PL2520645T3 - Kompozycje i sposoby wytwarzania metioniny - Google Patents
Kompozycje i sposoby wytwarzania metioninyInfo
- Publication number
- PL2520645T3 PL2520645T3 PL12165779T PL12165779T PL2520645T3 PL 2520645 T3 PL2520645 T3 PL 2520645T3 PL 12165779 T PL12165779 T PL 12165779T PL 12165779 T PL12165779 T PL 12165779T PL 2520645 T3 PL2520645 T3 PL 2520645T3
- Authority
- PL
- Poland
- Prior art keywords
- compositions
- methods
- producing methionine
- methionine
- producing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/12—Methionine; Cysteine; Cystine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y203/00—Acyltransferases (2.3)
- C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
- C12Y203/01046—Homoserine O-succinyltransferase (2.3.1.46)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2007/009146 WO2008127240A1 (en) | 2007-04-11 | 2007-04-11 | Compositions and methods of producing methionine |
| EP20120165779 EP2520645B1 (en) | 2007-04-11 | 2007-04-11 | Compositions and methods of producing methionine |
| EP07775377A EP2132306B1 (en) | 2007-04-11 | 2007-04-11 | Compositions and methods of producing methionine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2520645T3 true PL2520645T3 (pl) | 2015-05-29 |
Family
ID=38800923
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL14173993.8T PL2808381T3 (pl) | 2007-04-11 | 2007-04-11 | Kompozycje i sposoby wytwarzania metioniny |
| PL14173994.6T PL2808382T3 (pl) | 2007-04-11 | 2007-04-11 | Kompozycje i sposoby wytwarzania metioniny |
| PL07775377T PL2132306T3 (pl) | 2007-04-11 | 2007-04-11 | Kompozycje i sposoby wytwarzania metioniny |
| PL12165779T PL2520645T3 (pl) | 2007-04-11 | 2007-04-11 | Kompozycje i sposoby wytwarzania metioniny |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL14173993.8T PL2808381T3 (pl) | 2007-04-11 | 2007-04-11 | Kompozycje i sposoby wytwarzania metioniny |
| PL14173994.6T PL2808382T3 (pl) | 2007-04-11 | 2007-04-11 | Kompozycje i sposoby wytwarzania metioniny |
| PL07775377T PL2132306T3 (pl) | 2007-04-11 | 2007-04-11 | Kompozycje i sposoby wytwarzania metioniny |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US8551742B2 (pl) |
| EP (4) | EP2520645B1 (pl) |
| JP (1) | JP5497628B2 (pl) |
| KR (1) | KR101140906B1 (pl) |
| CN (1) | CN101688190B (pl) |
| ES (4) | ES2575082T3 (pl) |
| PL (4) | PL2808381T3 (pl) |
| WO (1) | WO2008127240A1 (pl) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100905381B1 (ko) | 2006-07-28 | 2009-06-30 | 씨제이제일제당 (주) | Ｌ-메치오닌 전구체 생산 균주 및 상기 ｌ-메치오닌전구체로부터의 ｌ-메치오닌 및 유기산의 생산방법 |
| PL2808381T3 (pl) | 2007-04-11 | 2016-09-30 | Kompozycje i sposoby wytwarzania metioniny | |
| KR100966324B1 (ko) * | 2008-01-08 | 2010-06-28 | 씨제이제일제당 (주) | 향상된 ｌ－쓰레오닌 생산능을 갖는 대장균 및 이를 이용한ｌ－쓰레오닌의 생산 방법 |
| US9005952B2 (en) * | 2008-04-04 | 2015-04-14 | Cj Cheiljedang Corporation | Microorganism producing L-methionine precursor and the method of producing L-methionine precursor using the microorganism |
| US7851180B2 (en) * | 2008-04-04 | 2010-12-14 | Cj Cheiljedang Corporation | Microorganism producing L-methionine precursor and the method of producing L-methionine precursor using the microorganism |
| US8283152B2 (en) * | 2009-08-28 | 2012-10-09 | Cj Cheiljedang Corporation | Microorganism producing O-acetyl-homoserine and the method of producing O-acetyl-homoserine using the microorganism |
| US8609396B2 (en) * | 2009-08-28 | 2013-12-17 | Cj Cheiljedang Corporation | Microorganism producing O-acetyl-homoserine and the method of producing O-acetyl-homoserine using the microorganism |
| RU2009136544A (ru) * | 2009-10-05 | 2011-04-10 | Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) (RU) | Способ получения l-цистеина с использованием бактерии семейства enterobacteriaceae |
| JP2013522213A (ja) | 2010-03-09 | 2013-06-13 | ノーバス・インターナショナル・インコーポレイテッド | ラクトン中間体を経由するホモセリンからのメチオニンまたはセレノメチオニンの製造 |
| WO2012087039A2 (ko) | 2010-12-21 | 2012-06-28 | 씨제이제일제당 (주) | 호모세린 아세틸 트랜스퍼라제 활성을 가지는 변이형 폴리펩티드 및 이를 발현하는 미생물 |
| WO2012091479A2 (en) * | 2010-12-29 | 2012-07-05 | Cj Cheiljedang Corporation | Methods for production of l-methionine and related products |
| WO2012090021A1 (en) * | 2010-12-30 | 2012-07-05 | Metabolic Explorer | Recombinant microorganism for the fermentative production of methionine |
| EP2479279A1 (de) | 2011-01-20 | 2012-07-25 | Evonik Degussa GmbH | Verfahren zur fermentativen Herstellung schwefelhaltiger Aminosäuren |
| WO2012137689A1 (ja) | 2011-04-01 | 2012-10-11 | 味の素株式会社 | Ｌ－システインの製造法 |
| US9234223B2 (en) | 2011-04-01 | 2016-01-12 | Ajinomoto Co., Inc. | Method for producing L-cysteine |
| EP2628792A1 (de) | 2012-02-17 | 2013-08-21 | Evonik Industries AG | Zelle mit verringerter ppGppase-Aktivität |
| PL2700715T3 (pl) | 2012-08-20 | 2019-03-29 | Evonik Degussa Gmbh | Sposób fermentacyjnego wytwarzania L-aminokwasów z zastosowaniem ulepszonych szczepów z rodziny Enterobacteriaceae |
| RU2013118637A (ru) * | 2013-04-23 | 2014-10-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") | СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ СЕМЕЙСТВА ENTEROBACTERIACEAE, В КОТОРОЙ РАЗРЕГУЛИРОВАН ГЕН yjjK |
| CA2922597A1 (en) * | 2013-08-30 | 2015-03-05 | Metabolic Explorer | Microorganism for methionine production with improved methionine synthase activity and methionine efflux |
| RU2678757C2 (ru) * | 2013-08-30 | 2019-01-31 | Эвоник Дегусса Гмбх | Микроорганизмы для производства метионина с улучшенным выходом метионина |
| KR101555749B1 (ko) * | 2013-10-23 | 2015-09-25 | 씨제이제일제당 (주) | O-숙시닐호모세린 생산 미생물 및 이를 이용한 o-숙시닐호모세린의 생산방법 |
| KR101555750B1 (ko) * | 2013-10-23 | 2015-09-25 | 씨제이제일제당 (주) | O-숙시닐호모세린 생산 미생물 및 이를 이용한 o-숙시닐호모세린의 생산방법 |
| KR101565213B1 (ko) | 2013-10-23 | 2015-11-03 | 씨제이제일제당 (주) | Ｏ-숙시닐호모세린 생산 미생물 및 이를 이용한 ｏ-숙시닐호모세린의 생산방법 |
| KR101580785B1 (ko) * | 2014-04-10 | 2015-12-29 | 씨제이제일제당 주식회사 | O-숙시닐호모세린 생산 미생물 및 이를 이용한 o-숙시닐호모세린의 생산방법 |
| KR20160111285A (ko) * | 2015-03-16 | 2016-09-26 | 씨제이제일제당 (주) | 사료 첨가제용 조성물 및 이를 포함하는 동물 사료 조성물 |
| EP3292208B1 (en) * | 2015-05-06 | 2020-08-19 | Trelys, Inc. | Compositions and methods for biological production of methionine |
| EP3331998B1 (en) | 2015-08-07 | 2020-06-24 | Evonik Operations GmbH | Protein thiocarboxylate-dependent l-methionine production by fermentation |
| WO2017089077A1 (en) | 2015-11-27 | 2017-06-01 | Evonik Degussa Gmbh | Method for producing l-methionine |
| CN106083992B (zh) * | 2016-06-17 | 2019-08-20 | 四川松麒医药科技有限公司 | 一种肌肽衍生物的制备方法、产品及应用 |
| US20190276859A1 (en) | 2016-07-08 | 2019-09-12 | Evonik Degussa Gmbh | Method for the fermentative production of methionine or its hydroxy analog form by microorganisms comprising genes coding sugar phosphotransferase system (pts) |
| WO2018136425A1 (en) * | 2017-01-17 | 2018-07-26 | White Dog Labs, Inc. | Proteinic biomass preparation comprising a non-native organism of the clostridia class |
| WO2020198258A1 (en) * | 2019-03-26 | 2020-10-01 | Zymergen Inc. | Engineered biosynthetic pathways for production of l-homocysteine by fermentation |
| US20220315965A1 (en) * | 2019-06-25 | 2022-10-06 | Zymergen Inc. | Engineered biosynthetic pathways for production of cystathionine by fermentation |
| KR102377500B1 (ko) * | 2019-10-28 | 2022-03-23 | 씨제이제일제당 주식회사 | 외래 metZ 유전자에 의해 코딩되는 단백질이 도입된 L-메티오닌 생산 미생물 및 이를 이용한 L-메티오닌 생산방법 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR920008365B1 (ko) | 1990-12-31 | 1992-09-26 | 제일제당 주식회사 | L-스레오닌 제조방법 |
| JP4110641B2 (ja) * | 1998-11-17 | 2008-07-02 | 味の素株式会社 | 発酵法によるｌ−メチオニンの製造法 |
| US20020049305A1 (en) | 2000-08-02 | 2002-04-25 | Degussa Ag | Nucleotide sequences which code for the metF gene |
| DE10109690A1 (de) | 2000-09-02 | 2002-03-14 | Degussa | Neue für das metY-Gen kodierende Nukleotidsequenzen |
| US7160711B2 (en) | 2001-08-06 | 2007-01-09 | Degussa Ag | Coryneform bacteria which produce chemical compounds I |
| CN1160467C (zh) * | 2001-11-30 | 2004-08-04 | 中国科学院上海生物化学研究所 | 一种生产腺苷甲硫氨酸的方法 |
| DE10247437A1 (de) | 2002-10-11 | 2004-04-29 | Consortium für elektrochemische Industrie GmbH | Feedback-resistente Homoserin-Transsuccinylasen |
| DE10249642A1 (de) * | 2002-10-24 | 2004-05-13 | Consortium für elektrochemische Industrie GmbH | Feedback-resistente Homoserin-Transsuccinylasen mit modifiziertem C-Terminus |
| MXPA05008857A (es) * | 2003-02-18 | 2006-03-09 | Metabolic Explorer Sa | Procedimiento de preparacion de microorganismos evolucionados que permite la creacion o la modificacion de vias metabolicas. |
| AU2004245988A1 (en) * | 2003-05-30 | 2004-12-16 | Microbia, Inc. | Methods and compositions for amino acid production |
| WO2005111202A1 (en) | 2004-05-12 | 2005-11-24 | Metabolic Explorer | Recombinant enzyme with altered feedback sensitivity |
| KR100620092B1 (ko) | 2004-12-16 | 2006-09-08 | 씨제이 주식회사 | 코리네박테리움 속 세포로부터 유래된 신규한 프로모터서열, 그를 포함하는 발현 카세트 및 벡터, 상기 벡터를포함하는 숙주 세포 및 그를 이용하여 유전자를 발현하는방법 |
| WO2006082254A2 (en) * | 2005-02-07 | 2006-08-10 | Metabolic Explorer | Microorganisms comprising enzymes expressed with low gamma-elimination activity |
| CN101223444B (zh) | 2005-04-20 | 2013-04-24 | 嘉吉有限公司 | 在体内分泌莫纳甜的方法 |
| WO2006138689A2 (en) | 2005-06-17 | 2006-12-28 | Microbia, Inc. | Improved amino acid and metabolite biosynthesis |
| CA2615315C (en) | 2005-07-18 | 2015-10-06 | Basf Aktiengesellschaft | Use of dimethyl disulfide for methionine production in microorganisms |
| US20090221027A1 (en) * | 2005-07-18 | 2009-09-03 | Basf Ag | Use of a bacillus meti gene to improve methionine production in microorganisms |
| PL2808381T3 (pl) * | 2007-04-11 | 2016-09-30 | Kompozycje i sposoby wytwarzania metioniny | |
| US7851180B2 (en) | 2008-04-04 | 2010-12-14 | Cj Cheiljedang Corporation | Microorganism producing L-methionine precursor and the method of producing L-methionine precursor using the microorganism |
-
2007
- 2007-04-11 PL PL14173993.8T patent/PL2808381T3/pl unknown
- 2007-04-11 EP EP20120165779 patent/EP2520645B1/en active Active
- 2007-04-11 ES ES14173993.8T patent/ES2575082T3/es active Active
- 2007-04-11 PL PL14173994.6T patent/PL2808382T3/pl unknown
- 2007-04-11 EP EP14173994.6A patent/EP2808382B1/en active Active
- 2007-04-11 ES ES14173994.6T patent/ES2575906T3/es active Active
- 2007-04-11 US US12/595,817 patent/US8551742B2/en active Active
- 2007-04-11 ES ES07775377T patent/ES2400261T3/es active Active
- 2007-04-11 EP EP07775377A patent/EP2132306B1/en active Active
- 2007-04-11 ES ES12165779.5T patent/ES2534375T3/es active Active
- 2007-04-11 JP JP2010502984A patent/JP5497628B2/ja active Active
- 2007-04-11 WO PCT/US2007/009146 patent/WO2008127240A1/en active Application Filing
- 2007-04-11 CN CN200780052545.5A patent/CN101688190B/zh active Active
- 2007-04-11 KR KR1020097021713A patent/KR101140906B1/ko active IP Right Grant
- 2007-04-11 PL PL07775377T patent/PL2132306T3/pl unknown
- 2007-04-11 PL PL12165779T patent/PL2520645T3/pl unknown
- 2007-04-11 EP EP14173993.8A patent/EP2808381B1/en active Active
-
2013
- 2013-03-15 US US13/832,462 patent/US9150893B2/en active Active
-
2015
- 2015-08-06 US US14/820,453 patent/US9493801B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ES2400261T3 (es) | 2013-04-08 |
| US9493801B2 (en) | 2016-11-15 |
| US20110183383A1 (en) | 2011-07-28 |
| JP5497628B2 (ja) | 2014-05-21 |
| WO2008127240A1 (en) | 2008-10-23 |
| KR20100019417A (ko) | 2010-02-18 |
| EP2808382B1 (en) | 2016-03-16 |
| EP2132306A1 (en) | 2009-12-16 |
| CN101688190B (zh) | 2014-06-04 |
| ES2575082T3 (es) | 2016-06-24 |
| US20160024541A1 (en) | 2016-01-28 |
| JP2010523145A (ja) | 2010-07-15 |
| US20130260424A1 (en) | 2013-10-03 |
| CN101688190A (zh) | 2010-03-31 |
| KR101140906B1 (ko) | 2012-07-13 |
| PL2808381T3 (pl) | 2016-09-30 |
| US8551742B2 (en) | 2013-10-08 |
| ES2534375T3 (es) | 2015-04-22 |
| PL2132306T3 (pl) | 2013-05-31 |
| EP2520645A2 (en) | 2012-11-07 |
| EP2808381A1 (en) | 2014-12-03 |
| ES2575906T3 (es) | 2016-07-04 |
| EP2808382A1 (en) | 2014-12-03 |
| EP2132306B1 (en) | 2012-12-19 |
| US9150893B2 (en) | 2015-10-06 |
| EP2808381B1 (en) | 2016-03-09 |
| PL2808382T3 (pl) | 2016-09-30 |
| EP2520645A3 (en) | 2013-02-20 |
| EP2520645B1 (en) | 2015-01-14 |
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