PL2132306T3 - Kompozycje i sposoby wytwarzania metioniny - Google Patents

Kompozycje i sposoby wytwarzania metioniny

Info

Publication number
PL2132306T3
PL2132306T3 PL07775377T PL07775377T PL2132306T3 PL 2132306 T3 PL2132306 T3 PL 2132306T3 PL 07775377 T PL07775377 T PL 07775377T PL 07775377 T PL07775377 T PL 07775377T PL 2132306 T3 PL2132306 T3 PL 2132306T3
Authority
PL
Poland
Prior art keywords
compositions
methods
producing methionine
methionine
producing
Prior art date
Application number
PL07775377T
Other languages
English (en)
Inventor
Brian Brazeau
Jin-Sook Chang
Young Wook Cho
Mervyn Desouza
Holly J Jessen
So-Young Kim
Wei Niu
Fernando A Sanchez-Riera
Yong-Uk Shin
Hyewon Um
Kwang Myung Cho
Original Assignee
Cj Cheiljedang Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cj Cheiljedang Corp filed Critical Cj Cheiljedang Corp
Publication of PL2132306T3 publication Critical patent/PL2132306T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01046—Homoserine O-succinyltransferase (2.3.1.46)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
PL07775377T 2007-04-11 2007-04-11 Kompozycje i sposoby wytwarzania metioniny PL2132306T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US2007/009146 WO2008127240A1 (en) 2007-04-11 2007-04-11 Compositions and methods of producing methionine
EP07775377A EP2132306B1 (en) 2007-04-11 2007-04-11 Compositions and methods of producing methionine

Publications (1)

Publication Number Publication Date
PL2132306T3 true PL2132306T3 (pl) 2013-05-31

Family

ID=38800923

Family Applications (4)

Application Number Title Priority Date Filing Date
PL12165779T PL2520645T3 (pl) 2007-04-11 2007-04-11 Kompozycje i sposoby wytwarzania metioniny
PL14173994.6T PL2808382T3 (pl) 2007-04-11 2007-04-11 Kompozycje i sposoby wytwarzania metioniny
PL07775377T PL2132306T3 (pl) 2007-04-11 2007-04-11 Kompozycje i sposoby wytwarzania metioniny
PL14173993.8T PL2808381T3 (pl) 2007-04-11 2007-04-11 Kompozycje i sposoby wytwarzania metioniny

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PL12165779T PL2520645T3 (pl) 2007-04-11 2007-04-11 Kompozycje i sposoby wytwarzania metioniny
PL14173994.6T PL2808382T3 (pl) 2007-04-11 2007-04-11 Kompozycje i sposoby wytwarzania metioniny

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL14173993.8T PL2808381T3 (pl) 2007-04-11 2007-04-11 Kompozycje i sposoby wytwarzania metioniny

Country Status (8)

Country Link
US (3) US8551742B2 (pl)
EP (4) EP2808381B1 (pl)
JP (1) JP5497628B2 (pl)
KR (1) KR101140906B1 (pl)
CN (1) CN101688190B (pl)
ES (4) ES2575082T3 (pl)
PL (4) PL2520645T3 (pl)
WO (1) WO2008127240A1 (pl)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100905381B1 (ko) 2006-07-28 2009-06-30 씨제이제일제당 (주) Ｌ-메치오닌 전구체 생산 균주 및 상기 ｌ-메치오닌전구체로부터의 ｌ-메치오닌 및 유기산의 생산방법
EP2808381B1 (en) * 2007-04-11 2016-03-09 CJ CheilJedang Corporation Compositions and methods of producing methionine
KR100966324B1 (ko) 2008-01-08 2010-06-28 씨제이제일제당 (주) 향상된 ｌ－쓰레오닌 생산능을 갖는 대장균 및 이를 이용한ｌ－쓰레오닌의 생산 방법
US9005952B2 (en) 2008-04-04 2015-04-14 Cj Cheiljedang Corporation Microorganism producing L-methionine precursor and the method of producing L-methionine precursor using the microorganism
US7851180B2 (en) * 2008-04-04 2010-12-14 Cj Cheiljedang Corporation Microorganism producing L-methionine precursor and the method of producing L-methionine precursor using the microorganism
US8283152B2 (en) * 2009-08-28 2012-10-09 Cj Cheiljedang Corporation Microorganism producing O-acetyl-homoserine and the method of producing O-acetyl-homoserine using the microorganism
US8609396B2 (en) * 2009-08-28 2013-12-17 Cj Cheiljedang Corporation Microorganism producing O-acetyl-homoserine and the method of producing O-acetyl-homoserine using the microorganism
RU2009136544A (ru) * 2009-10-05 2011-04-10 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) (RU) Способ получения l-цистеина с использованием бактерии семейства enterobacteriaceae
CN102869646A (zh) * 2010-03-09 2013-01-09 诺华丝国际股份有限公司 由高丝氨酸经由内酯中间体制备甲硫氨酸或硒代甲硫氨酸的方法
BR112013015991A2 (pt) * 2010-12-21 2018-07-10 Cj Cheiljedang Corp polipeptídeos variante tendo homosserina atividade acetiltransferase e microorganismos expressando o mesmo
CN106480120B (zh) 2010-12-29 2020-03-03 Cj 第一制糖株式会社 L-甲硫氨酸和相关产物的生产方法
WO2012090021A1 (en) * 2010-12-30 2012-07-05 Metabolic Explorer Recombinant microorganism for the fermentative production of methionine
EP2479279A1 (de) 2011-01-20 2012-07-25 Evonik Degussa GmbH Verfahren zur fermentativen Herstellung schwefelhaltiger Aminosäuren
US9234223B2 (en) 2011-04-01 2016-01-12 Ajinomoto Co., Inc. Method for producing L-cysteine
JP6020443B2 (ja) * 2011-04-01 2016-11-02 味の素株式会社 Ｌ−システインの製造法
EP2628792A1 (de) 2012-02-17 2013-08-21 Evonik Industries AG Zelle mit verringerter ppGppase-Aktivität
EP2700715B1 (de) 2012-08-20 2018-07-25 Evonik Degussa GmbH Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae
RU2013118637A (ru) * 2013-04-23 2014-10-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ СЕМЕЙСТВА ENTEROBACTERIACEAE, В КОТОРОЙ РАЗРЕГУЛИРОВАН ГЕН yjjK
KR20160044038A (ko) * 2013-08-30 2016-04-22 메타볼릭 익스플로러 메티오닌 유출이 증진된 메티오닌 생산용 미생물
WO2015028674A1 (en) * 2013-08-30 2015-03-05 Metabolic Explorer Microorganism for methionine production with improved methionine synthase activity and methionine efflux
KR101555749B1 (ko) * 2013-10-23 2015-09-25 씨제이제일제당 (주) O-숙시닐호모세린 생산 미생물 및 이를 이용한 o-숙시닐호모세린의 생산방법
KR101565213B1 (ko) 2013-10-23 2015-11-03 씨제이제일제당 (주) Ｏ-숙시닐호모세린 생산 미생물 및 이를 이용한 ｏ-숙시닐호모세린의 생산방법
KR101555750B1 (ko) * 2013-10-23 2015-09-25 씨제이제일제당 (주) O-숙시닐호모세린 생산 미생물 및 이를 이용한 o-숙시닐호모세린의 생산방법
KR101580785B1 (ko) * 2014-04-10 2015-12-29 씨제이제일제당 주식회사 O-숙시닐호모세린 생산 미생물 및 이를 이용한 o-숙시닐호모세린의 생산방법
KR20160111285A (ko) * 2015-03-16 2016-09-26 씨제이제일제당 (주) 사료 첨가제용 조성물 및 이를 포함하는 동물 사료 조성물
EP3292208B1 (en) * 2015-05-06 2020-08-19 Trelys, Inc. Compositions and methods for biological production of methionine
PL3331998T3 (pl) * 2015-08-07 2020-12-28 Evonik Operations Gmbh Wytwarzanie przez fermentację l-metioniny zależne od tiokarboksylanu białka
PL3380627T3 (pl) 2015-11-27 2020-01-31 Evonik Degussa Gmbh Sposób wytwarzania L-metioniny
CN106083992B (zh) * 2016-06-17 2019-08-20 四川松麒医药科技有限公司 一种肌肽衍生物的制备方法、产品及应用
US20190276859A1 (en) 2016-07-08 2019-09-12 Evonik Degussa Gmbh Method for the fermentative production of methionine or its hydroxy analog form by microorganisms comprising genes coding sugar phosphotransferase system (pts)
WO2018136425A1 (en) * 2017-01-17 2018-07-26 White Dog Labs, Inc. Proteinic biomass preparation comprising a non-native organism of the clostridia class
WO2020198258A1 (en) * 2019-03-26 2020-10-01 Zymergen Inc. Engineered biosynthetic pathways for production of l-homocysteine by fermentation
US20220315965A1 (en) * 2019-06-25 2022-10-06 Zymergen Inc. Engineered biosynthetic pathways for production of cystathionine by fermentation
KR102377500B1 (ko) * 2019-10-28 2022-03-23 씨제이제일제당 주식회사 외래 metZ 유전자에 의해 코딩되는 단백질이 도입된 L-메티오닌 생산 미생물 및 이를 이용한 L-메티오닌 생산방법

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR920008365B1 (ko) 1990-12-31 1992-09-26 제일제당 주식회사 L-스레오닌 제조방법
JP4110641B2 (ja) * 1998-11-17 2008-07-02 味の素株式会社 発酵法によるｌ−メチオニンの製造法
US20020049305A1 (en) 2000-08-02 2002-04-25 Degussa Ag Nucleotide sequences which code for the metF gene
DE10109690A1 (de) * 2000-09-02 2002-03-14 Degussa Neue für das metY-Gen kodierende Nukleotidsequenzen
US7160711B2 (en) 2001-08-06 2007-01-09 Degussa Ag Coryneform bacteria which produce chemical compounds I
CN1160467C (zh) * 2001-11-30 2004-08-04 中国科学院上海生物化学研究所 一种生产腺苷甲硫氨酸的方法
DE10247437A1 (de) 2002-10-11 2004-04-29 Consortium für elektrochemische Industrie GmbH Feedback-resistente Homoserin-Transsuccinylasen
DE10249642A1 (de) * 2002-10-24 2004-05-13 Consortium für elektrochemische Industrie GmbH Feedback-resistente Homoserin-Transsuccinylasen mit modifiziertem C-Terminus
MXPA05008857A (es) 2003-02-18 2006-03-09 Metabolic Explorer Sa Procedimiento de preparacion de microorganismos evolucionados que permite la creacion o la modificacion de vias metabolicas.
KR20060018868A (ko) 2003-05-30 2006-03-02 마이크로비아 인코포레이티드 아미노산 생산 방법 및 아미노산 생산용 조성물
WO2005111202A1 (en) * 2004-05-12 2005-11-24 Metabolic Explorer Recombinant enzyme with altered feedback sensitivity
KR100620092B1 (ko) 2004-12-16 2006-09-08 씨제이 주식회사 코리네박테리움 속 세포로부터 유래된 신규한 프로모터서열, 그를 포함하는 발현 카세트 및 벡터, 상기 벡터를포함하는 숙주 세포 및 그를 이용하여 유전자를 발현하는방법
MX2007009489A (es) * 2005-02-07 2007-09-19 Metabolic Explorer Sa Microorganismos que comprenden enzimas expresadas con baja actividad de eliminacion gamma.
RU2007142666A (ru) 2005-04-20 2009-05-27 Карджилл, Инкорпорейтед (Us) Продукты и способы для секреции монатина in vivo
WO2006138689A2 (en) 2005-06-17 2006-12-28 Microbia, Inc. Improved amino acid and metabolite biosynthesis
RU2413001C2 (ru) 2005-07-18 2011-02-27 Эвоник Дегусса Гмбх Применение диметилдисульфида для продукции метионина микроорганизмами
CA2615419A1 (en) 2005-07-18 2007-01-25 Basf Aktiengesellschaft Use of a bacillus meti gene to improve methionine production in microorganisms
EP2808381B1 (en) * 2007-04-11 2016-03-09 CJ CheilJedang Corporation Compositions and methods of producing methionine
US7851180B2 (en) 2008-04-04 2010-12-14 Cj Cheiljedang Corporation Microorganism producing L-methionine precursor and the method of producing L-methionine precursor using the microorganism

Also Published As

Publication number Publication date
PL2808382T3 (pl) 2016-09-30
EP2808381B1 (en) 2016-03-09
EP2520645A3 (en) 2013-02-20
US9150893B2 (en) 2015-10-06
ES2400261T3 (es) 2013-04-08
PL2808381T3 (pl) 2016-09-30
EP2808382B1 (en) 2016-03-16
KR101140906B1 (ko) 2012-07-13
PL2520645T3 (pl) 2015-05-29
ES2575906T3 (es) 2016-07-04
CN101688190B (zh) 2014-06-04
US8551742B2 (en) 2013-10-08
EP2808382A1 (en) 2014-12-03
US20130260424A1 (en) 2013-10-03
ES2534375T3 (es) 2015-04-22
US20160024541A1 (en) 2016-01-28
EP2132306A1 (en) 2009-12-16
KR20100019417A (ko) 2010-02-18
EP2520645B1 (en) 2015-01-14
JP2010523145A (ja) 2010-07-15
EP2520645A2 (en) 2012-11-07
EP2808381A1 (en) 2014-12-03
EP2132306B1 (en) 2012-12-19
CN101688190A (zh) 2010-03-31
ES2575082T3 (es) 2016-06-24
US9493801B2 (en) 2016-11-15
US20110183383A1 (en) 2011-07-28
WO2008127240A1 (en) 2008-10-23
JP5497628B2 (ja) 2014-05-21

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