PL3644982T3 - Związki 3-hydroksymaślanu do zastosowania w redukowaniu tłuszczu wątrobowego - Google Patents
Związki 3-hydroksymaślanu do zastosowania w redukowaniu tłuszczu wątrobowegoInfo
- Publication number
- PL3644982T3 PL3644982T3 PL18737388.1T PL18737388T PL3644982T3 PL 3644982 T3 PL3644982 T3 PL 3644982T3 PL 18737388 T PL18737388 T PL 18737388T PL 3644982 T3 PL3644982 T3 PL 3644982T3
- Authority
- PL
- Poland
- Prior art keywords
- liver fat
- reducing liver
- hydroxybutyrate compounds
- hydroxybutyrate
- compounds
- Prior art date
Links
- WHBMMWSBFZVSSR-UHFFFAOYSA-N 3-hydroxybutyric acid Chemical class CC(O)CC(O)=O WHBMMWSBFZVSSR-UHFFFAOYSA-N 0.000 title 1
- 210000004185 liver Anatomy 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/30—Dietetic or nutritional methods, e.g. for losing weight
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Epidemiology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Food Science & Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Emergency Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Non-Alcoholic Beverages (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Meat, Egg Or Seafood Products (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1710229.4A GB201710229D0 (en) | 2017-06-27 | 2017-06-27 | Compounds for new use |
| PCT/GB2018/051752 WO2019002828A1 (en) | 2017-06-27 | 2018-06-22 | 3-HYDROXYBUTYRATE COMPOUNDS FOR USE IN THE REDUCTION OF HEPATIC FAT |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3644982T3 true PL3644982T3 (pl) | 2023-08-14 |
Family
ID=59523693
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL18737388.1T PL3644982T3 (pl) | 2017-06-27 | 2018-06-22 | Związki 3-hydroksymaślanu do zastosowania w redukowaniu tłuszczu wątrobowego |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US12439944B2 (https=) |
| EP (2) | EP4215189A1 (https=) |
| JP (2) | JP7374000B2 (https=) |
| KR (1) | KR102680437B1 (https=) |
| CN (1) | CN110869012B (https=) |
| AU (1) | AU2018293398B2 (https=) |
| CA (1) | CA3066948A1 (https=) |
| DK (1) | DK3644982T3 (https=) |
| ES (1) | ES2945964T3 (https=) |
| GB (2) | GB201710229D0 (https=) |
| PL (1) | PL3644982T3 (https=) |
| TW (1) | TWI811222B (https=) |
| WO (1) | WO2019002828A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201710229D0 (en) * | 2017-06-27 | 2017-08-09 | Tdeltas Ltd | Compounds for new use |
| GB201715654D0 (en) | 2017-09-27 | 2017-11-08 | Tdeltas Ltd | Method of treatment |
| GB2577723A (en) | 2018-10-04 | 2020-04-08 | Tdeltas Ltd | Compounds for new use |
| ES2941943T3 (es) | 2019-01-17 | 2023-05-26 | Ketolipix Therapeutics Gmbh | Método para la producción de glicéridos de ácidos hidroxicarboxílicos |
| CN109700021A (zh) * | 2019-03-04 | 2019-05-03 | 清华大学 | 3-羟基丁酸及其衍生物在制备预防和治疗肥胖及肥胖相关疾病的产品中的应用 |
| CN110776425B (zh) * | 2019-10-23 | 2021-02-26 | 清华大学 | 一种(r)-3-羟基丁酸及其低聚物的制备方法 |
| JP7638693B2 (ja) * | 2020-12-15 | 2025-03-04 | 大阪瓦斯株式会社 | ヒドロキシアルカン酸結晶の製造方法及びヒドロキシアルカン酸の結晶多形体 |
| US20240196917A1 (en) * | 2021-06-01 | 2024-06-20 | Osaka Gas Co., Ltd. | Oil and fat composition containing 3-hydroxybutyric acid |
| WO2023283654A1 (en) * | 2021-07-09 | 2023-01-12 | Georgia State University Research Foundation, Inc. | The use of beta-hydroxybutyrates for the treatment or prevention of aneurysms and dissections |
| IT202100020441A1 (it) * | 2021-07-30 | 2023-01-30 | Unichem Estense S R L | Miscela di un mono-estere e un di-estere, in cui detti mono-estere e di-estere sono esteri dell’acido (R)-3-idrossibutanoico con un polialcol, processo per la preparazione della miscela e relativi usi medici |
| CN113712140A (zh) * | 2021-09-13 | 2021-11-30 | 珠海麦得发生物科技股份有限公司 | 一种含(r)-3羟基丁酸的固体饮料及其制备方法 |
| AU2022381752B2 (en) * | 2021-11-04 | 2026-01-08 | Vdf Futureceuticals, Inc | Ketone precursors and methods therefor |
| CN118591523A (zh) * | 2021-11-12 | 2024-09-03 | 阿萨达股份公司 | 多元醇衍生的化合物 |
| AU2022411334A1 (en) * | 2021-12-14 | 2024-06-13 | Suntory Holdings Limited | Carbonated beverage, and method for enhancing sense of carbonation of beverage |
| CN118382365A (zh) * | 2021-12-14 | 2024-07-23 | 三得利控股株式会社 | 含有3羟基丁酸及低级脂肪族醇的饮料及呈味改善方法 |
| JP7223193B1 (ja) | 2022-05-26 | 2023-02-15 | 大阪瓦斯株式会社 | 内臓脂肪低減剤およびその用途 |
| CN116966173A (zh) * | 2023-06-15 | 2023-10-31 | 浙江大学 | 3-羟基苯乙酸在制备改善非酒精性脂肪肝药物中的应用 |
| CN118903420A (zh) * | 2024-07-02 | 2024-11-08 | 南方医科大学 | Irf4抑制剂在治疗非酒精性脂肪性肝炎的应用 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1248321B (it) * | 1991-05-15 | 1995-01-05 | Sigma Tau Ind Farmaceuti | Uso di esteri di acil l-carnitine con l'acido gamma-idrossibutirrico per produrre composizioni farmaceutiche per il trattamento di epatopatie |
| US6323237B1 (en) | 1997-03-17 | 2001-11-27 | Btg International Limited | Therapeutic compositions |
| US20090253781A1 (en) | 2002-05-24 | 2009-10-08 | Btg International Limited | Therapeutic compositions |
| CN1315473C (zh) | 1997-03-17 | 2007-05-16 | 英国技术集团国际有限公司 | 治疗组合物 |
| EP2258742A1 (en) * | 1997-12-22 | 2010-12-08 | Metabolix, Inc. | Polyhydroxyalkanoate compositons having controlled degradation rates |
| EP2275468A1 (en) * | 2000-07-14 | 2011-01-19 | Metabolix, Inc. | Polyurethanes obtained from hydroxyalkanoates and isocyanates |
| EP1648952B1 (en) * | 2003-06-03 | 2018-03-07 | THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | Nutritional supplements and therapeutic compositions comprising (r)-3-hydroxybutyrate derivatives |
| SE0400355D0 (sv) * | 2004-02-17 | 2004-02-17 | Synbiotics Ab | New synbiotec use |
| WO2006020137A2 (en) * | 2004-07-16 | 2006-02-23 | Ketocytonyx Inc. | Oligomeric compounds |
| EP1778615A4 (en) | 2004-07-20 | 2010-01-06 | Btg Int Ltd | OLIGOMERE KETONE COMPOUNDS |
| WO2008110034A1 (en) | 2007-03-14 | 2008-09-18 | Shantou University | 3-hydroxy fatty acid and its derivatives for improving of learning and/or memory of subjects |
| EP2240017B1 (en) | 2008-01-04 | 2019-03-13 | Oxford University Innovation Limited | Ketone bodies and ketone body esters as blood lipid lowering agents |
| US8642654B2 (en) | 2009-04-16 | 2014-02-04 | Isis Innovation Limited | Hydroxybutyrate ester and medical use thereof |
| JP5773870B2 (ja) * | 2008-08-21 | 2015-09-02 | アイシス イノヴェイション リミテッド | ヒドロキシ酪酸エステル及びその医学的使用 |
| WO2011078204A1 (ja) | 2009-12-24 | 2011-06-30 | 浜理薬品工業株式会社 | 高脂血症の予防または治療剤、および抗疲労剤 |
| US8865641B2 (en) * | 2011-06-16 | 2014-10-21 | The Feinstein Institute For Medical Research | Methods of treatment of fatty liver disease by pharmacological activation of cholinergic pathways |
| GB201206192D0 (en) | 2012-04-05 | 2012-05-23 | Tdeltas Ltd | Ketone bodies and ketone body esters and for maintaining or improving muscle power output |
| GB2515603B (en) | 2013-03-14 | 2015-10-14 | Isis Innovation | Process for producing (R)-3-Hydroxybutyl (R)-3-Hydroxybutyrate |
| CA2902603C (en) | 2013-03-19 | 2021-03-02 | University Of South Florida | Compositions and methods for producing elevated and sustained ketosis |
| IN2013MU01468A (https=) * | 2013-04-22 | 2015-04-17 | Cadila Healthcare Ltd | |
| US11814664B2 (en) * | 2013-05-24 | 2023-11-14 | Genomatica, Inc. | Microorganisms and methods for producing (3R)-hydroxybutyl (3R)-hydroxybutyrate |
| GB201314127D0 (en) | 2013-08-07 | 2013-09-18 | Tdeltas Ltd | Ketone body and ketone body ester for reducing muscle breakdown |
| US20150283163A1 (en) | 2014-04-04 | 2015-10-08 | Organic Medical Ventures, L.L.C. | Muscle treatment composition and method making same |
| US20180008629A1 (en) | 2015-01-29 | 2018-01-11 | Yale University | Compositions and Methods for Treating NLRP3 Inflammasome-Related Diseases and Disorders |
| EA201791982A1 (ru) * | 2015-03-09 | 2020-02-17 | Интекрин Терапьютикс, Инк. | Способы лечения неалкогольной жировой болезни печени и/или липодистрофии |
| CA3021784A1 (en) | 2016-04-19 | 2017-10-26 | Keto Patent Group, Inc. | Administration of butyrate, beta-hydroxybutyrate, and related compounds in humans |
| US10336812B2 (en) * | 2016-05-10 | 2019-07-02 | Janssen Biotech, Inc. | GDF15 fusion proteins and uses thereof |
| GB201710229D0 (en) | 2017-06-27 | 2017-08-09 | Tdeltas Ltd | Compounds for new use |
-
2017
- 2017-06-27 GB GBGB1710229.4A patent/GB201710229D0/en not_active Ceased
-
2018
- 2018-06-22 PL PL18737388.1T patent/PL3644982T3/pl unknown
- 2018-06-22 EP EP23161905.7A patent/EP4215189A1/en active Pending
- 2018-06-22 US US16/626,293 patent/US12439944B2/en active Active
- 2018-06-22 CA CA3066948A patent/CA3066948A1/en active Pending
- 2018-06-22 GB GB1810300.2A patent/GB2567273B/en active Active
- 2018-06-22 AU AU2018293398A patent/AU2018293398B2/en active Active
- 2018-06-22 KR KR1020207002473A patent/KR102680437B1/ko active Active
- 2018-06-22 ES ES18737388T patent/ES2945964T3/es active Active
- 2018-06-22 DK DK18737388.1T patent/DK3644982T3/da active
- 2018-06-22 CN CN201880042880.5A patent/CN110869012B/zh active Active
- 2018-06-22 JP JP2019572783A patent/JP7374000B2/ja active Active
- 2018-06-22 EP EP18737388.1A patent/EP3644982B1/en active Active
- 2018-06-22 WO PCT/GB2018/051752 patent/WO2019002828A1/en not_active Ceased
- 2018-06-22 TW TW107121496A patent/TWI811222B/zh active
-
2023
- 2023-06-30 JP JP2023107837A patent/JP7632979B2/ja active Active
-
2025
- 2025-09-18 US US19/332,258 patent/US20260007157A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US12439944B2 (en) | 2025-10-14 |
| AU2018293398A1 (en) | 2020-01-16 |
| TW201904568A (zh) | 2019-02-01 |
| JP2023120442A (ja) | 2023-08-29 |
| KR102680437B1 (ko) | 2024-07-01 |
| EP4215189A1 (en) | 2023-07-26 |
| AU2018293398B2 (en) | 2023-11-23 |
| JP7632979B2 (ja) | 2025-02-19 |
| ES2945964T3 (es) | 2023-07-11 |
| GB201810300D0 (en) | 2018-08-08 |
| JP7374000B2 (ja) | 2023-11-06 |
| EP3644982A1 (en) | 2020-05-06 |
| CA3066948A1 (en) | 2019-01-03 |
| KR20200019745A (ko) | 2020-02-24 |
| GB2567273A (en) | 2019-04-10 |
| TWI811222B (zh) | 2023-08-11 |
| CN110869012A (zh) | 2020-03-06 |
| CN110869012B (zh) | 2024-06-11 |
| DK3644982T3 (da) | 2023-07-17 |
| JP2020527547A (ja) | 2020-09-10 |
| US20200113220A1 (en) | 2020-04-16 |
| GB2567273B (en) | 2020-10-07 |
| WO2019002828A1 (en) | 2019-01-03 |
| US20260007157A1 (en) | 2026-01-08 |
| GB201710229D0 (en) | 2017-08-09 |
| EP3644982B1 (en) | 2023-04-12 |
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