PL349348A1 - Functionalized heterocycles as chemokine receptor modulators - Google Patents

Functionalized heterocycles as chemokine receptor modulators

Info

Publication number
PL349348A1
PL349348A1 PL99349348A PL34934899A PL349348A1 PL 349348 A1 PL349348 A1 PL 349348A1 PL 99349348 A PL99349348 A PL 99349348A PL 34934899 A PL34934899 A PL 34934899A PL 349348 A1 PL349348 A1 PL 349348A1
Authority
PL
Poland
Prior art keywords
chemokine receptor
receptor modulators
functionalized heterocycles
heterocycles
functionalized
Prior art date
Application number
PL99349348A
Other languages
English (en)
Inventor
Geraldine Harriman
Christine Nylund Kolz
Jay R Luly
Bruce David Roth
Yuntao Song
Bharat Kalidas Trivedi
Original Assignee
Millennium Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharmaceuticals filed Critical Millennium Pharmaceuticals
Publication of PL349348A1 publication Critical patent/PL349348A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
PL99349348A 1999-01-13 1999-12-20 Functionalized heterocycles as chemokine receptor modulators PL349348A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11565499P 1999-01-13 1999-01-13
PCT/US1999/030434 WO2000042045A2 (en) 1999-01-13 1999-12-20 Functionalized heterocycles as chemokine receptor modulators

Publications (1)

Publication Number Publication Date
PL349348A1 true PL349348A1 (en) 2002-07-15

Family

ID=22362668

Family Applications (1)

Application Number Title Priority Date Filing Date
PL99349348A PL349348A1 (en) 1999-01-13 1999-12-20 Functionalized heterocycles as chemokine receptor modulators

Country Status (20)

Country Link
EP (1) EP1144415A2 (ko)
JP (1) JP2002534526A (ko)
KR (1) KR20010086166A (ko)
CN (1) CN1344270A (ko)
AP (1) AP2001002228A0 (ko)
AU (1) AU1940900A (ko)
BR (1) BR9916905A (ko)
CA (1) CA2372197A1 (ko)
CZ (1) CZ20012502A3 (ko)
EA (1) EA200100774A1 (ko)
HK (1) HK1044539A1 (ko)
HU (1) HUP0202932A3 (ko)
IL (1) IL144289A0 (ko)
MX (1) MXPA01007033A (ko)
NO (1) NO20013456L (ko)
OA (1) OA11820A (ko)
PL (1) PL349348A1 (ko)
SK (1) SK9972001A3 (ko)
WO (1) WO2000042045A2 (ko)
ZA (1) ZA200106592B (ko)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6951848B2 (en) 2001-03-12 2005-10-04 Millennium Pharmaceuticals, Inc., Functionalized heterocycles as modulators of chemokine receptor function and methods of use therefor
ATE372768T1 (de) * 2001-03-29 2007-09-15 Lilly Co Eli N-(2-arylethyl) benzylamine als 5-ht6 rezeptor- antagoniste
WO2003035650A1 (fr) * 2001-09-25 2003-05-01 Takeda Chemical Industries, Ltd. Inhibiteur d'entree
EP2385040A1 (en) 2003-03-14 2011-11-09 ONO Pharmaceutical Co., Ltd. Nitrogen-containing heterocyclic derivatives and drugs containing the same as the active ingredient
US7498323B2 (en) 2003-04-18 2009-03-03 Ono Pharmaceuticals Co., Ltd. Spiro-piperidine compounds and medicinal use thereof
KR101231466B1 (ko) 2004-09-13 2013-02-07 오노 야꾸힝 고교 가부시키가이샤 질소 함유 복소환 유도체 및 이들을 유효 성분으로 하는약제
EP1889622A4 (en) 2005-05-31 2009-12-23 Ono Pharmaceutical Co SPIROPIPERIDINE COMPOUND AND MEDICINAL USE THEREOF
US7915286B2 (en) 2005-09-16 2011-03-29 Ranbaxy Laboratories Limited Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase inhibitors
DK1942108T3 (da) 2005-10-28 2013-12-09 Ono Pharmaceutical Co Forbindelse indeholdende basisk gruppe samt anvendelse deraf
EP1961744B1 (en) 2005-11-18 2013-04-17 Ono Pharmaceutical Co., Ltd. Basic group-containing compound and use thereof
EP1984334B1 (en) * 2006-02-15 2014-04-09 Allergan, Inc. Indole-3-carboxylic acid amide, ester, thioamide and thiol ester compounds bearing aryl or heteroaryl groups having sphingosine-1-phosphate (s1p) receptor antagonist biological activity
CN101460458A (zh) 2006-02-15 2009-06-17 阿勒根公司 具有1－磷酸－鞘氨醇(s1p)受体拮抗剂生物活性的带芳基或者杂芳基基团的吲哚－3－羧酸的酰胺、酯、硫代酰胺和硫羟酸酯化合物
CN101443322A (zh) 2006-03-10 2009-05-27 小野药品工业株式会社 含氮杂环衍生物及含有该衍生物作为活性成分的药物
WO2007132846A1 (ja) 2006-05-16 2007-11-22 Ono Pharmaceutical Co., Ltd. 保護されていてもよい酸性基を含有する化合物およびその用途
EP2036889A4 (en) * 2006-05-23 2009-11-04 Alla Chem Llc SUBSTITUTED INDOLES AND PROCESS FOR PRODUCTION AND USE THEREOF
JP5245827B2 (ja) 2006-07-31 2013-07-24 小野薬品工業株式会社 スピロ結合した環状基を含有する化合物およびその用途
US8524917B2 (en) 2007-01-11 2013-09-03 Allergan, Inc. 6-substituted indole-3-carboxylic acid amide compounds having sphingosine-1-phosphate (S1P) receptor antagonist biological activity
EP2125723A1 (en) 2007-01-11 2009-12-02 Allergan, Inc. 6-substituted indole-3-carboxylic acid amide compounds having sphingosine-1-phosphate (s1p) receptor antagonist biological activity
WO2010129351A1 (en) 2009-04-28 2010-11-11 Schepens Eye Research Institute Method to identify and treat age-related macular degeneration
CN102958927A (zh) 2010-05-12 2013-03-06 Abbvie公司 激酶的吲唑抑制剂
EP2741777B1 (en) 2011-08-12 2017-01-18 INSERM - Institut National de la Santé et de la Recherche Médicale Methods and pharmaceutical compositions for treatment of pulmonary hypertension
JO3459B1 (ar) 2012-09-09 2020-07-05 H Lundbeck As تركيبات صيدلانية لعلاج مرض الزهايمر
CN104193669B (zh) * 2014-08-01 2016-12-07 大连理工大学 一类阿比朵尔类似物或其盐、其制备方法及应用
WO2016112088A1 (en) * 2015-01-06 2016-07-14 Spero Therapeutics, Inc. Aryloxyacetylindoles and analogs as antibiotic tolerance inhibitors
CN110256324A (zh) * 2019-06-13 2019-09-20 苏州莱安医药化学技术有限公司 一种2-甲基-5-羟基吲哚的制备方法
US11629196B2 (en) 2020-04-27 2023-04-18 Incelldx, Inc. Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3549641A (en) * 1966-06-28 1970-12-22 Warner Lambert Pharmaceutical Pyrano pyridines and process for their production
US3518258A (en) * 1967-05-09 1970-06-30 Warner Lambert Pharmaceutical Pyrano(3,2-i)quinolizine and process for the production
US3565903A (en) * 1967-11-24 1971-02-23 Warner Lambert Pharmaceutical Pyrano(2,3-b)quinolines and process for their production
US5635510A (en) * 1993-05-06 1997-06-03 Merrell Pharmaceuticals Inc. Substituted pyrrolidin-3-yl-alkyl-piperidines
HRP960352A2 (en) * 1996-07-26 1998-08-31 Pliva Pharm & Chem Works Novel coumarin quinoline carboxylic acids
YU41399A (sh) * 1997-02-26 2001-09-28 Pfizer Inc. Derivati amida heteroaril-kapronske kiseline, njihovo dobijanje i njihova upotreba kao selektivnih inhibitora mip-1.alfa vezivanjem za njegov ccr1 receptor
WO1999038514A1 (en) * 1998-02-02 1999-08-05 Merck & Co., Inc. Cyclic amine modulators of chemokine receptor activity

Also Published As

Publication number Publication date
AP2001002228A0 (en) 2001-09-30
EP1144415A2 (en) 2001-10-17
HUP0202932A3 (en) 2003-07-28
HK1044539A1 (zh) 2002-10-25
KR20010086166A (ko) 2001-09-08
HUP0202932A2 (hu) 2002-12-28
ZA200106592B (en) 2002-08-12
JP2002534526A (ja) 2002-10-15
OA11820A (en) 2005-08-17
CA2372197A1 (en) 2000-07-20
WO2000042045A3 (en) 2000-11-09
MXPA01007033A (es) 2003-07-21
NO20013456D0 (no) 2001-07-12
WO2000042045A2 (en) 2000-07-20
IL144289A0 (en) 2002-05-23
EA200100774A1 (ru) 2002-02-28
BR9916905A (pt) 2002-01-29
NO20013456L (no) 2001-09-12
CN1344270A (zh) 2002-04-10
SK9972001A3 (en) 2002-03-05
AU1940900A (en) 2000-08-01
CZ20012502A3 (cs) 2002-03-13

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Legal Events

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REFS Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)