PL3591057T3 - Indukowalny układ do koekspresji - Google Patents

Indukowalny układ do koekspresji

Info

Publication number
PL3591057T3
PL3591057T3 PL19187102.9T PL19187102T PL3591057T3 PL 3591057 T3 PL3591057 T3 PL 3591057T3 PL 19187102 T PL19187102 T PL 19187102T PL 3591057 T3 PL3591057 T3 PL 3591057T3
Authority
PL
Poland
Prior art keywords
inducible coexpression
coexpression system
inducible
coexpression
Prior art date
Application number
PL19187102.9T
Other languages
English (en)
Inventor
Sean Mcclain
Mark VALASEK
Original Assignee
Absci Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Absci Corporation filed Critical Absci Corporation
Publication of PL3591057T3 publication Critical patent/PL3591057T3/pl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6429—Thrombin (3.4.21.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0051—Oxidoreductases (1.) acting on a sulfur group of donors (1.8)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y108/00—Oxidoreductases acting on sulfur groups as donors (1.8)
    • C12Y108/01—Oxidoreductases acting on sulfur groups as donors (1.8) with NAD+ or NADP+ as acceptor (1.8.1)
    • C12Y108/01007—Glutathione-disulfide reductase (1.8.1.7), i.e. glutathione reductase (NADPH)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y503/00—Intramolecular oxidoreductases (5.3)
    • C12Y503/04—Intramolecular oxidoreductases (5.3) transposing S-S bonds (5.3.4)
    • C12Y503/04001—Protein disulfide-isomerase (5.3.4.1), i.e. disufide bond-forming enzyme
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
    • C12Y603/02—Acid—amino-acid ligases (peptide synthases)(6.3.2)
    • C12Y603/02003—Glutathione synthase (6.3.2.3)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Two-Way Televisions, Distribution Of Moving Picture Or The Like (AREA)
  • Circuit Arrangement For Electric Light Sources In General (AREA)
  • Slot Machines And Peripheral Devices (AREA)
PL19187102.9T 2012-08-05 2013-08-05 Indukowalny układ do koekspresji PL3591057T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261679751P 2012-08-05 2012-08-05
US201261747246P 2012-12-29 2012-12-29

Publications (1)

Publication Number Publication Date
PL3591057T3 true PL3591057T3 (pl) 2023-10-02

Family

ID=49111529

Family Applications (1)

Application Number Title Priority Date Filing Date
PL19187102.9T PL3591057T3 (pl) 2012-08-05 2013-08-05 Indukowalny układ do koekspresji

Country Status (12)

Country Link
US (8) US9617335B2 (pl)
EP (4) EP3591057B9 (pl)
JP (3) JP6457387B2 (pl)
CN (2) CN104603274B (pl)
AU (3) AU2013299910B2 (pl)
CA (1) CA2880285C (pl)
DK (2) DK2880168T3 (pl)
ES (3) ES2750005T3 (pl)
HK (1) HK1210804A1 (pl)
IL (3) IL236975B (pl)
PL (1) PL3591057T3 (pl)
WO (1) WO2014025663A1 (pl)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013176916A1 (en) 2012-05-25 2013-11-28 Roman Galetto Use of pre t alpha or functional variant thereof for expanding tcr alpha deficient t cells
US20180282405A1 (en) * 2012-08-05 2018-10-04 Absci, Llc Cytoplasmic expression system
US20150353940A1 (en) * 2013-08-05 2015-12-10 Absci, Llc Vectors for use in an inducible coexpression system
US11077144B2 (en) 2013-05-13 2021-08-03 Cellectis CD19 specific chimeric antigen receptor and uses thereof
JP6788255B2 (ja) * 2015-11-19 2020-11-25 国立大学法人信州大学 新規ベクター及びこれを用いた可溶化タンパク質の製造方法
CN106190940B (zh) * 2016-07-19 2019-06-14 北京三元基因药业股份有限公司 表达抗TNF抗体Fab片段的重组大肠杆菌工程菌
HRP20191966T4 (hr) 2016-09-13 2022-09-16 Allergan, Inc. Stabilizirani neproteinski klostridijalni pripravci toksina
WO2019175881A1 (en) * 2018-03-14 2019-09-19 Technion Research & Development Foundation Limited A prognostic biomarker in cancer
JP7174990B2 (ja) * 2018-07-23 2022-11-18 国立大学法人山口大学 原核生物用発現ベクター
BR112021005634A2 (pt) 2018-09-25 2021-06-29 Absci, Llc métodos de purificação de proteína
JP7426389B2 (ja) * 2018-11-08 2024-02-01 ストロ バイオファーマ， インコーポレイテッド 酸化的細胞質を有する大腸菌株
CN109371049A (zh) * 2018-11-14 2019-02-22 天津大学 分子伴侣在促进单克隆抗体的形成和/或提高单克隆抗体的表达量中的应用
CN111269294B (zh) * 2018-12-05 2023-03-28 广州中国科学院先进技术研究所 纤维寡糖转运蛋白LacY的突变位点、突变转运蛋白LacY及其制备方法和应用
CN114008197A (zh) * 2019-04-04 2022-02-01 布拉斯科公司 用于同时消耗木糖和葡萄糖以从第二代糖产生化学物质的代谢工程
CN110616181A (zh) * 2019-09-27 2019-12-27 北京理工大学 一株基于大肠杆菌改造的工程菌株
CN112980891B (zh) * 2019-12-16 2023-12-12 中国科学院分子植物科学卓越创新中心 一种基于CRISPR-Cas的大肠杆菌基因组编辑工具
CN113122552B (zh) * 2021-04-21 2022-07-26 西北农林科技大学 黄瓜谷氧还蛋白基因CsGRX4及其灰霉菌感病性的应用
IL311389A (en) 2021-09-17 2024-05-01 Absci Corp Transfer RNA composition and use in the production of proteins containing non-standard amino acids
WO2024006269A1 (en) * 2022-06-29 2024-01-04 Absci Corporation Affinity screening method
WO2024040020A1 (en) 2022-08-15 2024-02-22 Absci Corporation Quantitative affinity activity specific cell enrichment
WO2024137918A1 (en) 2022-12-21 2024-06-27 Donald Danforth Plant Science Center Antimicrobial peptides and modifications thereof
CN116875524B (zh) * 2023-09-08 2024-03-26 清华大学 一种在微生物中调控多基因表达的方法及其应用

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2660397A (en) 1996-04-05 1997-10-29 Board Of Regents, The University Of Texas System Methods for producing soluble, biologically-active disulfide bond-containing eukaryotic proteins in bacterial cells
US6083715A (en) * 1997-06-09 2000-07-04 Board Of Regents, The University Of Texas System Methods for producing heterologous disulfide bond-containing polypeptides in bacterial cells
CN1064052C (zh) * 1997-09-29 2001-04-04 中国科学院微生物研究所 甲状旁腺素相关蛋白人源化抗体及其制备方法
US6872563B1 (en) * 1999-10-05 2005-03-29 President And Fellows Of Harvard College Compositions and methods for production of disulfide bond containing proteins in host cells
DE60131261T2 (de) 2000-03-24 2008-09-04 Xoma Technology Ltd., Berkeley Verbesserte verfahren und zellen zur expression von rekombinanter proteinprodukte
US6979556B2 (en) * 2000-12-14 2005-12-27 Genentech, Inc. Separate-cistron contructs for secretion of aglycosylated antibodies from prokaryotes
MXPA04001566A (es) * 2001-08-27 2004-05-17 Genentech Inc Un sistema para expresion y ensamblado de anticuerpos.
EP1511772B1 (en) * 2002-05-28 2011-11-23 Omrix Biopharmaceuticals Inc. Method for obtaining anti-idiotype antibodies
EP1539794B1 (en) * 2002-07-03 2008-12-31 Dow Global Technologies Inc. Benzoate- and anthranilate-inducible promoters
DK1570060T3 (da) * 2002-12-02 2007-11-05 Basf Ag L-rhamnoseinducerbare ekspressionssystemer
AU2006255060B2 (en) * 2005-06-06 2012-08-30 Pelican Technology Holdings, Inc. Mannitol induced promoter systems in bacterial host cells
US7351563B2 (en) 2005-06-10 2008-04-01 The Board Of Trustees Of The Leland Stanford Junior University Cell-free extracts and synthesis of active hydrogenase
US8178338B2 (en) 2005-07-01 2012-05-15 The Regents Of The University Of California Inducible expression vectors and methods of use thereof
JP4270466B2 (ja) * 2005-09-02 2009-06-03 国立大学法人福井大学 ＮＡＤａｓｅ、ＳＮＩおよびＳＬＯ遺伝子を含むオペロンから発現するタンパク質の製造方法、それにより得られるタンパク質およびその使用
US7816117B2 (en) 2006-04-26 2010-10-19 President And Fellows Of Harvard College Prokaryotic host cells for expressing proteins rich in disulfide bonds
EP2155868A2 (en) * 2007-04-19 2010-02-24 Codon Devices, Inc Engineered nucleases and their uses for nucleic acid assembly
EP2155789B1 (en) 2007-05-01 2013-07-24 Research Development Foundation Immunoglobulin fc libraries
JP5667880B2 (ja) 2008-01-03 2015-02-12 コーネル リサーチ ファンデーション インコーポレイテッド 原核生物におけるグリコシル化されたタンパク質の発現方法
FI20095615A0 (fi) * 2009-06-02 2009-06-02 Oulun Yliopisto Menetelmä luonnollisesti laskostuneiden proteiinien tuottamiseksi prokaryootti-isännässä
WO2011116184A2 (en) * 2010-03-17 2011-09-22 Cornell University Methods and compositions for targeted mutagenesis in bacteria
EP2386641A1 (en) * 2010-05-11 2011-11-16 Université Catholique De Louvain Method for extracellular production of recombinant biomolecules in a microorganism
FI20115115A0 (fi) 2011-02-04 2011-02-04 Oulun Yliopisto Menetelmä disulfidisidoksia sisältävien proteiinien tuottamiseksi prokaryoottisytoplasmassa

Also Published As

Publication number Publication date
US10604761B2 (en) 2020-03-31
US20170159061A1 (en) 2017-06-08
US20160152701A1 (en) 2016-06-02
AU2013299910B2 (en) 2019-01-24
ES2621320T3 (es) 2017-07-03
JP2022068332A (ja) 2022-05-09
JP2019068830A (ja) 2019-05-09
CN104603274A (zh) 2015-05-06
AU2013299910A1 (en) 2015-03-12
JP2015524281A (ja) 2015-08-24
EP3591057C0 (en) 2023-06-07
US20200032276A1 (en) 2020-01-30
DK3187586T3 (da) 2019-10-14
US11214807B2 (en) 2022-01-04
CA2880285A1 (en) 2014-02-13
US20200063116A1 (en) 2020-02-27
AU2019202844B2 (en) 2022-03-17
IL276141A (en) 2020-09-30
US20230340501A1 (en) 2023-10-26
IL264384B (en) 2020-08-31
IL236975B (en) 2019-06-30
ES2750005T3 (es) 2020-03-24
CN111748510A (zh) 2020-10-09
EP4273257A3 (en) 2024-02-28
EP3187586B1 (en) 2019-09-25
CN104603274B (zh) 2020-08-18
AU2019202844A1 (en) 2019-05-16
EP3187586A1 (en) 2017-07-05
EP3591057B1 (en) 2023-06-07
WO2014025663A1 (en) 2014-02-13
AU2022204192A1 (en) 2022-07-07
EP2880168A1 (en) 2015-06-10
CA2880285C (en) 2022-11-01
EP3591057A1 (en) 2020-01-08
ES2954516T3 (es) 2023-11-22
IL236975A0 (en) 2015-03-31
IL276141B (en) 2022-03-01
IL264384A (en) 2019-02-28
EP3591057B9 (en) 2023-07-19
EP4273257A2 (en) 2023-11-08
US20200172915A1 (en) 2020-06-04
US20220090093A1 (en) 2022-03-24
JP7032292B2 (ja) 2022-03-08
CN111748510B (zh) 2023-08-15
EP2880168B1 (en) 2017-01-11
US10465197B2 (en) 2019-11-05
JP6457387B2 (ja) 2019-01-23
DK2880168T3 (en) 2017-04-18
US11447781B2 (en) 2022-09-20
US20150225731A1 (en) 2015-08-13
HK1210804A1 (en) 2016-05-06
US9617335B2 (en) 2017-04-11

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