
Glaxosmithkline Ip Dev Ltd |
Novel compounds
|
|
KR102647026B1
(ko)
*
|
2015-02-19 |
2024-03-12 |
사이플루어 라이프 사이언시즈, 인크 |
플루오르화 테트라히드로나프티리디닐 노난산 유도체 및 이의 용도
|
|
ES2877707T3
(es)
|
2015-03-25 |
2021-11-17 |
Fujifilm Corp |
Método para producir un nuevo compuesto que contiene nitrógeno o una sal del mismo, y producto intermedio de producción del mismo
|
|
KR20170141757A
(ko)
|
2015-04-30 |
2017-12-26 |
사이플루어 라이프 사이언시즈, 인크 |
테트라하이드로나프티리디닐 프로피온산 유도체 및 이의 용도
|
|
BR112018012981A2
(pt)
|
2015-12-30 |
2018-12-04 |
Saint Louis University |
derivados do ácido meta-azacíclico amino benzoico como antagonistas de pan integrina com melhores propriedades farmacocinéticas
|
|
GB201604589D0
(en)
|
2016-03-18 |
2016-05-04 |
Glaxosmithkline Ip Dev Ltd |
Chemical compound
|
|
GB201604680D0
(en)
|
2016-03-21 |
2016-05-04 |
Glaxosmithkline Ip Dev Ltd |
Chemical Compounds
|
|
GB201604681D0
(en)
|
2016-03-21 |
2016-05-04 |
Glaxosmithkline Ip Dev Ltd |
Chemical Compounds
|
|
DE102016003731A1
(de)
*
|
2016-03-24 |
2017-09-28 |
Friedrich-Alexander-Universität Erlangen-Nürnberg |
Verfahren zum Erzeugen eines Kompositmaterials mit hierarchischer Porosität
|
|
EP3481814B1
(en)
|
2016-07-05 |
2022-04-27 |
The Rockefeller University |
Tetrahydronaphthyridinepentanamide integrin antagonists
|
|
CN109996541A
(zh)
|
2016-09-07 |
2019-07-09 |
普利安特治疗公司 |
N-酰基氨基酸化合物及其使用方法
|
|
SI3535397T1
(sl)
|
2016-11-01 |
2022-04-29 |
Arrowhead Pharmaceuticals, Inc. |
Ligandi alfa-V beta-6 integrina in njihove uporabe
|
|
WO2018085552A1
(en)
|
2016-11-02 |
2018-05-11 |
Saint Louis University |
Integrin antagonists
|
|
WO2018085578A1
(en)
|
2016-11-02 |
2018-05-11 |
Saint Louis University |
Integrin inhibitors in combination with an agent which interacts with a chemokine receptor
|
|
SI3538528T1
(sl)
|
2016-11-08 |
2021-03-31 |
Bristol-Myers Squibb Company |
Pirol amidi kot alfa v integrin inhibitorji
|
|
WO2018089353A1
(en)
|
2016-11-08 |
2018-05-17 |
Bristol-Myers Squibb Company |
3-substituted propionic acids as alpha v integrin inhibitors
|
|
AU2017359025A1
(en)
|
2016-11-08 |
2019-06-20 |
Bristol-Myers Squibb Company |
Cyclobutane- and azetidine-containing mono and spirocyclic compounds as alpha V integrin inhibitors
|
|
MX2019005234A
(es)
|
2016-11-08 |
2019-08-12 |
Squibb Bristol Myers Co |
Amidas y aminas de azol como inhibidores de integrina alfa v.
|
|
KR102506327B1
(ko)
|
2016-11-08 |
2023-03-03 |
브리스톨-마이어스 스큅 컴퍼니 |
αV 인테그린 길항제로서의 인다졸 유도체
|
|
USRE50554E1
(en)
|
2016-12-23 |
2025-08-26 |
Pliant Therapeutics, Inc. |
Amino acid compounds and methods of use
|
|
CN110177787A
(zh)
|
2016-12-29 |
2019-08-27 |
圣路易斯大学 |
整合素拮抗剂
|
|
MA47697A
(fr)
|
2017-02-28 |
2020-01-08 |
Morphic Therapeutic Inc |
Inhibiteurs de l'(alpha-v)(bêta-6) intégrine
|
|
MA52117A
(fr)
|
2017-02-28 |
2022-04-06 |
Morphic Therapeutic Inc |
Inhibiteurs de l'intégrine (alpha-v) (bêta-6)
|
|
PL3761980T3
(pl)
|
2018-03-07 |
2024-06-10 |
Pliant Therapeutics, Inc. |
Związki aminokwasowe i sposoby zastosowania
|
|
TWI841573B
(zh)
|
2018-06-27 |
2024-05-11 |
美商普萊恩醫療公司 |
具有未分支連接子之胺基酸化合物及使用方法
|
|
WO2020009889A1
(en)
|
2018-07-03 |
2020-01-09 |
Saint Louis University |
ALPHAvBETA1 INTEGRIN ANTAGONISTS
|
|
WO2020047207A1
(en)
|
2018-08-29 |
2020-03-05 |
Morphic Therapeutics, Inc. |
Inhibitors of (alpha-v)(beta-6) integrin
|
|
FI3844162T3
(fi)
|
2018-08-29 |
2025-03-27 |
Morphic Therapeutic Inc |
Alfa v beeta6 -integriinin estäjiä
|
|
EP4086254B1
(en)
|
2018-08-29 |
2024-12-18 |
Morphic Therapeutic, Inc. |
Integrin inhibitors
|
|
WO2020047208A1
(en)
|
2018-08-29 |
2020-03-05 |
Morphic Therapeutic, Inc. |
Inhibitors of (alpha-v)(beta-6) integrin
|
|
TW202028179A
(zh)
|
2018-10-08 |
2020-08-01 |
美商普萊恩醫療公司 |
胺基酸化合物及使用方法
|
|
US11419869B2
(en)
|
2019-04-08 |
2022-08-23 |
Pliant Therapeutics, Inc. |
Dosage forms and regimens for amino acid compounds
|