PL358877A1 - Pochodne 2-acyloindolu i ich zastosowanie jako środków przeciwnowotworowych - Google Patents
Pochodne 2-acyloindolu i ich zastosowanie jako środków przeciwnowotworowychInfo
- Publication number
- PL358877A1 PL358877A1 PL01358877A PL35887701A PL358877A1 PL 358877 A1 PL358877 A1 PL 358877A1 PL 01358877 A PL01358877 A PL 01358877A PL 35887701 A PL35887701 A PL 35887701A PL 358877 A1 PL358877 A1 PL 358877A1
- Authority
- PL
- Poland
- Prior art keywords
- tumour agents
- indol derivatives
- acyl indol
- acyl
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2000120852 DE10020852A1 (de) | 2000-04-28 | 2000-04-28 | 2-Acryl-indolderivate und deren Verwendung als Antitumormittel |
DE2001102629 DE10102629A1 (de) | 2001-01-20 | 2001-01-20 | 2-Acyl-indolderivate und deren Verwendung als Antitumormittel |
Publications (1)
Publication Number | Publication Date |
---|---|
PL358877A1 true PL358877A1 (pl) | 2004-08-23 |
Family
ID=26005501
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL01358877A PL358877A1 (pl) | 2000-04-28 | 2001-04-27 | Pochodne 2-acyloindolu i ich zastosowanie jako środków przeciwnowotworowych |
Country Status (27)
Country | Link |
---|---|
US (2) | US20020091124A1 (pl) |
EP (1) | EP1276720B1 (pl) |
JP (1) | JP2004501092A (pl) |
KR (1) | KR20030024661A (pl) |
CN (1) | CN1286810C (pl) |
AR (1) | AR029915A1 (pl) |
AT (1) | ATE348805T1 (pl) |
AU (1) | AU783459B2 (pl) |
BG (1) | BG107309A (pl) |
BR (1) | BR0110414A (pl) |
CA (1) | CA2407677A1 (pl) |
CZ (1) | CZ20023544A3 (pl) |
DE (1) | DE50111690D1 (pl) |
EE (1) | EE200200607A (pl) |
GE (1) | GEP20063751B (pl) |
HK (1) | HK1054549B (pl) |
HR (1) | HRP20020940A2 (pl) |
HU (1) | HUP0300480A3 (pl) |
IL (1) | IL152477A0 (pl) |
IS (1) | IS6594A (pl) |
MX (1) | MXPA02010627A (pl) |
NO (1) | NO20025150L (pl) |
NZ (1) | NZ522246A (pl) |
PL (1) | PL358877A1 (pl) |
RU (1) | RU2002132253A (pl) |
SK (1) | SK15432002A3 (pl) |
WO (1) | WO2001082909A2 (pl) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7030123B2 (en) | 2000-05-31 | 2006-04-18 | Astrazeneca Ab | Indole derivatives with vascular damaging activity |
US7005445B2 (en) | 2001-10-22 | 2006-02-28 | The Research Foundation Of State University Of New York | Protein kinase and phosphatase inhibitors and methods for designing them |
DE10152306A1 (de) * | 2001-10-26 | 2003-07-24 | Asta Medica Ag | 2-Acylindolderivate mit neuen therapeutisch wertvollen Eigenschaften |
US7125906B2 (en) | 2002-04-03 | 2006-10-24 | Astrazeneca Ab | Indole derivatives having anti-angiogenetic activity |
UA78999C2 (en) | 2002-06-04 | 2007-05-10 | Wyeth Corp | 1-(aminoalkyl)-3-sulfonylazaindoles as ligands of 5-hydroxytryptamine-6 |
TW200400177A (en) | 2002-06-04 | 2004-01-01 | Wyeth Corp | 1-(Aminoalkyl)-3-sulfonylindole and-indazole derivatives as 5-hydroxytryptamine-6 ligands |
SE0300908D0 (sv) * | 2003-03-31 | 2003-03-31 | Astrazeneca Ab | Azaindole derivatives, preparations thereof, uses thereof and compositions containing them |
WO2005056547A2 (en) * | 2003-12-04 | 2005-06-23 | Vertex Pharmaceuticals Incorporated | Quinoxalines useful as inhibitors of protein kinases |
WO2005121140A1 (en) | 2004-06-09 | 2005-12-22 | Glaxo Group Limited | Pyrrolopyridine derivatives |
KR20070056138A (ko) * | 2004-10-05 | 2007-05-31 | 메르츠 파마 게엠베하 운트 코. 카가아 | Cns 장애를 치료하기 위한 신규 환상 및 비환상프로페논 |
JP2008530030A (ja) * | 2005-02-14 | 2008-08-07 | バイオノミックス リミテッド | 新規なチューブリン重合阻害剤 |
US20060293345A1 (en) * | 2005-05-20 | 2006-12-28 | Christoph Steeneck | Heterobicyclic metalloprotease inhibitors |
US20070155738A1 (en) * | 2005-05-20 | 2007-07-05 | Alantos Pharmaceuticals, Inc. | Heterobicyclic metalloprotease inhibitors |
US7838542B2 (en) | 2006-06-29 | 2010-11-23 | Kinex Pharmaceuticals, Llc | Bicyclic compositions and methods for modulating a kinase cascade |
FR2950053B1 (fr) * | 2009-09-11 | 2014-08-01 | Fournier Lab Sa | Utilisation de derives d'indole benzoique comme activateurs de nurr-1, pour le traitement de la maladie de parkinson |
WO2014033497A1 (en) | 2012-08-27 | 2014-03-06 | Centre National De La Recherche Scientifique | 5-azaindole compounds with anticancer and antiangiogenic activities |
US9353150B2 (en) | 2012-12-04 | 2016-05-31 | Massachusetts Institute Of Technology | Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment |
WO2014144715A1 (en) | 2013-03-15 | 2014-09-18 | Memorial Sloan-Kettering Cancer Center | Hsp90-targeted cardiac imaging and therapy |
WO2016114816A1 (en) * | 2015-01-18 | 2016-07-21 | Sri International | MAP4K4 (HGK) Inhibitors |
CN104945376B (zh) * | 2015-07-09 | 2017-03-15 | 安徽理工大学 | 一种3‑芳酰基吲哚化合物的合成方法 |
WO2017197045A1 (en) | 2016-05-11 | 2017-11-16 | Movassaghi Mohammad | Convergent and enantioselective total synthesis of communesin analogs |
CN107722013B (zh) * | 2016-08-11 | 2021-01-12 | 中国科学院上海药物研究所 | 去氮嘌呤类化合物及其药物组合物、制备方法和用途 |
WO2018209239A1 (en) | 2017-05-11 | 2018-11-15 | Massachusetts Institute Of Technology | Potent agelastatin derivatives as modulators for cancer invasion and metastasis |
US10640508B2 (en) | 2017-10-13 | 2020-05-05 | Massachusetts Institute Of Technology | Diazene directed modular synthesis of compounds with quaternary carbon centers |
WO2020247054A1 (en) | 2019-06-05 | 2020-12-10 | Massachusetts Institute Of Technology | Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof |
US12030888B2 (en) | 2021-02-24 | 2024-07-09 | Massachusetts Institute Of Technology | Himastatin derivatives, and processes of preparation thereof, and uses thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3660430A (en) * | 1969-11-04 | 1972-05-02 | American Home Prod | 2-substituted-3-arylindoles |
US3838167A (en) * | 1972-08-01 | 1974-09-24 | Lilly Co Eli | Process for preparing indoles |
DK3375A (pl) * | 1974-01-25 | 1975-09-15 | Ciba Geigy Ag | |
US5436265A (en) * | 1993-11-12 | 1995-07-25 | Merck Frosst Canada, Inc. | 1-aroyl-3-indolyl alkanoic acids and derivatives thereof useful as anti-inflammatory agents |
EP0938474B1 (en) * | 1996-09-12 | 2005-11-23 | Auckland Uniservices Limited | Cyclopropylindole compounds and their use as prodrugs |
AP9801302A0 (en) * | 1997-07-23 | 2000-01-23 | Pfizer | Indole compounds as anti-inflammatory/analgesic agents.. |
-
2001
- 2001-04-27 AT AT01947247T patent/ATE348805T1/de not_active IP Right Cessation
- 2001-04-27 SK SK1543-2002A patent/SK15432002A3/sk not_active Application Discontinuation
- 2001-04-27 PL PL01358877A patent/PL358877A1/pl unknown
- 2001-04-27 CN CNB018104762A patent/CN1286810C/zh not_active Expired - Fee Related
- 2001-04-27 BR BR0110414-4A patent/BR0110414A/pt not_active IP Right Cessation
- 2001-04-27 HU HU0300480A patent/HUP0300480A3/hu unknown
- 2001-04-27 AU AU68984/01A patent/AU783459B2/en not_active Ceased
- 2001-04-27 EP EP01947247A patent/EP1276720B1/de not_active Expired - Lifetime
- 2001-04-27 KR KR1020027014523A patent/KR20030024661A/ko not_active Application Discontinuation
- 2001-04-27 WO PCT/EP2001/004783 patent/WO2001082909A2/de active IP Right Grant
- 2001-04-27 AR ARP010102016A patent/AR029915A1/es not_active Application Discontinuation
- 2001-04-27 GE GE5060A patent/GEP20063751B/en unknown
- 2001-04-27 CA CA002407677A patent/CA2407677A1/en not_active Abandoned
- 2001-04-27 IL IL15247701A patent/IL152477A0/xx unknown
- 2001-04-27 DE DE50111690T patent/DE50111690D1/de not_active Expired - Fee Related
- 2001-04-27 MX MXPA02010627A patent/MXPA02010627A/es active IP Right Grant
- 2001-04-27 RU RU2002132253/04A patent/RU2002132253A/ru not_active Application Discontinuation
- 2001-04-27 US US09/843,139 patent/US20020091124A1/en not_active Abandoned
- 2001-04-27 EE EEP200200607A patent/EE200200607A/xx unknown
- 2001-04-27 JP JP2001579784A patent/JP2004501092A/ja not_active Withdrawn
- 2001-04-27 CZ CZ20023544A patent/CZ20023544A3/cs unknown
- 2001-04-27 NZ NZ522246A patent/NZ522246A/en unknown
-
2002
- 2002-10-24 US US10/279,123 patent/US20030158216A1/en not_active Abandoned
- 2002-10-25 IS IS6594A patent/IS6594A/is unknown
- 2002-10-25 NO NO20025150A patent/NO20025150L/no not_active Application Discontinuation
- 2002-11-25 BG BG107309A patent/BG107309A/bg unknown
- 2002-11-27 HR HR20020940A patent/HRP20020940A2/hr not_active Application Discontinuation
-
2003
- 2003-07-21 HK HK03105237.9A patent/HK1054549B/zh not_active IP Right Cessation
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