PL3119882T3 - Sposoby wytwarzania rekombinowanych glikoprotein zmodyfikowaną glikozylacją - Google Patents

Sposoby wytwarzania rekombinowanych glikoprotein zmodyfikowaną glikozylacją

Info

Publication number
PL3119882T3
PL3119882T3 PL15770138T PL15770138T PL3119882T3 PL 3119882 T3 PL3119882 T3 PL 3119882T3 PL 15770138 T PL15770138 T PL 15770138T PL 15770138 T PL15770138 T PL 15770138T PL 3119882 T3 PL3119882 T3 PL 3119882T3
Authority
PL
Poland
Prior art keywords
methods
producing recombinant
modified glycosylation
recombinant glycoproteins
glycoproteins
Prior art date
Application number
PL15770138T
Other languages
English (en)
Inventor
Nien-Yi Chen
Che-Haorz Wu
Hung-Chi Chen
Winston Town
Original Assignee
Oneness Biotech Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oneness Biotech Co., Ltd. filed Critical Oneness Biotech Co., Ltd.
Publication of PL3119882T3 publication Critical patent/PL3119882T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/005Glycopeptides, glycoproteins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4283Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
    • C07K16/4291Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/24Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/24Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405Glucanases
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y302/00Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01051Alpha-L-fucosidase (3.2.1.51)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y302/00Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01096Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase (3.2.1.96)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/40Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41Glycosylation, sialylation, or fucosylation
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/52Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
PL15770138T 2014-03-17 2015-03-17 Sposoby wytwarzania rekombinowanych glikoprotein zmodyfikowaną glikozylacją PL3119882T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461954337P 2014-03-17 2014-03-17
EP15770138.4A EP3119882B1 (en) 2014-03-17 2015-03-17 Methods for producing recombinant glycoproteins with modified glycosylation
PCT/IB2015/001203 WO2015145268A2 (en) 2014-03-17 2015-03-17 Methods for producing recombinant glycoproteins with modified glycosylation

Publications (1)

Publication Number Publication Date
PL3119882T3 true PL3119882T3 (pl) 2022-05-16

Family

ID=54068262

Family Applications (1)

Application Number Title Priority Date Filing Date
PL15770138T PL3119882T3 (pl) 2014-03-17 2015-03-17 Sposoby wytwarzania rekombinowanych glikoprotein zmodyfikowaną glikozylacją

Country Status (19)

Country Link
US (2) US9540673B2 (pl)
EP (1) EP3119882B1 (pl)
JP (2) JP6701089B2 (pl)
KR (1) KR102333923B1 (pl)
CN (1) CN106715686B (pl)
AU (1) AU2015237951B2 (pl)
BR (1) BR112016021284A2 (pl)
CA (1) CA2942618A1 (pl)
DK (1) DK3119882T3 (pl)
ES (1) ES2904993T3 (pl)
HU (1) HUE057904T2 (pl)
IL (1) IL247776B (pl)
MX (1) MX2016012085A (pl)
PL (1) PL3119882T3 (pl)
PT (1) PT3119882T (pl)
RU (1) RU2704830C2 (pl)
SG (1) SG11201607759RA (pl)
TW (1) TWI682033B (pl)
WO (1) WO2015145268A2 (pl)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102576850B1 (ko) * 2014-05-27 2023-09-11 아카데미아 시니카 박테로이드 기원의 푸코시다제 및 이의 사용 방법
KR20220025721A (ko) * 2019-08-05 2022-03-03 초 파마 인크. 항체 글리코폼을 리모델링하기 위한 융합 단백질
CN110885809B (zh) * 2019-12-04 2021-08-17 中国农业大学 α-L-岩藻糖苷酶及其相关生物材料与应用
AR126089A1 (es) 2021-06-07 2023-09-13 Amgen Inc Uso de fucosidasa para controlar el nivel de afucosilación de proteínas glucosiladas

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2180007T4 (da) 1998-04-20 2017-11-27 Roche Glycart Ag Glycosyleringsteknik for antistoffer til forbedring af antistofafhængig cellecytotoxicitet
WO2007146847A2 (en) 2006-06-09 2007-12-21 University Of Maryland, Baltimore Glycosylation engineered antibody therapy
CN101466402A (zh) * 2006-06-09 2009-06-24 马里兰卅大学(巴尔的摩) 糖基化改造的抗体治疗
GB0624874D0 (en) * 2006-12-13 2007-01-24 Hansa Medical Ab Treatment
CA2679732A1 (en) * 2007-03-07 2008-09-18 Glycofi, Inc. Production of glycoproteins with modified fucosylation
KR101054362B1 (ko) * 2008-07-03 2011-08-05 재단법인 목암생명공학연구소 재조합 단백질의 푸코스 함량을 감소시키는 방법
WO2010036443A1 (en) * 2008-09-26 2010-04-01 Eureka Therapeutics, Inc. Cell lines and proteins with variant glycosylation pattern
GB0821100D0 (en) * 2008-11-18 2008-12-24 Hansa Medical Ab Antibodies
CN102333872B (zh) * 2009-02-25 2014-07-09 默沙东公司 在糖工程化的酵母巴斯德毕赤酵母中对半乳糖同化途径的代谢工程化
WO2011039150A1 (en) * 2009-10-02 2011-04-07 Roche Glycart Ag A-fucosylation detection in antibodies
US10087236B2 (en) * 2009-12-02 2018-10-02 Academia Sinica Methods for modifying human antibodies by glycan engineering
WO2013120066A1 (en) * 2012-02-10 2013-08-15 University Of Maryland, Baltimore Chemoenzymatic glycoengineering of antibodies and fc fragments thereof

Also Published As

Publication number Publication date
HUE057904T2 (hu) 2022-06-28
EP3119882A4 (en) 2017-08-16
WO2015145268A2 (en) 2015-10-01
PT3119882T (pt) 2022-01-20
RU2016140528A3 (pl) 2018-10-18
CN106715686A (zh) 2017-05-24
US20170145463A1 (en) 2017-05-25
MX2016012085A (es) 2017-05-23
US9540673B2 (en) 2017-01-10
TW201623620A (zh) 2016-07-01
DK3119882T3 (da) 2022-01-31
US20150259720A1 (en) 2015-09-17
CA2942618A1 (en) 2015-10-01
IL247776A0 (en) 2016-11-30
TWI682033B (zh) 2020-01-11
AU2015237951A1 (en) 2016-10-20
KR20160127830A (ko) 2016-11-04
WO2015145268A3 (en) 2016-01-21
WO2015145268A8 (en) 2015-12-03
US10745729B2 (en) 2020-08-18
AU2015237951B2 (en) 2021-07-01
ES2904993T3 (es) 2022-04-06
JP2017507664A (ja) 2017-03-23
JP6701089B2 (ja) 2020-05-27
CN106715686B (zh) 2021-03-16
JP2020072667A (ja) 2020-05-14
IL247776B (en) 2021-05-31
RU2704830C2 (ru) 2019-10-31
RU2016140528A (ru) 2018-04-17
EP3119882B1 (en) 2021-11-17
EP3119882A2 (en) 2017-01-25
SG11201607759RA (en) 2016-10-28
KR102333923B1 (ko) 2021-12-02
BR112016021284A2 (pt) 2017-10-03

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