PL2694073T3 - Kombinacje inhibitorów AKT i MEK do leczenia nowotworu - Google Patents
Kombinacje inhibitorów AKT i MEK do leczenia nowotworuInfo
- Publication number
- PL2694073T3 PL2694073T3 PL12764894T PL12764894T PL2694073T3 PL 2694073 T3 PL2694073 T3 PL 2694073T3 PL 12764894 T PL12764894 T PL 12764894T PL 12764894 T PL12764894 T PL 12764894T PL 2694073 T3 PL2694073 T3 PL 2694073T3
- Authority
- PL
- Poland
- Prior art keywords
- akt
- combinations
- treating cancer
- mek inhibitors
- mek
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 title 1
- 239000003197 protein kinase B inhibitor Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161471038P | 2011-04-01 | 2011-04-01 | |
| EP12764894.7A EP2694073B1 (en) | 2011-04-01 | 2012-03-30 | Combinations of akt and mek inhibitors for treating cancer |
| PCT/US2012/031716 WO2012135779A1 (en) | 2011-04-01 | 2012-03-30 | Combinations of akt and mek inhibitor compounds, and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2694073T3 true PL2694073T3 (pl) | 2019-06-28 |
Family
ID=46931964
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL12764894T PL2694073T3 (pl) | 2011-04-01 | 2012-03-30 | Kombinacje inhibitorów AKT i MEK do leczenia nowotworu |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9682082B2 (https=) |
| EP (1) | EP2694073B1 (https=) |
| JP (1) | JP6147246B2 (https=) |
| KR (1) | KR20140022053A (https=) |
| CN (2) | CN103841976A (https=) |
| AU (1) | AU2012236164A1 (https=) |
| BR (1) | BR112013025397A2 (https=) |
| CA (1) | CA2831932A1 (https=) |
| ES (1) | ES2688809T3 (https=) |
| IL (1) | IL228643A0 (https=) |
| MX (1) | MX2013011333A (https=) |
| PL (1) | PL2694073T3 (https=) |
| RU (1) | RU2013148817A (https=) |
| SG (1) | SG194047A1 (https=) |
| TR (1) | TR201815685T4 (https=) |
| WO (1) | WO2012135779A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2776944A1 (en) * | 2009-10-12 | 2011-05-12 | F. Hoffmann-La Roche Ag | Combinations of a pi3k inhibitor and a mek inhibitor |
| JP2016502974A (ja) * | 2012-12-07 | 2016-02-01 | ザ ジェネラル ホスピタル コーポレイション | Ｐｉ３ｋ／ａｋｔ阻害剤化合物とｈｅｒ３／ｅｇｆｒ阻害剤化合物との組み合わせ及び高増殖性疾患の治療におけるその使用 |
| EP2959014B1 (en) * | 2013-02-25 | 2019-11-13 | Genentech, Inc. | Methods and compositions for detecting and treating drug resistant akt mutant |
| WO2015035146A2 (en) * | 2013-09-05 | 2015-03-12 | Memorial Sloan-Kettering Cancer Center | Ddx43 as a biomarker of resistance to mek1/2 inhibitors |
| TWI719765B (zh) | 2018-12-19 | 2021-02-21 | 美商建南德克公司 | 使用包含akt抑制劑、紫杉烷及pd-l1抑制劑之組合療法之乳癌治療 |
| AU2021246141A1 (en) * | 2020-04-03 | 2022-12-01 | Beigene, Ltd. | Co-administration of mirdametinib and lifirafenib for use in treating cancers |
| US11066358B1 (en) * | 2021-02-17 | 2021-07-20 | Warner-Lambert Company Llc | Compositions of essentially pure form IV of N-((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide and uses thereof |
| US11084780B1 (en) * | 2021-02-17 | 2021-08-10 | Springworks Therapeutics, Inc. | Crystalline solids of MEK inhibitor N-((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide and uses thereof |
| WO2024255830A1 (zh) * | 2023-06-14 | 2024-12-19 | 南京正大天晴制药有限公司 | Akt抑制剂在制备预防或治疗卵巢癌药物中的用途 |
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-
2012
- 2012-03-30 RU RU2013148817/15A patent/RU2013148817A/ru not_active Application Discontinuation
- 2012-03-30 KR KR1020137029126A patent/KR20140022053A/ko not_active Withdrawn
- 2012-03-30 CN CN201280027030.0A patent/CN103841976A/zh active Pending
- 2012-03-30 CN CN201910098566.5A patent/CN110433165A/zh active Pending
- 2012-03-30 SG SG2013073739A patent/SG194047A1/en unknown
- 2012-03-30 ES ES12764894.7T patent/ES2688809T3/es active Active
- 2012-03-30 AU AU2012236164A patent/AU2012236164A1/en not_active Abandoned
- 2012-03-30 MX MX2013011333A patent/MX2013011333A/es not_active Application Discontinuation
- 2012-03-30 WO PCT/US2012/031716 patent/WO2012135779A1/en not_active Ceased
- 2012-03-30 CA CA2831932A patent/CA2831932A1/en not_active Abandoned
- 2012-03-30 BR BR112013025397A patent/BR112013025397A2/pt not_active IP Right Cessation
- 2012-03-30 TR TR2018/15685T patent/TR201815685T4/tr unknown
- 2012-03-30 JP JP2014502884A patent/JP6147246B2/ja active Active
- 2012-03-30 EP EP12764894.7A patent/EP2694073B1/en active Active
- 2012-03-30 US US14/009,320 patent/US9682082B2/en active Active
- 2012-03-30 PL PL12764894T patent/PL2694073T3/pl unknown
-
2013
- 2013-09-30 IL IL228643A patent/IL228643A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2014512355A (ja) | 2014-05-22 |
| EP2694073A4 (en) | 2014-09-03 |
| SG194047A1 (en) | 2013-11-29 |
| AU2012236164A1 (en) | 2013-11-21 |
| CN103841976A (zh) | 2014-06-04 |
| US9682082B2 (en) | 2017-06-20 |
| ES2688809T3 (es) | 2018-11-07 |
| WO2012135779A1 (en) | 2012-10-04 |
| CN110433165A (zh) | 2019-11-12 |
| NZ617243A (en) | 2016-02-26 |
| IL228643A0 (en) | 2013-12-31 |
| EP2694073A1 (en) | 2014-02-12 |
| MX2013011333A (es) | 2014-04-16 |
| RU2013148817A (ru) | 2015-05-10 |
| KR20140022053A (ko) | 2014-02-21 |
| EP2694073B1 (en) | 2018-08-08 |
| JP6147246B2 (ja) | 2017-06-14 |
| TR201815685T4 (tr) | 2018-11-21 |
| US20140155372A1 (en) | 2014-06-05 |
| CA2831932A1 (en) | 2012-10-04 |
| BR112013025397A2 (pt) | 2019-09-24 |
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