TW200533653A - Piperazine and piperidine derivatives - Google Patents
Piperazine and piperidine derivatives Download PDFInfo
- Publication number
- TW200533653A TW200533653A TW093109385A TW93109385A TW200533653A TW 200533653 A TW200533653 A TW 200533653A TW 093109385 A TW093109385 A TW 093109385A TW 93109385 A TW93109385 A TW 93109385A TW 200533653 A TW200533653 A TW 200533653A
- Authority
- TW
- Taiwan
- Prior art keywords
- straight
- branched
- disease
- branched alkyl
- group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41613402P | 2002-10-03 | 2002-10-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200533653A true TW200533653A (en) | 2005-10-16 |
Family
ID=32069937
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW093109385A TW200533653A (en) | 2002-10-03 | 2004-04-05 | Piperazine and piperidine derivatives |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20040180880A1 (enExample) |
| EP (1) | EP1546103B1 (enExample) |
| JP (1) | JP2006504717A (enExample) |
| KR (1) | KR20050047132A (enExample) |
| CN (1) | CN100395236C (enExample) |
| AT (1) | ATE425967T1 (enExample) |
| AU (1) | AU2003299145A1 (enExample) |
| CA (1) | CA2500672A1 (enExample) |
| DE (1) | DE60326742D1 (enExample) |
| ES (1) | ES2324293T3 (enExample) |
| MX (1) | MXPA05003471A (enExample) |
| NO (1) | NO20052153L (enExample) |
| PL (1) | PL376149A1 (enExample) |
| RU (1) | RU2005113247A (enExample) |
| TW (1) | TW200533653A (enExample) |
| WO (1) | WO2004031148A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7393656B2 (en) * | 2001-07-10 | 2008-07-01 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for risk stratification |
| GB0508319D0 (en) | 2005-04-25 | 2005-06-01 | Novartis Ag | Organic compounds |
| CN101282953A (zh) * | 2005-08-08 | 2008-10-08 | 阿斯利康(瑞典)有限公司 | 治疗剂 |
| US7943622B2 (en) * | 2006-06-06 | 2011-05-17 | Cornerstone Therapeutics, Inc. | Piperazines, pharmaceutical compositions and methods of use thereof |
| JP5706337B2 (ja) * | 2009-04-16 | 2015-04-22 | 武田薬品工業株式会社 | （とりわけ）糖尿病の予防または治療に有用なｎ−アシル−ｎ’−フェニルピペラジンの誘導体 |
| RU2486918C1 (ru) * | 2011-10-25 | 2013-07-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | Способ стимулирования восстановления периферической иннервации тканей с помощью векторных конструкций |
| MX2018005342A (es) | 2015-11-02 | 2018-08-15 | Janseen Pharmaceutica Nv | Compuesto de [1,2,4]triazolo[1,5-a]pirimidin-7-ilo. |
| BR112019008163A2 (pt) | 2016-11-02 | 2019-07-09 | Janssen Pharmaceutica Nv | compostos de [1,2,4]triazolo[1,5-a]pirimidina como inibidores de pde2 |
| SG11201903892UA (en) | 2016-11-02 | 2019-05-30 | Janssen Pharmaceutica Nv | [1,2,4]triazolo[1,5-a]pyrimidine derivatives as pde2 inhibitors |
| ES2912264T3 (es) | 2016-11-02 | 2022-05-25 | Janssen Pharmaceutica Nv | Compuestos de [1,2,4]triazolo[1,5-a]pirimidina como inhibidores de PDE2 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2597100A1 (fr) * | 1986-01-21 | 1987-10-16 | Nippon Shinyaku Co Ltd | Derives du pyroglutamide |
| US5889006A (en) * | 1995-02-23 | 1999-03-30 | Schering Corporation | Muscarinic antagonists |
| US5811434A (en) * | 1996-11-13 | 1998-09-22 | Vertex Pharmacueticals Incorporated | Methods and compositions for stimulating neurite growth |
| US5780484A (en) * | 1996-11-13 | 1998-07-14 | Vertex Pharmaceuticals Incorporated | Methods for stimulating neurite growth with piperidine compounds |
| US5721256A (en) | 1997-02-12 | 1998-02-24 | Gpi Nil Holdings, Inc. | Method of using neurotrophic sulfonamide compounds |
| NZ502820A (en) * | 1997-08-29 | 2002-10-25 | Vertex Pharma | Heteroaryl or aryl substituted carboxylic acid or carboxamide derivatives optionally substituted with a sulphonamido group |
| US6331537B1 (en) * | 1998-06-03 | 2001-12-18 | Gpi Nil Holdings, Inc. | Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds |
| US6264991B1 (en) * | 1998-08-18 | 2001-07-24 | Southern Research Institute | Compositions and methods for treating intracellular infections |
| HUP0301391A3 (en) * | 2000-02-11 | 2010-03-29 | Vertex Pharma | Piperazine and piperidine derivatives pharmaceutical compositions containing them and their use |
| US20040034019A1 (en) * | 2002-08-08 | 2004-02-19 | Ronald Tomlinson | Piperazine and piperidine derivatives |
-
2003
- 2003-10-02 KR KR1020057005779A patent/KR20050047132A/ko not_active Withdrawn
- 2003-10-02 JP JP2004541991A patent/JP2006504717A/ja active Pending
- 2003-10-02 CN CNB2003801041723A patent/CN100395236C/zh not_active Expired - Fee Related
- 2003-10-02 CA CA002500672A patent/CA2500672A1/en not_active Abandoned
- 2003-10-02 PL PL03376149A patent/PL376149A1/xx not_active Application Discontinuation
- 2003-10-02 US US10/677,631 patent/US20040180880A1/en not_active Abandoned
- 2003-10-02 EP EP03756899A patent/EP1546103B1/en not_active Expired - Lifetime
- 2003-10-02 AU AU2003299145A patent/AU2003299145A1/en not_active Abandoned
- 2003-10-02 MX MXPA05003471A patent/MXPA05003471A/es not_active Application Discontinuation
- 2003-10-02 DE DE60326742T patent/DE60326742D1/de not_active Expired - Lifetime
- 2003-10-02 ES ES03756899T patent/ES2324293T3/es not_active Expired - Lifetime
- 2003-10-02 AT AT03756899T patent/ATE425967T1/de not_active IP Right Cessation
- 2003-10-02 WO PCT/US2003/031080 patent/WO2004031148A1/en not_active Ceased
- 2003-10-02 RU RU2005113247/04A patent/RU2005113247A/ru not_active Application Discontinuation
-
2004
- 2004-04-05 TW TW093109385A patent/TW200533653A/zh unknown
-
2005
- 2005-05-02 NO NO20052153A patent/NO20052153L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DE60326742D1 (de) | 2009-04-30 |
| CA2500672A1 (en) | 2004-04-15 |
| ATE425967T1 (de) | 2009-04-15 |
| MXPA05003471A (es) | 2005-07-01 |
| WO2004031148A1 (en) | 2004-04-15 |
| CN1717390A (zh) | 2006-01-04 |
| KR20050047132A (ko) | 2005-05-19 |
| EP1546103B1 (en) | 2009-03-18 |
| CN100395236C (zh) | 2008-06-18 |
| JP2006504717A (ja) | 2006-02-09 |
| AU2003299145A1 (en) | 2004-04-23 |
| RU2005113247A (ru) | 2006-01-20 |
| ES2324293T3 (es) | 2009-08-04 |
| EP1546103A1 (en) | 2005-06-29 |
| NO20052153L (no) | 2005-05-31 |
| US20040180880A1 (en) | 2004-09-16 |
| PL376149A1 (en) | 2005-12-27 |
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