PL3223013T3 - Fluorescencyjne nanocząstki na bazie krzemionki - Google Patents

Fluorescencyjne nanocząstki na bazie krzemionki

Info

Publication number
PL3223013T3
PL3223013T3 PL17165118T PL17165118T PL3223013T3 PL 3223013 T3 PL3223013 T3 PL 3223013T3 PL 17165118 T PL17165118 T PL 17165118T PL 17165118 T PL17165118 T PL 17165118T PL 3223013 T3 PL3223013 T3 PL 3223013T3
Authority
PL
Poland
Prior art keywords
based nanoparticles
fluorescent silica
fluorescent
silica
nanoparticles
Prior art date
Application number
PL17165118T
Other languages
English (en)
Inventor
Michelle S. BRADBURY
Ulrich Wiesner
Medina Oula Penate
Hooisweng Ow
Andrew Burns
Jason Lewis
Steven Larson
Original Assignee
Sloan-Kettering Institute For Cancer Research
Cornell University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sloan-Kettering Institute For Cancer Research, Cornell University filed Critical Sloan-Kettering Institute For Cancer Research
Publication of PL3223013T3 publication Critical patent/PL3223013T3/pl

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    • A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Optics & Photonics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Medical Informatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Inorganic Chemistry (AREA)
PL17165118T 2009-07-02 2010-07-02 Fluorescencyjne nanocząstki na bazie krzemionki PL3223013T3 (pl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US22285109P 2009-07-02 2009-07-02
US31282710P 2010-03-11 2010-03-11
EP10794842.4A EP2449379B1 (en) 2009-07-02 2010-07-02 Fluorescent silica-based nanoparticles
PCT/US2010/040994 WO2011003109A1 (en) 2009-07-02 2010-07-02 Fluorescent silica-based nanoparticles
EP17165118.5A EP3223013B1 (en) 2009-07-02 2010-07-02 Fluorescent silica-based nanoparticles

Publications (1)

Publication Number Publication Date
PL3223013T3 true PL3223013T3 (pl) 2019-07-31

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Family Applications (2)

Application Number Title Priority Date Filing Date
PL17165118T PL3223013T3 (pl) 2009-07-02 2010-07-02 Fluorescencyjne nanocząstki na bazie krzemionki
PL10794842T PL2449379T3 (pl) 2009-07-02 2010-07-02 Fluorescencyjne nanocząstki na bazie krzemionki

Family Applications After (1)

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PL10794842T PL2449379T3 (pl) 2009-07-02 2010-07-02 Fluorescencyjne nanocząstki na bazie krzemionki

Country Status (7)

Country Link
US (2) US9625456B2 (pl)
EP (3) EP3499233A3 (pl)
CN (3) CN102713612B (pl)
DK (2) DK2449379T3 (pl)
ES (2) ES2639310T3 (pl)
PL (2) PL3223013T3 (pl)
WO (1) WO2011003109A1 (pl)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010500917A (ja) 2006-06-15 2010-01-14 マイクロベンション， インコーポレイテッド 膨張性ポリマーで構成される塞栓形成デバイス
US8470035B2 (en) 2007-12-21 2013-06-25 Microvention, Inc. Hydrogel filaments for biomedical uses
CN102713612B (zh) 2009-07-02 2016-10-05 斯隆-凯特林癌症研究院 基于二氧化硅的荧光纳米颗粒
AU2010313530B2 (en) 2009-10-26 2015-12-17 Microvention, Inc. Embolization device constructed from expansile polymer
WO2012007567A1 (en) * 2010-07-16 2012-01-19 Technical University Of Denmark Nanoparticle-guided radiotherapy
EP3779433A3 (en) * 2010-08-30 2021-05-19 Konica Minolta, Inc. Tissue staining method, tissue evaluation method and biosubstance detection method
EP2687234A4 (en) * 2011-03-18 2014-09-24 Konica Minolta Inc SILICA NANOPARTICLES FOR DIAGNOSTIC PICTURE GENERATION, MANUFACTURING METHOD AND BIOSUBSTANCES MARKING AGENT
US9456823B2 (en) 2011-04-18 2016-10-04 Terumo Corporation Embolic devices
US9763891B2 (en) 2011-07-22 2017-09-19 The General Hospital Corporation Therapeutic nanoparticles and methods of use thereof
GB201117675D0 (en) 2011-10-13 2011-11-23 Univ St Andrews Nanocolloids for local temperature monitoring
KR101355985B1 (ko) 2011-11-29 2014-01-29 (주)유 바이오메드 다중 암 진단용 조성물
ITTO20120132A1 (it) * 2012-02-15 2013-08-16 Univ Degli Studi Torino Procedimento di identificazione di cellule apoptotiche
WO2013146694A1 (ja) * 2012-03-28 2013-10-03 コニカミノルタ株式会社 生体物質の検出方法
US9011884B2 (en) 2012-04-18 2015-04-21 Microvention, Inc. Embolic devices
CN102617852B (zh) * 2012-04-24 2013-07-17 华东师范大学 马来酰亚胺-聚谷氨酸-天冬氨酸聚合物和其复合物、及其制备方法和用途
US11339208B1 (en) 2012-05-31 2022-05-24 United States Of America As Represented By The Secretary Of The Air Force Camelidae single-domain antibodies against Yersinia pestis and methods of use
KR102133611B1 (ko) 2012-06-14 2020-07-13 마이크로벤션, 인코포레이티드 중합체 치료 조성물
KR20140015763A (ko) * 2012-07-24 2014-02-07 삼성디스플레이 주식회사 Ｌｅｄ 패키지 및 이를 갖는 표시 장치
WO2014062696A1 (en) 2012-10-15 2014-04-24 Microvention, Inc. Polymeric treatment compositions
WO2014081419A2 (en) * 2012-11-20 2014-05-30 The Board Of Trustees Of The Leland Stanford Junior University High resolution imaging using near-infrared-ii fluorescence
US20140147381A1 (en) * 2012-11-29 2014-05-29 Gregory David Espenan 89zr compounds, to include somatostatin, apparatus and products comprising such compounds, methods of making same, and methods of using same for radio imaging and/or treatment
US20160018404A1 (en) * 2013-02-20 2016-01-21 Cornell University Multilayer fluorescent nanoparticles and methods of making and using same
EP2968621B1 (en) 2013-03-15 2022-08-10 Memorial Sloan-Kettering Cancer Center Multimodal silica-based nanoparticles
CN103264987B (zh) * 2013-04-22 2014-12-24 浙江师范大学 金纳米簇的制备方法及其应用
JP6354754B2 (ja) * 2013-06-19 2018-07-11 コニカミノルタ株式会社 生体分子染色用の蛍光ナノ粒子およびその製造方法
US10352859B2 (en) * 2013-09-26 2019-07-16 Konica Minolta, Inc. Method for determining quantity of biological material in tissue section
US20160243263A1 (en) * 2013-09-30 2016-08-25 BOARD OFf REGENTS, THE UNIVERSITY OF TEXAS SYSTEM Pegylated nanoparticle compositions
BR112016015198A2 (pt) 2013-12-31 2017-08-08 Memorial Sloan Kettering Cancer Center Sistemas, métodos e aparelho para a produção de imagens multicanal de fontes fluorescentes em tempo real
US10124090B2 (en) 2014-04-03 2018-11-13 Terumo Corporation Embolic devices
US10953110B2 (en) 2014-04-25 2021-03-23 Board Of Regents, The University Of Texas System Dual emissive metal nanoparticles as ratiometric pH indicators
CN110433326A (zh) 2014-04-29 2019-11-12 微仙美国有限公司 包含活性剂的聚合物
WO2015167751A1 (en) 2014-04-29 2015-11-05 Microvention, Inc. Polymers
ES2788865T3 (es) 2014-05-29 2020-10-23 Memorial Sloan Kettering Cancer Center Conjugados farmacéuticos de nanopartículas
WO2016004043A1 (en) * 2014-06-30 2016-01-07 Blend Therapeutics, Inc. Targeted conjugates and particles and formulations thereof
CA2953371C (en) 2014-06-30 2021-08-24 Tarveda Therapeutics, Inc. Targeted conjugates and particles and formulations thereof
EP3215176A4 (en) 2014-10-03 2018-05-23 Ntercept, LLC Compositions and methods for inhibiting the biological activity of soluble biomolecules
CA2970719C (en) 2014-12-15 2023-08-01 Memorial Sloan Kettering Cancer Center Cyclic peptides with enhanced nerve-binding selectivity, nanoparticles bound with said cyclic peptides, and use of same for real-time in vivo nerve tissue imaging
CN107735110B (zh) 2015-04-07 2021-11-26 纪念斯隆-凯特琳癌症中心 纳米粒子免疫偶联物
AU2016257431B2 (en) * 2015-05-04 2021-08-05 Cornell University Ultrasmall nanoparticles and methods of making and using same
WO2016196201A1 (en) 2015-05-29 2016-12-08 Memorial Sloan Kettering Cancer Center Methods of treatment using ultrasmall nanoparticles to induce cell death of nutrient-deprived cancer cells via ferroptosis
WO2016201250A1 (en) 2015-06-11 2016-12-15 Microvention, Inc. Expansile device for implantation
US10925852B2 (en) 2015-06-30 2021-02-23 The Trustees Of Columbia University In The City Of New York Talc-bound compositions and uses thereof
CN107708676A (zh) * 2015-06-30 2018-02-16 塔弗达治疗有限公司 靶向缀合物及其颗粒和制剂
US11660436B1 (en) 2015-08-04 2023-05-30 Verily Life Sciences Llc Device, system, and formulation for oral delivery of functionalized particles
KR20180075565A (ko) * 2015-10-21 2018-07-04 더 리젠츠 오브 더 유니버시티 오브 미시건 나노입자를 이용한 충치 및 미세공동의 검출 및 치료
JP7057278B2 (ja) 2015-10-28 2022-04-19 ターベダ セラピューティクス インコーポレイテッド Ｓｓｔｒ標的化コンジュゲート及び粒子並びにその製剤
CN105510574B (zh) * 2015-11-25 2018-11-20 深圳出入境检验检疫局食品检验检疫技术中心 荧光纳米探针及其制备方法和用于食品中多种危害因子同步检测的方法
WO2017106525A1 (en) 2015-12-15 2017-06-22 Memorial Sloan Kettering Cancer Center Imaging systems and methods for tissue differentiation, e.g., for intraoperative visualization
US11696959B2 (en) * 2015-12-31 2023-07-11 City Of Hope Nanoparticle-cell construct with platinum anti-cancer agent
US10548881B2 (en) 2016-02-23 2020-02-04 Tarveda Therapeutics, Inc. HSP90 targeted conjugates and particles and formulations thereof
WO2017176762A1 (en) 2016-04-06 2017-10-12 Nanotics, Llc Particles comprising subparticles or nucleic acid scaffolds
US20210220494A1 (en) 2016-04-29 2021-07-22 Memorial Sloan Kettering Cancer Center Compositions and methods for targeted particle penetration, distribution, and response in malignant brain tumors
EP3481272A4 (en) 2016-07-07 2020-03-11 Memorial Sloan Kettering Cancer Center IMAGING SYSTEMS AND METHODS FOR PARTICLE CONTROLLED, KNOWLEDGE-BASED AND PREDICTIVE CANCER RADIOGENOMICS
US10368874B2 (en) 2016-08-26 2019-08-06 Microvention, Inc. Embolic compositions
JP7492826B2 (ja) 2016-10-21 2024-05-30 ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ 分子ナノタグ
EP3548096A1 (en) 2016-11-30 2019-10-09 Memorial Sloan Kettering Cancer Center Inhibitor-functionalized ultrasmall nanoparticles and methods thereof
CN107050471A (zh) * 2016-12-27 2017-08-18 中国药科大学 基于富勒烯的靶向且具有快速清除特征的显像纳米探针及其制备方法和应用
FR3064364A1 (fr) * 2017-03-27 2018-09-28 S.P.C.M. Sa Methode de dosage de polymeres cationiques
JP6898603B2 (ja) * 2017-04-07 2021-07-07 ビュー ポイント メディカル， インコーポレーテッドＶｉｅｗ Ｐｏｉｎｔ Ｍｅｄｉｃａｌ， Ｉｎｃ． マルチモードイメージングマーカー
EP3624777A4 (en) * 2017-05-19 2021-03-10 Cornell University FUNCTIONALIZED NANOPARTICLE AND METHOD FOR MANUFACTURING AND USING THEREOF
CA3064253A1 (en) * 2017-05-25 2018-11-29 Memorial Sloan Kettering Cancer Center Ultrasmall nanoparticles labeled with zirconium-89 and methods thereof
KR20200014917A (ko) * 2017-06-09 2020-02-11 엔에이취 테라귁스 실리카 나노입자를 합성하는 방법
EP3642599A1 (en) 2017-06-23 2020-04-29 Memorial Sloan-Kettering Cancer Center Method of imaging in vivo tissues using nanoparticles comprising a reference dye and a sensor dye.
EP3694422A4 (en) 2017-10-09 2021-06-30 Microvention, Inc. EMBOLIC RADIOACTIVE LIQUID
CN107871677B (zh) * 2017-10-31 2020-08-25 合肥京东方光电科技有限公司 一种显示面板、封装监测装置及其封装监测方法
CN111373246A (zh) * 2017-11-22 2020-07-03 希成生物医药 包括硼替佐米的聚合物纳米颗粒
WO2019113004A1 (en) 2017-12-04 2019-06-13 Memorial Sloan Kettering Cancer Center Methods of cancer treatment via regulated ferroptosis
CN108245688A (zh) * 2017-12-18 2018-07-06 中国科学院自动化研究所 肝细胞癌诊断试剂及其制备方法
WO2019213458A1 (en) * 2018-05-02 2019-11-07 Cornell University Inorganic nanophotosensitizers and methods of making and using same
EP3787684A1 (en) 2018-05-02 2021-03-10 Memorial Sloan Kettering Cancer Center Nanotherapeutic systems and methods using particle-driven photodynamic therapy (pdt)
US11666411B2 (en) 2018-05-10 2023-06-06 Memorial Sloan Kettering Cancer Center Systems for augmented reality surgical and clinical visualization
EP3588063A1 (en) * 2018-06-21 2020-01-01 Universität Basel Method and computer program for determining a pharmacokinetic parameter in a biological sample by means of fluorsecence correlation spectroscopy
US20210268128A1 (en) * 2018-07-10 2021-09-02 The Board Of Trustees Of The Leland Stanford Junior University Fluorescent nanoparticles and imaging uses
CN109110764A (zh) * 2018-08-13 2019-01-01 河南师范大学 一种以微生物细胞分泌液为基质还原制备单质硅纳米颗粒的方法及其应用
CN109490265A (zh) * 2018-11-08 2019-03-19 深圳先进技术研究院 监测植物内物质运输的方法及其应用
WO2020131930A1 (en) * 2018-12-17 2020-06-25 Memorial Sloan Kettering Cancer Center Inducing favorable effects on tumor microenvironment via administration of nanoparticle compositions
CN109900670B (zh) * 2019-04-02 2021-07-06 济南大学 一种识别铁离子和氟离子的双功能探针及其制备和应用
US12042281B2 (en) 2019-07-17 2024-07-23 Terumo Cardiovascular Systems Corporation Fluorescent nanomaterial sensors and related methods
TW202108183A (zh) * 2019-08-01 2021-03-01 中央研究院 奈米複合材料及其用途
DE102019129924A1 (de) * 2019-08-21 2021-02-25 Endress+Hauser Conducta Gmbh+Co. Kg Optochemischer Sensor, Sensorkappe, Verwendung des optochemischen Sensors und Verfahren zur Herstellung einer analyt-sensitiven Schicht des optochemischen Sensors
EP4021306A4 (en) 2019-08-28 2023-08-23 View Point Medical, Inc. ULTRASONIC MARKER DETECTION, MARKER AND ASSOCIATED SYSTEMS, METHODS AND ARTICLES
CN110551497B (zh) * 2019-09-15 2022-06-10 四川农业大学 一种分子印迹量子点磷光探针的制备方法及其应用
EP4051331A4 (en) 2019-10-31 2022-12-28 Terumo Cardiovascular Systems Corporation HEART LUNG MACHINE WITH AUGMENTED REALITY DISPLAY
US11882992B2 (en) 2019-11-27 2024-01-30 View Point Medical, Inc. Composite tissue markers detectable via multiple detection modalities including radiopaque element
US11903767B2 (en) 2019-11-27 2024-02-20 View Point Medical, Inc. Composite tissue markers detectable via multiple detection modalities
CN111840551B (zh) * 2020-07-28 2022-07-19 苏州大学 治疗糖尿病的非侵入式近红外光控的纳米材料
KR102379752B1 (ko) * 2020-08-19 2022-03-28 국민대학교산학협력단 X-선 감쇠 기반 생체 이미징용 나노입자 및 조성물
EP4103236B1 (en) 2020-10-27 2023-08-16 Elucida Oncology, Inc. Folate receptor targeted nanoparticle drug conjugates and uses thereof
CN113281317B (zh) * 2021-05-14 2022-04-29 北京指真生物科技有限公司 一种含有花菁类化合物的编码微球及其制备方法和应用
CN114394602B (zh) * 2021-12-22 2023-09-22 中国人民解放军陆军军医大学第一附属医院 一种锰掺杂的中空介孔二氧化硅纳米材料及其制备方法与应用
CN114431160B (zh) * 2021-12-30 2023-07-21 中国科学院上海技术物理研究所 一种适用于太空微重力环境的动物排泄物收集系统
WO2023172674A2 (en) * 2022-03-09 2023-09-14 The Regents Of The University Of California One-step supramolecular multifunctional coating on plant virus nanoparticles for bioimaging and therapeutic applications
CN115092938B (zh) * 2022-06-21 2024-02-06 苏州拉索生物芯片科技有限公司 一种氨基改性二氧化硅微球的制备方法及应用

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3870791A (en) 1972-04-24 1975-03-11 Heskel M Haddad Solid state ophthalmic medication delivery method
US3867519A (en) 1972-04-27 1975-02-18 Alza Corp Bioerodible drug delivery device
US4051842A (en) 1975-09-15 1977-10-04 International Medical Corporation Electrode and interfacing pad for electrical physiological systems
DE2626348C3 (de) 1976-06-11 1980-01-31 Siemens Ag, 1000 Berlin Und 8000 Muenchen Implantierbare Dosiereinrichtung
US4136177A (en) 1977-01-31 1979-01-23 American Home Products Corp. Xanthan gum therapeutic compositions
US4255415A (en) 1978-11-22 1981-03-10 Schering Corporation Polyvinyl alcohol ophthalmic gel
US4383529A (en) 1980-11-03 1983-05-17 Wescor, Inc. Iontophoretic electrode device, method and gel insert
US4668506A (en) 1985-08-16 1987-05-26 Bausch & Lomb Incorporated Sustained-release formulation containing and amino acid polymer
US4931279A (en) 1985-08-16 1990-06-05 Bausch & Lomb Incorporated Sustained release formulation containing an ion-exchange resin
US4788603A (en) 1985-10-19 1988-11-29 Fuji Photo Film Co., Ltd. Camera for sequentially photographing a subject using a reference optical system and a telescopic optical system
US4812409A (en) 1986-01-31 1989-03-14 Eastman Kodak Company Hydrolyzable fluorescent substrates and analytical determinations using same
US4713224A (en) 1986-03-31 1987-12-15 The Boc Group, Inc. One-step process for purifying an inert gas
US4810636A (en) 1986-12-09 1989-03-07 Miles Inc. Chromogenic acridinone enzyme substrates
US4774339A (en) 1987-08-10 1988-09-27 Molecular Probes, Inc. Chemically reactive dipyrrometheneboron difluoride dyes
US5433896A (en) 1994-05-20 1995-07-18 Molecular Probes, Inc. Dibenzopyrrometheneboron difluoride dyes
US5274113A (en) 1991-11-01 1993-12-28 Molecular Probes, Inc. Long wavelength chemically reactive dipyrrometheneboron difluoride dyes and conjugates
US5248782A (en) 1990-12-18 1993-09-28 Molecular Probes, Inc. Long wavelength heteroaryl-substituted dipyrrometheneboron difluoride dyes
US5187288A (en) 1991-05-22 1993-02-16 Molecular Probes, Inc. Ethenyl-substituted dipyrrometheneboron difluoride dyes and their synthesis
US5660827A (en) 1992-03-05 1997-08-26 Board Of Regents, The University Of Texas System Antibodies that bind to endoglin
US5830912A (en) 1996-11-15 1998-11-03 Molecular Probes, Inc. Derivatives of 6,8-difluoro-7-hydroxycoumarin
US6344272B1 (en) 1997-03-12 2002-02-05 Wm. Marsh Rice University Metal nanoshells
GB2330907A (en) 1997-10-28 1999-05-05 Applied Imaging Int Ltd A karyotyper and methods for producing karyotypes
JP3468750B2 (ja) 1998-01-22 2003-11-17 ルミネックス コーポレイション 多数の蛍光シグナルを有する微小粒子
US6428811B1 (en) 1998-03-11 2002-08-06 Wm. Marsh Rice University Temperature-sensitive polymer/nanoshell composites for photothermally modulated drug delivery
US6254852B1 (en) * 1999-07-16 2001-07-03 Dupont Pharmaceuticals Company Porous inorganic targeted ultrasound contrast agents
US20050250854A1 (en) 2000-11-03 2005-11-10 Amgen Inc. Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents
US7279150B2 (en) * 2002-01-24 2007-10-09 Barnes-Jewish Hospital Chelating agents with lipophilic carriers
US20030219785A1 (en) 2002-02-01 2003-11-27 Vanderbilt University Targeted drug delivery methods
US8620410B2 (en) 2002-03-12 2013-12-31 Beth Israel Deaconess Medical Center Multi-channel medical imaging system
US20040101822A1 (en) 2002-11-26 2004-05-27 Ulrich Wiesner Fluorescent silica-based nanoparticles
US20060173362A1 (en) 2004-10-08 2006-08-03 The Cleveland Clinic Foundation And Vanderbilt University Methods of medical imaging using quantum dots
US7653427B2 (en) 2004-11-12 2010-01-26 Intra-Medical Imaging LLC Method and instrument for minimally invasive sentinel lymph node location and biopsy
KR101364374B1 (ko) 2005-03-14 2014-02-17 더 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 생활성 ｆｕｓ1 펩티드 및 나노입자-폴리펩티드 복합체
CN101389314A (zh) * 2005-03-14 2009-03-18 得克萨斯大学体系董事会 生物活性fus1肽和纳米颗粒-多肽复合物
US20070065359A1 (en) 2005-03-14 2007-03-22 Shiladitya Sengupta Nanocells for diagnosis and treatment of diseases and disorders
WO2007053189A2 (en) 2005-06-01 2007-05-10 Northwestern University Compositions and methods for altering immune function
AU2006261917A1 (en) 2005-06-24 2007-01-04 The Trustees Of The University Of Pennsylvania Radiolabeled-pegylation of ligands for use as imaging agents
FR2888753B1 (fr) * 2005-07-21 2008-04-04 Commissariat Energie Atomique Vecteur cible avec fonction d'imagerie activable
WO2008044138A1 (en) 2006-10-12 2008-04-17 Syddansk Universitet Optical nanosensor for detection of reactive oxygen species
US8838213B2 (en) 2006-10-19 2014-09-16 The General Hospital Corporation Apparatus and method for obtaining and providing imaging information associated with at least one portion of a sample, and effecting such portion(s)
US7902332B2 (en) * 2006-11-30 2011-03-08 General Electric Company Fluorine-labeled compounds
WO2008073856A2 (en) * 2006-12-08 2008-06-19 Massachusetts Institute Of Technology Delivery of nanoparticles and/or agents to cells
US8239007B2 (en) 2007-04-13 2012-08-07 Ethicon Endo-Surgert, Inc. Biocompatible nanoparticle compositions and methods
EP1995327A1 (en) 2007-05-21 2008-11-26 Humboldt Universität zu Berlin Probe for detecting a particular nucleic acid sequence
CN101903290B (zh) 2007-08-31 2013-01-09 混合硅晶科技公司 Peg包覆的核-壳二氧化硅纳米颗粒及其制备方法和应用
DE102007052517A1 (de) 2007-10-29 2009-04-30 Autoimmun Diagnostika Gmbh ELISPOT-Verfahren mit zwei Filtersystemen
WO2009064964A2 (en) 2007-11-15 2009-05-22 The University Of California Switchable nano-vehicle delivery systems, and methods for making and using them
JP5526036B2 (ja) 2007-12-21 2014-06-18 プレジデント アンド フェローズ オブ ハーバード カレッジ 三次元の回折限界未満の画像解像技術
WO2010091294A2 (en) * 2009-02-05 2010-08-12 The Regents Of The University Of California New targeted antimicrobial moieties
US9005575B2 (en) * 2009-06-12 2015-04-14 Stc.Unm Arg-Gly-Asp-conjugated alpha-melanocyte stimulating hormone hybrid peptide for use in diagnosing and treating melanoma, including metastatic melanoma and methods related to same
CN102713612B (zh) 2009-07-02 2016-10-05 斯隆-凯特林癌症研究院 基于二氧化硅的荧光纳米颗粒
US20130017265A1 (en) 2009-12-16 2013-01-17 Massachusetts Institute Of Technology Particles for multiple agent delivery
MA34277B1 (fr) 2010-04-15 2013-06-01 Spirogen Developments Sarl Pyrrolobenzodiazépines et conjugués de celles-ci
CN104703625B (zh) 2012-06-22 2017-08-29 康奈尔大学 介孔氧化物纳米颗粒以及制备和使用其的方法
WO2014011973A2 (en) 2012-07-13 2014-01-16 The Trustees Of Columbia University In The City Of New York Quinazolinone-based oncogenic-ras-selective lethal compounds and their use
CN112587671A (zh) 2012-07-18 2021-04-02 博笛生物科技有限公司 癌症的靶向免疫治疗
EP2968621B1 (en) 2013-03-15 2022-08-10 Memorial Sloan-Kettering Cancer Center Multimodal silica-based nanoparticles
ES2788865T3 (es) 2014-05-29 2020-10-23 Memorial Sloan Kettering Cancer Center Conjugados farmacéuticos de nanopartículas
WO2016196201A1 (en) 2015-05-29 2016-12-08 Memorial Sloan Kettering Cancer Center Methods of treatment using ultrasmall nanoparticles to induce cell death of nutrient-deprived cancer cells via ferroptosis
EP3642599A1 (en) 2017-06-23 2020-04-29 Memorial Sloan-Kettering Cancer Center Method of imaging in vivo tissues using nanoparticles comprising a reference dye and a sensor dye.
CN112291219B (zh) 2020-10-22 2023-06-13 格力博(江苏)股份有限公司 通信交互方法及系统

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