TWI562985B - Process for the preparation of enolate salts of 4-fluoro-2-hydroxymethylene-3-oxobutyrates - Google Patents
Process for the preparation of enolate salts of 4-fluoro-2-hydroxymethylene-3-oxobutyratesInfo
- Publication number
- TWI562985B TWI562985B TW100124167A TW100124167A TWI562985B TW I562985 B TWI562985 B TW I562985B TW 100124167 A TW100124167 A TW 100124167A TW 100124167 A TW100124167 A TW 100124167A TW I562985 B TWI562985 B TW I562985B
- Authority
- TW
- Taiwan
- Prior art keywords
- oxobutyrates
- hydroxymethylene
- fluoro
- preparation
- enolate salts
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/58—Preparation of carboxylic acid halides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/58—Preparation of carboxylic acid halides
- C07C51/62—Preparation of carboxylic acid halides by reactions not involving the carboxylic acid halide group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/14—Preparation of carboxylic acid esters from carboxylic acid halides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
- C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
- C07C69/12—Acetic acid esters
- C07C69/14—Acetic acid esters of monohydroxylic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10007208 | 2010-07-13 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201206879A TW201206879A (en) | 2012-02-16 |
| TWI562985B true TWI562985B (en) | 2016-12-21 |
Family
ID=43086152
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW100124167A TWI562985B (en) | 2010-07-13 | 2011-07-08 | Process for the preparation of enolate salts of 4-fluoro-2-hydroxymethylene-3-oxobutyrates |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9156771B2 (en) |
| EP (1) | EP2593420B1 (en) |
| JP (1) | JP5911859B2 (en) |
| KR (1) | KR101870462B1 (en) |
| CN (1) | CN103153939B (en) |
| AR (1) | AR082159A1 (en) |
| AU (1) | AU2011278705A1 (en) |
| BR (1) | BR112013000763A2 (en) |
| CA (1) | CA2806717A1 (en) |
| ES (1) | ES2610147T3 (en) |
| HK (1) | HK1186172A1 (en) |
| HU (1) | HUE033005T2 (en) |
| TW (1) | TWI562985B (en) |
| UY (1) | UY33507A (en) |
| WO (1) | WO2012007142A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114105792B (en) * | 2022-01-14 | 2023-03-31 | 山东国邦药业有限公司 | Preparation method of ciprofloxacin key intermediate |
| CN114933543B (en) * | 2022-07-21 | 2022-10-28 | 山东国邦药业有限公司 | Synthetic method of 3-cyclopropylamino-2- (2,4-dichloro-5-fluorobenzoyl) methyl acrylate |
| CN115010753A (en) * | 2022-07-27 | 2022-09-06 | 南京工业大学 | Method for preparing phosphorylated gem-difluorodiene compound in aqueous phase |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5434267A (en) * | 1991-12-20 | 1995-07-18 | Bayer Aktiengesellschaft | Process for the preparation of substituted 3-alkoxyacrylates |
| JP2007326784A (en) * | 2006-06-06 | 2007-12-20 | Sagami Chem Res Center | Method for producing 1-substituted-5-fluoroalkylpyrazole-4-carboxylic acid ester |
| WO2009106619A1 (en) * | 2008-02-29 | 2009-09-03 | Basf Se | Process for preparing alkyl 2-alkoxymethylene-4,4-difluoro-3-oxobutyrates |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2394255A (en) * | 1942-04-07 | 1946-02-05 | American Cyanamid Co | Formylacetic ester |
| US3637812A (en) * | 1967-10-02 | 1972-01-25 | Merck & Co Inc | Acylation of reactive organic acid esters |
| DE2952070C2 (en) * | 1979-12-22 | 1983-09-08 | Dynamit Nobel Ag, 5210 Troisdorf | Process for the preparation of alkyl alkali formyl acetic acid |
| JPS61152640A (en) * | 1984-12-26 | 1986-07-11 | Daicel Chem Ind Ltd | Production of alkali formylcarboxylic acid ester |
| JPH0822853B2 (en) | 1987-10-23 | 1996-03-06 | 三井東圧化学株式会社 | Pyrazole-4-carboxylic acids and method for producing the same |
| US5093347A (en) | 1991-01-28 | 1992-03-03 | Monsanto Company | 3-difluoromethylpyrazolecarboxamide fungicides, compositions and use |
| US5616713A (en) * | 1996-07-22 | 1997-04-01 | Development Center For Biotechnology | Process of preparing 2-hydroxymethyl-3,5-dimethyl-4-methoxypyridine |
| JP2004325727A (en) * | 2003-04-24 | 2004-11-18 | Konica Minolta Medical & Graphic Inc | Heat development apparatus |
| CN1968934A (en) | 2004-06-18 | 2007-05-23 | 巴斯福股份公司 | 1-methyl-3-difluoromethyl-pyrazol-4-carbonic acid-(ortho-phenyl)-anilides, and use thereof as a fungicide |
| CN101133031B (en) * | 2005-02-25 | 2010-07-21 | 财团法人相模中央化学研究所 | Method for producing 1-substituted-3-fluoroalkyl pyrazole-4-carboxylate |
| JP5340287B2 (en) | 2007-08-16 | 2013-11-13 | ソルヴェイ（ソシエテ アノニム） | Process for the preparation of esters of 4-fluoro-substituted 3-oxo-alkanoic acids |
-
2011
- 2011-07-08 TW TW100124167A patent/TWI562985B/en not_active IP Right Cessation
- 2011-07-11 CA CA2806717A patent/CA2806717A1/en not_active Abandoned
- 2011-07-11 US US13/809,739 patent/US9156771B2/en not_active Expired - Fee Related
- 2011-07-11 CN CN201180032843.4A patent/CN103153939B/en not_active Expired - Fee Related
- 2011-07-11 BR BR112013000763A patent/BR112013000763A2/en not_active Application Discontinuation
- 2011-07-11 KR KR1020137000594A patent/KR101870462B1/en active IP Right Grant
- 2011-07-11 WO PCT/EP2011/003445 patent/WO2012007142A1/en active Application Filing
- 2011-07-11 JP JP2013518985A patent/JP5911859B2/en active Active
- 2011-07-11 HU HUE11731280A patent/HUE033005T2/en unknown
- 2011-07-11 ES ES11731280.1T patent/ES2610147T3/en active Active
- 2011-07-11 AU AU2011278705A patent/AU2011278705A1/en not_active Abandoned
- 2011-07-11 EP EP11731280.1A patent/EP2593420B1/en not_active Not-in-force
- 2011-07-12 AR ARP110102507A patent/AR082159A1/en unknown
- 2011-07-12 UY UY0001033507A patent/UY33507A/en not_active Application Discontinuation
-
2013
- 2013-12-10 HK HK13113700.9A patent/HK1186172A1/en not_active IP Right Cessation
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5434267A (en) * | 1991-12-20 | 1995-07-18 | Bayer Aktiengesellschaft | Process for the preparation of substituted 3-alkoxyacrylates |
| JP2007326784A (en) * | 2006-06-06 | 2007-12-20 | Sagami Chem Res Center | Method for producing 1-substituted-5-fluoroalkylpyrazole-4-carboxylic acid ester |
| WO2009106619A1 (en) * | 2008-02-29 | 2009-09-03 | Basf Se | Process for preparing alkyl 2-alkoxymethylene-4,4-difluoro-3-oxobutyrates |
Also Published As
| Publication number | Publication date |
|---|---|
| US9156771B2 (en) | 2015-10-13 |
| JP2013535430A (en) | 2013-09-12 |
| CN103153939B (en) | 2016-01-20 |
| UY33507A (en) | 2012-01-31 |
| HK1186172A1 (en) | 2014-03-07 |
| HUE033005T2 (en) | 2017-11-28 |
| US20130338394A1 (en) | 2013-12-19 |
| CN103153939A (en) | 2013-06-12 |
| EP2593420A1 (en) | 2013-05-22 |
| AU2011278705A1 (en) | 2013-02-28 |
| WO2012007142A8 (en) | 2013-02-28 |
| AR082159A1 (en) | 2012-11-14 |
| JP5911859B2 (en) | 2016-04-27 |
| KR101870462B1 (en) | 2018-06-22 |
| CA2806717A1 (en) | 2012-01-19 |
| EP2593420B1 (en) | 2016-10-19 |
| ES2610147T3 (en) | 2017-04-26 |
| TW201206879A (en) | 2012-02-16 |
| KR20130140603A (en) | 2013-12-24 |
| BR112013000763A2 (en) | 2016-05-24 |
| WO2012007142A1 (en) | 2012-01-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Annulment or lapse of patent due to non-payment of fees |