SI3131577T1 - Modificirane gostiljske celice in uporabe le-teh - Google Patents

Modificirane gostiljske celice in uporabe le-teh

Info

Publication number
SI3131577T1
SI3131577T1 SI201431611T SI201431611T SI3131577T1 SI 3131577 T1 SI3131577 T1 SI 3131577T1 SI 201431611 T SI201431611 T SI 201431611T SI 201431611 T SI201431611 T SI 201431611T SI 3131577 T1 SI3131577 T1 SI 3131577T1
Authority
SI
Slovenia
Prior art keywords
host cells
modified host
modified
cells
host
Prior art date
Application number
SI201431611T
Other languages
English (en)
Inventor
Michael Kowarik
Stefan J. Kemmler
Julien L. QUEBATTE
Christiane Marie-Paule Simone Jeanne Feron
Original Assignee
Glaxosmithkline Biologicals S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Biologicals S.A. filed Critical Glaxosmithkline Biologicals S.A.
Publication of SI3131577T1 publication Critical patent/SI3131577T1/sl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1048Glycosyltransferases (2.4)
    • C12N9/1051Hexosyltransferases (2.4.1)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/104Pseudomonadales, e.g. Pseudomonas
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6415Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/21Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1048Glycosyltransferases (2.4)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y204/00Glycosyltransferases (2.4)
    • C12Y204/01Hexosyltransferases (2.4.1)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031Proteins
    • A61K2039/6037Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
SI201431611T 2014-04-17 2014-10-13 Modificirane gostiljske celice in uporabe le-teh SI3131577T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461980988P 2014-04-17 2014-04-17
PCT/EP2014/071898 WO2015158403A1 (en) 2014-04-17 2014-10-13 Modified host cells and uses thereof
EP14784210.8A EP3131577B1 (en) 2014-04-17 2014-10-13 Modified host cells and uses thereof

Publications (1)

Publication Number Publication Date
SI3131577T1 true SI3131577T1 (sl) 2020-08-31

Family

ID=51726491

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201431611T SI3131577T1 (sl) 2014-04-17 2014-10-13 Modificirane gostiljske celice in uporabe le-teh

Country Status (17)

Country Link
US (1) US20170035900A1 (sl)
EP (2) EP3711776B1 (sl)
JP (2) JP6682451B2 (sl)
CN (1) CN106794237B (sl)
BR (1) BR112016023688B1 (sl)
CA (1) CA2945542C (sl)
CY (1) CY1123403T1 (sl)
DK (1) DK3131577T3 (sl)
ES (2) ES2939470T3 (sl)
HR (1) HRP20201021T1 (sl)
HU (1) HUE049806T2 (sl)
LT (1) LT3131577T (sl)
MX (1) MX2016013631A (sl)
PL (1) PL3131577T3 (sl)
PT (1) PT3131577T (sl)
SI (1) SI3131577T1 (sl)
WO (1) WO2015158403A1 (sl)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201518668D0 (en) * 2015-10-21 2015-12-02 Glaxosmithkline Biolog Sa Immunogenic Comosition
CN105732818B (zh) * 2016-03-02 2019-06-07 中国人民解放军第三军医大学 一种铜绿假单胞菌重组蛋白pop及其制备方法和应用
US11612647B2 (en) 2017-06-23 2023-03-28 University Of Maryland, Baltimore Immunogenic compositions
CA3104531A1 (en) * 2018-06-27 2020-01-02 Pivot Bio, Inc. Guided microbial remodeling, a platform for the rational improvement of microbial species for agriculture
CA3134216A1 (en) 2019-03-18 2020-09-24 Janssen Pharmaceuticals, Inc. Bioconjugates of e. coli o-antigen polysaccharides, methods of production thereof, and methods of use thereof
CA3134045A1 (en) 2019-03-18 2020-09-24 Janssen Pharmaceuticals, Inc. Methods of producing bioconjugates of e. coli o-antigen polysaccharides, compositions thereof, and methods of use thereof
CA3170889A1 (en) * 2020-03-12 2021-09-16 Christine Neupert Vaccines comprising glycoengineered bacteria
AU2021342797B2 (en) 2020-09-17 2024-02-08 Janssen Pharmaceuticals, Inc. Multivalent vaccine compositions and uses thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5057540A (en) 1987-05-29 1991-10-15 Cambridge Biotech Corporation Saponin adjuvant
US4912094B1 (en) 1988-06-29 1994-02-15 Ribi Immunochem Research Inc. Modified lipopolysaccharides and process of preparation
ES2258214T3 (es) 2002-03-07 2006-08-16 Eidgenossische Technische Hochschule Zurich Sistema y procedimiento para la produccion de proteinas glucosiladas recombinantes en un huesped procariotico.
KR101524636B1 (ko) * 2005-05-11 2015-06-03 에테하 취리히 원핵 세포로부터의 재조합 n-글리코실화 단백질
CA2646539A1 (en) 2006-03-23 2007-09-27 Novartis Ag Imidazoquinoxaline compounds as immunomodulators
CA2646891A1 (en) 2006-03-23 2007-09-27 Novartis Ag Immunopotentiating compounds
SI2257307T1 (sl) * 2008-02-20 2018-09-28 Glaxosmithkline Biologicals S.A. Biokonjugati, izdelani iz rekombinantnih N-glikoziliranih proteinov iz prokariontskih celic
PT2501406T (pt) * 2009-11-19 2018-02-21 Glaxosmithkline Biologicals Sa Sistema de biossíntese que produz polissacáridos imunogénicos em células procariotas
ES2844596T3 (es) * 2010-05-06 2021-07-22 Glaxosmithkline Biologicals Sa Vacunas de bioconjugados de bacterias grampositivas capsulares
JP2014526449A (ja) * 2011-09-06 2014-10-06 グリコヴァキシン アーゲー 原核細胞において製造されるバイオコンジュゲートワクチン
BR112015004817A2 (pt) * 2012-09-10 2017-07-04 Glycovaxyn Ag bioconjugados compreendendo antígenos modificados e seus usos
EP3527663B1 (en) * 2012-10-12 2021-12-01 GlaxoSmithKline Biologicals SA Methods of host cell modification
JP6412875B2 (ja) * 2012-11-07 2018-10-24 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 酵素的コンジュゲート化による大腸菌での組み換えワクチンの製造
EA201690529A1 (ru) * 2013-10-11 2016-11-30 Гликоваксин Аг Способы модификации клетки-хозяина

Also Published As

Publication number Publication date
CN106794237A (zh) 2017-05-31
EP3131577B1 (en) 2020-04-22
HRP20201021T1 (hr) 2020-10-16
CY1123403T1 (el) 2022-03-24
JP2017513480A (ja) 2017-06-01
HUE049806T2 (hu) 2020-10-28
ES2939470T3 (es) 2023-04-24
PT3131577T (pt) 2020-07-17
JP6682451B2 (ja) 2020-04-15
DK3131577T3 (da) 2020-07-13
US20170035900A1 (en) 2017-02-09
LT3131577T (lt) 2020-07-27
JP2020114232A (ja) 2020-07-30
EP3131577A1 (en) 2017-02-22
WO2015158403A1 (en) 2015-10-22
BR112016023688A2 (pt) 2018-01-30
CA2945542A1 (en) 2015-10-22
CN106794237B (zh) 2022-04-12
MX2016013631A (es) 2017-02-28
PL3131577T3 (pl) 2020-10-19
EP3711776B1 (en) 2023-01-11
EP3711776A1 (en) 2020-09-23
CA2945542C (en) 2024-03-05
ES2805000T3 (es) 2021-02-10
BR112016023688B1 (pt) 2024-01-09

Similar Documents

Publication Publication Date Title
HK1243332A1 (zh) 改變在修飾的t細胞中的基因表達及其用途
HK1231471A1 (zh) -雜芳氧基-和 芳氧基-喹啉- -甲酰胺及其用途
IL247344B (en) A new polysaccharide and its uses
IL252216B (en) Difluoromethyl-aminopyridines and difluoromethyl-aminopyrimidines
SG11201609118RA (en) Modified natural killer cells and uses thereof
IL246755A0 (en) The heteroaryls and their use
HUE044571T2 (hu) Módosított ciklopentapeptidek és alkalmazásaik
HK1231555A1 (zh) 生物標誌物及其用途
HUE049806T2 (hu) Módosított gazdasejtek és alkalmazásaik
SG11201704473WA (en) New methods and uses
HK1243077A1 (zh) 呱啶基吡唑並嘧啶酮及其用途
SG11201610514SA (en) Bioreactor and uses thereof
GB201408091D0 (en) Methods and uses
GB201622225D0 (en) Modified host cells and uses thereof
GB201419897D0 (en) Host cell
PL3229772T3 (pl) 6-arylo-9-glikozylopuryny i ich zastosowanie
EP3233107A4 (en) Nbp158 and uses thereof
GB201416086D0 (en) Methods and uses
GB201416073D0 (en) Methods and uses
AU2014901390A0 (en) Immune cell markers and uses thereof
AU2014901388A0 (en) Immune cell markers and uses thereof
AU2014901389A0 (en) Immune cell markers and uses thereof
AU2014904616A0 (en) Biomarkers and uses thereof
GB201415379D0 (en) Gamma T cells and uses thereof
GB201407419D0 (en) Conductive materials and uses thereof