PL360290A1 - Imidazopyridine and imidazopyrimidine antiviral agents - Google Patents

Imidazopyridine and imidazopyrimidine antiviral agents

Info

Publication number
PL360290A1
PL360290A1 PL36029001A PL36029001A PL360290A1 PL 360290 A1 PL360290 A1 PL 360290A1 PL 36029001 A PL36029001 A PL 36029001A PL 36029001 A PL36029001 A PL 36029001A PL 360290 A1 PL360290 A1 PL 360290A1
Authority
PL
Poland
Prior art keywords
imidazopyridine
antiviral agents
imidazopyrimidine
imidazopyrimidine antiviral
agents
Prior art date
Application number
PL36029001A
Other languages
English (en)
Polish (pl)
Inventor
Kuo-Long Yu
Rita L. Civiello
Keith D. Combrink
Hatice Belgin Gulgeze
Ny Sin
Xiangdong Wang
Nicholas A. Meanwell
Brian Lee Venables
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of PL360290A1 publication Critical patent/PL360290A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PL36029001A 2000-06-13 2001-05-08 Imidazopyridine and imidazopyrimidine antiviral agents PL360290A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21144700P 2000-06-13 2000-06-13
US26336301P 2001-01-22 2001-01-22
PCT/US2001/014775 WO2001095910A1 (en) 2000-06-13 2001-05-08 Imidazopyridine and imidazopyrimidine antiviral agents

Publications (1)

Publication Number Publication Date
PL360290A1 true PL360290A1 (en) 2004-09-06

Family

ID=26906145

Family Applications (1)

Application Number Title Priority Date Filing Date
PL36029001A PL360290A1 (en) 2000-06-13 2001-05-08 Imidazopyridine and imidazopyrimidine antiviral agents

Country Status (20)

Country Link
US (1) US6489338B2 (OSRAM)
EP (1) EP1311268A4 (OSRAM)
JP (1) JP2004503501A (OSRAM)
KR (1) KR20030008151A (OSRAM)
CN (1) CN1436079A (OSRAM)
AR (1) AR029128A1 (OSRAM)
AU (2) AU2001272906B2 (OSRAM)
BR (1) BR0111569A (OSRAM)
CA (1) CA2412327A1 (OSRAM)
CZ (1) CZ20024078A3 (OSRAM)
HU (1) HUP0400766A2 (OSRAM)
IL (1) IL152889A0 (OSRAM)
MX (1) MXPA02012204A (OSRAM)
NO (1) NO20025977L (OSRAM)
NZ (1) NZ523566A (OSRAM)
PE (1) PE20011348A1 (OSRAM)
PL (1) PL360290A1 (OSRAM)
RU (1) RU2003100828A (OSRAM)
UY (1) UY26758A1 (OSRAM)
WO (1) WO2001095910A1 (OSRAM)

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WO2003049688A2 (en) * 2001-12-10 2003-06-19 Bristol-Myers Squibb Company Bis hydrochloride monohydrate salt of rsv fusion inhibitor
US6919331B2 (en) * 2001-12-10 2005-07-19 Bristol-Myers Squibb Company Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents
WO2004043913A2 (en) * 2002-11-08 2004-05-27 Trimeris, Inc. Hetero-substituted benzimidazole compounds and antiviral uses thereof
WO2005016275A2 (en) * 2003-08-05 2005-02-24 3M Innovative Properties Company Formulations containing an immune response modifier
EP1682547B1 (en) 2003-10-30 2012-10-24 Boehringer Ingelheim (Canada) Ltd. Rsv polymerase inhibitors
NZ551468A (en) 2003-12-24 2010-05-28 Biota Scient Management Polycyclic agents for the treatment of respiratory syncytial virus infections
GB0406282D0 (en) * 2004-03-19 2004-04-21 Arrow Therapeutics Ltd Therapeutic compounds
GB0406279D0 (en) * 2004-03-19 2004-04-21 Arrow Therapeutics Ltd Therapeutic compounds
CN101027303A (zh) 2004-07-27 2007-08-29 吉里德科学公司 咪唑并[4，5－d]嘧啶类、其应用和制备方法
CN101203507B (zh) 2005-06-20 2012-05-23 泰博特克药品有限公司 2-取代的苯并咪唑
US8034835B2 (en) 2005-06-20 2011-10-11 Tibotec Pharmaceuticals Ltd. 1-[[2-amino-3-(substituted alkyl)-3H-benzimidazolyl[methyl]-3-substituted-1,3-dihydro-benzoimidazol-2-ones and structural analogs
JP5094716B2 (ja) 2005-06-20 2012-12-12 テイボテク・フアーマシユーチカルズ ヘテロシクリルアミノアルキル置換ベンズイミダゾール
TWI423972B (zh) 2006-09-28 2014-01-21 Biota Scient Management 治療呼吸系融合細胞病毒感染之多環劑
WO2009084544A1 (ja) * 2007-12-27 2009-07-09 Idemitsu Kosan Co., Ltd. 含窒素複素環誘導体及びそれを用いた有機エレクトロルミネッセンス素子
US20100278835A1 (en) 2009-03-10 2010-11-04 Astrazeneca Uk Limited Novel compounds 660
RU2407738C1 (ru) * 2009-07-03 2010-12-27 Общество с ограниченной ответственностью "Интеллектуальный Диалог" Противовирусный активный компонент, фармацевтическая композиция, лекарственное средство, способ лечения вирусных заболеваний
TWI508968B (zh) 2010-02-08 2015-11-21 Biota Scient Management 用於治療呼吸道融合性病毒感染的化合物
WO2011115150A1 (ja) * 2010-03-18 2011-09-22 興和株式会社 ベンゾチアジン化合物の製造方法
US8796303B2 (en) 2010-11-26 2014-08-05 Biota Scientific Management Pty Ltd. Imidazo[2,1-G][1,7]naphthyridines for treating respiratory syncytial virus infections
TWI527814B (zh) 2010-12-16 2016-04-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類
TWI501967B (zh) 2010-12-16 2015-10-01 Janssen R&D Ireland 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類
TWI541241B (zh) * 2010-12-16 2016-07-11 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類
TWI530495B (zh) * 2010-12-16 2016-04-21 健生科學愛爾蘭無限公司 苯并咪唑呼吸道融合病毒抑制劑
TWI515187B (zh) 2010-12-16 2016-01-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之吲哚類
CN103860538B (zh) * 2011-03-23 2016-03-02 上海市第一人民医院 靶向人La蛋白的先导化合物及其在制备抗乙型肝炎病毒的药物中的用途
WO2013186229A1 (en) * 2012-06-11 2013-12-19 Ucb Pharma S.A. Tnf -alpha modulating benzimidazoles
KR102092612B1 (ko) * 2012-06-15 2020-03-25 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 호흡기 합포체 바이러스의 항바이러스제로서의 헤테로사이클로 치환된 1,3-디하이드로-2h-벤즈이미다졸-2-온 유도체
CA2873916A1 (en) * 2012-06-15 2013-12-19 Janssen R&D Ireland 4-substituted 1,3-dihydro-2h-benzimidazol-2-one derivatives substituted with benzimidazoles as respiratory syncytial virus antivira agents
JP2015523350A (ja) * 2012-06-15 2015-08-13 ヤンセン・アールアンドデイ・アイルランド Ｒｓウイルス抗ウイルス薬としての、ベンゾイミダゾールによって置換された新規１，３−ジヒドロ−２ｈ−ベンゾイミダゾル−２−オン誘導体
WO2013186335A1 (en) * 2012-06-15 2013-12-19 Janssen R&D Ireland 1,3 -dihydro-2h-benzimidazol-2-one derivatives substituted with heterocycles as respiratory syncytial virus antiviral agents
MY172021A (en) * 2012-10-16 2019-11-12 Janssen Sciences Ireland Uc Rsv antiviral compounds
JP2016145155A (ja) * 2013-04-30 2016-08-12 日本農薬株式会社 フタルアミド誘導体及び該誘導体を含有する農園芸用殺虫剤並びにその使用方法
BR112016009757A8 (pt) * 2013-10-29 2018-01-30 Medivir Ab “inibidores do vírus sincicial respiratório com base em quinazolina”
WO2015065336A1 (en) * 2013-10-29 2015-05-07 Medivir Ab Respiratory syncytial virus inhibitors
CA3008653A1 (en) * 2015-10-14 2017-04-20 Zibo Biopolar Changsheng Pharmaceutical Co. Ltd. Bruton's tyrosine kinase inhibitors
WO2019046364A1 (en) * 2017-08-29 2019-03-07 Emory University INHIBITORS OF SYNCYTIAL RESPIRATORY VIRUS (RSV) REPLICATION AND USES THEREOF
MX2022005257A (es) * 2019-10-30 2022-06-09 Janssen Sciences Ireland Unlimited Co Sintesis de 3-({5-cloro-1-[3-(metilsulfonil)propil]-1h-indol-2-il} metil)-1-(2,2,2-trifluoroetil)-1,3-dihidro-2h-imidazo[4,5-c]pirid in-2-ona.
CN114630820B (zh) * 2019-10-30 2023-10-31 杨森科学爱尔兰无限公司 3-硝基-n-(2,2,2-三氟乙基)-4-吡啶胺的合成
EP4165034A1 (en) 2020-06-11 2023-04-19 Janssen Sciences Ireland Unlimited Company Hemi (l)-tartrate forms of 3-({5-chloro-1-[3-(methylsulfonyl)propyl]-1h-indol-2 yl} methyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2h-imidazo[4,5-c]pyridin-2-one and pharmaceutical compositions comprising the same
WO2022184606A1 (en) * 2021-03-01 2022-09-09 Janssen Sciences Ireland Unlimited Company Synthesis of rilematovir
JP2025502943A (ja) * 2022-01-28 2025-01-30 インシリコ メディシン アイピー リミテッド エクトヌクレオチドピロホスファターゼ－ホスホジエステラーゼ１（ｅｎｐｐ１）阻害剤およびその使用
WO2025026383A1 (en) * 2023-08-02 2025-02-06 Insilico Medicine Ip Limited Crytsalline forms of ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp1) inhibitors and uses thereof

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US4324794A (en) 1980-08-26 1982-04-13 Research Triangle Institute Inhibition of respiratory syncytial virus-induced cell fusion by amidino compounds
DK154078C (da) 1981-02-06 1989-05-22 Ucb Sa Analogifremgangsmaade til fremstilling af 2-(2-(4-(diphenyl-methyl)-1-piperazinyl)ethoxy)-acetamider eller syreadditionssalte heraf
US5256668A (en) 1993-03-17 1993-10-26 American Home Products Corporation Aminopyrimidine derivatives as antiviral agents for respiratory syncytial virus
BR9700939A (pt) 1996-02-13 1998-09-01 American Cyanamid Co Compostos aniônicos contendo traiazina úteis como agentes antivirais
BR9908522A (pt) 1998-01-29 2001-10-02 Viropharma Inc Composto, pró-droga, intermediário para a preparação de um composto, composição farmacêutica, processos para tratar e prevenir infecção por pneumovìrus, para tratar células em cultura, para tratar materiais biológicos, e, para preparar um composto
CA2338147A1 (en) 1998-07-20 2000-02-03 Kuo-Long Yu Substituted benzimidazole antiviral agents
HRP20010934A2 (en) 1999-06-28 2003-06-30 Janssen Pharmaceutica Nv Respiratory syncytial virus replication inhibitors

Also Published As

Publication number Publication date
AU7290601A (en) 2001-12-24
NO20025977D0 (no) 2002-12-12
RU2003100828A (ru) 2004-06-27
KR20030008151A (ko) 2003-01-24
AR029128A1 (es) 2003-06-04
UY26758A1 (es) 2002-01-31
CN1436079A (zh) 2003-08-13
WO2001095910A1 (en) 2001-12-20
EP1311268A4 (en) 2004-06-30
BR0111569A (pt) 2003-04-29
NO20025977L (no) 2003-01-29
PE20011348A1 (es) 2002-02-07
HUP0400766A2 (hu) 2004-07-28
IL152889A0 (en) 2003-06-24
US6489338B2 (en) 2002-12-03
NZ523566A (en) 2004-08-27
CA2412327A1 (en) 2001-12-20
US20020016309A1 (en) 2002-02-07
MXPA02012204A (es) 2003-10-15
JP2004503501A (ja) 2004-02-05
AU2001272906B2 (en) 2004-08-26
EP1311268A1 (en) 2003-05-21
CZ20024078A3 (cs) 2003-08-13

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