PL3131577T3 - Zmodyfikowane komórki gospodarze i ich zastosowanie - Google Patents

Zmodyfikowane komórki gospodarze i ich zastosowanie

Info

Publication number
PL3131577T3
PL3131577T3 PL14784210T PL14784210T PL3131577T3 PL 3131577 T3 PL3131577 T3 PL 3131577T3 PL 14784210 T PL14784210 T PL 14784210T PL 14784210 T PL14784210 T PL 14784210T PL 3131577 T3 PL3131577 T3 PL 3131577T3
Authority
PL
Poland
Prior art keywords
host cells
modified host
modified
cells
host
Prior art date
Application number
PL14784210T
Other languages
English (en)
Inventor
Michael Kowarik
Stefan J. Kemmler
Julien L. QUÉBATTE
Christiane Marie-Paule Simone Jeanne FERON
Original Assignee
Glaxosmithkline Biologicals S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Biologicals S.A. filed Critical Glaxosmithkline Biologicals S.A.
Publication of PL3131577T3 publication Critical patent/PL3131577T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1048Glycosyltransferases (2.4)
    • C12N9/1051Hexosyltransferases (2.4.1)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/104Pseudomonadales, e.g. Pseudomonas
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6415Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/21Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1048Glycosyltransferases (2.4)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y204/00Glycosyltransferases (2.4)
    • C12Y204/01Hexosyltransferases (2.4.1)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031Proteins
    • A61K2039/6037Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
PL14784210T 2014-04-17 2014-10-13 Zmodyfikowane komórki gospodarze i ich zastosowanie PL3131577T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461980988P 2014-04-17 2014-04-17
PCT/EP2014/071898 WO2015158403A1 (en) 2014-04-17 2014-10-13 Modified host cells and uses thereof
EP14784210.8A EP3131577B1 (en) 2014-04-17 2014-10-13 Modified host cells and uses thereof

Publications (1)

Publication Number Publication Date
PL3131577T3 true PL3131577T3 (pl) 2020-10-19

Family

ID=51726491

Family Applications (1)

Application Number Title Priority Date Filing Date
PL14784210T PL3131577T3 (pl) 2014-04-17 2014-10-13 Zmodyfikowane komórki gospodarze i ich zastosowanie

Country Status (17)

Country Link
US (1) US20170035900A1 (pl)
EP (2) EP3711776B1 (pl)
JP (2) JP6682451B2 (pl)
CN (1) CN106794237B (pl)
BR (1) BR112016023688B1 (pl)
CA (1) CA2945542C (pl)
CY (1) CY1123403T1 (pl)
DK (1) DK3131577T3 (pl)
ES (2) ES2939470T3 (pl)
HR (1) HRP20201021T1 (pl)
HU (1) HUE049806T2 (pl)
LT (1) LT3131577T (pl)
MX (1) MX378857B (pl)
PL (1) PL3131577T3 (pl)
PT (1) PT3131577T (pl)
SI (1) SI3131577T1 (pl)
WO (1) WO2015158403A1 (pl)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX421690B (es) 2015-07-13 2025-03-14 Pivot Bio Inc Metodos y composiciones para mejorar atributos de plantas
GB201518668D0 (en) * 2015-10-21 2015-12-02 Glaxosmithkline Biolog Sa Immunogenic Comosition
CN105732818B (zh) * 2016-03-02 2019-06-07 中国人民解放军第三军医大学 一种铜绿假单胞菌重组蛋白pop及其制备方法和应用
ES2967001T3 (es) * 2017-06-23 2024-04-25 Affinivax Inc Composiciones inmunogénicas
CN117757706A (zh) 2017-10-25 2024-03-26 皮沃特生物股份有限公司 靶向改良植物性状的固氮的基因靶标
AU2018354221B2 (en) 2017-10-25 2025-04-17 Pivot Bio, Inc. Methods and compositions for improving engineered microbes that fix nitrogen
CA3104531A1 (en) * 2018-06-27 2020-01-02 Pivot Bio, Inc. Guided microbial remodeling, a platform for the rational improvement of microbial species for agriculture
IL286467B1 (en) 2019-03-18 2025-10-01 Janssen Pharmaceuticals Inc Methods for producing bioconjugates of E. COLI O-antigen polysaccharides, preparations thereof and methods for using them
TWI751513B (zh) 2019-03-18 2022-01-01 美商詹森藥物公司 E. coli O-抗原多醣生物結合物、其製備方法及其使用方法
EP4118193A1 (en) * 2020-03-12 2023-01-18 Malcisbo AG Vaccines comprising glycoengineered bacteria
PE20231385A1 (es) 2020-09-17 2023-09-12 Janssen Pharmaceuticals Inc Composiciones de vacunas multivalentes y usos de las mismas

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5057540A (en) 1987-05-29 1991-10-15 Cambridge Biotech Corporation Saponin adjuvant
US4912094B1 (en) 1988-06-29 1994-02-15 Ribi Immunochem Research Inc. Modified lipopolysaccharides and process of preparation
DK1481057T3 (da) 2002-03-07 2006-05-15 Eidgenoess Tech Hochschule System og fremgangsmåde til fremstilling af rekombinante glycosylerede proteiner i en prokaryot vært
KR101524636B1 (ko) * 2005-05-11 2015-06-03 에테하 취리히 원핵 세포로부터의 재조합 n-글리코실화 단백질
ATE539079T1 (de) 2006-03-23 2012-01-15 Novartis Ag Imidazochinoxalinverbindungen als immunmodulatoren
WO2007109812A2 (en) 2006-03-23 2007-09-27 Novartis Ag Immunopotentiating compounds
US8895014B2 (en) * 2008-02-20 2014-11-25 Glycovaxyn Ag Bioconjugates made from recombinant N-glycosylated proteins from procaryotic cells
ES2660227T3 (es) 2009-11-19 2018-03-21 Glaxosmithkline Biologicals S.A. Sistema biosintético que produce polisacáridos inmunogénicos en células procariotas
PL2566507T3 (pl) * 2010-05-06 2018-05-30 Glaxosmithkline Biologicals Sa Szczepionki na bazie biokoniugatu przeciw otoczkowym bakteriom gram-dodatnim
WO2013034664A1 (en) * 2011-09-06 2013-03-14 Glycovaxyn Ag Bioconjugate vaccines made in prokaryotic cells
WO2014037585A1 (en) * 2012-09-10 2014-03-13 Glycovaxyn Ag Bioconjugates comprising modified antigens and uses thereof
EP2906681B1 (en) * 2012-10-12 2019-01-09 GlaxoSmithKline Biologicals S.A. Methods of host cell modification
ES2882282T3 (es) * 2012-11-07 2021-12-01 Glaxosmithkline Biologicals Sa Producción de vacuna recombinante en E. coli mediante conjugación enzimática
CN106062203B (zh) * 2013-10-11 2020-08-07 葛兰素史密丝克莱恩生物有限公司 宿主细胞修饰的方法

Also Published As

Publication number Publication date
CA2945542C (en) 2024-03-05
JP6682451B2 (ja) 2020-04-15
CN106794237B (zh) 2022-04-12
JP2020114232A (ja) 2020-07-30
BR112016023688A2 (pt) 2018-01-30
EP3131577B1 (en) 2020-04-22
PT3131577T (pt) 2020-07-17
CA2945542A1 (en) 2015-10-22
US20170035900A1 (en) 2017-02-09
BR112016023688B1 (pt) 2024-01-09
WO2015158403A1 (en) 2015-10-22
JP2017513480A (ja) 2017-06-01
CY1123403T1 (el) 2022-03-24
MX2016013631A (es) 2017-02-28
CN106794237A (zh) 2017-05-31
EP3711776A1 (en) 2020-09-23
ES2939470T3 (es) 2023-04-24
MX378857B (es) 2025-03-10
DK3131577T3 (da) 2020-07-13
HRP20201021T1 (hr) 2020-10-16
ES2805000T3 (es) 2021-02-10
HUE049806T2 (hu) 2020-10-28
EP3711776B1 (en) 2023-01-11
LT3131577T (lt) 2020-07-27
SI3131577T1 (sl) 2020-08-31
EP3131577A1 (en) 2017-02-22

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