PL3194570T3 - Sposoby i kompozycje do inżynierii genomowej w której pośredniczy nukleaza i korekty hematopoetycznych komórek macierzystych - Google Patents

Sposoby i kompozycje do inżynierii genomowej w której pośredniczy nukleaza i korekty hematopoetycznych komórek macierzystych

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Publication number
PL3194570T3
PL3194570T3 PL15841477T PL15841477T PL3194570T3 PL 3194570 T3 PL3194570 T3 PL 3194570T3 PL 15841477 T PL15841477 T PL 15841477T PL 15841477 T PL15841477 T PL 15841477T PL 3194570 T3 PL3194570 T3 PL 3194570T3
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PL
Poland
Prior art keywords
nuclease
correction
compositions
methods
stem cells
Prior art date
Application number
PL15841477T
Other languages
English (en)
Inventor
Gregory J. Cost
Jeffrey C. Miller
Lei Zhang
Original Assignee
Sangamo Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sangamo Therapeutics, Inc. filed Critical Sangamo Therapeutics, Inc.
Publication of PL3194570T3 publication Critical patent/PL3194570T3/pl

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    • C12N5/0645—Macrophages, e.g. Kuepfer cells in the liver; Monocytes
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    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2121/00—Preparations for use in therapy
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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    • C12N2800/00—Nucleic acids vectors
    • C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites

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  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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PL15841477T 2014-09-16 2015-09-16 Sposoby i kompozycje do inżynierii genomowej w której pośredniczy nukleaza i korekty hematopoetycznych komórek macierzystych PL3194570T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462051159P 2014-09-16 2014-09-16
PCT/US2015/050411 WO2016044416A1 (en) 2014-09-16 2015-09-16 Methods and compositions for nuclease-mediated genome engineering and correction in hematopoietic stem cells
EP15841477.1A EP3194570B1 (en) 2014-09-16 2015-09-16 Methods and compositions for nuclease-mediated genome engineering and correction in hematopoietic stem cells

Publications (1)

Publication Number Publication Date
PL3194570T3 true PL3194570T3 (pl) 2021-12-20

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PL15841477T PL3194570T3 (pl) 2014-09-16 2015-09-16 Sposoby i kompozycje do inżynierii genomowej w której pośredniczy nukleaza i korekty hematopoetycznych komórek macierzystych

Country Status (18)

Country Link
US (1) US10435677B2 (pl)
EP (2) EP3194570B1 (pl)
JP (3) JP6722176B2 (pl)
KR (1) KR20170054445A (pl)
CN (2) CN106795488B (pl)
AU (2) AU2015317793B2 (pl)
CA (1) CA2960769A1 (pl)
DK (1) DK3194570T3 (pl)
ES (1) ES2886012T3 (pl)
HR (1) HRP20211468T1 (pl)
HU (1) HUE055583T2 (pl)
LT (1) LT3194570T (pl)
PL (1) PL3194570T3 (pl)
PT (1) PT3194570T (pl)
RS (1) RS62334B1 (pl)
SG (2) SG10202011572XA (pl)
SI (1) SI3194570T1 (pl)
WO (1) WO2016044416A1 (pl)

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