PL2663575T3 - Humanizowane IL-6 i receptor IL-6 - Google Patents
Humanizowane IL-6 i receptor IL-6Info
- Publication number
- PL2663575T3 PL2663575T3 PL12795905T PL12795905T PL2663575T3 PL 2663575 T3 PL2663575 T3 PL 2663575T3 PL 12795905 T PL12795905 T PL 12795905T PL 12795905 T PL12795905 T PL 12795905T PL 2663575 T3 PL2663575 T3 PL 2663575T3
- Authority
- PL
- Poland
- Prior art keywords
- humanized
- receptor
- Prior art date
Links
- 102000010781 Interleukin-6 Receptors Human genes 0.000 title 1
- 108010038501 Interleukin-6 Receptors Proteins 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5412—IL-6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Environmental Sciences (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Developmental Biology & Embryology (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161552900P | 2011-10-28 | 2011-10-28 | |
| US201161556579P | 2011-11-07 | 2011-11-07 | |
| PCT/US2012/062379 WO2013063556A1 (en) | 2011-10-28 | 2012-10-29 | Humanized il-6 and il-6 receptor |
| EP12795905.4A EP2663575B1 (en) | 2011-10-28 | 2012-10-29 | Humanized il-6 and il-6 receptor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2663575T3 true PL2663575T3 (pl) | 2015-03-31 |
Family
ID=47295138
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL12795905T PL2663575T3 (pl) | 2011-10-28 | 2012-10-29 | Humanizowane IL-6 i receptor IL-6 |
| PL14177863T PL2818478T3 (pl) | 2011-10-28 | 2012-10-29 | Humanizowane il-6 i receptor il-6 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL14177863T PL2818478T3 (pl) | 2011-10-28 | 2012-10-29 | Humanizowane il-6 i receptor il-6 |
Country Status (27)
| Country | Link |
|---|---|
| US (10) | US8878001B2 (enExample) |
| EP (2) | EP2663575B1 (enExample) |
| JP (2) | JP6120451B2 (enExample) |
| KR (2) | KR102234632B1 (enExample) |
| CN (2) | CN104039821A (enExample) |
| AU (1) | AU2015207889B2 (enExample) |
| BR (1) | BR112014008529A2 (enExample) |
| CA (1) | CA2853731C (enExample) |
| CY (2) | CY1116614T1 (enExample) |
| DK (2) | DK2818478T3 (enExample) |
| ES (2) | ES2624605T3 (enExample) |
| HR (2) | HRP20141192T1 (enExample) |
| HU (1) | HUE033400T2 (enExample) |
| IL (4) | IL231896B (enExample) |
| IN (1) | IN2014CN03920A (enExample) |
| LT (1) | LT2818478T (enExample) |
| MX (1) | MX358390B (enExample) |
| MY (2) | MY186903A (enExample) |
| PL (2) | PL2663575T3 (enExample) |
| PT (2) | PT2663575E (enExample) |
| RS (2) | RS55949B1 (enExample) |
| RU (2) | RU2751240C2 (enExample) |
| SG (3) | SG10202100485XA (enExample) |
| SI (2) | SI2818478T1 (enExample) |
| SM (2) | SMT201700222T1 (enExample) |
| WO (1) | WO2013063556A1 (enExample) |
| ZA (1) | ZA201402635B (enExample) |
Families Citing this family (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4502152A3 (en) | 2009-10-06 | 2025-04-30 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice and engraftment |
| PT4233537T (pt) | 2011-02-15 | 2025-09-08 | Regeneron Pharma | Ratinhos humanizados para m-csf e utilizações dos mesmos |
| SI2818478T1 (sl) | 2011-10-28 | 2017-07-31 | Regeneron Pharmaceuticals, Inc. | Humanizirani il-6 in receptor il-6 |
| US20130261016A1 (en) * | 2012-03-28 | 2013-10-03 | Meso Scale Technologies, Llc | Diagnostic methods for inflammatory disorders |
| US8962913B2 (en) | 2012-06-18 | 2015-02-24 | Regeneron Pharmaceuticals, Inc. | Humanized IL-7 rodents |
| KR102241962B1 (ko) | 2012-09-07 | 2021-04-20 | 예일 유니버시티 | 유전적으로 변형된 비-인간 동물 및 이것들의 사용 방법 |
| EP2896291B1 (en) * | 2012-09-13 | 2019-03-20 | Chugai Seiyaku Kabushiki Kaisha | Gene knock-in non-human animal |
| DK4389764T3 (da) * | 2012-11-05 | 2026-04-13 | Regeneron Pharma | Genetisk modificerede gnavere og fremgangsmåder til anvendelse heraf |
| US9848587B2 (en) | 2013-02-20 | 2017-12-26 | Regeneron Pharmaceuticals, Inc. | Humanized T cell co-receptor mice |
| SI2958937T1 (sl) | 2013-02-22 | 2018-12-31 | Regeneron Pharmaceuticals, Inc. | Miš, ki izraža humanizirani poglavitni histokompatibilnostni kompleks |
| GB2513884B (en) | 2013-05-08 | 2015-06-17 | Univ Bristol | Method and apparatus for producing an acoustic field |
| HRP20231121T1 (hr) * | 2013-09-23 | 2023-12-22 | Regeneron Pharmaceuticals, Inc. | Životinje koje nisu ljudi, koje imaju gen za humanizirani protein koji regulira signale |
| JP6492095B2 (ja) * | 2013-10-15 | 2019-03-27 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | ヒト化ｉｌ−１５動物 |
| MY183188A (en) | 2013-11-19 | 2021-02-18 | Regeneron Pharma | Non-human animals having a humanized b-cell activating factor gene |
| US20150143559A1 (en) | 2013-11-19 | 2015-05-21 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized a proliferation-inducing ligand gene |
| US9612658B2 (en) | 2014-01-07 | 2017-04-04 | Ultrahaptics Ip Ltd | Method and apparatus for providing tactile sensations |
| CA2934965A1 (en) | 2014-01-31 | 2016-03-17 | Boehringer Ingelheim International Gmbh | Novel anti-baff antibodies |
| RS60398B1 (sr) | 2014-04-08 | 2020-07-31 | Regeneron Pharma | Ne-humane životinje sa humanizovanim fc-gama receptorima |
| MX2016014504A (es) | 2014-05-05 | 2017-05-23 | Regeneron Pharma | Animales c5 y c3 humanizados. |
| NO2785538T3 (enExample) | 2014-05-07 | 2018-08-04 | ||
| EP3482629B1 (en) | 2014-05-19 | 2020-11-25 | Regeneron Pharmaceuticals, Inc. | Genetically modified non-human animals expressing human epo |
| ES2691529T3 (es) | 2014-05-30 | 2018-11-27 | Regeneron Pharmaceuticals, Inc. | Animales con dipeptidil peptidasa iv (dpp4) humanizada |
| WO2015196051A1 (en) * | 2014-06-19 | 2015-12-23 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized programmed cell death 1 gene |
| GB2530036A (en) | 2014-09-09 | 2016-03-16 | Ultrahaptics Ltd | Method and apparatus for modulating haptic feedback |
| BR112017010793A2 (pt) | 2014-11-24 | 2017-12-26 | Regeneron Pharma | animal não humano geneticamente modificado, camundongo, métodos para produzir um animal não humano geneticamente modificado e de triagem de candidatos a fármaco direcionados a um antígeno de interesse, e, modelo de camundongo. |
| BR112017010490A2 (pt) | 2014-12-05 | 2018-04-03 | Regeneron Pharma | roedor, polipeptídeo cd47, célula ou tecido de roedor isolado, célula-tronco emprionária de roedor, embrião de roedor, e, métodos de produzir um roedor, de fornecimento de um roedor, de enxerto de células humanas em um roedor, de avaliação de eficácia terapêutica de uma droga direcionada a células humanas e de avaliar as propriedades farmacocinéticas, de avaliar a toxicidade específica e inespecífica de uma droga direcionada ao cd47 humano. |
| ES2841353T3 (es) | 2014-12-09 | 2021-07-08 | Regeneron Pharma | Animales no humanos que tienen un gen del grupo de diferenciación 274 humanizado |
| KR102524966B1 (ko) | 2015-02-20 | 2023-04-21 | 울트라햅틱스 아이피 엘티디 | 햅틱 시스템에서의 알고리즘 개선 |
| EP3537265B1 (en) | 2015-02-20 | 2021-09-29 | Ultrahaptics Ip Ltd | Perceptions in a haptic system |
| MX2017012829A (es) | 2015-04-06 | 2018-02-23 | Regeneron Pharma | Respuestas inmunitarias mediadas por células t humanizadas en animales no humanos. |
| ES2950399T3 (es) | 2015-04-13 | 2023-10-09 | Regeneron Pharma | Ratones humanizados Sirpa-IL15 insertados y métodos de uso de los mismos |
| US10818162B2 (en) | 2015-07-16 | 2020-10-27 | Ultrahaptics Ip Ltd | Calibration techniques in haptic systems |
| CN108366548B (zh) | 2015-11-20 | 2021-10-08 | 瑞泽恩制药公司 | 具有人源化淋巴细胞活化基因3的非人动物 |
| MY207684A (en) | 2015-12-08 | 2025-03-12 | Regeneron Pharma | Compositions and methods for internalizing enzymes |
| US11189140B2 (en) | 2016-01-05 | 2021-11-30 | Ultrahaptics Ip Ltd | Calibration and detection techniques in haptic systems |
| WO2017136712A1 (en) | 2016-02-04 | 2017-08-10 | Regeneron Pharmaceuticals, Inc. | Non-human animals having an engineered angptl8 gene |
| CN109068621B (zh) | 2016-02-29 | 2021-07-20 | 再生元制药公司 | 具有人源化的tmprss基因的啮齿类动物 |
| CN109640644B (zh) | 2016-06-03 | 2021-10-26 | 瑞泽恩制药公司 | 表达外源末端脱氧核苷酸转移酶的非人动物 |
| US10531212B2 (en) | 2016-06-17 | 2020-01-07 | Ultrahaptics Ip Ltd. | Acoustic transducers in haptic systems |
| US10268275B2 (en) | 2016-08-03 | 2019-04-23 | Ultrahaptics Ip Ltd | Three-dimensional perceptions in haptic systems |
| US10755538B2 (en) | 2016-08-09 | 2020-08-25 | Ultrahaptics ilP LTD | Metamaterials and acoustic lenses in haptic systems |
| CN107815467B (zh) | 2016-08-31 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | 人源化基因改造动物模型的制备方法及应用 |
| US10943578B2 (en) | 2016-12-13 | 2021-03-09 | Ultrahaptics Ip Ltd | Driving techniques for phased-array systems |
| US10497358B2 (en) | 2016-12-23 | 2019-12-03 | Ultrahaptics Ip Ltd | Transducer driver |
| CN108467873B (zh) | 2017-03-17 | 2020-03-13 | 百奥赛图江苏基因生物技术有限公司 | 一种cd132基因缺失的免疫缺陷动物模型的制备方法及应用 |
| WO2018177441A1 (en) | 2017-03-31 | 2018-10-04 | Beijing Biocytogen Co., Ltd | GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC SIRPα |
| CN108588126B (zh) | 2017-03-31 | 2020-04-10 | 北京百奥赛图基因生物技术有限公司 | Cd47基因人源化改造动物模型的制备方法及应用 |
| WO2019067875A1 (en) | 2017-09-29 | 2019-04-04 | Regeneron Pharmaceuticals, Inc. | NON-HUMAN ANIMALS COMPRISING A HUMANIZED TTR LOCUS AND METHODS OF USE |
| US11531395B2 (en) | 2017-11-26 | 2022-12-20 | Ultrahaptics Ip Ltd | Haptic effects from focused acoustic fields |
| JP7361031B2 (ja) | 2017-11-30 | 2023-10-13 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化ｔｒｋｂ遺伝子座を含む非ヒト動物 |
| JP7483610B2 (ja) | 2017-12-22 | 2024-05-15 | ウルトラハプティクス アイピー リミテッド | 触覚システムにおける不要な応答の最小化 |
| US11360546B2 (en) | 2017-12-22 | 2022-06-14 | Ultrahaptics Ip Ltd | Tracking in haptic systems |
| IL277355B2 (en) | 2018-03-26 | 2025-01-01 | Regeneron Pharma | Humanized rodents for testing therapeutic agents |
| AU2019264014A1 (en) | 2018-05-02 | 2020-12-03 | Ultrahaptics Ip Ltd | Blocking plate structure for improved acoustic transmission efficiency |
| CA3098040A1 (en) | 2018-07-16 | 2020-01-23 | Regeneron Pharmaceuticals, Inc. | Non-human animal models of ditra disease and uses thereof |
| US11098951B2 (en) | 2018-09-09 | 2021-08-24 | Ultrahaptics Ip Ltd | Ultrasonic-assisted liquid manipulation |
| US11378997B2 (en) | 2018-10-12 | 2022-07-05 | Ultrahaptics Ip Ltd | Variable phase and frequency pulse-width modulation technique |
| US20220015343A1 (en) * | 2018-12-17 | 2022-01-20 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animal with human or chimeric genes |
| WO2020141330A2 (en) | 2019-01-04 | 2020-07-09 | Ultrahaptics Ip Ltd | Mid-air haptic textures |
| US12373033B2 (en) | 2019-01-04 | 2025-07-29 | Ultrahaptics Ip Ltd | Mid-air haptic textures |
| WO2020147829A1 (zh) * | 2019-01-17 | 2020-07-23 | 北京百奥赛图基因生物技术有限公司 | 人源化转基因动物 |
| JP7506686B2 (ja) | 2019-04-04 | 2024-06-26 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化凝固因子１２遺伝子座を含む非ヒト動物 |
| US11842517B2 (en) | 2019-04-12 | 2023-12-12 | Ultrahaptics Ip Ltd | Using iterative 3D-model fitting for domain adaptation of a hand-pose-estimation neural network |
| EP3978607B1 (en) | 2019-05-27 | 2025-08-20 | Transgenic Inc. | Exon-humanized mouse |
| WO2020247452A1 (en) | 2019-06-04 | 2020-12-10 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized ttr locus with a beta-slip mutation and methods of use |
| CN113939595A (zh) | 2019-06-07 | 2022-01-14 | 瑞泽恩制药公司 | 包括人源化白蛋白基因座的非人动物 |
| US11374586B2 (en) | 2019-10-13 | 2022-06-28 | Ultraleap Limited | Reducing harmonic distortion by dithering |
| CN114631139A (zh) | 2019-10-13 | 2022-06-14 | 超飞跃有限公司 | 利用虚拟麦克风进行动态封顶 |
| WO2021090028A1 (en) | 2019-11-08 | 2021-05-14 | Ultraleap Limited | Tracking techniques in haptics systems |
| CN111304246B (zh) * | 2019-12-17 | 2021-05-04 | 百奥赛图江苏基因生物技术有限公司 | 一种人源化细胞因子动物模型、制备方法及应用 |
| US11715453B2 (en) | 2019-12-25 | 2023-08-01 | Ultraleap Limited | Acoustic transducer structures |
| WO2021154791A1 (en) * | 2020-01-28 | 2021-08-05 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized pnpla3 locus and methods of use |
| KR20230004472A (ko) | 2020-04-21 | 2023-01-06 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화 cxcl13 유전자를 갖는 비인간 동물 |
| US11816267B2 (en) | 2020-06-23 | 2023-11-14 | Ultraleap Limited | Features of airborne ultrasonic fields |
| US11886639B2 (en) | 2020-09-17 | 2024-01-30 | Ultraleap Limited | Ultrahapticons |
| CN116981357A (zh) | 2021-03-31 | 2023-10-31 | 瑞泽恩制药公司 | 包含具有改善的tcrb组库多样性的人源化细胞免疫系统组分的基因修饰的小鼠 |
| US12517585B2 (en) | 2021-07-15 | 2026-01-06 | Ultraleap Limited | Control point manipulation techniques in haptic systems |
| US12688761B2 (en) | 2022-01-02 | 2026-07-21 | Sim Ip Hxr Llc | Mid-air haptic generation analytic techniques |
| EP4593590A1 (en) | 2022-09-29 | 2025-08-06 | Regeneron Pharmaceuticals, Inc. | Correction of hepatosteatosis in humanized liver animals through restoration of il6/il6r/gp130 signaling in human hepatocytes |
| US12659636B2 (en) | 2022-10-11 | 2026-06-16 | Sim Ip Hxr Llc | Acoustic transducer mounts |
| WO2025212991A1 (en) | 2024-04-05 | 2025-10-09 | Regeneron Pharmaceuticals, Inc. | Rodent models of disease |
| WO2025250495A1 (en) | 2024-05-28 | 2025-12-04 | Regeneron Pharmaceuticals, Inc. | Acceleration of human hepatocyte engraftment in humanized liver animals by supplementing paracrine ligands or agonists that activate human liver regeneration signals |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2202549C (en) * | 1994-10-14 | 2003-08-05 | Tara Seshadri | Transgenic nonhuman animal having functionally disrupted interleukin-1.beta. converting enzyme gene |
| PL182089B1 (en) | 1994-10-21 | 2001-11-30 | Chugai Pharmaceutical Co Ltd | Pharmaceutic compositions for treating diseases caused by production of il-6 |
| US20030082721A1 (en) * | 2001-01-17 | 2003-05-01 | Tai-Jay Chang | Transgenic animals expressing androgen receptor complex-associated protein |
| CN1560081A (zh) * | 2004-02-17 | 2005-01-05 | 大连帝恩生物工程有限公司 | 用能产生人IgGl重链－κ轻链小鼠作为制备人源化单克隆抗体和应用 |
| EP1802193B1 (en) | 2004-10-19 | 2014-04-30 | Regeneron Pharmaceuticals, Inc. | Method for generating a mouse homozygous for a genetic modification |
| US7759541B2 (en) * | 2004-12-13 | 2010-07-20 | Iti Life Sciences | Transgenic animals for assessing drug metabolism and toxicity |
| GB2434578A (en) | 2006-01-26 | 2007-08-01 | Univ Basel | Transgenic animals |
| ATE537190T1 (de) | 2006-06-02 | 2011-12-15 | Regeneron Pharma | Hochaffine antikörper gegen den humanen il-6- rezeptor |
| EP2064325B1 (en) * | 2006-09-01 | 2011-12-07 | Therapeutic Human Polyclonals, Inc. | Enhanced expression of human or humanized immunoglobulin in non-human transgenic animals |
| FR2942218A1 (fr) | 2009-02-13 | 2010-08-20 | Eurocave Sa | Appareil de service au verre d'un liquide, notamment de vin |
| EP4502152A3 (en) * | 2009-10-06 | 2025-04-30 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice and engraftment |
| EP3498730B1 (en) * | 2009-12-21 | 2026-01-28 | Regeneron Pharmaceuticals, Inc. | Humanized fc gamma r mice |
| PT4233537T (pt) | 2011-02-15 | 2025-09-08 | Regeneron Pharma | Ratinhos humanizados para m-csf e utilizações dos mesmos |
| KR102366029B1 (ko) | 2011-09-30 | 2022-02-23 | 추가이 세이야쿠 가부시키가이샤 | 표적 항원에 대한 면역응답을 유도하는 항원 결합 분자 |
| SI2818478T1 (sl) | 2011-10-28 | 2017-07-31 | Regeneron Pharmaceuticals, Inc. | Humanizirani il-6 in receptor il-6 |
| RS63220B1 (sr) | 2011-10-28 | 2022-06-30 | Regeneron Pharma | Genetski modifikovani miševi sa ekspresijom himernih molekula klase ii glavnog kompleksa histokompatibilnosti (mhc) |
| KR102295746B1 (ko) | 2011-10-28 | 2021-09-01 | 리제너론 파아마슈티컬스, 인크. | 유전자 변형된 주요 조직적합성 복합체 마우스 |
-
2012
- 2012-10-29 SI SI201230941A patent/SI2818478T1/sl unknown
- 2012-10-29 RU RU2017129763A patent/RU2751240C2/ru active
- 2012-10-29 PL PL12795905T patent/PL2663575T3/pl unknown
- 2012-10-29 IN IN3920CHN2014 patent/IN2014CN03920A/en unknown
- 2012-10-29 CN CN201280065013.6A patent/CN104039821A/zh active Pending
- 2012-10-29 CN CN201810620759.8A patent/CN108866101A/zh active Pending
- 2012-10-29 RU RU2014121324A patent/RU2634417C2/ru active
- 2012-10-29 HR HRP20141192AT patent/HRP20141192T1/hr unknown
- 2012-10-29 DK DK14177863.9T patent/DK2818478T3/en active
- 2012-10-29 SG SG10202100485XA patent/SG10202100485XA/en unknown
- 2012-10-29 BR BR112014008529A patent/BR112014008529A2/pt not_active Application Discontinuation
- 2012-10-29 EP EP12795905.4A patent/EP2663575B1/en active Active
- 2012-10-29 WO PCT/US2012/062379 patent/WO2013063556A1/en not_active Ceased
- 2012-10-29 PL PL14177863T patent/PL2818478T3/pl unknown
- 2012-10-29 KR KR1020207005686A patent/KR102234632B1/ko active Active
- 2012-10-29 ES ES14177863.9T patent/ES2624605T3/es active Active
- 2012-10-29 LT LTEP14177863.9T patent/LT2818478T/lt unknown
- 2012-10-29 SI SI201230111T patent/SI2663575T1/sl unknown
- 2012-10-29 US US13/662,880 patent/US8878001B2/en active Active
- 2012-10-29 SM SM20170222T patent/SMT201700222T1/it unknown
- 2012-10-29 MY MYPI2017703646A patent/MY186903A/en unknown
- 2012-10-29 JP JP2014539105A patent/JP6120451B2/ja active Active
- 2012-10-29 RS RS20170430A patent/RS55949B1/sr unknown
- 2012-10-29 PT PT127959054T patent/PT2663575E/pt unknown
- 2012-10-29 MY MYPI2014000768A patent/MY172726A/en unknown
- 2012-10-29 KR KR1020147014316A patent/KR102084927B1/ko active Active
- 2012-10-29 HU HUE14177863A patent/HUE033400T2/en unknown
- 2012-10-29 ES ES12795905.4T patent/ES2525368T3/es active Active
- 2012-10-29 RS RS20140677A patent/RS53683B1/sr unknown
- 2012-10-29 PT PT141778639T patent/PT2818478T/pt unknown
- 2012-10-29 CA CA2853731A patent/CA2853731C/en active Active
- 2012-10-29 SG SG10201600965YA patent/SG10201600965YA/en unknown
- 2012-10-29 MX MX2014004900A patent/MX358390B/es active IP Right Grant
- 2012-10-29 EP EP14177863.9A patent/EP2818478B1/en active Active
- 2012-10-29 SG SG11201400945UA patent/SG11201400945UA/en unknown
- 2012-10-29 DK DK12795905.4T patent/DK2663575T3/en active
-
2014
- 2014-04-03 IL IL231896A patent/IL231896B/en active IP Right Grant
- 2014-04-10 ZA ZA2014/02635A patent/ZA201402635B/en unknown
- 2014-09-19 US US14/490,877 patent/US9078418B2/en active Active
- 2014-09-19 US US14/490,875 patent/US9125386B2/en active Active
- 2014-12-11 CY CY20141101035T patent/CY1116614T1/el unknown
- 2014-12-15 SM SM201400187T patent/SMT201400187B/xx unknown
-
2015
- 2015-06-10 US US14/735,710 patent/US9392777B2/en active Active
- 2015-07-30 AU AU2015207889A patent/AU2015207889B2/en active Active
-
2016
- 2016-01-18 IL IL243665A patent/IL243665B/en active IP Right Grant
- 2016-01-18 IL IL243666A patent/IL243666B/en active IP Right Grant
- 2016-06-09 US US15/177,582 patent/US9622460B2/en active Active
- 2016-11-14 US US15/350,739 patent/US10004211B2/en active Active
- 2016-11-18 JP JP2016224713A patent/JP2017035115A/ja active Pending
-
2017
- 2017-04-28 HR HRP20170656TT patent/HRP20170656T1/hr unknown
- 2017-04-28 CY CY20171100474T patent/CY1118952T1/el unknown
-
2018
- 2018-06-06 US US16/001,074 patent/US10433528B2/en active Active
-
2019
- 2019-01-28 IL IL264508A patent/IL264508B/en active IP Right Grant
- 2019-07-03 US US16/502,197 patent/US11102962B2/en active Active
-
2021
- 2021-07-26 US US17/385,039 patent/US12239111B2/en active Active
-
2025
- 2025-01-29 US US19/039,847 patent/US20250287931A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL264508B (en) | Humanized interleukin-6 and interleukin-6 receptor | |
| ES3065861T3 (en) | Interleukin-31 monoclonal antibody | |
| IL259826A (en) | Anti-alphabetatisiar antibody | |
| IL220404A (en) | Antiseptic antibodies | |
| ZA201307983B (en) | Anti-b7-h3 antibody | |
| AP2013007135A0 (en) | Anti-sclerostin antibody crystals and formulationsthereof | |
| TWI563004B (en) | Anti-hxcr1 antibody | |
| ZA201309636B (en) | Trough | |
| EP2714074A4 (en) | ANTIBODIES AGAINST EMR1 | |
| GB201113354D0 (en) | Leptin receptor structure | |
| GB201108614D0 (en) | CarryEase |