PL2569008T3 - Chimery ospa i ich zastosowanie w szczepionkach - Google Patents

Chimery ospa i ich zastosowanie w szczepionkach

Info

Publication number
PL2569008T3
PL2569008T3 PL11720967T PL11720967T PL2569008T3 PL 2569008 T3 PL2569008 T3 PL 2569008T3 PL 11720967 T PL11720967 T PL 11720967T PL 11720967 T PL11720967 T PL 11720967T PL 2569008 T3 PL2569008 T3 PL 2569008T3
Authority
PL
Poland
Prior art keywords
vaccines
ospa chimeras
ospa
chimeras
Prior art date
Application number
PL11720967T
Other languages
English (en)
Inventor
Brian A. Crowe
Ian Livey
Maria O'rourke
Michael Schwendinger
John J. Dunn
Benjamin J. Luft
Original Assignee
Baxalta Incorporated
Baxalta GmbH
The Research Foundation For The State University Of New York
Brookhaven Science Associates Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxalta Incorporated, Baxalta GmbH, The Research Foundation For The State University Of New York, Brookhaven Science Associates Llc filed Critical Baxalta Incorporated
Publication of PL2569008T3 publication Critical patent/PL2569008T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/0225Spirochetes, e.g. Treponema, Leptospira, Borrelia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/14Ectoparasiticides, e.g. scabicides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/57Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6018Lipids, e.g. in lipopeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/70Multivalent vaccine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/20Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Plant Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL11720967T 2010-05-14 2011-05-13 Chimery ospa i ich zastosowanie w szczepionkach PL2569008T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33490110P 2010-05-14 2010-05-14
EP11720967.6A EP2569008B1 (en) 2010-05-14 2011-05-13 Ospa chimeras and use thereof in vaccines
PCT/US2011/036533 WO2011143623A1 (en) 2010-05-14 2011-05-13 Ospa chimeras and use thereof in vaccines

Publications (1)

Publication Number Publication Date
PL2569008T3 true PL2569008T3 (pl) 2021-04-19

Family

ID=44121257

Family Applications (2)

Application Number Title Priority Date Filing Date
PL11722243T PL2569009T3 (pl) 2010-05-14 2011-05-13 Chimery ospa i ich zastosowanie do szczepień
PL11720967T PL2569008T3 (pl) 2010-05-14 2011-05-13 Chimery ospa i ich zastosowanie w szczepionkach

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL11722243T PL2569009T3 (pl) 2010-05-14 2011-05-13 Chimery ospa i ich zastosowanie do szczepień

Country Status (13)

Country Link
US (6) US8623375B2 (pl)
EP (4) EP3705133B1 (pl)
JP (6) JP6030052B2 (pl)
KR (7) KR20130062954A (pl)
CN (3) CN103108652B (pl)
AU (2) AU2011252850B2 (pl)
BR (2) BR112012027315B1 (pl)
CA (2) CA2798331C (pl)
MX (2) MX340739B (pl)
PL (2) PL2569009T3 (pl)
RU (2) RU2583289C2 (pl)
SI (2) SI2569009T1 (pl)
WO (2) WO2011143617A1 (pl)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2798331C (en) 2010-05-14 2022-03-15 Baxter International Inc. Ospa chimeras and use thereof in vaccines
US8571937B2 (en) 2010-10-20 2013-10-29 Playspan Inc. Dynamic payment optimization apparatuses, methods and systems
US10438176B2 (en) 2011-07-17 2019-10-08 Visa International Service Association Multiple merchant payment processor platform apparatuses, methods and systems
US10318941B2 (en) 2011-12-13 2019-06-11 Visa International Service Association Payment platform interface widget generation apparatuses, methods and systems
WO2013090611A2 (en) * 2011-12-13 2013-06-20 Visa International Service Association Dynamic widget generator apparatuses, methods and systems
US8986704B2 (en) 2012-07-06 2015-03-24 Valneva Austria Gmbh Mutant fragments of OspA and methods and uses relating thereto
KR20200068756A (ko) * 2012-07-27 2020-06-15 박스알타 인코퍼레이티드 키메라 ospa 분자를 포함하는 조성물 및 이의 사용 방법
PL223175B1 (pl) 2012-10-22 2016-10-31 Inst Chemii Bioorganicznej Polskiej Akademii Nauk Szczepionka przeciw boreliozie, konstrukt genetyczny, rekombinowane białko, sposób otrzymywania konstruktu genetycznego, sposób otrzymywania szczepionki, sposób otrzymywania rekombinowanych białek, zastosowanie rekombinowanych białek do wytwarzania szczepionki przeciwko boreliozie
WO2015041710A1 (en) * 2013-09-23 2015-03-26 Ventria Bioscience, Inc. Ospa fusion protein for vaccination against lyme disease
TR201910117T4 (tr) * 2014-01-09 2019-07-22 Valneva Austria Gmbh OspA nın mutant fragmanları ve bunlara ilişkin yöntemler ve kullanımları.
CZ2014320A3 (cs) * 2014-05-09 2015-11-18 VÝZKUMNÝ ÚSTAV VETERINÁRNÍHO LÉKAŘSTVÍ, v.v.i. Polyepitopový antigen, vakcinační konstrukt a vakcína pro prevenci lymeské boreliózy
EP3180024B1 (en) 2014-08-11 2022-05-18 University of Massachusetts Anti-ospa antibodies and methods of use
US11216468B2 (en) 2015-02-08 2022-01-04 Visa International Service Association Converged merchant processing apparatuses, methods and systems
WO2017029000A1 (en) * 2015-08-14 2017-02-23 Telefonaktiebolaget Lm Ericsson (Publ) A node and method for managing a packet data network connection
US20190284261A1 (en) * 2016-11-07 2019-09-19 The Trustees Of The University Of Pennsylvania Dna antibody constructs for use against lyme disease
WO2018189372A1 (en) * 2017-04-13 2018-10-18 Valneva Austria Gmbh Multivalent ospa polypeptides and methods and uses relating thereto
CN112512564A (zh) 2018-04-03 2021-03-16 赛诺菲 铁蛋白蛋白
KR20210018205A (ko) 2018-04-03 2021-02-17 사노피 항원성 OspA 폴리펩타이드
WO2019195314A2 (en) 2018-04-03 2019-10-10 Sanofi Antigenic epstein barr virus polypeptides
CN110483624B (zh) * 2019-08-22 2021-02-09 中国疾病预防控制中心传染病预防控制所 伽氏疏螺旋体OspA蛋白C端肽段及其应用
CN111196842A (zh) * 2020-01-09 2020-05-26 济南大学 一种外膜转运通道蛋白的非跨膜结构域的表达纯化方法
US20230398210A1 (en) 2020-04-09 2023-12-14 Valneva Austria Gmbh Improvements in vaccine formulations for medical use
WO2022261050A1 (en) * 2021-06-07 2022-12-15 The University Of Massachusetts Apparatus and method for continuous production of rna
WO2023170680A1 (en) 2022-03-08 2023-09-14 Equashield Medical Ltd Fluid transfer station in a robotic pharmaceutical preparation system

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK590288D0 (da) 1988-10-24 1988-10-24 Symbicom Ab Kemiske forbindelser
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
SE8205892D0 (sv) 1982-10-18 1982-10-18 Bror Morein Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
EP0154316B1 (en) 1984-03-06 1989-09-13 Takeda Chemical Industries, Ltd. Chemically modified lymphokine and production thereof
SE8405493D0 (sv) 1984-11-01 1984-11-01 Bror Morein Immunogent komplex samt sett for framstellning derav och anvendning derav som immunstimulerande medel
US4877612A (en) 1985-05-20 1989-10-31 Frank M. Berger Immunological adjuvant and process for preparing the same, pharmaceutical compositions, and process
DE3521994A1 (de) 1985-06-20 1987-01-02 Bayer Ag N-(2-aminoacylamido-2-desoxy-hexosyl)-amide-, -carbamate und -harnstoffe, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
DK166762B1 (da) 1986-01-14 1993-07-12 Nederlanden Staat Fremgangsmaade til fremstilling af immunogenkomplekser og farmaceutisk sammensaetning indeholdende saadanne komplekser
US4806352A (en) 1986-04-15 1989-02-21 Ribi Immunochem Research Inc. Immunological lipid emulsion adjuvant
US4830885A (en) 1987-06-08 1989-05-16 Allied-Signal Inc. Chlorine-resistant semipermeable membranes
US5777095A (en) 1988-10-24 1998-07-07 Symbicom Aktiebolag Osp A and B Sequence of Borrelia burgdonferi strains ACA1 and IP90
US6143872A (en) * 1988-10-24 2000-11-07 Symbicom Aktiebolag Borrelia burdorferi Osp A and B proteins and immunogenic peptides
US7094391B1 (en) 1988-10-24 2006-08-22 The University Of Texas System Compositions and methods for administering Borrelia burgdorferi antigens
ATE135370T1 (de) 1988-12-22 1996-03-15 Kirin Amgen Inc Chemisch modifizierte granulocytenkolonie erregender faktor
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
SG47447A1 (en) * 1990-06-15 1998-04-17 Univ Yale Compositions and methods for the prevention and diagnosis of lyme disease
US5252714A (en) 1990-11-28 1993-10-12 The University Of Alabama In Huntsville Preparation and use of polyethylene glycol propionaldehyde
DK0571538T5 (da) 1991-02-15 2002-03-04 Uab Research Foundation Strukturgen for pneumokokprotein
CA2115554A1 (en) 1991-08-15 1993-03-04 Yves Lobet Osp a proteins of borrelia burgdorferi subgroups, encoding genes and vaccines
US6676942B1 (en) 1991-08-15 2004-01-13 Smithkline Beecham Biologicals (S.A.) Osp a proteins of Borrelia burgdorferi subgroups, encoding genes and vaccines
US5234784A (en) 1992-04-01 1993-08-10 Eastman Kodak Company Method of making a projection viewable transparency comprising an electrostatographic toner image
US7008625B2 (en) 1993-11-01 2006-03-07 Research Foundation Of The State University Of New York Recombinant constructs of Borrelia burgdorferi
EP0726955B1 (en) 1993-11-01 2004-04-07 Brookhaven Science Associates Chimeric proteins comprising borrelia polypeptides: uses therefor
US6248562B1 (en) 1993-11-01 2001-06-19 Research Foundation State University Of New York Chimeric proteins comprising borrelia polypeptides and uses therefor
CA2244110A1 (en) 1996-02-12 1997-08-14 Cobra Therapeutics Limited Novel methods of vaccination and vaccines thereof comprising a nucleic acid encoding a first epitope and a peptide containing a second epitope
US6368603B1 (en) * 1997-03-05 2002-04-09 Merial Limited Lyme combination compositions and uses
DE69835682T2 (de) * 1997-06-30 2007-08-23 The Administrators Of The Tulane Educational Fund Oberflächenantigene und proteine für zusammensetzungen zu diagnose und vorbeugung der lyme-kkrankheit
US6342220B1 (en) 1997-08-25 2002-01-29 Genentech, Inc. Agonist antibodies
GB9726555D0 (en) 1997-12-16 1998-02-11 Smithkline Beecham Plc Vaccine
US6541011B2 (en) * 1998-02-11 2003-04-01 Maxygen, Inc. Antigen library immunization
GB9811219D0 (en) 1998-05-26 1998-07-22 Smithkline Beecham Biolog Novel process
EP1939294A1 (en) * 2000-08-18 2008-07-02 Research Foundation Of State University Of New York Recombinant constructs of borrelia burgdorferi
PT1311682E (pt) 2000-08-18 2008-03-11 Brookhaven Sciences Ass Llc Construcões recombinantes de borrelia burgdorferi
PT1311540E (pt) 2000-08-18 2008-03-20 Univ New York State Res Found Ospa de borrelia burgdorferi modificada
ATE420887T1 (de) 2003-04-02 2009-01-15 Us Gov Health & Human Serv Cholesterol enthaltende verbindungen und deren verwendung als immunogen gegen borellia burgdorferi
EP1618185A4 (en) * 2003-04-16 2009-05-27 Wyeth Corp NEW IMMUNOLOGICAL COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF MENINGOCOCCOULAR DISEASE
PL1730175T3 (pl) * 2004-03-24 2010-09-30 Merck Sharp & Dohme Optymalizowana ekspresja L1 HPV 52 w drożdżach
WO2006014292A2 (en) * 2004-07-02 2006-02-09 Dattwyler Raymond J Oral vaccine for borrelia
GB0417494D0 (en) 2004-08-05 2004-09-08 Glaxosmithkline Biolog Sa Vaccine
JP5390189B2 (ja) * 2005-11-29 2014-01-15 ヴァージニア コモンウェルス ユニバーシティ 多価キメラospcワクシノーゲンおよび診断用抗原
RU2008126239A (ru) * 2005-11-29 2010-01-10 Вирджиния Коммонвелт Юниверсити (Us) Поливалентный химерный вакциноген и диагностический антиген ospc
JP2010503384A (ja) 2006-09-15 2010-02-04 インターセル アーゲー ボレリア(Borrelia)抗原
CA2677023C (en) 2007-02-22 2016-08-30 Baxter International Inc. Method of purification of hydrophobic proteins
EP2687228B1 (en) * 2007-06-26 2017-07-19 GlaxoSmithKline Biologicals S.A. Vaccine comprising streptococcus pneumoniae capsular polysaccharide conjugates
MX2010007461A (es) * 2008-01-11 2010-10-20 VGX Pharmaceuticals LLC Nuevas vacunas contra multiples subtipos del virus del dengue.
WO2009131665A1 (en) 2008-04-22 2009-10-29 Research Foundation Of State University Of New York Borrelia burgdorferi cell envelope protein array
US20110262475A1 (en) 2008-05-02 2011-10-27 Earnhart Christopher G Lyme disease vaccine
CA2798331C (en) * 2010-05-14 2022-03-15 Baxter International Inc. Ospa chimeras and use thereof in vaccines
KR20200068756A (ko) * 2012-07-27 2020-06-15 박스알타 인코퍼레이티드 키메라 ospa 분자를 포함하는 조성물 및 이의 사용 방법

Also Published As

Publication number Publication date
US9303073B2 (en) 2016-04-05
KR102222869B1 (ko) 2021-03-04
AU2011252844B2 (en) 2014-07-03
EP2569008A1 (en) 2013-03-20
KR20180082633A (ko) 2018-07-18
WO2011143617A1 (en) 2011-11-17
EP2569008B1 (en) 2019-12-25
RU2583289C2 (ru) 2016-05-10
KR20130062954A (ko) 2013-06-13
BR112012027315A8 (pt) 2020-09-01
US20110293652A1 (en) 2011-12-01
SI2569008T1 (sl) 2020-02-28
JP2018150386A (ja) 2018-09-27
EP2569009B1 (en) 2019-10-09
MX340739B (es) 2016-07-22
RU2636455C2 (ru) 2017-11-23
US20140141029A1 (en) 2014-05-22
AU2011252850B2 (en) 2016-03-17
US9334311B2 (en) 2016-05-10
JP2013529078A (ja) 2013-07-18
JP2013529077A (ja) 2013-07-18
BR112012029058A2 (pt) 2020-06-23
US9895434B2 (en) 2018-02-20
US11305000B2 (en) 2022-04-19
KR102130584B1 (ko) 2020-07-07
WO2011143623A1 (en) 2011-11-17
JP6227407B2 (ja) 2017-11-08
BR112012027315B1 (pt) 2021-08-17
BR112012029058B1 (pt) 2022-03-29
SI2569009T1 (sl) 2020-02-28
KR20130133120A (ko) 2013-12-06
KR20180031814A (ko) 2018-03-28
US20140141030A1 (en) 2014-05-22
JP6030052B2 (ja) 2016-11-24
PL2569009T3 (pl) 2020-06-15
RU2012153752A (ru) 2014-06-20
MX2012013264A (es) 2014-12-05
MX348113B (es) 2017-05-29
EP3705133A3 (en) 2021-01-06
CA2798331C (en) 2022-03-15
JP2016171816A (ja) 2016-09-29
CA2799181A1 (en) 2011-11-17
KR20200084062A (ko) 2020-07-09
US20160235830A1 (en) 2016-08-18
JP2020178719A (ja) 2020-11-05
CN107641151B (zh) 2021-10-01
US8623375B2 (en) 2014-01-07
KR20190027955A (ko) 2019-03-15
RU2017138652A3 (pl) 2021-03-15
AU2011252850A1 (en) 2012-11-29
CN103118701B (zh) 2017-10-24
EP3650041A1 (en) 2020-05-13
JP6965417B2 (ja) 2021-11-10
CN103108652A (zh) 2013-05-15
AU2011252844A1 (en) 2012-11-29
CN107641151A (zh) 2018-01-30
MX2012013261A (es) 2013-04-19
EP3705133B1 (en) 2024-06-26
US20120020973A1 (en) 2012-01-26
JP2016168057A (ja) 2016-09-23
CN103118701A (zh) 2013-05-22
KR102230562B1 (ko) 2021-03-22
KR102085465B1 (ko) 2020-03-05
EP3705133A2 (en) 2020-09-09
EP2569009A1 (en) 2013-03-20
US20180296656A1 (en) 2018-10-18
RU2012153972A (ru) 2014-06-20
RU2017138652A (ru) 2019-02-11
CA2798331A1 (en) 2011-11-17
KR20200024354A (ko) 2020-03-06
US8623376B2 (en) 2014-01-07
BR112012027315A2 (pt) 2016-11-16
CN103108652B (zh) 2016-05-11
CA2799181C (en) 2023-10-24

Similar Documents

Publication Publication Date Title
PL2569008T3 (pl) Chimery ospa i ich zastosowanie w szczepionkach
HUS2100032I1 (hu) Helyettesített 5-fluor-1H-pirazolopiridin-származékok és alkalmazásuk
HK1187049A1 (en) Bisaryl-bonded aryltriazolones and use thereof
HK1192879A1 (zh) 取代的 -苄基環烷基羧酸及其用途
IL215389A0 (en) Pneumococcal vaccine and uses thereof
ZA201208173B (en) Peptices and their use
HK1184488A1 (en) Human facilitating cells and uses thereof
EP2536293A4 (en) METHODS AND COMPOSITIONS FOR USE IN AQUACULTURE
HRP20182083T1 (hr) Nova kombinacija i uporaba
ZA201302168B (en) Electrode unit for use in a fryer and fryer comprising a said electrode unit
PT2521445T (pt) Formulação e utilização da mesma
PT2563806E (pt) Leucolectinas humanas e suas utilizações
GB201008286D0 (en) Device and use
GB201005441D0 (en) Improvements in wheelchairs
GB201001170D0 (en) Novel peptides and their use in therepy and diagnosis
GB201021105D0 (en) Improvements in and relating to parathas