PL3660154T3 - Antysensowne kwasy nukleinowe do zastosowania do leczenia dystrofii mięśniowej duchenne'a - Google Patents
Antysensowne kwasy nukleinowe do zastosowania do leczenia dystrofii mięśniowej duchenne'aInfo
- Publication number
- PL3660154T3 PL3660154T3 PL19208809.4T PL19208809T PL3660154T3 PL 3660154 T3 PL3660154 T3 PL 3660154T3 PL 19208809 T PL19208809 T PL 19208809T PL 3660154 T3 PL3660154 T3 PL 3660154T3
- Authority
- PL
- Poland
- Prior art keywords
- nucleic acid
- antisense nucleic
- muscular dystrophy
- duchenne muscular
- treating duchenne
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3233—Morpholino-type ring
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/10—Applications; Uses in screening processes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/33—Alteration of splicing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2330/00—Production
- C12N2330/30—Production chemically synthesised
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Plant Pathology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014124157 | 2014-06-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3660154T3 true PL3660154T3 (pl) | 2025-07-28 |
Family
ID=54935505
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL19208809.4T PL3660154T3 (pl) | 2014-06-17 | 2015-06-16 | Antysensowne kwasy nukleinowe do zastosowania do leczenia dystrofii mięśniowej duchenne'a |
| PL15810097T PL3159409T3 (pl) | 2014-06-17 | 2015-06-16 | Antysensowne kwasy nukleinowe do zastosowania do leczenia dystrofii mięśniowej duchenne'a |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL15810097T PL3159409T3 (pl) | 2014-06-17 | 2015-06-16 | Antysensowne kwasy nukleinowe do zastosowania do leczenia dystrofii mięśniowej duchenne'a |
Country Status (30)
| Country | Link |
|---|---|
| US (4) | US9840706B2 (pl) |
| EP (3) | EP3660154B1 (pl) |
| JP (5) | JP6208349B2 (pl) |
| KR (1) | KR102335810B1 (pl) |
| CN (2) | CN106661577B (pl) |
| AU (3) | AU2015277924B2 (pl) |
| BR (2) | BR122020020864B1 (pl) |
| CA (1) | CA2951221A1 (pl) |
| CO (1) | CO2017000357A2 (pl) |
| CY (1) | CY1122462T1 (pl) |
| DK (1) | DK3159409T3 (pl) |
| ES (2) | ES2765463T3 (pl) |
| HR (1) | HRP20200042T1 (pl) |
| HU (1) | HUE047502T2 (pl) |
| IL (1) | IL249574B (pl) |
| LT (1) | LT3159409T (pl) |
| MX (2) | MX420315B (pl) |
| MY (2) | MY194170A (pl) |
| PH (1) | PH12016502501A1 (pl) |
| PL (2) | PL3660154T3 (pl) |
| PT (1) | PT3159409T (pl) |
| RS (1) | RS59764B1 (pl) |
| RU (1) | RU2695430C2 (pl) |
| SG (2) | SG11201610130VA (pl) |
| SI (1) | SI3159409T1 (pl) |
| SM (1) | SMT202000006T1 (pl) |
| TW (2) | TWI666317B (pl) |
| UA (1) | UA121117C2 (pl) |
| WO (1) | WO2015194520A1 (pl) |
| ZA (1) | ZA201700142B (pl) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY194170A (en) | 2014-06-17 | 2022-11-16 | Nippon Shinyaku Co Ltd | Antisense nucleic acids |
| LT3351633T (lt) | 2015-09-15 | 2020-08-10 | Nippon Shinyaku Co., Ltd. | Priešprasmė nukleorūgštis |
| JP6875684B2 (ja) * | 2015-09-16 | 2021-05-26 | 日本新薬株式会社 | 筋萎縮症治療用アンチセンス核酸 |
| SG10201912902TA (en) | 2015-10-09 | 2020-02-27 | Wave Life Sciences Ltd | Oligonucleotide compositions and methods thereof |
| MA45328A (fr) | 2016-04-01 | 2019-02-06 | Avidity Biosciences Llc | Compositions acide nucléique-polypeptide et utilisations de celles-ci |
| TW201811807A (zh) | 2016-06-30 | 2018-04-01 | 美商薩羅塔治療公司 | 用於肌肉萎縮症之外顯子跳躍寡聚物 |
| SMT202200403T1 (it) | 2016-12-19 | 2022-11-18 | Sarepta Therapeutics Inc | Coniugati di oligomeri per salto di esone per distrofia muscolare |
| MX2019006882A (es) | 2016-12-19 | 2019-08-16 | Sarepta Therapeutics Inc | Conjugados de oligomeros de omision de exon para distrofia muscular. |
| CN110337308B (zh) | 2016-12-19 | 2023-09-01 | 萨勒普塔医疗公司 | 用于肌肉萎缩症的外显子跳跃寡聚体缀合物 |
| MX2019008199A (es) | 2017-01-06 | 2019-11-25 | Avidity Biosciences Llc | Composiciones de acido nucleico polipeptido y metodos de induccion de la omision de exon. |
| GB201711809D0 (en) | 2017-07-21 | 2017-09-06 | Governors Of The Univ Of Alberta | Antisense oligonucleotide |
| EA201991450A1 (ru) | 2017-09-22 | 2019-12-30 | Сарепта Терапьютикс, Инк. | Конъюгаты олигомеров для пропуска экзона при мышечной дистрофии |
| CN111770757A (zh) * | 2017-09-22 | 2020-10-13 | 艾维迪提生物科学公司 | 诱导外显子跳读的核酸-多肽组合物和方法 |
| WO2019113393A1 (en) | 2017-12-06 | 2019-06-13 | Avidity Biosciences Llc | Compositions and methods of treating muscle atrophy and myotonic dystrophy |
| US10758629B2 (en) | 2018-05-29 | 2020-09-01 | Sarepta Therapeutics, Inc. | Exon skipping oligomer conjugates for muscular dystrophy |
| US11168141B2 (en) | 2018-08-02 | 2021-11-09 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| SG11202100934PA (en) | 2018-08-02 | 2021-02-25 | Dyne Therapeutics Inc | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| US12018087B2 (en) | 2018-08-02 | 2024-06-25 | Dyne Therapeutics, Inc. | Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject |
| KR20210081324A (ko) | 2018-08-02 | 2021-07-01 | 다인 세라퓨틱스, 인크. | 근육 표적화 복합체 및 안면견갑상완 근육 이영양증을 치료하기 위한 그의 용도 |
| CN113286887A (zh) | 2018-11-02 | 2021-08-20 | 比奥马林技术公司 | 用于肌营养不良蛋白外显子跳跃的双特异性反义低聚核苷酸 |
| AU2020263487A1 (en) | 2019-04-25 | 2021-12-16 | Avidity Biosciences, Inc. | Nucleic acid compositions and methods of multi-exon skipping |
| EP4007633A4 (en) * | 2019-08-02 | 2024-05-08 | Research Institute at Nationwide Children's Hospital | EXON 44-TARGETED NUCLEIC ACIDS AND RECOMBINANT ADENOA-ASSOCIATED VIRUS FOR THE TREATMENT OF DYSTROPHIN-BASED MYOPATHIES |
| TW202144572A (zh) | 2020-03-19 | 2021-12-01 | 美商亞維代堤生物科學公司 | 治療臉肩胛肱骨肌肉失養症之組合物及方法 |
| EP4121088A4 (en) | 2020-03-20 | 2024-07-03 | Keros Therapeutics, Inc. | Methods of using activin receptor type iib variants |
| EP4330395A1 (en) | 2021-04-30 | 2024-03-06 | Sarepta Therapeutics, Inc. | Treatment methods for muscular dystrophy |
| US11771776B2 (en) | 2021-07-09 | 2023-10-03 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| AU2022309028A1 (en) | 2021-07-09 | 2024-01-25 | Dyne Therapeutics, Inc. | Muscle targeting complexes and formulations for treating dystrophinopathies |
| US11969475B2 (en) | 2021-07-09 | 2024-04-30 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy |
| US11638761B2 (en) | 2021-07-09 | 2023-05-02 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating Facioscapulohumeral muscular dystrophy |
| US20240390508A1 (en) | 2021-08-21 | 2024-11-28 | Takeda Pharmaceutical Company Limited | Human transferrin receptor binding peptide-drug conjugate |
| IL311025A (en) | 2021-08-24 | 2024-04-01 | Peptidream Inc | Human transferrin receptor-binding antibody-peptide conjugate |
| CN118265544A (zh) | 2021-09-16 | 2024-06-28 | 艾维迪提生物科学公司 | 治疗面肩肱型肌营养不良的组合物和方法 |
| WO2023127918A1 (ja) | 2021-12-27 | 2023-07-06 | 日本新薬株式会社 | オリゴ核酸化合物の製造方法 |
| EP4215614A1 (en) | 2022-01-24 | 2023-07-26 | Dynacure | Combination therapy for dystrophin-related diseases |
| EP4230196A1 (en) | 2022-02-21 | 2023-08-23 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of dystrophinopathies |
| WO2023168427A1 (en) | 2022-03-03 | 2023-09-07 | Yale University | Compositions and methods for delivering therapeutic polynucleotides for exon skipping |
| CA3252177A1 (en) | 2022-03-17 | 2023-09-21 | Sarepta Therapeutics, Inc. | MORPHOLINO PHOSPHORODIAMIDATE OLIGOMER CONJUGATE |
| US12071621B2 (en) | 2022-04-05 | 2024-08-27 | Avidity Biosciences, Inc. | Anti-transferrin receptor antibody-PMO conjugates for inducing DMD exon 44 skipping |
| WO2025174995A1 (en) * | 2024-02-13 | 2025-08-21 | Keros Therapeutics, Inc. | Methods of using activin a and myostatin signaling inhibitors |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2069869C (en) | 1989-12-20 | 1995-12-19 | James E. Summerton | Uncharged morpholino-based polymers having phosphorous-containing chiral intersubunit linkages |
| JP2924179B2 (ja) | 1993-02-19 | 1999-07-26 | 日本新薬株式会社 | グリセロール誘導体，デバイス及び医薬組成物 |
| FR2705361B1 (fr) * | 1993-05-18 | 1995-08-04 | Centre Nat Rech Scient | Vecteurs viraux et utilisation en thérapie génique. |
| CA2796924C (en) | 2002-11-25 | 2016-12-13 | Nonprofit Organization Translational Research Organization Of Duchenne Muscular Dystrophy | Ena nucleic acid pharmaceuticals capable of modifying splicing of mrna precursors |
| AU2003225410A1 (en) | 2003-03-21 | 2004-10-11 | Academisch Ziekenhuis Leiden | Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure |
| EP1766010B1 (en) * | 2004-06-28 | 2011-02-16 | The University Of Western Australia | Antisense oligonucleotides for inducing exon skipping and methods of use thereof |
| EP1857548A1 (en) | 2006-05-19 | 2007-11-21 | Academisch Ziekenhuis Leiden | Means and method for inducing exon-skipping |
| JP5143450B2 (ja) | 2007-03-14 | 2013-02-13 | 斉 大戸 | Ｈｌａ−ｂローカスにおける新規アリル |
| PL2203173T3 (pl) * | 2007-10-26 | 2016-06-30 | Academisch Ziekenhuis Leiden | Środki i sposoby przeciwdziałania zaburzeniom mięśni |
| MX2010004955A (es) | 2007-11-15 | 2010-06-30 | Avi Biopharma Inc | Metodo de sintesis de oligomeros de morfolina. |
| EP2119783A1 (en) | 2008-05-14 | 2009-11-18 | Prosensa Technologies B.V. | Method for efficient exon (44) skipping in Duchenne Muscular Dystrophy and associated means |
| US8084601B2 (en) | 2008-09-11 | 2011-12-27 | Royal Holloway And Bedford New College Royal Holloway, University Of London | Oligomers |
| KR20180118828A (ko) * | 2008-10-24 | 2018-10-31 | 사렙타 쎄러퓨틱스 인코퍼레이티드 | Dmd를 위한 다중 엑손 스키핑 조성물 |
| WO2010123369A1 (en) * | 2009-04-24 | 2010-10-28 | Prosensa Technologies B.V. | Oligonucleotide comprising an inosine for treating dmd |
| EP3431603A1 (en) | 2009-11-12 | 2019-01-23 | The University Of Western Australia | Antisense molecules and methods for treating pathologies |
| TWI541024B (zh) * | 2010-09-01 | 2016-07-11 | 日本新藥股份有限公司 | 反義核酸 |
| EP2672977A1 (en) | 2011-02-08 | 2013-12-18 | The Charlotte-Mecklenburg Hospital Authority d/b/a Carolina Healthcare System | Antisense oligonucleotides |
| CN104024414A (zh) | 2011-12-28 | 2014-09-03 | 日本新药株式会社 | 反义核酸 |
| JP2015509922A (ja) * | 2012-01-27 | 2015-04-02 | プロセンサ テクノロジーズ ビー．ブイ．Ｐｒｏｓｅｎｓａ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｂ．Ｖ． | デュシェンヌ型及びベッカー型筋ジストロフィーの治療のための改善された特徴を有するｒｎａ調節オリゴヌクレオチド |
| CN110257379B (zh) | 2012-07-03 | 2023-08-11 | 马林生物科技有限公司 | 用于治疗肌肉萎缩症患者的寡核苷酸 |
| JP2014124157A (ja) | 2012-12-27 | 2014-07-07 | Nihon Cornstarch Corp | コーヒー飲料 |
| LT3118311T (lt) | 2014-03-12 | 2019-04-10 | Nippon Shinyaku Co., Ltd. | Priešprasminė nukleorūgštis |
| MY194170A (en) * | 2014-06-17 | 2022-11-16 | Nippon Shinyaku Co Ltd | Antisense nucleic acids |
-
2015
- 2015-06-16 MY MYPI2016704648A patent/MY194170A/en unknown
- 2015-06-16 BR BR122020020864-3A patent/BR122020020864B1/pt active IP Right Grant
- 2015-06-16 UA UAA201700424A patent/UA121117C2/uk unknown
- 2015-06-16 RS RS20200002A patent/RS59764B1/sr unknown
- 2015-06-16 SM SM20200006T patent/SMT202000006T1/it unknown
- 2015-06-16 HU HUE15810097A patent/HUE047502T2/hu unknown
- 2015-06-16 JP JP2016529346A patent/JP6208349B2/ja active Active
- 2015-06-16 PT PT158100974T patent/PT3159409T/pt unknown
- 2015-06-16 EP EP19208809.4A patent/EP3660154B1/en active Active
- 2015-06-16 PL PL19208809.4T patent/PL3660154T3/pl unknown
- 2015-06-16 MY MYPI2022005307A patent/MY202674A/en unknown
- 2015-06-16 SG SG11201610130VA patent/SG11201610130VA/en unknown
- 2015-06-16 TW TW104119378A patent/TWI666317B/zh active
- 2015-06-16 LT LTEP15810097.4T patent/LT3159409T/lt unknown
- 2015-06-16 KR KR1020167036291A patent/KR102335810B1/ko active Active
- 2015-06-16 EP EP25170049.8A patent/EP4596047A3/en active Pending
- 2015-06-16 RU RU2017101172A patent/RU2695430C2/ru active
- 2015-06-16 MX MX2020004417A patent/MX420315B/es unknown
- 2015-06-16 CA CA2951221A patent/CA2951221A1/en active Pending
- 2015-06-16 ES ES15810097T patent/ES2765463T3/es active Active
- 2015-06-16 CN CN201580037016.2A patent/CN106661577B/zh active Active
- 2015-06-16 US US15/314,535 patent/US9840706B2/en active Active
- 2015-06-16 ES ES19208809T patent/ES3027057T3/es active Active
- 2015-06-16 AU AU2015277924A patent/AU2015277924B2/en active Active
- 2015-06-16 PL PL15810097T patent/PL3159409T3/pl unknown
- 2015-06-16 SG SG10201912858VA patent/SG10201912858VA/en unknown
- 2015-06-16 HR HRP20200042TT patent/HRP20200042T1/hr unknown
- 2015-06-16 CN CN202010289118.6A patent/CN111575282B/zh active Active
- 2015-06-16 TW TW108121749A patent/TWI721461B/zh active
- 2015-06-16 MX MX2016016526A patent/MX373052B/es active IP Right Grant
- 2015-06-16 BR BR112016029369-0A patent/BR112016029369B1/pt active IP Right Grant
- 2015-06-16 EP EP15810097.4A patent/EP3159409B1/en active Active
- 2015-06-16 WO PCT/JP2015/067238 patent/WO2015194520A1/ja not_active Ceased
- 2015-06-16 SI SI201531057T patent/SI3159409T1/sl unknown
- 2015-06-16 DK DK15810097.4T patent/DK3159409T3/da active
-
2016
- 2016-12-14 IL IL249574A patent/IL249574B/en active IP Right Grant
- 2016-12-14 PH PH12016502501A patent/PH12016502501A1/en unknown
-
2017
- 2017-01-06 ZA ZA2017/00142A patent/ZA201700142B/en unknown
- 2017-01-16 CO CONC2017/0000357A patent/CO2017000357A2/es unknown
- 2017-08-15 US US15/677,071 patent/US11193125B2/en active Active
- 2017-09-06 JP JP2017171127A patent/JP6701139B2/ja active Active
-
2020
- 2020-01-08 CY CY20201100011T patent/CY1122462T1/el unknown
- 2020-05-01 JP JP2020080938A patent/JP7041879B2/ja active Active
-
2021
- 2021-05-25 AU AU2021203383A patent/AU2021203383B2/en active Active
- 2021-11-02 US US17/517,006 patent/US12060556B2/en active Active
-
2022
- 2022-03-01 JP JP2022030557A patent/JP2022082539A/ja not_active Withdrawn
-
2023
- 2023-12-26 JP JP2023218761A patent/JP2024023899A/ja active Pending
-
2024
- 2024-02-27 AU AU2024201290A patent/AU2024201290A1/en active Pending
- 2024-08-12 US US18/800,306 patent/US20250084412A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PL3660154T3 (pl) | Antysensowne kwasy nukleinowe do zastosowania do leczenia dystrofii mięśniowej duchenne'a | |
| IL290160A (en) | Preparations and methods for the treatment of Duchenne muscular dystrophy and related disorders | |
| LT3118311T (lt) | Priešprasminė nukleorūgštis | |
| IL250448A0 (en) | Modified double helix RNA materials | |
| DK3604544T3 (en) | Improved methods for processing dna substrates | |
| SG11201802138TA (en) | Antisense nucleic acid | |
| IL258211A (en) | Methods for treating muscular dystrophy | |
| PL3094731T3 (pl) | Cząsteczki kwasu nukleinowego zmodyfikowane sacharydem | |
| SI3307296T1 (sl) | TIMP2 za uporabo pri zdravljenju s starostjo povezanih stanj | |
| GB201408841D0 (en) | Nucleic acid processing | |
| SG10201600867XA (en) | Nucleic acid extracting device | |
| IL238588A0 (en) | Anti-flt-1 antibodies in the treatment of Duchenne muscular dystrophy | |
| PL3307065T3 (pl) | Komórki chimeryczne związane z dystrofią mięśniową i sposób leczenia dystrofii mięśniowych | |
| PL3280734T3 (pl) | Przeciwciała anty-flt-1 do leczenia dystrofii mięśniowej duchenne'a | |
| SI3026116T1 (sl) | Oligonukleotidno zaporedje za uporabo v metabolnem inženiringu | |
| GB201516505D0 (en) | Antisense oligonucleotides | |
| GB201508733D0 (en) | Antisense oligonucleotides |