PL2513147T3 - Nowe antagonistyczne przeciwciała i ich fragmenty Fab przeciwko GPVI i ich zastosowanie - Google Patents

Nowe antagonistyczne przeciwciała i ich fragmenty Fab przeciwko GPVI i ich zastosowanie

Info

Publication number
PL2513147T3
PL2513147T3 PL10813028T PL10813028T PL2513147T3 PL 2513147 T3 PL2513147 T3 PL 2513147T3 PL 10813028 T PL10813028 T PL 10813028T PL 10813028 T PL10813028 T PL 10813028T PL 2513147 T3 PL2513147 T3 PL 2513147T3
Authority
PL
Poland
Prior art keywords
fab fragments
antagonist antibodies
fragments against
novel antagonist
against gpvi
Prior art date
Application number
PL10813028T
Other languages
English (en)
Inventor
Nicolas Baurin
Francis Blanche
Béatrice Cameron
Carsten Corvey
Tarik Dabdoubi
Christian Engel
Peter Florian
Ingo Focken
Katja Kroll
Jochen Kruip
Christian Lange
Thomas Langer
Martin Lorenz
Vincent Mikol
Ercole Rao
Peter Wonerow
Original Assignee
Sanofi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP09306283A external-priority patent/EP2336188A1/en
Priority claimed from EP10305660A external-priority patent/EP2397495A1/en
Priority claimed from EP10305721A external-priority patent/EP2402371A1/en
Application filed by Sanofi filed Critical Sanofi
Publication of PL2513147T3 publication Critical patent/PL2513147T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Biotechnology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
PL10813028T 2009-12-18 2010-12-17 Nowe antagonistyczne przeciwciała i ich fragmenty Fab przeciwko GPVI i ich zastosowanie PL2513147T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP09306283A EP2336188A1 (en) 2009-12-18 2009-12-18 Novel antagonist antibodies and their Fab fragments against GPVI and uses thereof
EP10305660A EP2397495A1 (en) 2010-06-21 2010-06-21 Novel antagonist antibodies and their Fab fragments against GPVI and uses thereof
EP10305721A EP2402371A1 (en) 2010-07-01 2010-07-01 Novel antagonist antibodies and their Fab fragments against GPVI and uses thereof
EP10813028.7A EP2513147B1 (en) 2009-12-18 2010-12-17 Novel antagonist antibodies and their fab fragments against gpvi and uses thereof

Publications (1)

Publication Number Publication Date
PL2513147T3 true PL2513147T3 (pl) 2017-08-31

Family

ID=44060924

Family Applications (1)

Application Number Title Priority Date Filing Date
PL10813028T PL2513147T3 (pl) 2009-12-18 2010-12-17 Nowe antagonistyczne przeciwciała i ich fragmenty Fab przeciwko GPVI i ich zastosowanie

Country Status (30)

Country Link
US (2) US8852593B2 (pl)
EP (2) EP2513147B1 (pl)
JP (1) JP5843783B2 (pl)
KR (1) KR20120102125A (pl)
CN (1) CN102725309B (pl)
AR (1) AR079645A1 (pl)
AU (1) AU2010331807B2 (pl)
BR (1) BR112012014975A2 (pl)
CA (1) CA2784498A1 (pl)
CL (1) CL2012001650A1 (pl)
CY (1) CY1118389T1 (pl)
DK (1) DK2513147T3 (pl)
EA (1) EA201290525A1 (pl)
ES (1) ES2596254T3 (pl)
HK (1) HK1216537A1 (pl)
HR (1) HRP20161298T1 (pl)
HU (1) HUE029824T2 (pl)
IL (1) IL220447A0 (pl)
LT (1) LT2513147T (pl)
MA (1) MA33930B1 (pl)
MX (2) MX347613B (pl)
PH (1) PH12012501219A1 (pl)
PL (1) PL2513147T3 (pl)
PT (1) PT2513147T (pl)
SG (2) SG181707A1 (pl)
SI (1) SI2513147T1 (pl)
TW (1) TW201132759A (pl)
UY (1) UY33115A (pl)
WO (1) WO2011073954A2 (pl)
ZA (1) ZA201204421B (pl)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011051333A1 (en) 2009-10-30 2011-05-05 Novartis Ag Universal fibronectin type iii bottom-side binding domain libraries
MX347613B (es) * 2009-12-18 2017-05-04 Sanofi Sa Nuevos anticuerpos antagonistas y sus fragmentos fab contra gpvi y sus usos.
US11644471B2 (en) 2010-09-30 2023-05-09 Ablynx N.V. Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
EP2621953B1 (en) 2010-09-30 2017-04-05 Ablynx N.V. Biological materials related to c-met
DK2663579T3 (en) 2011-01-14 2017-07-31 Univ California THERAPEUTIC ANTIBODIES AGAINST ROR-1 PROTEIN AND PROCEDURES FOR USE THEREOF
EP3363812A1 (en) * 2011-06-23 2018-08-22 Ablynx NV Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobin single variable domains
EP4350345A3 (en) * 2011-06-23 2024-07-24 Ablynx N.V. Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobin single variable domains
EP4218933A1 (en) 2011-06-23 2023-08-02 Ablynx NV Serum albumin binding proteins
PL2723769T5 (pl) * 2011-06-23 2022-10-17 Ablynx Nv Techniki przewidywania, wykrywania i redukcji niespecyficznej interferencji białka w testach z udziałem pojedynczych domen zmiennych immunoglobuliny
MY167125A (en) * 2011-08-17 2018-08-13 Glaxo Group Ltd Modified proteins and peptides
US9346884B2 (en) 2011-09-30 2016-05-24 Ablynx N.V. Biological materials related to c-Met
US9328174B2 (en) 2012-05-09 2016-05-03 Novartis Ag Chemokine receptor binding polypeptides
JP2015531350A (ja) * 2012-09-13 2015-11-02 ノバルティス アーゲー 末端修飾を有する抗原結合分子
CN103396492A (zh) * 2013-08-06 2013-11-20 安徽新标志科技有限公司 抗人血小板胶原蛋白受体的人源性单克隆抗体片段及其应用
HRP20220910T1 (hr) * 2015-08-05 2022-10-28 Acticor Biotech Nova anti-humana gpvi antitijela i njihove uporabe
EP3538552B1 (en) 2016-11-14 2023-09-13 MorphoSys AG Fab molecules with a rodent hinge region and a non-rodent ch1 region
EP3577136A1 (en) * 2017-02-03 2019-12-11 Acticor Biotech Inhibition of platelet aggregation using anti-human gpvi antibodies
JP7080352B2 (ja) * 2018-05-16 2022-06-03 モルフォシス・アーゲー 糖タンパク質ｖｉを標的とする抗体
GB202020602D0 (en) * 2020-12-24 2021-02-10 Univ Birmingham Nanobody
WO2022257106A1 (zh) * 2021-06-11 2022-12-15 江苏丰华生物制药有限公司 一种人源化抗人GPVI单克隆抗体Fab片段及其应用
WO2023133470A2 (en) * 2022-01-07 2023-07-13 BioLegend, Inc. Tmprss2 binding antibodies and antigen binding fragments thereof
CN115991780B (zh) * 2022-12-29 2025-06-10 盖普思药业(重庆)有限公司 一种抗人血小板胶原蛋白受体gp-vi抗体或其抗原结合片段及其应用
EP4431526A1 (en) 2023-03-16 2024-09-18 Emfret Analytics GmbH & Co. KG Anti-gpvi antibodies and functional fragments thereof

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6451983B2 (en) 1989-08-07 2002-09-17 Peptech Limited Tumor necrosis factor antibodies
US5919452A (en) * 1991-03-18 1999-07-06 New York University Methods of treating TNFα-mediated disease using chimeric anti-TNF antibodies
GB9109478D0 (en) * 1991-05-02 1991-06-26 Therapeutic Antibodies Inc Antivenoms
US7062219B2 (en) * 1997-01-31 2006-06-13 Odyssey Thera Inc. Protein fragment complementation assays for high-throughput and high-content screening
US20040001826A1 (en) * 1999-06-30 2004-01-01 Millennium Pharmaceuticals, Inc. Glycoprotein VI and uses thereof
US7291714B1 (en) 1999-06-30 2007-11-06 Millennium Pharmaceuticals, Inc. Glycoprotein VI and uses thereof
WO2001016321A1 (en) * 1999-09-01 2001-03-08 Otsuka Pharmaceutical Co., Ltd. Platelet membrane glycoprotein vi (gpvi) dna and protein sequences, and uses thereof
WO2001032688A1 (en) * 1999-10-29 2001-05-10 Rutgers, The State University Of New Jersey Renilla reniformis green fluorescent protein
WO2002026195A2 (en) * 2000-09-29 2002-04-04 Clinomics Biosciences, Inc. Oncology tissue microarrays
EP1224942A1 (en) * 2001-01-23 2002-07-24 Bernhard Dr. Nieswandt Use of JAQ1 (monoclonal antibody anti GPVI) as a medicament for the protection against thrombotic diseases
GB0130543D0 (en) * 2001-12-20 2002-02-06 Univ Cambridge Tech Human antibodies and their use
EP1538165A1 (en) * 2003-12-03 2005-06-08 Procorde GmbH Inhibitors of glycoprotein VI based on monoclonal antibody hgp 5c4
GB0511590D0 (en) * 2005-06-07 2005-07-13 Procorde Gmbh Anti-thrombotic agents
EP1369128A1 (en) 2002-06-07 2003-12-10 Procorde GmbH Inhibitors of glycoprotein VI and their therapeutic use
WO2006061650A2 (en) * 2004-12-10 2006-06-15 Trigen Gmbh Methods, products and uses involving platelets and/or the vasculature
CA2532781A1 (en) * 2003-07-18 2005-01-27 Mochida Pharmaceutical Co., Ltd The anti-platelet membrane glycoprotein vi monoclonal antibody
RU2402569C2 (ru) * 2004-03-19 2010-10-27 Имклоун Элэлси Человеческие антитела к рецептору эпидермального фактора роста
CA2565063A1 (en) * 2004-04-29 2005-11-24 Otsuka Pharmaceutical Co., Ltd. Glycoprotein vi antibodies and method thereof
GB0502358D0 (en) * 2005-02-04 2005-03-16 Novartis Ag Organic compounds
WO2006117910A1 (ja) * 2005-04-28 2006-11-09 Mochida Pharmaceutical Co., Ltd. 抗血小板膜糖蛋白質ⅵモノクローナル抗体
EP1876240B1 (en) 2005-04-28 2012-08-22 Mochida Pharmaceutical Co., Ltd. Anti-human platelet membrane glycoprotein vi monoclonal antibody
JP5224707B2 (ja) * 2005-04-28 2013-07-03 持田製薬株式会社 抗血小板膜糖蛋白質ｖｉモノクローナル抗体
JPWO2007091719A1 (ja) * 2006-02-07 2009-07-02 持田製薬株式会社 抗ｇｐｖｉ抗体の併用療法及び新規医薬用途
JPWO2007116779A1 (ja) * 2006-03-31 2009-08-20 持田製薬株式会社 新規血小板活性化マーカー及びその測定方法
EP1916259A1 (en) * 2006-10-26 2008-04-30 Institut National De La Sante Et De La Recherche Medicale (Inserm) Anti-glycoprotein VI SCFV fragment for treatment of thrombosis
MY159201A (en) 2007-08-29 2016-12-30 Sanofi Aventis Humanized anti-cxcr5 antibodies, derivatives thereof and their uses
KR20100075585A (ko) * 2007-10-31 2010-07-02 오쓰까 세이야꾸 가부시키가이샤 당단백질 ｖｉ (ｇｐｖｉ) 억제제의 용도
CN102753193A (zh) * 2008-10-31 2012-10-24 比奥根艾迪克Ma公司 Light靶向分子及其用途
MX347613B (es) * 2009-12-18 2017-05-04 Sanofi Sa Nuevos anticuerpos antagonistas y sus fragmentos fab contra gpvi y sus usos.

Also Published As

Publication number Publication date
SG181707A1 (en) 2012-07-30
JP2013514077A (ja) 2013-04-25
HUE029824T2 (en) 2017-04-28
US20120244152A1 (en) 2012-09-27
HK1216537A1 (en) 2016-11-18
WO2011073954A3 (en) 2012-03-08
CN102725309B (zh) 2016-01-06
AU2010331807B2 (en) 2016-08-04
EP2513147A2 (en) 2012-10-24
SG10201405259PA (en) 2014-10-30
MA33930B1 (fr) 2013-01-02
CL2012001650A1 (es) 2012-12-14
ES2596254T3 (es) 2017-01-05
CY1118389T1 (el) 2017-06-28
IL220447A0 (en) 2012-08-30
JP5843783B2 (ja) 2016-01-13
AR079645A1 (es) 2012-02-08
MX347613B (es) 2017-05-04
WO2011073954A2 (en) 2011-06-23
EA201290525A1 (ru) 2013-01-30
PT2513147T (pt) 2016-10-11
PH12012501219A1 (en) 2017-08-23
HRP20161298T1 (hr) 2016-11-18
BR112012014975A2 (pt) 2019-09-24
TW201132759A (en) 2011-10-01
DK2513147T3 (en) 2016-10-24
US8852593B2 (en) 2014-10-07
CN102725309A (zh) 2012-10-10
AU2010331807A1 (en) 2012-07-12
US20150098939A1 (en) 2015-04-09
UY33115A (es) 2011-07-29
MX2012007153A (es) 2012-07-03
EP2933269A1 (en) 2015-10-21
US9441040B2 (en) 2016-09-13
CA2784498A1 (en) 2011-06-23
EP2513147B1 (en) 2016-07-20
LT2513147T (lt) 2016-10-25
KR20120102125A (ko) 2012-09-17
SI2513147T1 (sl) 2016-11-30
ZA201204421B (en) 2013-09-25

Similar Documents

Publication Publication Date Title
IL220447A0 (en) Novel antagonist antibodies and their fab fragments against gpvi and uses thereof
GB0922434D0 (en) antibodies and fragments thereof
EP2501724A4 (en) MONOCLONAL ANTIBODIES AND DIAGNOSTIC USES THEREOF
EP2494062A4 (en) ANTI-GLP-1R ANTIBODIES AND THEIR USES
ZA201107486B (en) Anti-tnf-x antibodies and their uses
SI2510011T1 (sl) Monoklonska protitelesa, ki veĹľejo B7H6 in njihova uporaba
ZA201109098B (en) Anti-vegf antibodies and their uses
EP2533810A4 (en) CD20 ANTIBODIES AND ITS USE
IL216304A0 (en) Blocking anti- dkk-1 antibodies and their uses
ZA201106666B (en) Multispecific antibodies comprising full length antibodies and single chain fab fragments
ZA201105573B (en) Novel anti-alpha5beta1 antibodies and uses thereof
ZA201207484B (en) Humanized anti-egfl7 antibodies and methods using same
IL218621A0 (en) Monoclonal antibodies
IL236237A (en) Tmem154 antibodies and their segments and uses
IL220536A0 (en) Anti - bv8 antibodies and uses thereof
IL214527A0 (en) Anti-mst1r antibodies and uses thereof
GB0903151D0 (en) Antibody uses and methods
IL208188A0 (en) Compositions comprising antibodies or antibody fragments
HK1170251A (en) Novel antagonist antibodies and their fab fragments against gpvi and uses thereof
GB0906115D0 (en) Antibody and uses thereof