PL3287142T3 - Sposoby leczenia chorób związanych z aktywacją dopełniacza zależną od masp-2 - Google Patents

Sposoby leczenia chorób związanych z aktywacją dopełniacza zależną od masp-2

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Publication number
PL3287142T3
PL3287142T3 PL17191208T PL17191208T PL3287142T3 PL 3287142 T3 PL3287142 T3 PL 3287142T3 PL 17191208 T PL17191208 T PL 17191208T PL 17191208 T PL17191208 T PL 17191208T PL 3287142 T3 PL3287142 T3 PL 3287142T3
Authority
PL
Poland
Prior art keywords
masp
compound
treatment
methods
dependent activation
Prior art date
Application number
PL17191208T
Other languages
English (en)
Inventor
Gregory A. Demopulos
Tom DUDLER
Hans-Wilhelm Schwaeble
Original Assignee
University Of Leicester
Omeros Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Of Leicester, Omeros Corporation filed Critical University Of Leicester
Publication of PL3287142T3 publication Critical patent/PL3287142T3/pl

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    • C—CHEMISTRY; METALLURGY
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    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54—F(ab')2
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    • C07K—PEPTIDES
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Oncology (AREA)
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PL17191208T 2011-04-08 2012-04-06 Sposoby leczenia chorób związanych z aktywacją dopełniacza zależną od masp-2 PL3287142T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161473698P 2011-04-08 2011-04-08
PCT/US2012/032650 WO2012139081A2 (en) 2011-04-08 2012-04-06 Methods for treating conditions associated with masp-2 dependent complement activation
EP17191208.2A EP3287142B1 (en) 2011-04-08 2012-04-06 Methods for treating conditions associated with masp-2 dependent complement activation
EP12767899.3A EP2694108B1 (en) 2011-04-08 2012-04-06 Methods for treating conditions associated with masp-2 dependent complement activation

Publications (1)

Publication Number Publication Date
PL3287142T3 true PL3287142T3 (pl) 2021-12-27

Family

ID=46966283

Family Applications (1)

Application Number Title Priority Date Filing Date
PL17191208T PL3287142T3 (pl) 2011-04-08 2012-04-06 Sposoby leczenia chorób związanych z aktywacją dopełniacza zależną od masp-2

Country Status (17)

Country Link
US (5) US8951522B2 (pl)
EP (3) EP2694108B1 (pl)
JP (4) JP5937197B2 (pl)
KR (6) KR20220044616A (pl)
CN (3) CN103781492A (pl)
AU (1) AU2012239889B2 (pl)
BR (1) BR112013025917A2 (pl)
CA (4) CA3237802A1 (pl)
CL (1) CL2013002874A1 (pl)
DK (2) DK3287142T3 (pl)
ES (2) ES2894342T3 (pl)
IL (3) IL228758B (pl)
MX (3) MX339002B (pl)
NZ (5) NZ709997A (pl)
PL (1) PL3287142T3 (pl)
RU (2) RU2743409C2 (pl)
WO (1) WO2012139081A2 (pl)

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NZ709997A (en) 2011-04-08 2016-03-31 Univ Leicester Methods for treating conditions associated with masp-2 dependent complement activation
US9644035B2 (en) 2011-04-08 2017-05-09 Omeros Corporation Methods for treating conditions associated with MASP-2 dependent complement activation
AU2012356170B2 (en) 2011-12-21 2016-06-16 Novartis Ag Compositions and methods for antibodies targeting Factor P
PL2833907T3 (pl) * 2012-04-06 2018-08-31 Omeros Corporation Kompozycje i sposoby hamowania masp-1 i/lub masp-3 do leczenia napadowej nocnej hemoglobinurii
CN118924900A (zh) * 2012-06-18 2024-11-12 奥默罗斯公司 抑制masp-1和/或masp-2和/或masp-3的组合物和方法
EP2912065A4 (en) 2012-10-25 2016-10-19 True North Therapeutics Inc ANTI COMPLEMENT C1S ANTIBODIES AND USES THEREOF
CA2889197A1 (en) 2012-11-02 2014-05-08 True North Therapeutics, Inc. Anti-complement c1s antibodies and uses thereof
CA2906096C (en) * 2013-03-15 2022-03-15 Omeros Corporation Methods of generating bioactive peptide-bearing antibodies and compositions comprising the same
US20140363433A1 (en) 2013-03-15 2014-12-11 Omeros Corporation Methods of Generating Bioactive Peptide-bearing Antibodies and Compositions Comprising the Same
KR20160062186A (ko) * 2013-10-17 2016-06-01 오메로스 코포레이션 Masp-2 의존성 보체 활성화와 관련된 상태의 치료 방법
WO2015070041A1 (en) * 2013-11-08 2015-05-14 Icahn School Of Medicine At Mount Sinai Methods for monitoring kidney dysfunction
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HUE056613T2 (hu) 2015-01-28 2022-02-28 Ra Pharmaceuticals Inc Komplementaktivitás modulátorai
MX389703B (es) 2015-04-06 2025-03-20 Bioverativ Usa Inc Anticuerpos anti-c1s humanizados y metodos para usarlos.
JP6814802B2 (ja) 2015-11-09 2021-01-20 オメロス コーポレーション Ｍａｓｐ−２依存性補体活性化に関連した状態を治療するための方法
KR20180094913A (ko) 2015-12-16 2018-08-24 라 파마슈티컬스 인코포레이티드 보체 활성의 조절인자
CA3009393C (en) * 2015-12-23 2023-08-22 Greenovation Biotech Gmbh Polypeptides for inhibiting complement activation
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KR20230019991A (ko) * 2016-03-31 2023-02-09 오메로스 코포레이션 혈관 형성의 억제를 필요로 하는 대상체에서 혈관 형성을 억제하는 방법
UY37376A (es) * 2016-08-26 2018-03-23 Amgen Inc Construcciones de arni para inhibir expresión de asgr1 y métodos para su uso
JOP20170170B1 (ar) 2016-08-31 2022-09-15 Omeros Corp صيغ لجسم مضاد تثبيطية لـ masp-2 بتركيز عالي ولزوجة منخفضة وأطقم، وطرق
AR110677A1 (es) 2016-10-12 2019-04-24 Bioverativ Usa Inc Anticuerpos anti-c1s y métodos para usarlos
JOP20190068A1 (ar) * 2016-10-13 2019-04-01 Omeros Corp طرق لتقليل البول البروتيني في خاضع بشري يعاني من الاعتلال الكلوي a الناتج عن الجلوبيولين المناعي
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JP6442703B2 (ja) * 2016-12-26 2018-12-26 日本ビーシージー製造株式会社 細菌細胞壁骨格成分を含有する水中油型エマルション製剤
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