PL2785693T3 - Arylodihydropirydynony i piperydynony jako inhibitory mgat2 - Google Patents

Arylodihydropirydynony i piperydynony jako inhibitory mgat2

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Publication number
PL2785693T3
PL2785693T3 PL12821212.3T PL12821212T PL2785693T3 PL 2785693 T3 PL2785693 T3 PL 2785693T3 PL 12821212 T PL12821212 T PL 12821212T PL 2785693 T3 PL2785693 T3 PL 2785693T3
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PL
Poland
Prior art keywords
piperidinones
mgat2 inhibitors
dihydropyridinones
aryl
aryl dihydropyridinones
Prior art date
Application number
PL12821212.3T
Other languages
English (en)
Inventor
Huji Turdi
Jon J. Hangeland
R. Michael Lawrence
Dong Cheng
Saleem Ahmad
Wei Meng
Robert Paul Brigance
Pratik Devasthale
Guohua Zhao
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of PL2785693T3 publication Critical patent/PL2785693T3/pl

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/86—Oxygen atoms
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07F9/40—Esters thereof
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PL12821212.3T 2011-12-02 2012-11-30 Arylodihydropirydynony i piperydynony jako inhibitory mgat2 PL2785693T3 (pl)

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US201161566039P 2011-12-02 2011-12-02
US13/688,584 US8791091B2 (en) 2011-12-02 2012-11-29 Aryl dihydropyridinone and piperidinone MGAT2 inhibitors

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PL2785693T3 true PL2785693T3 (pl) 2016-11-30

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EP (2) EP2785693B1 (pl)
JP (2) JP5806417B2 (pl)
KR (2) KR20160120797A (pl)
CN (2) CN104080768B (pl)
AR (1) AR090041A1 (pl)
AU (1) AU2012345863B2 (pl)
BR (1) BR112014013228B1 (pl)
CA (1) CA2857689C (pl)
CL (1) CL2014001437A1 (pl)
CO (1) CO6990718A2 (pl)
CY (1) CY1118128T1 (pl)
DK (1) DK2785693T3 (pl)
EA (1) EA026367B1 (pl)
ES (2) ES2584070T3 (pl)
HR (1) HRP20161011T1 (pl)
HU (1) HUE030547T2 (pl)
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Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8791091B2 (en) 2011-12-02 2014-07-29 Bristol-Myers Squibb Company Aryl dihydropyridinone and piperidinone MGAT2 inhibitors
US9656963B2 (en) 2012-11-16 2017-05-23 Bristol-Myers Squibb Company Dihydropyrazole GPR40 modulators
BR112015010649A2 (pt) 2012-11-16 2017-07-11 Bristol Myers Squibb Co moduladores de gpr40 à base de pirrolidina
KR20150082618A (ko) 2012-11-16 2015-07-15 브리스톨-마이어스 스큅 컴퍼니 디히드로피라졸 gpr40 조절제
HUE032401T2 (en) 2012-11-16 2017-09-28 Bristol Myers Squibb Co Dihydropyrazole GPR40 modulators
WO2014085528A1 (en) 2012-11-29 2014-06-05 Merck Patent Gmbh Azaquinazoline carboxamide derivatives
TW201534585A (zh) * 2013-05-29 2015-09-16 必治妥美雅史谷比公司 二氫吡啶酮ｍｇａｔ２抑制劑
ES2719713T3 (es) * 2014-03-07 2019-07-12 Bristol Myers Squibb Co Inhibidores de MGAT2 de dihidropiridinona sustituidos con tetrazolona
AU2015227142A1 (en) * 2014-03-07 2016-10-20 Bristol-Myers Squibb Company Dihydropyridinone MGAT2 inhibitors for use in the treatment of metabolic disorders
ES2666569T3 (es) 2014-06-11 2018-05-07 Bristol-Myers Squibb Company Piridinonas sustituidas como inhibidores de MGAT2
KR101750392B1 (ko) * 2014-12-03 2017-06-26 한국도로공사 교량 점검용 거더의 유도 레일장치 및 그 교량 점검장치
WO2017069224A1 (ja) * 2015-10-22 2017-04-27 塩野義製薬株式会社 Ｍｇａｔ２阻害活性を有するスピロ環誘導体
JPWO2017110841A1 (ja) 2015-12-21 2018-10-11 塩野義製薬株式会社 Ｍｇａｔ２阻害活性を有する非芳香族複素環誘導体
EP3301094A1 (en) * 2016-09-30 2018-04-04 Mutabilis Heterocyclic compounds and their use in preventing or treating bacterial infections
JP2020158390A (ja) * 2017-06-20 2020-10-01 塩野義製薬株式会社 Ｍｇａｔ２阻害活性を有する非芳香族複素環誘導体およびそれらを含有する医薬組成物
TWI782056B (zh) 2017-07-14 2022-11-01 日商鹽野義製藥股份有限公司 具有ｍｇａｔ２抑制活性的縮合環衍生物
CN107759498A (zh) * 2017-11-08 2018-03-06 南京大学 抗肿瘤化合物、制备方法及其用途
WO2020145369A1 (ja) 2019-01-11 2020-07-16 塩野義製薬株式会社 Ｍｇａｔ２阻害活性を有するジヒドロピラゾロピラジノン誘導体
KR20210135521A (ko) 2019-03-06 2021-11-15 다이이찌 산쿄 가부시키가이샤 피롤로피라졸 유도체
PH12022551856A1 (en) 2020-01-22 2024-01-03 Seelos Therapeutics Inc Reducing side effects of nmda antagonists

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3073838A (en) * 1963-01-15 Derivatives of hydkogenateb pyridones
US5614492A (en) 1986-05-05 1997-03-25 The General Hospital Corporation Insulinotropic hormone GLP-1 (7-36) and uses thereof
MX2007003332A (es) 2004-09-20 2007-06-05 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores de estearoil-coa-desaturasa.
EP1893625A4 (en) * 2005-06-22 2012-12-26 Biocryst Pharm Inc PROCESS FOR THE PREPARATION OF 9-DEAZAPURINE DERIVATIVES
EP2078719A4 (en) * 2006-09-28 2009-11-11 Dainippon Sumitomo Pharma Co COMPOUND WITH BICYCLIC PYRIMIDINE STRUCTURE AND THE COMPOUND CONTAINING PHARMACEUTICAL COMPOSITION
US8232447B2 (en) 2007-01-31 2012-07-31 Msd K.K. Animal having modification in MGAT2 gene
AU2010216633A1 (en) 2009-02-23 2011-09-08 Msd K.K. Pyrimidin-4(3H)-one derivatives
EP2687507B1 (en) 2011-03-14 2016-03-09 Taisho Pharmaceutical Co., Ltd. Nitrogen-containing condensed heterocyclic compound
US8791091B2 (en) 2011-12-02 2014-07-29 Bristol-Myers Squibb Company Aryl dihydropyridinone and piperidinone MGAT2 inhibitors
AU2015227142A1 (en) 2014-03-07 2016-10-20 Bristol-Myers Squibb Company Dihydropyridinone MGAT2 inhibitors for use in the treatment of metabolic disorders
ES2719713T3 (es) 2014-03-07 2019-07-12 Bristol Myers Squibb Co Inhibidores de MGAT2 de dihidropiridinona sustituidos con tetrazolona

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