PL375754A1 - 2,5-Dioksoimidazolidyn-4-yloacetamidy i analogi jako inhibitory metaloproteinazy MMP-12 - Google Patents

2,5-Dioksoimidazolidyn-4-yloacetamidy i analogi jako inhibitory metaloproteinazy MMP-12

Info

Publication number
PL375754A1
PL375754A1 PL03375754A PL37575403A PL375754A1 PL 375754 A1 PL375754 A1 PL 375754A1 PL 03375754 A PL03375754 A PL 03375754A PL 37575403 A PL37575403 A PL 37575403A PL 375754 A1 PL375754 A1 PL 375754A1
Authority
PL
Poland
Prior art keywords
dioxoimidazolidin
acetamides
analogues
inhibitors
mmp12
Prior art date
Application number
PL03375754A
Other languages
English (en)
Inventor
Krister Henriksson
af Rosenschöld Magnus Munck
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PL375754A1 publication Critical patent/PL375754A1/pl

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C07D233/78—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Surgery (AREA)
  • Epidemiology (AREA)
PL03375754A 2002-08-27 2003-08-26 2,5-Dioksoimidazolidyn-4-yloacetamidy i analogi jako inhibitory metaloproteinazy MMP-12 PL375754A1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0202539A SE0202539D0 (sv) 2002-08-27 2002-08-27 Compounds

Publications (1)

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PL375754A1 true PL375754A1 (pl) 2005-12-12

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PL03375754A PL375754A1 (pl) 2002-08-27 2003-08-26 2,5-Dioksoimidazolidyn-4-yloacetamidy i analogi jako inhibitory metaloproteinazy MMP-12

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Country Link
US (2) US7354940B2 (pl)
EP (1) EP1542977B1 (pl)
JP (1) JP2006503019A (pl)
KR (1) KR20050059093A (pl)
CN (1) CN100398521C (pl)
AR (1) AR041066A1 (pl)
AT (1) ATE348816T1 (pl)
AU (1) AU2003253557B2 (pl)
BR (1) BR0313635A (pl)
CA (1) CA2495853A1 (pl)
CY (1) CY1106027T1 (pl)
DE (1) DE60310582T2 (pl)
DK (1) DK1542977T3 (pl)
ES (1) ES2277143T3 (pl)
IL (1) IL166826A (pl)
IS (1) IS2415B (pl)
MX (1) MXPA05002066A (pl)
MY (1) MY137562A (pl)
NO (1) NO20051540L (pl)
NZ (1) NZ538443A (pl)
PL (1) PL375754A1 (pl)
PT (1) PT1542977E (pl)
RU (1) RU2326117C2 (pl)
SE (1) SE0202539D0 (pl)
TW (1) TWI332500B (pl)
UA (1) UA81635C2 (pl)
WO (1) WO2004020415A1 (pl)
ZA (1) ZA200501139B (pl)

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US7662845B2 (en) 2010-02-16
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