SG11201607759RA - Methods for producing recombinant glycoproteins with modified glycosylation - Google Patents

Methods for producing recombinant glycoproteins with modified glycosylation

Info

Publication number
SG11201607759RA
SG11201607759RA SG11201607759RA SG11201607759RA SG11201607759RA SG 11201607759R A SG11201607759R A SG 11201607759RA SG 11201607759R A SG11201607759R A SG 11201607759RA SG 11201607759R A SG11201607759R A SG 11201607759RA SG 11201607759R A SG11201607759R A SG 11201607759RA
Authority
SG
Singapore
Prior art keywords
methods
producing recombinant
modified glycosylation
recombinant glycoproteins
glycoproteins
Prior art date
Application number
SG11201607759RA
Inventor
Nien-Yi Chen
Che-Haorz Wu
Hung-Chi Chen
Winston Town
Original Assignee
Fountain Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fountain Biopharma Inc filed Critical Fountain Biopharma Inc
Publication of SG11201607759RA publication Critical patent/SG11201607759RA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
    • C07K16/4291—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01051—Alpha-L-fucosidase (3.2.1.51)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01096—Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase (3.2.1.96)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
SG11201607759RA 2014-03-17 2015-03-17 Methods for producing recombinant glycoproteins with modified glycosylation SG11201607759RA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461954337P 2014-03-17 2014-03-17
PCT/IB2015/001203 WO2015145268A2 (en) 2014-03-17 2015-03-17 Methods for producing recombinant glycoproteins with modified glycosylation

Publications (1)

Publication Number Publication Date
SG11201607759RA true SG11201607759RA (en) 2016-10-28

Family

ID=54068262

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201607759RA SG11201607759RA (en) 2014-03-17 2015-03-17 Methods for producing recombinant glycoproteins with modified glycosylation

Country Status (19)

Country Link
US (2) US9540673B2 (en)
EP (1) EP3119882B1 (en)
JP (2) JP6701089B2 (en)
KR (1) KR102333923B1 (en)
CN (1) CN106715686B (en)
AU (1) AU2015237951B2 (en)
BR (1) BR112016021284A2 (en)
CA (1) CA2942618A1 (en)
DK (1) DK3119882T3 (en)
ES (1) ES2904993T3 (en)
HU (1) HUE057904T2 (en)
IL (1) IL247776B (en)
MX (1) MX2016012085A (en)
PL (1) PL3119882T3 (en)
PT (1) PT3119882T (en)
RU (1) RU2704830C2 (en)
SG (1) SG11201607759RA (en)
TW (1) TWI682033B (en)
WO (1) WO2015145268A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015267052A1 (en) * 2014-05-27 2016-12-15 Academia Sinica Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
CA3143262A1 (en) * 2019-08-05 2021-02-11 Cho Pharma, Inc. Fusion protein for remodeling antibody glycoform
CN110885809B (en) * 2019-12-04 2021-08-17 中国农业大学 alpha-L-fucosidase and related biological material and application thereof
TW202317614A (en) 2021-06-07 2023-05-01 美商安進公司 Using fucosidase to control afucosylation level of glycosylated proteins

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2340112T3 (en) 1998-04-20 2010-05-28 Glycart Biotechnology Ag ANTIBODY GLICOSILATION ENGINEERING FOR THE IMPROVEMENT OF DEPENDENT CELLULAR CYTOTOXICITY OF ANTIBODIES.
CN101466402A (en) * 2006-06-09 2009-06-24 马里兰卅大学(巴尔的摩) Glycosylation engineered antibody therapy
US20100173323A1 (en) * 2006-06-09 2010-07-08 University Of Maryland, Baltimore Glycosylation engineered antibody therapy
GB0624874D0 (en) * 2006-12-13 2007-01-24 Hansa Medical Ab Treatment
CN101679934B (en) * 2007-03-07 2014-04-02 格利科菲公司 Production of glycoproteins with modified fucosylation
KR101054362B1 (en) * 2008-07-03 2011-08-05 재단법인 목암생명공학연구소 How to reduce the fucose content of recombinant protein
JP2012503656A (en) * 2008-09-26 2012-02-09 エウレカ セラピューティクス，インコーポレイテッド Cell lines and proteins with mutant glycosylation patterns
GB0821100D0 (en) 2008-11-18 2008-12-24 Hansa Medical Ab Antibodies
JP2012518419A (en) * 2009-02-25 2012-08-16 メルク・シャープ・エンド・ドーム・コーポレイション Metabolic manipulation of the galactose assimilation pathway in the sugar-engineered yeast Pichia pastoris
US20120196310A1 (en) * 2009-10-02 2012-08-02 Christiane Jaeger A-fucosylation detection in antibodies
US10087236B2 (en) * 2009-12-02 2018-10-02 Academia Sinica Methods for modifying human antibodies by glycan engineering
IN2014DN06806A (en) * 2012-02-10 2015-05-22 Univ Maryland

Also Published As

Publication number Publication date
PT3119882T (en) 2022-01-20
CA2942618A1 (en) 2015-10-01
KR102333923B1 (en) 2021-12-02
HUE057904T2 (en) 2022-06-28
IL247776A0 (en) 2016-11-30
JP2017507664A (en) 2017-03-23
WO2015145268A2 (en) 2015-10-01
AU2015237951B2 (en) 2021-07-01
DK3119882T3 (en) 2022-01-31
WO2015145268A3 (en) 2016-01-21
WO2015145268A8 (en) 2015-12-03
TW201623620A (en) 2016-07-01
RU2704830C2 (en) 2019-10-31
US10745729B2 (en) 2020-08-18
US20150259720A1 (en) 2015-09-17
US9540673B2 (en) 2017-01-10
KR20160127830A (en) 2016-11-04
EP3119882A2 (en) 2017-01-25
RU2016140528A3 (en) 2018-10-18
EP3119882A4 (en) 2017-08-16
BR112016021284A2 (en) 2017-10-03
JP6701089B2 (en) 2020-05-27
AU2015237951A1 (en) 2016-10-20
MX2016012085A (en) 2017-05-23
CN106715686B (en) 2021-03-16
JP2020072667A (en) 2020-05-14
RU2016140528A (en) 2018-04-17
IL247776B (en) 2021-05-31
EP3119882B1 (en) 2021-11-17
TWI682033B (en) 2020-01-11
US20170145463A1 (en) 2017-05-25
ES2904993T3 (en) 2022-04-06
PL3119882T3 (en) 2022-05-16
CN106715686A (en) 2017-05-24

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