PL2534149T3 - Maleinian 6-amino-2-{[(1s)-1-metylobutylo]oksy}-9-[5-(1-piperydynylo)pentylo]-7,9-dihydro-8h-puryn-8-onu - Google Patents

Maleinian 6-amino-2-{[(1s)-1-metylobutylo]oksy}-9-[5-(1-piperydynylo)pentylo]-7,9-dihydro-8h-puryn-8-onu

Info

Publication number
PL2534149T3
PL2534149T3 PL11709025T PL11709025T PL2534149T3 PL 2534149 T3 PL2534149 T3 PL 2534149T3 PL 11709025 T PL11709025 T PL 11709025T PL 11709025 T PL11709025 T PL 11709025T PL 2534149 T3 PL2534149 T3 PL 2534149T3
Authority
PL
Poland
Prior art keywords
purin
methylbutyl
piperidinyl
maleate
dihydro
Prior art date
Application number
PL11709025T
Other languages
English (en)
Polish (pl)
Inventor
Robert Hermann Gibbon
Amanda Lucas
Stephen Andrew Hermitage
Original Assignee
Glaxosmithkline Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Llc filed Critical Glaxosmithkline Llc
Publication of PL2534149T3 publication Critical patent/PL2534149T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
PL11709025T 2010-02-10 2011-02-08 Maleinian 6-amino-2-{[(1s)-1-metylobutylo]oksy}-9-[5-(1-piperydynylo)pentylo]-7,9-dihydro-8h-puryn-8-onu PL2534149T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30301010P 2010-02-10 2010-02-10
EP11709025.8A EP2534149B1 (en) 2010-02-10 2011-02-08 6-amino-2-{[(1s)-1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro-8h-purin-8-one maleate
PCT/EP2011/051830 WO2011098452A1 (en) 2010-02-10 2011-02-08 6-amino-2-{ [ (1s)-1-methylbutyl] oxy}-9-[5-(1-piperidinyl)-7,9-dihydro-8h-purin-8-one maleate

Publications (1)

Publication Number Publication Date
PL2534149T3 true PL2534149T3 (pl) 2015-03-31

Family

ID=43836817

Family Applications (1)

Application Number Title Priority Date Filing Date
PL11709025T PL2534149T3 (pl) 2010-02-10 2011-02-08 Maleinian 6-amino-2-{[(1s)-1-metylobutylo]oksy}-9-[5-(1-piperydynylo)pentylo]-7,9-dihydro-8h-puryn-8-onu

Country Status (23)

Country Link
US (1) US8703754B2 (US07585860-20090908-C00112.png)
EP (1) EP2534149B1 (US07585860-20090908-C00112.png)
JP (1) JP5922587B2 (US07585860-20090908-C00112.png)
KR (1) KR101773541B1 (US07585860-20090908-C00112.png)
CN (1) CN102753553B (US07585860-20090908-C00112.png)
AU (1) AU2011214468B2 (US07585860-20090908-C00112.png)
BR (1) BR112012018904A2 (US07585860-20090908-C00112.png)
CA (1) CA2786973C (US07585860-20090908-C00112.png)
DK (1) DK2534149T3 (US07585860-20090908-C00112.png)
EA (1) EA021048B1 (US07585860-20090908-C00112.png)
ES (1) ES2525826T3 (US07585860-20090908-C00112.png)
HR (1) HRP20141258T1 (US07585860-20090908-C00112.png)
IL (1) IL220845A (US07585860-20090908-C00112.png)
ME (1) ME01926B (US07585860-20090908-C00112.png)
MX (1) MX2012009316A (US07585860-20090908-C00112.png)
PL (1) PL2534149T3 (US07585860-20090908-C00112.png)
PT (1) PT2534149E (US07585860-20090908-C00112.png)
RS (1) RS53745B1 (US07585860-20090908-C00112.png)
SG (1) SG182471A1 (US07585860-20090908-C00112.png)
SI (1) SI2534149T1 (US07585860-20090908-C00112.png)
SM (1) SMT201400196B (US07585860-20090908-C00112.png)
WO (1) WO2011098452A1 (US07585860-20090908-C00112.png)
ZA (1) ZA201205995B (US07585860-20090908-C00112.png)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA103195C2 (uk) 2008-08-11 2013-09-25 Глаксосмитклайн Ллк Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань
BRPI0923225A2 (pt) 2008-12-02 2016-10-04 Chiralgen Ltd metodo para sintese de acidos nucleicos modificados no atomo de fosforo
BR112012000828A8 (pt) 2009-07-06 2017-10-10 Ontorii Inc Novas pró-drogas de ácido nucleico e métodos de uso das mesmas
AU2010310813B2 (en) 2009-10-22 2015-06-18 Gilead Sciences, Inc. Derivatives of purine or deazapurine useful for the treatment of (inter alia) viral infections
WO2012039448A1 (ja) 2010-09-24 2012-03-29 株式会社キラルジェン 不斉補助基
EP3248982A1 (en) 2011-07-19 2017-11-29 Wave Life Sciences Ltd. Thiosulfonate reagents for the synthesis of functionalized nucleic acids
WO2013014052A1 (en) * 2011-07-22 2013-01-31 Glaxosmithkline Llc Composition
PT2872485T (pt) 2012-07-13 2021-03-05 Wave Life Sciences Ltd Grupo auxiliar assimétrico
RU2015104762A (ru) 2012-07-13 2018-08-31 Уэйв Лайф Сайенсес Лтд. Хиральный контроль
SG11201500243WA (en) * 2012-07-13 2015-04-29 Shin Nippon Biomedical Lab Ltd Chiral nucleic acid adjuvant
NZ704224A (en) 2012-08-24 2018-04-27 Glaxosmithkline Llc Pyrazolopyrimidine compounds
ES2632448T3 (es) 2012-11-20 2017-09-13 Glaxosmithkline Llc Nuevos compuestos
MX358025B (es) 2012-11-20 2018-08-02 Glaxosmithkline Llc Star Compuestos novedosos.
CN104780923B (zh) 2012-11-20 2017-03-15 葛兰素史克有限责任公司 干扰素诱导剂化合物
US10322173B2 (en) 2014-01-15 2019-06-18 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
EP3095461A4 (en) 2014-01-15 2017-08-23 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
JPWO2015108048A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
KR20230152178A (ko) 2014-01-16 2023-11-02 웨이브 라이프 사이언시스 리미티드 키랄 디자인
AU2015308618B2 (en) * 2014-08-29 2021-05-20 Corium Pharma Solutions, Inc. Microstructure array for delivery of active agents
BE1023340B1 (fr) * 2014-11-13 2017-02-08 Glaxosmithkline Biologicals S.A. Composes
US20220026404A1 (en) * 2018-11-28 2022-01-27 Shimadzu Corporation Analyzing method for azo compound

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB427857A (en) 1934-08-02 1935-05-01 Newsum Sons & Company Ltd H A new or improved system of construction for skeleton structures, particularly vehicle body frames and door frames
KR100321649B1 (ko) 1993-03-17 2002-07-22 미네소타 마이닝 앤드 매뉴팩춰링 캄파니 에스테르,아미드또는머캅토에스테르로부터유도된분산보조제를함유하는에어로졸제제
US6126919A (en) 1997-02-07 2000-10-03 3M Innovative Properties Company Biocompatible compounds for pharmaceutical drug delivery systems
EP1065213A3 (en) 1999-07-02 2003-11-05 Japan Tobacco Inc. HCV polymerase suitable for crystal structure analysis and method for using the enzyme
AU763356C (en) 1999-12-27 2004-08-26 Japan Tobacco Inc. Fused-ring compounds and use thereof as drugs
US6448281B1 (en) 2000-07-06 2002-09-10 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
US6310224B1 (en) 2001-01-19 2001-10-30 Arco Chemical Technology, L.P. Epoxidation catalyst and process
RS50236B (sr) 2001-01-22 2009-07-15 Merck & Co.Inc., Nukleozidni derivati kao inhibitori rnk-zavisne rnk virusne polimeraze
MXPA03008528A (es) 2001-03-19 2004-06-30 Ono Pharmaceutical Co Medicamentos que contienen derivados de triazaspiro [5.5] undecano como el ingrediente activo.
AR035543A1 (es) 2001-06-26 2004-06-16 Japan Tobacco Inc Agente terapeutico para la hepatitis c que comprende un compuesto de anillo condensado, compuesto de anillo condensado, composicion farmaceutica que lo comprende, compuestos de benzimidazol, tiazol y bifenilo utiles como intermediarios para producir dichos compuestos, uso del compuesto de anillo con
JP4558314B2 (ja) 2001-07-20 2010-10-06 ベーリンガー インゲルハイム （カナダ） リミテッド ウイルスポリメラーゼインヒビター
US20030215917A1 (en) 2002-04-04 2003-11-20 Mingjun Huang Assay for evaluation of activity of compounds against HCV using a novel detection system in the HCV replicon
DOP2003000641A (es) 2002-05-10 2003-11-15 Pfizer Inhibidores de las arn polimerasa dependiente de arn del virus de las hepatitis c y composiciones y tratamiento que los usan
BR0315417A (pt) 2002-10-24 2005-08-16 Glaxo Group Ltd Derivados 1-acil-pirrolidina para o tratamento de infecções virais
AU2003300952A1 (en) 2002-12-13 2004-07-09 Smithkline Beecham Corporation Indane compounds as ccr5 antagonists
US7271172B2 (en) 2002-12-13 2007-09-18 Smithkline Beecham Corporation Pyrrolidine and azetidine compounds as CCR5 antagonists
JP2006514950A (ja) 2002-12-13 2006-05-18 スミスクライン ビーチャム コーポレーション Ｃｃｒ５拮抗薬としてのシクロプロピル化合物
ATE405269T1 (de) 2002-12-13 2008-09-15 Smithkline Beecham Corp Cyclohexylverbindungen als ccr5-antagonisten
EP1569931B1 (en) 2002-12-13 2008-10-08 Smithkline Beecham Corporation Heterocyclic compounds as ccr5 antagonists
EP1569646A2 (en) 2002-12-13 2005-09-07 Smithkline Beecham Corporation Piperidine derivatives as ccr5 antagonists
US7098231B2 (en) 2003-01-22 2006-08-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7223785B2 (en) 2003-01-22 2007-05-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7148226B2 (en) 2003-02-21 2006-12-12 Agouron Pharmaceuticals, Inc. Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same
WO2005014543A1 (ja) 2003-08-06 2005-02-17 Japan Tobacco Inc. 縮合環化合物及びそのｈｃｖポリメラーゼ阻害剤としての利用
JP4641526B2 (ja) 2003-11-03 2011-03-02 グラクソ グループ リミテッド 流体分配デバイス
NZ549079A (en) 2004-02-20 2010-08-27 Boehringer Ingelheim Int Viral polymerase inhibitors
CA2564175A1 (en) 2004-04-28 2005-11-10 Arrow Therapeutics Limited Chemical compounds
US7153848B2 (en) 2004-08-09 2006-12-26 Bristol-Myers Squibb Company Inhibitors of HCV replication
GEP20115305B (en) 2004-08-18 2011-10-10 Pfizer Inhibitors of hepatitis c virus rna-dependent rna polymerase, compositions containing them and using the same for treatment
US20060045885A1 (en) 2004-08-27 2006-03-02 Kedl Ross M Method of eliciting an immune response against HIV
GB0423673D0 (en) 2004-10-25 2004-11-24 Glaxo Group Ltd Compounds
SG159561A1 (en) 2005-05-09 2010-03-30 Achillion Pharmaceuticals Inc Thiazole compounds and methods of use
WO2007034881A1 (ja) * 2005-09-22 2007-03-29 Dainippon Sumitomo Pharma Co., Ltd. 新規アデニン化合物
GB0610666D0 (en) 2006-05-30 2006-07-05 Glaxo Group Ltd Fluid dispenser
AR065372A1 (es) 2007-02-19 2009-06-03 Smithkline Beecham Corp Derivados de purina
PT2132209E (pt) * 2007-03-19 2014-04-15 Astrazeneca Ab Compostos de 8-oxo-adenina substituídos na posição 9, como moduladores do recetor de tipo ¿toll¿ (tlr7)
PE20091156A1 (es) * 2007-12-17 2009-09-03 Astrazeneca Ab Sales de (3-{[[3-(6-amino-2-butoxi-8-oxo-7,8-dihidro-9h-purin-9-il)propil](3-morfolin-4-ilpropil)amino]metil}fenil)acetato de metilo
US8777708B2 (en) 2008-06-27 2014-07-15 Microsoft Corporation Targeting control in a simulated environment
UA103195C2 (uk) * 2008-08-11 2013-09-25 Глаксосмитклайн Ллк Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань

Also Published As

Publication number Publication date
WO2011098452A1 (en) 2011-08-18
CA2786973C (en) 2018-04-10
AU2011214468B2 (en) 2015-05-28
PT2534149E (pt) 2014-12-23
US8703754B2 (en) 2014-04-22
BR112012018904A2 (pt) 2020-09-01
EP2534149A1 (en) 2012-12-19
SI2534149T1 (sl) 2015-02-27
MX2012009316A (es) 2012-09-12
SG182471A1 (en) 2012-08-30
EP2534149B1 (en) 2014-10-15
CN102753553A (zh) 2012-10-24
CN102753553B (zh) 2016-03-30
IL220845A (en) 2016-08-31
RS53745B1 (en) 2015-06-30
KR101773541B1 (ko) 2017-08-31
JP5922587B2 (ja) 2016-05-24
EA021048B1 (ru) 2015-03-31
DK2534149T3 (da) 2015-01-05
ES2525826T3 (es) 2014-12-30
JP2013519645A (ja) 2013-05-30
ZA201205995B (en) 2014-01-29
ME01926B (me) 2015-05-20
EA201290631A1 (ru) 2013-03-29
HRP20141258T1 (hr) 2015-02-27
KR20120135408A (ko) 2012-12-13
US20120308609A1 (en) 2012-12-06
AU2011214468A1 (en) 2012-08-09
SMT201400196B (it) 2015-01-15
CA2786973A1 (en) 2011-08-18

Similar Documents

Publication Publication Date Title
IL220845A (en) 6-amino-2 - {[(1 s) –1– methylbutyl] oxy} –9– [5– (1-piperidinyl) pentyl] –9,7 – dihydro-8 h– purine-8 – and malt
IL225622A0 (en) Furo[3, 2-di]pyrimidine compounds
IL237471A (en) Annals of [[(s1) –2– isopropoxy – 1 – methyl – 2 – oxo-ethyl] amino] –phenoxy – phosphoryl
EP2491043A4 (en) 2,7-SUBSTITUTED THIEN [3,2-D] PYRIMIDINE COMPOUNDS AS PROTEIN KINASE INHIBITORS
EP2589897A4 (en) Touch-control multifunctional refrigerating cup holder
ZA201105352B (en) Novel benzodiazepine derivatives
EP2507763A4 (en) LOCATION BASED SEARCH
WO2011163332A9 (en) Methods for detecting cancer
HK1170377A1 (en) Substituted xanthine derivatives
EP2524552A4 (en) Wireless sensor synchronization methods
ZA201209029B (en) Novel pyrimidine derivatives
EP2633062A4 (en) BIOTIN DERIVATIVES
HK1173149A1 (en) Camptothecin derivatives
EP2408303A4 (en) MORPHINANE DERIVATIVES HAVING HIGH ORAL BIOLOGICAL AVAILABILITY
EP2473052A4 (en) SUBSTITUTED XANTHINE DERIVATIVES
HK1171225A1 (en) Ethynyl derivatives
HK1163663A1 (en) Rifamycin derivatives
EP2616477A4 (en) 6-SUBSTITUTED DEMETHYL-ESTRADIOL DERIVATIVES AS ER-BETA AGONISTS
IL220307A0 (en) New secondary 8-hydroxyquinoline-7-carboxamide derivatives
AU2009904914A0 (en) Clothing for infants
AU2010101360A4 (en) Kiteboarding Dual Board Bag
AU2010901004A0 (en) Garment for ostymates
GB0902733D0 (en) Complex pants
AU2008905196A0 (en) Clothing for infants
AU2009905082A0 (en) Multi-Purpose Garment