PL2768827T3 - Sposób wytwarzania kwasów izoksazolilometoksynikotynowych - Google Patents
Sposób wytwarzania kwasów izoksazolilometoksynikotynowychInfo
- Publication number
- PL2768827T3 PL2768827T3 PL12772788T PL12772788T PL2768827T3 PL 2768827 T3 PL2768827 T3 PL 2768827T3 PL 12772788 T PL12772788 T PL 12772788T PL 12772788 T PL12772788 T PL 12772788T PL 2768827 T3 PL2768827 T3 PL 2768827T3
- Authority
- PL
- Poland
- Prior art keywords
- isoxazolyl
- methoxy
- preparation
- nicotinic acids
- nicotinic
- Prior art date
Links
- NGTZMAPSGKRYMY-UHFFFAOYSA-N 2-methoxy-6-(1,2-oxazol-3-yl)pyridine-3-carboxylic acid Chemical class C1=C(C(O)=O)C(OC)=NC(C2=NOC=C2)=C1 NGTZMAPSGKRYMY-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/05—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in nitriles (3.5.5)
- C12Y305/05001—Nitrilase (3.5.5.1)
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11185992 | 2011-10-20 | ||
| EP12772788.1A EP2768827B1 (en) | 2011-10-20 | 2012-10-17 | Process for the preparation of isoxazolyl-methoxy-nicotinic acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2768827T3 true PL2768827T3 (pl) | 2017-05-31 |
Family
ID=47019026
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL12772788T PL2768827T3 (pl) | 2011-10-20 | 2012-10-17 | Sposób wytwarzania kwasów izoksazolilometoksynikotynowych |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8604062B2 (https=) |
| EP (1) | EP2768827B1 (https=) |
| JP (1) | JP5923174B2 (https=) |
| KR (2) | KR20140084209A (https=) |
| CN (1) | CN103889978B (https=) |
| AR (1) | AR088358A1 (https=) |
| AU (1) | AU2012321095B2 (https=) |
| BR (1) | BR112014009266B1 (https=) |
| CA (2) | CA3112072C (https=) |
| DK (1) | DK2768827T3 (https=) |
| ES (1) | ES2613802T3 (https=) |
| HU (1) | HUE031276T2 (https=) |
| IL (1) | IL231645A (https=) |
| MX (1) | MX2014004688A (https=) |
| MY (1) | MY164880A (https=) |
| PL (1) | PL2768827T3 (https=) |
| RU (1) | RU2014118966A (https=) |
| SG (1) | SG11201401626UA (https=) |
| SI (1) | SI2768827T1 (https=) |
| WO (1) | WO2013057123A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112020004116A2 (pt) * | 2017-08-28 | 2020-09-01 | University Of Maryland, Baltimore | novos moduladores do receptor de ácido gama aminobutírico tipo a para distúrbios de humor |
| IL279266B2 (en) | 2018-06-13 | 2024-03-01 | Hoffmann La Roche | New isoxazolyl ether derivatives as gaba a alpha5 pam |
| HU231223B1 (hu) | 2018-09-28 | 2022-01-28 | Richter Gedeon Nyrt. | GABAA A5 receptor modulátor hatású biciklusos vegyületek |
| EP4126858B1 (en) | 2020-03-26 | 2026-03-18 | Richter Gedeon Nyrt. | Dihydro-2-pyrrolo[3,4-c]pyridine derivatives as gabaa a5 receptor modulators |
| GB202013765D0 (en) * | 2020-09-02 | 2020-10-14 | Gw Res Ltd | Method of preparing cannabinoids |
| CN116854680A (zh) | 2022-03-28 | 2023-10-10 | 上海赛默罗生物科技有限公司 | 异噁唑-杂环类衍生物、药物组合物和用途 |
| CN119265168B (zh) * | 2024-11-05 | 2025-06-20 | 江南大学 | 一种新型腈水解酶及其在烟酸生物合成中的应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1102755B1 (en) | 1998-08-07 | 2006-01-04 | Chiron Corporation | Substituted isoxazole derivatives as estrogen receptor modulators |
| US6551804B2 (en) * | 1999-07-12 | 2003-04-22 | E. I. Du Pont De Nemours And Company | Process for preparing 4-cyanopentanoic acid |
| US20060148858A1 (en) | 2002-05-24 | 2006-07-06 | Tsuyoshi Maekawa | 1, 2-Azole derivatives with hypoglycemic and hypolipidemic activity |
| GB0221443D0 (en) | 2002-09-16 | 2002-10-23 | Glaxo Group Ltd | Pyridine derivates |
| UA82292C2 (uk) * | 2004-04-14 | 2008-03-25 | Пфайзер Продактс Инк. | Спосіб стереоселективного біоперетворення аліфатичних динітрилів в ціанокарбонові кислоти (варіанти) |
| WO2005113519A1 (en) | 2004-05-14 | 2005-12-01 | Irm Llc | Compounds and compositions as ppar modulators |
| ATE415385T1 (de) | 2004-10-01 | 2008-12-15 | Hoffmann La Roche | Hexafluorisopropanolsubstituierte etherderivate |
| DE602006017694D1 (de) | 2005-06-27 | 2010-12-02 | Bristol Myers Squibb Co | C-verknüpfte zyklische antagonisten des p2y1-rezeptors mit eignung bei der behandlung thrombotischer leiden |
| EP1931661B1 (en) | 2005-09-19 | 2008-11-19 | F.Hoffmann-La Roche Ag | Isoxazolo derivatives as gaba a alpha5 inverse agonists |
| WO2007042420A1 (en) | 2005-10-11 | 2007-04-19 | F. Hoffmann-La Roche Ag | Isoxazole derivatives |
| RU2426731C2 (ru) | 2005-12-23 | 2011-08-20 | Ф. Хоффманн-Ля Рош Аг | Производные арил-изоксазоло-4-ил-оксадиазола |
| WO2009071464A1 (en) | 2007-12-04 | 2009-06-11 | F. Hoffmann-La Roche Ag | Isoxazolo-pyrazine derivatives |
| US7943619B2 (en) | 2007-12-04 | 2011-05-17 | Hoffmann-La Roche Inc. | Isoxazolo-pyridazine derivatives |
| UA100132C2 (en) * | 2007-12-04 | 2012-11-26 | Ф. Хоффманн-Ля Рош Аг | Isoxazolo-pyridine derivatives |
| JP2012040448A (ja) * | 2008-11-14 | 2012-03-01 | Yasutaka Sakamoto | マイクロバブル発生装置 |
| US8222246B2 (en) | 2009-04-02 | 2012-07-17 | Hoffmann-La Roche Inc. | Substituted isoxazoles |
| MX2011011484A (es) | 2009-05-07 | 2011-11-18 | Hoffmann La Roche | Derivados de isoxazol-piridina como moduladores del acido gamma-aminobutirico. |
-
2012
- 2012-10-12 US US13/650,202 patent/US8604062B2/en active Active
- 2012-10-17 KR KR1020147013309A patent/KR20140084209A/ko not_active Ceased
- 2012-10-17 EP EP12772788.1A patent/EP2768827B1/en active Active
- 2012-10-17 DK DK12772788.1T patent/DK2768827T3/en active
- 2012-10-17 CA CA3112072A patent/CA3112072C/en active Active
- 2012-10-17 WO PCT/EP2012/070521 patent/WO2013057123A1/en not_active Ceased
- 2012-10-17 RU RU2014118966/04A patent/RU2014118966A/ru not_active Application Discontinuation
- 2012-10-17 HU HUE12772788A patent/HUE031276T2/hu unknown
- 2012-10-17 MY MYPI2014001152A patent/MY164880A/en unknown
- 2012-10-17 SG SG11201401626UA patent/SG11201401626UA/en unknown
- 2012-10-17 AR ARP120103859A patent/AR088358A1/es active IP Right Grant
- 2012-10-17 CA CA2850440A patent/CA2850440C/en active Active
- 2012-10-17 PL PL12772788T patent/PL2768827T3/pl unknown
- 2012-10-17 BR BR112014009266-4A patent/BR112014009266B1/pt active IP Right Grant
- 2012-10-17 SI SI201230864A patent/SI2768827T1/sl unknown
- 2012-10-17 MX MX2014004688A patent/MX2014004688A/es unknown
- 2012-10-17 AU AU2012321095A patent/AU2012321095B2/en active Active
- 2012-10-17 CN CN201280051438.1A patent/CN103889978B/zh active Active
- 2012-10-17 ES ES12772788.1T patent/ES2613802T3/es active Active
- 2012-10-17 JP JP2014536208A patent/JP5923174B2/ja active Active
- 2012-10-17 KR KR1020207001557A patent/KR102262697B1/ko active Active
-
2014
- 2014-03-20 IL IL231645A patent/IL231645A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| WO2013057123A1 (en) | 2013-04-25 |
| KR20200008671A (ko) | 2020-01-28 |
| CA2850440C (en) | 2021-05-04 |
| EP2768827A1 (en) | 2014-08-27 |
| KR20140084209A (ko) | 2014-07-04 |
| JP5923174B2 (ja) | 2016-05-24 |
| IL231645A (en) | 2016-09-29 |
| BR112014009266A2 (pt) | 2017-06-13 |
| BR112014009266B1 (pt) | 2021-05-04 |
| DK2768827T3 (en) | 2017-02-13 |
| JP2014530831A (ja) | 2014-11-20 |
| US20130102778A1 (en) | 2013-04-25 |
| AU2012321095B2 (en) | 2015-08-20 |
| BR112014009266A8 (pt) | 2020-04-22 |
| KR102262697B1 (ko) | 2021-06-11 |
| RU2014118966A (ru) | 2015-11-27 |
| CA3112072C (en) | 2023-06-13 |
| NZ622214A (en) | 2016-08-26 |
| CA3112072A1 (en) | 2013-04-25 |
| HUE031276T2 (hu) | 2017-07-28 |
| MY164880A (en) | 2018-01-30 |
| ES2613802T3 (es) | 2017-05-26 |
| CN103889978B (zh) | 2017-02-15 |
| CN103889978A (zh) | 2014-06-25 |
| CA2850440A1 (en) | 2013-04-25 |
| SG11201401626UA (en) | 2014-05-29 |
| AU2012321095A1 (en) | 2013-05-09 |
| IL231645A0 (en) | 2014-05-28 |
| US8604062B2 (en) | 2013-12-10 |
| EP2768827B1 (en) | 2016-11-23 |
| AR088358A1 (es) | 2014-05-28 |
| SI2768827T1 (sl) | 2017-04-26 |
| MX2014004688A (es) | 2014-05-28 |
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