PL3645513T3 - Pochodne benzoazepiny - Google Patents

Pochodne benzoazepiny

Info

Publication number
PL3645513T3
PL3645513T3 PL18743103.6T PL18743103T PL3645513T3 PL 3645513 T3 PL3645513 T3 PL 3645513T3 PL 18743103 T PL18743103 T PL 18743103T PL 3645513 T3 PL3645513 T3 PL 3645513T3
Authority
PL
Poland
Prior art keywords
benzoazepine derivatives
benzoazepine
derivatives
Prior art date
Application number
PL18743103.6T
Other languages
English (en)
Inventor
Keizo Kan
Masatoshi TAKUWA
Hirotaka Tanaka
Hideto Fujiwara
Hokuto Yamabe
Satoshi Matsuda
Kazuhiro OHDACHI
Taiki HANARI
Yasuhiro Menjo
Tatsuya URUSHIMA
Shigekazu Fujita
Original Assignee
Otsuka Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co., Ltd. filed Critical Otsuka Pharmaceutical Co., Ltd.
Publication of PL3645513T3 publication Critical patent/PL3645513T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PL18743103.6T 2017-06-30 2018-06-29 Pochodne benzoazepiny PL3645513T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/JP2017/024211 WO2019003433A1 (ja) 2017-06-30 2017-06-30 ベンゾアゼピン誘導体
PCT/JP2018/024786 WO2019004421A1 (en) 2017-06-30 2018-06-29 BENZAZEPINE DERIVATIVES

Publications (1)

Publication Number Publication Date
PL3645513T3 true PL3645513T3 (pl) 2022-12-19

Family

ID=62976113

Family Applications (2)

Application Number Title Priority Date Filing Date
PL22164702.7T PL4056557T3 (pl) 2017-06-30 2018-06-29 Pochodne benzoazepiny użyteczne jako leki
PL18743103.6T PL3645513T3 (pl) 2017-06-30 2018-06-29 Pochodne benzoazepiny

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL22164702.7T PL4056557T3 (pl) 2017-06-30 2018-06-29 Pochodne benzoazepiny użyteczne jako leki

Country Status (23)

Country Link
US (4) US10889570B2 (pl)
EP (2) EP4056557B1 (pl)
JP (2) JP6688436B2 (pl)
KR (1) KR102632228B1 (pl)
CN (2) CN110891939A (pl)
AU (1) AU2018293081B2 (pl)
CA (1) CA3068396A1 (pl)
DK (2) DK4056557T3 (pl)
EA (1) EA202090131A1 (pl)
ES (2) ES2932854T3 (pl)
FI (1) FI4056557T3 (pl)
HR (2) HRP20221359T1 (pl)
HU (2) HUE060855T2 (pl)
IL (1) IL271665B2 (pl)
LT (2) LT4056557T (pl)
PH (1) PH12020500034A1 (pl)
PL (2) PL4056557T3 (pl)
PT (2) PT3645513T (pl)
SA (1) SA519410888B1 (pl)
SG (1) SG11201912757VA (pl)
SI (1) SI4056557T1 (pl)
TW (1) TWI798234B (pl)
WO (2) WO2019003433A1 (pl)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6868089B2 (ja) * 2018-12-28 2021-05-12 大塚製薬株式会社 医薬
CA3160645A1 (en) * 2019-11-07 2021-05-14 The Board Of Trustees Of The University Of Illinois Inhibitors of influenza viral entry
CN111450879A (zh) * 2020-05-08 2020-07-28 内蒙古自治区石油化工监督检验研究院 用于乙炔氢氯化反应的丙二胺改性低钌催化剂及制备方法
EP4253367A4 (en) * 2020-11-26 2024-10-23 Shanghai Jemincare Pharmaceuticals Co., Ltd. NOVEL BENZAZEPINESPIRO DERIVATIVE

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991005549A1 (en) 1989-10-20 1991-05-02 Otsuka Pharmaceutical Co., Ltd. Benzoheterocyclic compounds
US5985869A (en) * 1989-10-20 1999-11-16 Otsuka Pharmaceutical Company, Limited Benzoheterocyclic compounds
US5258510A (en) * 1989-10-20 1993-11-02 Otsuka Pharma Co Ltd Benzoheterocyclic compounds
JP2905909B2 (ja) 1991-04-19 1999-06-14 大塚製薬株式会社 バソプレシン拮抗剤
AU657424B2 (en) 1992-07-02 1995-03-09 Otsuka Pharmaceutical Co., Ltd. Oxytocin antagonist
JP2961291B2 (ja) * 1992-08-20 1999-10-12 大塚製薬株式会社 ベンゾヘテロ環化合物
EP0612319A1 (en) 1992-08-20 1994-08-31 Otsuka Pharmaceutical Co., Ltd. Benzoheterocyclic compounds as oxytocin and vasopressin antagonists
TW270927B (pl) 1992-10-16 1996-02-21 Otsuka Pharma Co Ltd
JP2913082B2 (ja) * 1992-10-16 1999-06-28 大塚製薬株式会社 バソプレシン拮抗剤及びオキシトシン拮抗剤
FI960867A7 (fi) * 1993-08-26 1996-02-26 Yamanouchi Pharma Co Ltd Bentsatsepiinijohdannainen, sen farmaseuttinen seos ja välituote
CA2192928C (en) 1994-06-15 2010-10-26 Hidenori Ogawa Benzoheterocyclic derivatives
JPH09221476A (ja) 1995-12-15 1997-08-26 Otsuka Pharmaceut Co Ltd 医薬組成物
JPH10120592A (ja) 1996-10-22 1998-05-12 Otsuka Pharmaceut Co Ltd メニエール病乃至メニエール症候群治療剤
AUPP150098A0 (en) * 1998-01-27 1998-02-19 Fujisawa Pharmaceutical Co., Ltd. Benzamide derivatives
JP4374088B2 (ja) * 1999-01-14 2009-12-02 東ソ−・エフテック株式会社 新規な4,4−ジフルオロベンゾアゼピンケタール誘導体、およびそれを経由する4,4−ジフルオロベンゾアゼピン−5−オン誘導体の製造方法
EP1627876A1 (en) * 2004-08-20 2006-02-22 Ferring B.V. Heterocyclic condensed compounds useful as antidiuretic agents
TWI459947B (zh) * 2007-06-26 2014-11-11 Otsuka Pharma Co Ltd 苯并氮呯化合物及藥學製劑
WO2011052519A1 (ja) 2009-10-26 2011-05-05 大塚製薬株式会社 ベンズアゼピン化合物
US8025813B2 (en) 2009-11-12 2011-09-27 Rohm And Haas Electronic Materials Cmp Holdings, Inc. Chemical mechanical polishing composition and methods relating thereto
EP2956441A4 (en) * 2013-02-18 2016-11-02 Scripps Research Inst MODULATORS OF VASOPRESSIN RECEPTORS WITH THERAPEUTIC POTENTIAL
TW201605488A (zh) 2013-10-15 2016-02-16 大塚製藥股份有限公司 用以預防及/或治療多囊腎病之藥物

Also Published As

Publication number Publication date
PH12020500034A1 (en) 2020-09-14
EP3645513A1 (en) 2020-05-06
US11673878B2 (en) 2023-06-13
HRP20221359T1 (hr) 2023-01-06
PT3645513T (pt) 2022-11-16
US20210078976A1 (en) 2021-03-18
LT3645513T (lt) 2022-11-25
DK3645513T3 (da) 2022-11-14
CA3068396A1 (en) 2019-01-03
ES2932854T3 (es) 2023-01-27
SA519410888B1 (ar) 2023-03-15
HUE065010T2 (hu) 2024-04-28
JP2020117525A (ja) 2020-08-06
KR20200020910A (ko) 2020-02-26
WO2019004421A1 (en) 2019-01-03
SI4056557T1 (sl) 2024-02-29
TWI798234B (zh) 2023-04-11
HUE060855T2 (hu) 2023-04-28
PL4056557T3 (pl) 2024-04-08
BR112019027678A2 (pt) 2020-09-15
EA202090131A1 (ru) 2020-04-14
PT4056557T (pt) 2023-12-15
AU2018293081A1 (en) 2019-12-19
IL271665A (en) 2020-02-27
ES2964569T3 (es) 2024-04-08
AU2018293081B2 (en) 2021-11-25
NZ759627A (en) 2025-07-25
IL271665B1 (en) 2023-01-01
US20250051310A1 (en) 2025-02-13
EP4056557B1 (en) 2023-11-22
LT4056557T (lt) 2023-12-27
US20190389838A1 (en) 2019-12-26
CN120025312A (zh) 2025-05-23
JP2020503346A (ja) 2020-01-30
EP3645513B1 (en) 2022-10-05
US20230265073A1 (en) 2023-08-24
JP7055160B2 (ja) 2022-04-15
US10889570B2 (en) 2021-01-12
TW201904946A (zh) 2019-02-01
DK4056557T3 (da) 2023-12-18
IL271665B2 (en) 2023-05-01
KR102632228B1 (ko) 2024-02-02
FI4056557T3 (fi) 2023-12-14
SG11201912757VA (en) 2020-01-30
WO2019003433A1 (ja) 2019-01-03
CN110891939A (zh) 2020-03-17
EP4056557A1 (en) 2022-09-14
HRP20231616T1 (hr) 2024-03-15
JP6688436B2 (ja) 2020-04-28

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