PL2737085T3 - Sposoby wykrywania modyfikacji nukleotydów - Google Patents
Sposoby wykrywania modyfikacji nukleotydówInfo
- Publication number
- PL2737085T3 PL2737085T3 PL12753553T PL12753553T PL2737085T3 PL 2737085 T3 PL2737085 T3 PL 2737085T3 PL 12753553 T PL12753553 T PL 12753553T PL 12753553 T PL12753553 T PL 12753553T PL 2737085 T3 PL2737085 T3 PL 2737085T3
- Authority
- PL
- Poland
- Prior art keywords
- detection
- methods
- nucleotide modification
- nucleotide
- modification
- Prior art date
Links
- 238000001514 detection method Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000012986 modification Methods 0.000 title 1
- 230000004048 modification Effects 0.000 title 1
- 239000002773 nucleotide Substances 0.000 title 1
- 125000003729 nucleotide group Chemical group 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
- C01G55/00—Compounds of ruthenium, rhodium, palladium, osmium, iridium, or platinum
- C01G55/002—Compounds containing ruthenium, rhodium, palladium, osmium, iridium or platinum, with or without oxygen or hydrogen, and containing two or more other elements
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161513356P | 2011-07-29 | 2011-07-29 | |
| US201261605702P | 2012-03-01 | 2012-03-01 | |
| US201261623461P | 2012-04-12 | 2012-04-12 | |
| US201261641134P | 2012-05-01 | 2012-05-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2737085T3 true PL2737085T3 (pl) | 2017-06-30 |
Family
ID=46763141
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL12753553T PL2737085T3 (pl) | 2011-07-29 | 2012-07-27 | Sposoby wykrywania modyfikacji nukleotydów |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US9290807B2 (pl) |
| EP (2) | EP3141616B1 (pl) |
| JP (3) | JP6138118B2 (pl) |
| CN (2) | CN107254539A (pl) |
| AU (2) | AU2012291873B2 (pl) |
| BR (1) | BR112014002252A2 (pl) |
| CA (1) | CA2843221A1 (pl) |
| DK (1) | DK2737085T3 (pl) |
| ES (2) | ES2811260T3 (pl) |
| GB (1) | GB2507231B (pl) |
| HK (1) | HK1198547A1 (pl) |
| IL (1) | IL230610A0 (pl) |
| PL (1) | PL2737085T3 (pl) |
| RU (1) | RU2612902C2 (pl) |
| WO (1) | WO2013017853A2 (pl) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010037001A2 (en) | 2008-09-26 | 2010-04-01 | Immune Disease Institute, Inc. | Selective oxidation of 5-methylcytosine by tet-family proteins |
| US9145580B2 (en) * | 2011-04-02 | 2015-09-29 | New England Biolabs, Inc. | Methods and compositions for enriching either target polynucleotides or non-target polynucleotides from a mixture of target and non-target polynucleotides |
| EP3141616B1 (en) | 2011-07-29 | 2020-05-13 | Cambridge Epigenetix Limited | Methods for detection of nucleotide modification |
| CN104955960A (zh) | 2012-11-30 | 2015-09-30 | 剑桥表现遗传学有限公司 | 用于修饰的核苷酸的氧化剂 |
| JP6243013B2 (ja) * | 2013-09-27 | 2017-12-06 | 北京大学Ｐｅｋｉｎｇ Ｕｎｉｖｅｒｓｉｔｙ | ５−ホルミルシトシン特異的な化学標識法及びその利用 |
| GB201403216D0 (en) | 2014-02-24 | 2014-04-09 | Cambridge Epigenetix Ltd | Nucleic acid sample preparation |
| GB201413318D0 (en) * | 2014-07-28 | 2014-09-10 | Cambridge Epigenetix Ltd | Nucleic acid sample preparation |
| GB201415761D0 (en) * | 2014-09-05 | 2014-10-22 | Cambridge Epigenetix Ltd | Methods for detection of Nucleotide modification |
| EP3280793A4 (en) | 2015-04-06 | 2018-10-03 | The Regents of the University of California | Methods for determining base locations in a polynucleotide |
| JPWO2017018408A1 (ja) * | 2015-07-30 | 2018-06-07 | 国立大学法人 東京大学 | 酸化剤とその使用 |
| WO2017035821A1 (zh) * | 2015-09-02 | 2017-03-09 | 中国科学院北京基因组研究所 | RNA 5mC重亚硫酸盐测序的文库构建方法及其应用 |
| CN105132409B (zh) * | 2015-09-02 | 2018-02-06 | 中国科学院北京基因组研究所 | RNA 5mC重亚硫酸盐测序的文库构建方法及其应用 |
| US20210214781A1 (en) * | 2016-02-14 | 2021-07-15 | Abhijit Ajit Patel | Measurement of nucleic acid |
| CN105891467B (zh) * | 2016-03-30 | 2017-10-31 | 苏州大学 | 一种rna中5‑羟甲基胞嘧啶的检测方法及其试剂盒 |
| US20170298422A1 (en) | 2016-04-18 | 2017-10-19 | The Board Of Trustees Of The Leland Stanford Junior University | Simultaneous single-molecule epigenetic imaging of dna methylation and hydroxymethylation |
| WO2018031760A1 (en) | 2016-08-10 | 2018-02-15 | Grail, Inc. | Methods of preparing dual-indexed dna libraries for bisulfite conversion sequencing |
| WO2018128706A2 (en) * | 2016-11-07 | 2018-07-12 | Ibis Biosciences, Inc. | Modified nucleic acids for nanopore analysis |
| GB2559319B (en) | 2016-12-23 | 2019-01-16 | Cs Genetics Ltd | Reagents and methods for the analysis of linked nucleic acids |
| CN110546549B (zh) | 2017-02-23 | 2022-06-07 | 奇跃公司 | 具有可变屈光力反射器的显示系统 |
| US11130991B2 (en) | 2017-03-08 | 2021-09-28 | The University Of Chicago | Method for highly sensitive DNA methylation analysis |
| MX395068B (es) * | 2018-01-08 | 2025-03-24 | Ludwig Inst For Cancer Res Ltd | Identificación libre de bisulfito de modificaciones de citosina por resolución de base. |
| AU2019222723B2 (en) * | 2018-02-14 | 2023-10-12 | Clearnote Health, Inc. | Methods for the epigenetic analysis of DNA, particularly cell-free DNA |
| GB2587939B (en) | 2018-04-02 | 2023-06-14 | Grail Llc | Methylation markers and targeted methylation probe panels |
| JP2021525507A (ja) * | 2018-05-25 | 2021-09-27 | ニューヨーク インスティチュート オブ テクノロジーＮｅｗ Ｙｏｒｋ Ｉｎｓｔｉｔｕｔｅ Ｏｆ Ｔｅｃｈｎｏｌｏｇｙ | 直接核酸配列決定方法 |
| US11530441B2 (en) | 2018-07-27 | 2022-12-20 | The University Of Chicago | Methods for the amplification of bisulfite-treated DNA |
| CA3111887A1 (en) | 2018-09-27 | 2020-04-02 | Grail, Inc. | Methylation markers and targeted methylation probe panel |
| SG11202102954QA (en) | 2018-10-04 | 2021-04-29 | Bluestar Genomics Inc | Simultaneous, sequencing-based analysis of proteins, nucleosomes, and cell-free nucleic acids from a single biological sample |
| MX2022000377A (es) | 2019-07-08 | 2022-03-25 | Ludwig Inst For Cancer Res Ltd | Analisis de metilacion del genoma completo sin bisulfito. |
| AU2021319150B2 (en) | 2020-07-30 | 2025-09-25 | Biomodal Limited | Compositions and methods for nucleic acid analysis |
| US20230357833A1 (en) | 2020-09-14 | 2023-11-09 | Ludwig Institute For Cancer Research Ltd | Cytosine modification analysis |
| EP3971302A1 (en) * | 2020-09-16 | 2022-03-23 | QIAGEN GmbH | Method for detecting 5-hydroxymethylated cytosine |
| GB202017653D0 (en) * | 2020-11-09 | 2020-12-23 | Cambridge Entpr Ltd | Methods for detection of nucleotide modification |
| CN113096798B (zh) * | 2021-04-19 | 2022-06-10 | 温州医科大学 | 一种基于5hmC修饰的lncRNA的肿瘤诊断设备 |
| WO2023288222A1 (en) * | 2021-07-12 | 2023-01-19 | The Trustees Of The University Of Pennsylvania | Modified adapters for enzymatic dna deamination and methods of use thereof for epigenetic sequencing of free and immobilized dna |
| AU2022313872A1 (en) * | 2021-07-20 | 2024-02-22 | Freenome Holdings, Inc. | Compositions and methods for improved 5-hydroxymethylated cytosine resolution in nucleic acid sequencing |
| KR20240046525A (ko) | 2021-07-27 | 2024-04-09 | 더 챈슬러 마스터즈 앤드 스칼라스 오브 더 유니버시티 오브 옥스포드 | 세포-유리 dna에 대한 tet-보조 피리딘 보란 시퀀싱과 관련된 조성물 및 방법 |
| AU2023233839A1 (en) * | 2022-03-15 | 2024-01-18 | Illumina, Inc. | Concurrent sequencing of forward and reverse complement strands on concatenated polynucleotides for methylation detection |
| CN118308491A (zh) * | 2023-01-06 | 2024-07-09 | 北京昌平实验室 | 单细胞dna甲基化检测方法 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1340248C (en) * | 1989-01-05 | 1998-12-15 | Morton International, Inc. | High yield sodium hydrosulfite generation |
| AU663089B2 (en) * | 1991-04-09 | 1995-09-28 | Abbott Laboratories | Macrocyclic lactam prokinetic agents |
| DE4207363A1 (de) * | 1992-03-04 | 1993-09-09 | Max Delbrueck Centrum | Antivirale nucleosidanaloga, ihre herstellung und ihre pharmazeutische verwendung |
| EP0652321B1 (en) * | 1993-11-04 | 1998-01-21 | Morton International, Inc. | Chemical pulp bleaching |
| US20060134643A1 (en) | 2000-06-19 | 2006-06-22 | Kurt Berlin | Bisulfite conversion of DNA |
| DE10038733A1 (de) | 2000-08-02 | 2002-02-21 | Epigenomics Ag | Verfahren zur Altersbestimmung von Individuen |
| IL154663A0 (en) * | 2000-09-01 | 2003-09-17 | Epigenomics Ag | Method for determining the degree of methylation of defined cytosines in genomic dna in the sequence context 5'-cpg-3' |
| DE10112515B4 (de) * | 2001-03-09 | 2004-02-12 | Epigenomics Ag | Verfahren zum Nachweis von Cytosin-Methylierungsmustern mit hoher Sensitivität |
| DE10131786A1 (de) * | 2001-07-04 | 2003-01-16 | Sungene Gmbh & Co Kgaa | Rekombinationssysteme und Verfahren zum Entfernen von Nukleinsäuresequenzen aus dem Genom eukaryotischer Organismen |
| AU2003236461B2 (en) | 2002-08-29 | 2009-05-28 | Epigenomics Ag | Improved method for bisulfite treatment |
| US20050271596A1 (en) * | 2002-10-25 | 2005-12-08 | Foamix Ltd. | Vasoactive kit and composition and uses thereof |
| EP2088210A3 (en) | 2003-10-09 | 2009-11-18 | Epigenomics AG | Improved bisulfite conversion of DNA |
| JP4765058B2 (ja) * | 2004-12-13 | 2011-09-07 | 国立大学法人 岡山大学 | 核酸修飾前の検体の前処理方法 |
| WO2006132022A1 (ja) * | 2005-06-08 | 2006-12-14 | Kyoto University | メチルシトシンの簡便検出法 |
| US20070037184A1 (en) * | 2005-06-16 | 2007-02-15 | Applera Corporation | Methods and kits for evaluating dna methylation |
| CN101033487B (zh) * | 2006-03-07 | 2011-04-06 | 中国医学科学院阜外心血管病医院 | 检测与原发性高血压相关的KLK1基因rs5517多态的方法 |
| EP2053131A1 (en) * | 2007-10-19 | 2009-04-29 | Ludwig-Maximilians-Universität München | Method for determining methylation at deoxycytosine residues |
| WO2010037001A2 (en) | 2008-09-26 | 2010-04-01 | Immune Disease Institute, Inc. | Selective oxidation of 5-methylcytosine by tet-family proteins |
| WO2011017760A1 (en) * | 2009-08-12 | 2011-02-17 | Commonwealth Scientific And Industrial Research Organisation | Detection and analysis of methylation in nucleic acid sequences |
| WO2011127136A1 (en) | 2010-04-06 | 2011-10-13 | University Of Chicago | Composition and methods related to modification of 5-hydroxymethylcytosine (5-hmc) |
| EP2694686B2 (en) | 2011-04-06 | 2023-07-19 | The University of Chicago | COMPOSITION AND METHODS RELATED TO MODIFICATION OF 5-METHYLCYTOSINE (5mC) |
| EP2698437B1 (en) | 2011-04-15 | 2017-05-31 | Riken | Method for detecting 5-hydroxymethylcytosine in nucleic acids |
| WO2012162139A1 (en) | 2011-05-20 | 2012-11-29 | The Regents Of The University Of California | Method to estimate age of individual based on epigenetic markers in biological sample |
| EP3141616B1 (en) | 2011-07-29 | 2020-05-13 | Cambridge Epigenetix Limited | Methods for detection of nucleotide modification |
| ES3018861T3 (en) | 2011-12-13 | 2025-05-19 | Univ Oslo Hf | Method for detection of hydroxymethylation status |
| US20140030727A1 (en) | 2012-01-20 | 2014-01-30 | Gerd PFEIFER | Loss of 5-hydroxymethylcytosine as a biomarker for cancer |
| US9175348B2 (en) | 2012-04-24 | 2015-11-03 | Pacific Biosciences Of California, Inc. | Identification of 5-methyl-C in nucleic acid templates |
| US9297806B2 (en) | 2012-08-01 | 2016-03-29 | The Johns Hopkins University | 5-hydroxymethylcytosine in human cancer |
| CN104955960A (zh) | 2012-11-30 | 2015-09-30 | 剑桥表现遗传学有限公司 | 用于修饰的核苷酸的氧化剂 |
| GB201222693D0 (en) | 2012-12-17 | 2013-01-30 | Babraham Inst | Novel method |
| US20160222448A1 (en) | 2013-09-27 | 2016-08-04 | The Regents Of The University Of California | Method to estimate the age of tissues and cell types based on epigenetic markers |
| JP6243013B2 (ja) | 2013-09-27 | 2017-12-06 | 北京大学Ｐｅｋｉｎｇ Ｕｎｉｖｅｒｓｉｔｙ | ５−ホルミルシトシン特異的な化学標識法及びその利用 |
| GB201403216D0 (en) | 2014-02-24 | 2014-04-09 | Cambridge Epigenetix Ltd | Nucleic acid sample preparation |
| GB201405226D0 (en) | 2014-03-24 | 2014-05-07 | Cambridge Entpr Ltd | Nucleic acid preparation method |
| GB201413318D0 (en) | 2014-07-28 | 2014-09-10 | Cambridge Epigenetix Ltd | Nucleic acid sample preparation |
| GB201415761D0 (en) | 2014-09-05 | 2014-10-22 | Cambridge Epigenetix Ltd | Methods for detection of Nucleotide modification |
| GB201418621D0 (en) | 2014-10-20 | 2014-12-03 | Cambridge Epigenetix Ltd | Improved nucleic acid sample preparation using concatenation |
| GB201418718D0 (en) | 2014-10-21 | 2014-12-03 | Cambridge Epigenetix Ltd | Improved nucleic acid re-sequencing using a reduced number of identified bases |
| GB201420428D0 (en) | 2014-11-18 | 2014-12-31 | Cambridge Epigenetix Ltd | Methods for nucleic acid isolation |
| GB201506669D0 (en) | 2015-04-20 | 2015-06-03 | Cambridge Epigenetix Ltd | Nucleic acid sample enrichment |
| WO2016189288A1 (en) | 2015-05-22 | 2016-12-01 | Cambridge Epigenetix Ltd | Nucleic acid sample enrichment |
| WO2017039002A1 (ja) | 2015-09-04 | 2017-03-09 | 国立大学法人東京大学 | ５－ヒドロキシメチルシトシン酸化剤及び５－ヒドロキシメチルシトシン解析方法 |
| CN105648537B (zh) | 2016-03-02 | 2018-06-29 | 上海易毕恩基因科技有限公司 | Dna5-甲基胞嘧啶与5-羟甲基胞嘧啶基因图谱测序方法 |
-
2012
- 2012-07-27 EP EP16193069.8A patent/EP3141616B1/en active Active
- 2012-07-27 ES ES16193069T patent/ES2811260T3/es active Active
- 2012-07-27 CA CA2843221A patent/CA2843221A1/en not_active Abandoned
- 2012-07-27 BR BR112014002252A patent/BR112014002252A2/pt not_active IP Right Cessation
- 2012-07-27 GB GB1402913.6A patent/GB2507231B/en active Active
- 2012-07-27 CN CN201710622707.XA patent/CN107254539A/zh active Pending
- 2012-07-27 JP JP2014522160A patent/JP6138118B2/ja active Active
- 2012-07-27 CN CN201280046897.0A patent/CN103827321B/zh active Active
- 2012-07-27 AU AU2012291873A patent/AU2012291873B2/en active Active
- 2012-07-27 US US14/235,707 patent/US9290807B2/en active Active
- 2012-07-27 HK HK14112035.6A patent/HK1198547A1/xx unknown
- 2012-07-27 ES ES12753553.2T patent/ES2609845T3/es active Active
- 2012-07-27 DK DK12753553.2T patent/DK2737085T3/en active
- 2012-07-27 RU RU2014101951A patent/RU2612902C2/ru not_active IP Right Cessation
- 2012-07-27 WO PCT/GB2012/051819 patent/WO2013017853A2/en not_active Ceased
- 2012-07-27 EP EP12753553.2A patent/EP2737085B1/en active Active
- 2012-07-27 PL PL12753553T patent/PL2737085T3/pl unknown
-
2014
- 2014-01-23 IL IL230610A patent/IL230610A0/en unknown
-
2016
- 2016-03-21 US US15/075,370 patent/US10428381B2/en active Active
- 2016-04-14 AU AU2016202081A patent/AU2016202081B2/en active Active
-
2017
- 2017-04-24 JP JP2017085084A patent/JP6679127B2/ja active Active
-
2019
- 2019-07-05 JP JP2019126152A patent/JP2019193661A/ja not_active Withdrawn
- 2019-08-02 US US16/530,275 patent/US20200095633A1/en not_active Abandoned
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