PL376149A1 - Piperazine and piperidine derivatives for treatment of neurological diseases - Google Patents
Piperazine and piperidine derivatives for treatment of neurological diseasesInfo
- Publication number
- PL376149A1 PL376149A1 PL03376149A PL37614903A PL376149A1 PL 376149 A1 PL376149 A1 PL 376149A1 PL 03376149 A PL03376149 A PL 03376149A PL 37614903 A PL37614903 A PL 37614903A PL 376149 A1 PL376149 A1 PL 376149A1
- Authority
- PL
- Poland
- Prior art keywords
- piperazine
- neurological diseases
- piperidine derivatives
- treatment
- treating
- Prior art date
Links
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title abstract 4
- 208000012902 Nervous system disease Diseases 0.000 title abstract 2
- 208000025966 Neurological disease Diseases 0.000 title abstract 2
- 150000003053 piperidines Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 210000005036 nerve Anatomy 0.000 abstract 2
- 230000003961 neuronal insult Effects 0.000 abstract 2
- 230000004936 stimulating effect Effects 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41613402P | 2002-10-03 | 2002-10-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL376149A1 true PL376149A1 (en) | 2005-12-27 |
Family
ID=32069937
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL03376149A PL376149A1 (en) | 2002-10-03 | 2003-10-02 | Piperazine and piperidine derivatives for treatment of neurological diseases |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20040180880A1 (enExample) |
| EP (1) | EP1546103B1 (enExample) |
| JP (1) | JP2006504717A (enExample) |
| KR (1) | KR20050047132A (enExample) |
| CN (1) | CN100395236C (enExample) |
| AT (1) | ATE425967T1 (enExample) |
| AU (1) | AU2003299145A1 (enExample) |
| CA (1) | CA2500672A1 (enExample) |
| DE (1) | DE60326742D1 (enExample) |
| ES (1) | ES2324293T3 (enExample) |
| MX (1) | MXPA05003471A (enExample) |
| NO (1) | NO20052153L (enExample) |
| PL (1) | PL376149A1 (enExample) |
| RU (1) | RU2005113247A (enExample) |
| TW (1) | TW200533653A (enExample) |
| WO (1) | WO2004031148A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7393656B2 (en) * | 2001-07-10 | 2008-07-01 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for risk stratification |
| GB0508319D0 (en) | 2005-04-25 | 2005-06-01 | Novartis Ag | Organic compounds |
| JP2009504637A (ja) * | 2005-08-08 | 2009-02-05 | アストラゼネカ・アクチエボラーグ | 治療薬 |
| US7943622B2 (en) | 2006-06-06 | 2011-05-17 | Cornerstone Therapeutics, Inc. | Piperazines, pharmaceutical compositions and methods of use thereof |
| EP2419413B1 (en) | 2009-04-16 | 2016-11-23 | Takeda Pharmaceutical Company Limited | Derivatives of n-acyl-n'-phenylpiperazine useful (inter alia) for the prophylaxis or treatment of diabetes |
| RU2486918C1 (ru) * | 2011-10-25 | 2013-07-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | Способ стимулирования восстановления периферической иннервации тканей с помощью векторных конструкций |
| HK1256751A1 (zh) | 2015-11-02 | 2019-10-04 | Janssen Pharmaceutica Nv | [1，2，4]三唑并[1，5-a]嘧啶-7-基化合物 |
| ES2912264T3 (es) | 2016-11-02 | 2022-05-25 | Janssen Pharmaceutica Nv | Compuestos de [1,2,4]triazolo[1,5-a]pirimidina como inhibidores de PDE2 |
| EA039102B1 (ru) | 2016-11-02 | 2021-12-03 | Янссен Фармацевтика Нв | Соединения [1,2,4]триазоло[1,5-a]пиримидина в качестве ингибиторов pde2 |
| TWI764950B (zh) | 2016-11-02 | 2022-05-21 | 比利時商健生藥品公司 | Ｐｄｅ２抑制劑 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2597100A1 (fr) * | 1986-01-21 | 1987-10-16 | Nippon Shinyaku Co Ltd | Derives du pyroglutamide |
| US5889006A (en) * | 1995-02-23 | 1999-03-30 | Schering Corporation | Muscarinic antagonists |
| US5780484A (en) * | 1996-11-13 | 1998-07-14 | Vertex Pharmaceuticals Incorporated | Methods for stimulating neurite growth with piperidine compounds |
| US5811434A (en) * | 1996-11-13 | 1998-09-22 | Vertex Pharmacueticals Incorporated | Methods and compositions for stimulating neurite growth |
| US5721256A (en) | 1997-02-12 | 1998-02-24 | Gpi Nil Holdings, Inc. | Method of using neurotrophic sulfonamide compounds |
| WO1999010340A1 (en) * | 1997-08-29 | 1999-03-04 | Vertex Pharmaceuticals Incorporated | Compounds possessing neuronal activity |
| US6331537B1 (en) * | 1998-06-03 | 2001-12-18 | Gpi Nil Holdings, Inc. | Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds |
| US6264991B1 (en) * | 1998-08-18 | 2001-07-24 | Southern Research Institute | Compositions and methods for treating intracellular infections |
| KR20020073586A (ko) * | 2000-02-11 | 2002-09-27 | 버텍스 파마슈티칼스 인코포레이티드 | 피페라진 및 피페리딘 유도체 |
| US20040034019A1 (en) * | 2002-08-08 | 2004-02-19 | Ronald Tomlinson | Piperazine and piperidine derivatives |
-
2003
- 2003-10-02 PL PL03376149A patent/PL376149A1/xx not_active Application Discontinuation
- 2003-10-02 MX MXPA05003471A patent/MXPA05003471A/es not_active Application Discontinuation
- 2003-10-02 RU RU2005113247/04A patent/RU2005113247A/ru not_active Application Discontinuation
- 2003-10-02 ES ES03756899T patent/ES2324293T3/es not_active Expired - Lifetime
- 2003-10-02 KR KR1020057005779A patent/KR20050047132A/ko not_active Withdrawn
- 2003-10-02 AU AU2003299145A patent/AU2003299145A1/en not_active Abandoned
- 2003-10-02 EP EP03756899A patent/EP1546103B1/en not_active Expired - Lifetime
- 2003-10-02 DE DE60326742T patent/DE60326742D1/de not_active Expired - Lifetime
- 2003-10-02 CN CNB2003801041723A patent/CN100395236C/zh not_active Expired - Fee Related
- 2003-10-02 US US10/677,631 patent/US20040180880A1/en not_active Abandoned
- 2003-10-02 AT AT03756899T patent/ATE425967T1/de not_active IP Right Cessation
- 2003-10-02 WO PCT/US2003/031080 patent/WO2004031148A1/en not_active Ceased
- 2003-10-02 JP JP2004541991A patent/JP2006504717A/ja active Pending
- 2003-10-02 CA CA002500672A patent/CA2500672A1/en not_active Abandoned
-
2004
- 2004-04-05 TW TW093109385A patent/TW200533653A/zh unknown
-
2005
- 2005-05-02 NO NO20052153A patent/NO20052153L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN100395236C (zh) | 2008-06-18 |
| US20040180880A1 (en) | 2004-09-16 |
| MXPA05003471A (es) | 2005-07-01 |
| NO20052153L (no) | 2005-05-31 |
| AU2003299145A1 (en) | 2004-04-23 |
| EP1546103B1 (en) | 2009-03-18 |
| EP1546103A1 (en) | 2005-06-29 |
| CA2500672A1 (en) | 2004-04-15 |
| WO2004031148A1 (en) | 2004-04-15 |
| RU2005113247A (ru) | 2006-01-20 |
| ES2324293T3 (es) | 2009-08-04 |
| KR20050047132A (ko) | 2005-05-19 |
| JP2006504717A (ja) | 2006-02-09 |
| DE60326742D1 (de) | 2009-04-30 |
| CN1717390A (zh) | 2006-01-04 |
| ATE425967T1 (de) | 2009-04-15 |
| TW200533653A (en) | 2005-10-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REFS | Decisions on refusal to grant patents (taken after the publication of the particulars of the applications) |