HK1044539A1 - 作為趨化因子受體調節劑的官能化雜環 - Google Patents
作為趨化因子受體調節劑的官能化雜環Info
- Publication number
- HK1044539A1 HK1044539A1 HK02106357.2A HK02106357A HK1044539A1 HK 1044539 A1 HK1044539 A1 HK 1044539A1 HK 02106357 A HK02106357 A HK 02106357A HK 1044539 A1 HK1044539 A1 HK 1044539A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- chemokine receptor
- receptor modulators
- functionalized heterocycles
- heterocycles
- functionalized
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11565499P | 1999-01-13 | 1999-01-13 | |
| PCT/US1999/030434 WO2000042045A2 (en) | 1999-01-13 | 1999-12-20 | Functionalized heterocycles as chemokine receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1044539A1 true HK1044539A1 (zh) | 2002-10-25 |
Family
ID=22362668
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK02106357.2A HK1044539A1 (zh) | 1999-01-13 | 2002-08-28 | 作為趨化因子受體調節劑的官能化雜環 |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1144415A2 (ko) |
| JP (1) | JP2002534526A (ko) |
| KR (1) | KR20010086166A (ko) |
| CN (1) | CN1344270A (ko) |
| AP (1) | AP2001002228A0 (ko) |
| AU (1) | AU1940900A (ko) |
| BR (1) | BR9916905A (ko) |
| CA (1) | CA2372197A1 (ko) |
| CZ (1) | CZ20012502A3 (ko) |
| EA (1) | EA200100774A1 (ko) |
| HK (1) | HK1044539A1 (ko) |
| HU (1) | HUP0202932A3 (ko) |
| IL (1) | IL144289A0 (ko) |
| MX (1) | MXPA01007033A (ko) |
| NO (1) | NO20013456L (ko) |
| OA (1) | OA11820A (ko) |
| PL (1) | PL349348A1 (ko) |
| SK (1) | SK9972001A3 (ko) |
| WO (1) | WO2000042045A2 (ko) |
| ZA (1) | ZA200106592B (ko) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1377549A1 (en) * | 2001-03-12 | 2004-01-07 | Millennium Pharmaceuticals, Inc. | Functionalized heterocycles as modulators of chemokine receptor function and methods of use therefor |
| EA007493B1 (ru) | 2001-03-29 | 2006-10-27 | Эли Лилли Энд Компани | N-(2-арилэтил)бензиламины в качестве антагонистов 5-ht-рецептора |
| WO2003035650A1 (fr) * | 2001-09-25 | 2003-05-01 | Takeda Chemical Industries, Ltd. | Inhibiteur d'entree |
| WO2004080966A1 (ja) | 2003-03-14 | 2004-09-23 | Ono Pharmaceutical Co., Ltd. | 含窒素複素環誘導体およびそれらを有効成分とする薬剤 |
| EP1619193A4 (en) | 2003-04-18 | 2010-08-11 | Ono Pharmaceutical Co | SPIROPIPERIDINE COMPOUND AND MEDICINAL USE THEREOF |
| NZ553696A (en) | 2004-09-13 | 2010-02-26 | Ono Pharmaceutical Co | Nitrogenous heterocyclic derivative and medicine containing the same as an active ingredient |
| WO2006129679A1 (ja) | 2005-05-31 | 2006-12-07 | Ono Pharmaceutical Co., Ltd. | スピロピペリジン化合物およびその医薬用途 |
| WO2007031838A1 (en) | 2005-09-16 | 2007-03-22 | Ranbaxy Laboratories Limited | Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase inhibitors |
| PT1942108E (pt) | 2005-10-28 | 2013-10-24 | Ono Pharmaceutical Co | Composto com um grupo básico e a sua utilização |
| ES2407115T3 (es) | 2005-11-18 | 2013-06-11 | Ono Pharmaceutical Co., Ltd. | Compuesto que contiene un grupo básico y uso del mismo |
| CN101460458A (zh) | 2006-02-15 | 2009-06-17 | 阿勒根公司 | 具有1－磷酸－鞘氨醇(s1p)受体拮抗剂生物活性的带芳基或者杂芳基基团的吲哚－3－羧酸的酰胺、酯、硫代酰胺和硫羟酸酯化合物 |
| CA2642668C (en) * | 2006-02-15 | 2013-01-08 | Allergan, Inc. | Indole-3-carboxylic acid amide and ester compounds bearing phenyl groups having sphingosine-1-phosphate (s1p) receptor antagonist biological activity |
| AU2007225836A1 (en) | 2006-03-10 | 2007-09-20 | Ono Pharmaceutical Co., Ltd. | Nitrogenated heterocyclic derivative, and pharmaceutical agent comprising the derivative as active ingredient |
| EP2042503B1 (en) | 2006-05-16 | 2013-01-30 | Ono Pharmaceutical Co., Ltd. | Compound having acidic group which may be protected, and use thereof |
| EA016633B1 (ru) | 2006-05-23 | 2012-06-29 | Общество С Ограниченной Ответственностью "Инновационная Фармацевтика" | Замещенные индолы, способ их получения и применения |
| WO2008016006A1 (en) | 2006-07-31 | 2008-02-07 | Ono Pharmaceutical Co., Ltd. | Compound having cyclic group bound thereto through spiro binding and use thereof |
| CA2674946A1 (en) * | 2007-01-11 | 2008-07-24 | Allergan, Inc. | 6-substituted indole-3-carboxylic acid amide compounds having sphingosine-1-phosphate (s1p) receptor antagonist biological activity |
| US8524917B2 (en) | 2007-01-11 | 2013-09-03 | Allergan, Inc. | 6-substituted indole-3-carboxylic acid amide compounds having sphingosine-1-phosphate (S1P) receptor antagonist biological activity |
| WO2010129351A1 (en) | 2009-04-28 | 2010-11-11 | Schepens Eye Research Institute | Method to identify and treat age-related macular degeneration |
| US8293738B2 (en) | 2010-05-12 | 2012-10-23 | Abbott Laboratories | Indazole inhibitors of kinase |
| EP2741777B1 (en) | 2011-08-12 | 2017-01-18 | INSERM - Institut National de la Santé et de la Recherche Médicale | Methods and pharmaceutical compositions for treatment of pulmonary hypertension |
| JO3459B1 (ar) | 2012-09-09 | 2020-07-05 | H Lundbeck As | تركيبات صيدلانية لعلاج مرض الزهايمر |
| CN104193669B (zh) * | 2014-08-01 | 2016-12-07 | 大连理工大学 | 一类阿比朵尔类似物或其盐、其制备方法及应用 |
| WO2016112088A1 (en) * | 2015-01-06 | 2016-07-14 | Spero Therapeutics, Inc. | Aryloxyacetylindoles and analogs as antibiotic tolerance inhibitors |
| CN110256324A (zh) * | 2019-06-13 | 2019-09-20 | 苏州莱安医药化学技术有限公司 | 一种2-甲基-5-羟基吲哚的制备方法 |
| US11629196B2 (en) | 2020-04-27 | 2023-04-18 | Incelldx, Inc. | Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3549641A (en) * | 1966-06-28 | 1970-12-22 | Warner Lambert Pharmaceutical | Pyrano pyridines and process for their production |
| US3518258A (en) * | 1967-05-09 | 1970-06-30 | Warner Lambert Pharmaceutical | Pyrano(3,2-i)quinolizine and process for the production |
| US3565903A (en) * | 1967-11-24 | 1971-02-23 | Warner Lambert Pharmaceutical | Pyrano(2,3-b)quinolines and process for their production |
| US5635510A (en) * | 1993-05-06 | 1997-06-03 | Merrell Pharmaceuticals Inc. | Substituted pyrrolidin-3-yl-alkyl-piperidines |
| HRP960352A2 (en) * | 1996-07-26 | 1998-08-31 | Pliva Pharm & Chem Works | Novel coumarin quinoline carboxylic acids |
| KR100447553B1 (ko) * | 1997-02-26 | 2004-09-08 | 화이자 인코포레이티드 | 헤테로아릴-헥사노산 아미드 유도체, 그의 제조 방법 및 ｍｉｐ-1 알파의 ｃｃｒ1 수용체로의 결합에 대한 선택적 저해제로서의 용도 |
| EP1052992A1 (en) * | 1998-02-02 | 2000-11-22 | Merck & Co., Inc. | Cyclic amine modulators of chemokine receptor activity |
-
1999
- 1999-12-20 CZ CZ20012502A patent/CZ20012502A3/cs unknown
- 1999-12-20 AP APAP/P/2001/002228A patent/AP2001002228A0/en unknown
- 1999-12-20 KR KR1020017008905A patent/KR20010086166A/ko not_active Application Discontinuation
- 1999-12-20 CN CN99816475A patent/CN1344270A/zh active Pending
- 1999-12-20 MX MXPA01007033A patent/MXPA01007033A/es unknown
- 1999-12-20 EP EP99963110A patent/EP1144415A2/en not_active Withdrawn
- 1999-12-20 IL IL14428999A patent/IL144289A0/xx unknown
- 1999-12-20 HU HU0202932A patent/HUP0202932A3/hu unknown
- 1999-12-20 EA EA200100774A patent/EA200100774A1/ru unknown
- 1999-12-20 PL PL99349348A patent/PL349348A1/xx not_active Application Discontinuation
- 1999-12-20 JP JP2000593612A patent/JP2002534526A/ja active Pending
- 1999-12-20 BR BR9916905-3A patent/BR9916905A/pt not_active Application Discontinuation
- 1999-12-20 OA OA1200100187A patent/OA11820A/en unknown
- 1999-12-20 WO PCT/US1999/030434 patent/WO2000042045A2/en not_active Application Discontinuation
- 1999-12-20 SK SK997-2001A patent/SK9972001A3/sk unknown
- 1999-12-20 AU AU19409/00A patent/AU1940900A/en not_active Abandoned
- 1999-12-20 CA CA002372197A patent/CA2372197A1/en not_active Abandoned
-
2001
- 2001-07-12 NO NO20013456A patent/NO20013456L/no not_active Application Discontinuation
- 2001-08-10 ZA ZA200106592A patent/ZA200106592B/en unknown
-
2002
- 2002-08-28 HK HK02106357.2A patent/HK1044539A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA01007033A (es) | 2003-07-21 |
| HUP0202932A3 (en) | 2003-07-28 |
| PL349348A1 (en) | 2002-07-15 |
| SK9972001A3 (en) | 2002-03-05 |
| JP2002534526A (ja) | 2002-10-15 |
| HUP0202932A2 (hu) | 2002-12-28 |
| NO20013456D0 (no) | 2001-07-12 |
| AP2001002228A0 (en) | 2001-09-30 |
| CN1344270A (zh) | 2002-04-10 |
| OA11820A (en) | 2005-08-17 |
| WO2000042045A3 (en) | 2000-11-09 |
| IL144289A0 (en) | 2002-05-23 |
| KR20010086166A (ko) | 2001-09-08 |
| WO2000042045A2 (en) | 2000-07-20 |
| CA2372197A1 (en) | 2000-07-20 |
| EA200100774A1 (ru) | 2002-02-28 |
| CZ20012502A3 (cs) | 2002-03-13 |
| NO20013456L (no) | 2001-09-12 |
| EP1144415A2 (en) | 2001-10-17 |
| AU1940900A (en) | 2000-08-01 |
| ZA200106592B (en) | 2002-08-12 |
| BR9916905A (pt) | 2002-01-29 |
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