BR0110414A - Derivados de 2-acil indol e seu uso como agentes antitumores - Google Patents

Derivados de 2-acil indol e seu uso como agentes antitumores

Info

Publication number
BR0110414A
BR0110414A BR0110414-4A BR0110414A BR0110414A BR 0110414 A BR0110414 A BR 0110414A BR 0110414 A BR0110414 A BR 0110414A BR 0110414 A BR0110414 A BR 0110414A
Authority
BR
Brazil
Prior art keywords
indole derivatives
antitumour agents
derivatives
acyl indole
acyl
Prior art date
Application number
BR0110414-4A
Other languages
English (en)
Inventor
Thomas Beckers
Silke Bassner
Thomas Klenner
Siavosh Mahboobi
Herwig Pongratz
Markus Frieser
Harald Hufsky
Joerg Hockemeyer
Heinz-Hubert Fiebig
Angelika Burger
Frank D Boehmer
Original Assignee
Baxter Healthcare Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2000120852 external-priority patent/DE10020852A1/de
Priority claimed from DE2001102629 external-priority patent/DE10102629A1/de
Application filed by Baxter Healthcare Sa filed Critical Baxter Healthcare Sa
Publication of BR0110414A publication Critical patent/BR0110414A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"DERIVADOS DE 2-ACIL INDOL E SEU USO COMO AGENTES ANTI-TUMORES". A invenção refere-se aos novos derivados de indol e heteroindol da fórmula geral (I), aos seus tautómeros, estereoisómeros, suas misturas e seus sais, à produção destes e ao uso de derivados de indol da fórmula (I) como medicamentos.
BR0110414-4A 2000-04-28 2001-04-27 Derivados de 2-acil indol e seu uso como agentes antitumores BR0110414A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE2000120852 DE10020852A1 (de) 2000-04-28 2000-04-28 2-Acryl-indolderivate und deren Verwendung als Antitumormittel
DE2001102629 DE10102629A1 (de) 2001-01-20 2001-01-20 2-Acyl-indolderivate und deren Verwendung als Antitumormittel
PCT/EP2001/004783 WO2001082909A2 (de) 2000-04-28 2001-04-27 2-acyl-indolderivate und deren verwendung als antitumormittel

Publications (1)

Publication Number Publication Date
BR0110414A true BR0110414A (pt) 2003-02-11

Family

ID=26005501

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0110414-4A BR0110414A (pt) 2000-04-28 2001-04-27 Derivados de 2-acil indol e seu uso como agentes antitumores

Country Status (27)

Country Link
US (2) US20020091124A1 (pt)
EP (1) EP1276720B1 (pt)
JP (1) JP2004501092A (pt)
KR (1) KR20030024661A (pt)
CN (1) CN1286810C (pt)
AR (1) AR029915A1 (pt)
AT (1) ATE348805T1 (pt)
AU (1) AU783459B2 (pt)
BG (1) BG107309A (pt)
BR (1) BR0110414A (pt)
CA (1) CA2407677A1 (pt)
CZ (1) CZ20023544A3 (pt)
DE (1) DE50111690D1 (pt)
EE (1) EE200200607A (pt)
GE (1) GEP20063751B (pt)
HK (1) HK1054549B (pt)
HR (1) HRP20020940A2 (pt)
HU (1) HUP0300480A3 (pt)
IL (1) IL152477A0 (pt)
IS (1) IS6594A (pt)
MX (1) MXPA02010627A (pt)
NO (1) NO20025150L (pt)
NZ (1) NZ522246A (pt)
PL (1) PL358877A1 (pt)
RU (1) RU2002132253A (pt)
SK (1) SK15432002A3 (pt)
WO (1) WO2001082909A2 (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL152682A0 (en) 2000-05-31 2003-06-24 Astrazeneca Ab Indole derivatives with vascular damaging activity
US7005445B2 (en) 2001-10-22 2006-02-28 The Research Foundation Of State University Of New York Protein kinase and phosphatase inhibitors and methods for designing them
DE10152306A1 (de) * 2001-10-26 2003-07-24 Asta Medica Ag 2-Acylindolderivate mit neuen therapeutisch wertvollen Eigenschaften
AU2003214462A1 (en) 2002-04-03 2003-10-13 Astrazeneca Ab Indole derivatives having anti-angiogenetic activity
UA78999C2 (en) 2002-06-04 2007-05-10 Wyeth Corp 1-(aminoalkyl)-3-sulfonylazaindoles as ligands of 5-hydroxytryptamine-6
TW200400177A (en) 2002-06-04 2004-01-01 Wyeth Corp 1-(Aminoalkyl)-3-sulfonylindole and-indazole derivatives as 5-hydroxytryptamine-6 ligands
SE0300908D0 (sv) * 2003-03-31 2003-03-31 Astrazeneca Ab Azaindole derivatives, preparations thereof, uses thereof and compositions containing them
AU2004297235A1 (en) * 2003-12-04 2005-06-23 Vertex Pharmaceuticals Incorporated Quinoxalines useful as inhibitors of protein kinases
PE20060430A1 (es) 2004-06-09 2006-05-25 Glaxo Group Ltd Derivados de pirrolopiridina como moduladores de los receptores cannabinoides
CA2580221A1 (en) * 2004-10-05 2006-04-13 Merz Pharma Gmbh & Co. Kgaa Novel cyclic and acyclic propenones for treating cns disorders
NZ556686A (en) * 2005-02-14 2010-01-29 Bionomics Ltd Novel tubulin polymerisation inhibitors
US20070155738A1 (en) * 2005-05-20 2007-07-05 Alantos Pharmaceuticals, Inc. Heterobicyclic metalloprotease inhibitors
KR20080087070A (ko) * 2005-05-20 2008-09-30 알란토스 파마슈티컬즈 홀딩, 인코포레이티드 피리미딘 또는 트리아진 융합된 비시클릭 메탈로프로테아제억제제
US7838542B2 (en) 2006-06-29 2010-11-23 Kinex Pharmaceuticals, Llc Bicyclic compositions and methods for modulating a kinase cascade
FR2950053B1 (fr) * 2009-09-11 2014-08-01 Fournier Lab Sa Utilisation de derives d'indole benzoique comme activateurs de nurr-1, pour le traitement de la maladie de parkinson
WO2014033497A1 (en) 2012-08-27 2014-03-06 Centre National De La Recherche Scientifique 5-azaindole compounds with anticancer and antiangiogenic activities
WO2014089177A2 (en) 2012-12-04 2014-06-12 Massachusetts Institute Of Technology Compounds, conjugates and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines
EP2972394A4 (en) 2013-03-15 2016-11-02 Sloan Kettering Inst Cancer HSP90 TARGETING CARDIAC IMAGING AND TREATMENT THEREOF
JP6820854B2 (ja) * 2015-01-18 2021-01-27 エスアールアイ インターナショナルＳＲＩ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｍａｐ４ｋ４（ｈｇｋ）インヒビター
CN104945376B (zh) * 2015-07-09 2017-03-15 安徽理工大学 一种3‑芳酰基吲哚化合物的合成方法
WO2017197045A1 (en) 2016-05-11 2017-11-16 Movassaghi Mohammad Convergent and enantioselective total synthesis of communesin analogs
CN107722013B (zh) * 2016-08-11 2021-01-12 中国科学院上海药物研究所 去氮嘌呤类化合物及其药物组合物、制备方法和用途
US11932650B2 (en) 2017-05-11 2024-03-19 Massachusetts Institute Of Technology Potent agelastatin derivatives as modulators for cancer invasion and metastasis
US10640508B2 (en) 2017-10-13 2020-05-05 Massachusetts Institute Of Technology Diazene directed modular synthesis of compounds with quaternary carbon centers
US11535634B2 (en) 2019-06-05 2022-12-27 Massachusetts Institute Of Technology Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3660430A (en) * 1969-11-04 1972-05-02 American Home Prod 2-substituted-3-arylindoles
US3838167A (en) * 1972-08-01 1974-09-24 Lilly Co Eli Process for preparing indoles
DK3375A (pt) * 1974-01-25 1975-09-15 Ciba Geigy Ag
US5436265A (en) * 1993-11-12 1995-07-25 Merck Frosst Canada, Inc. 1-aroyl-3-indolyl alkanoic acids and derivatives thereof useful as anti-inflammatory agents
NZ334344A (en) * 1996-09-12 2000-08-25 Cancer Res Campaign Tech benzo[e]indole and pyrrolo[3,2-e]indole compounds and their use as prodrugs
AP9801302A0 (en) * 1997-07-23 2000-01-23 Pfizer Indole compounds as anti-inflammatory/analgesic agents..

Also Published As

Publication number Publication date
NZ522246A (en) 2006-01-27
DE50111690D1 (de) 2007-02-01
RU2002132253A (ru) 2004-07-10
PL358877A1 (en) 2004-08-23
GEP20063751B (en) 2006-02-27
EP1276720A2 (de) 2003-01-22
WO2001082909A3 (de) 2002-03-14
US20030158216A1 (en) 2003-08-21
HUP0300480A3 (en) 2006-04-28
MXPA02010627A (es) 2004-05-17
EP1276720B1 (de) 2006-12-20
CA2407677A1 (en) 2002-10-28
AU6898401A (en) 2001-11-12
ATE348805T1 (de) 2007-01-15
CN1286810C (zh) 2006-11-29
NO20025150L (no) 2002-12-16
BG107309A (bg) 2003-09-30
AR029915A1 (es) 2003-07-23
AU783459B2 (en) 2005-10-27
US20020091124A1 (en) 2002-07-11
EE200200607A (et) 2004-04-15
SK15432002A3 (sk) 2004-01-08
HK1054549A1 (en) 2003-12-05
CZ20023544A3 (cs) 2004-07-14
NO20025150D0 (no) 2002-10-25
IL152477A0 (en) 2003-05-29
JP2004501092A (ja) 2004-01-15
HK1054549B (zh) 2007-02-23
WO2001082909A2 (de) 2001-11-08
IS6594A (is) 2002-10-25
CN1431997A (zh) 2003-07-23
HRP20020940A2 (en) 2005-02-28
KR20030024661A (ko) 2003-03-26
HUP0300480A2 (hu) 2003-06-28

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE 7A. E 8A. ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 2008 DE 30/06/2009.