BR112012014975A2 - novos anticorpos antagonistas e seus fragmentos fab contra gpvi e seus usos - Google Patents

novos anticorpos antagonistas e seus fragmentos fab contra gpvi e seus usos

Info

Publication number
BR112012014975A2
BR112012014975A2 BR112012014975A BR112012014975A BR112012014975A2 BR 112012014975 A2 BR112012014975 A2 BR 112012014975A2 BR 112012014975 A BR112012014975 A BR 112012014975A BR 112012014975 A BR112012014975 A BR 112012014975A BR 112012014975 A2 BR112012014975 A2 BR 112012014975A2
Authority
BR
Brazil
Prior art keywords
fab
antibodies
relates
fragments
gpvi
Prior art date
Application number
BR112012014975A
Other languages
English (en)
Inventor
Cameron Béatrice
Corvey Carsten
Engel Christian
Lange Christian
Rao Ercole
Blanche Francis
Focken Ingo
Kruip Jochen
Kroll Katja
Lorenz Martin
Baurin Nicolas
Florian Peter
Wonerow Peter
Dabdoubi Tarik
Langer Thomas
Mikol Vincent
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP09306283A external-priority patent/EP2336188A1/en
Priority claimed from EP10305660A external-priority patent/EP2397495A1/en
Priority claimed from EP10305721A external-priority patent/EP2402371A1/en
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of BR112012014975A2 publication Critical patent/BR112012014975A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biotechnology (AREA)
  • Vascular Medicine (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

novos anticorpos antagonistas e seus fragmentos fab contra gpvi e seus usos. a presente invenção refere-se a novos anticorpos que especificamente se ligam à proteína de membrana plaquetária humana glicoproteína vi (gpvi) e seus fragmentos ou derivados monovalentes. os anticorpos da invenção são anticorpos do clone de hibridoma 390 e fragmentos de anticorpo dos mesmos capazes de induzir um fenótipo de depleção de gpvi. estes anticorpos e fragmentos fab são capazes de bloquear a ligação de colágeno e dessa forma impedem a ativação plaquetária pelo colágeno. a invenção também se refere a clones de hibridoma e plasmídeos de expressão para a produção dos anticorpos e fragmentos fab revelados. a presente invenção ainda se refere aos usos de fragmentos de anticorpo monovalentes para produção de agentes para pesquisa, diagnóstico e imunoterapêuticos para o tratamento de trombose e outras doenças vasculares. a invenção também se refere um fab que carrega uma molécula na extremidade c-terminal, bem como método para impedimento do reconhecimento de fab por anticorpos usando tal fab modificado. a invenção se refere a um método para o impedimento da ativação plaquetária quando um fab anti-gp vi é usado.
BR112012014975A 2009-12-18 2010-12-17 novos anticorpos antagonistas e seus fragmentos fab contra gpvi e seus usos BR112012014975A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP09306283A EP2336188A1 (en) 2009-12-18 2009-12-18 Novel antagonist antibodies and their Fab fragments against GPVI and uses thereof
EP10305660A EP2397495A1 (en) 2010-06-21 2010-06-21 Novel antagonist antibodies and their Fab fragments against GPVI and uses thereof
EP10305721A EP2402371A1 (en) 2010-07-01 2010-07-01 Novel antagonist antibodies and their Fab fragments against GPVI and uses thereof
PCT/IB2010/055917 WO2011073954A2 (en) 2009-12-18 2010-12-17 Novel antagonist antibodies and their fab fragments against gpvi and uses thereof

Publications (1)

Publication Number Publication Date
BR112012014975A2 true BR112012014975A2 (pt) 2019-09-24

Family

ID=44060924

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012014975A BR112012014975A2 (pt) 2009-12-18 2010-12-17 novos anticorpos antagonistas e seus fragmentos fab contra gpvi e seus usos

Country Status (29)

Country Link
US (2) US8852593B2 (pt)
EP (2) EP2513147B1 (pt)
JP (1) JP5843783B2 (pt)
KR (1) KR20120102125A (pt)
CN (1) CN102725309B (pt)
AR (1) AR079645A1 (pt)
AU (1) AU2010331807B2 (pt)
BR (1) BR112012014975A2 (pt)
CA (1) CA2784498A1 (pt)
CL (1) CL2012001650A1 (pt)
CY (1) CY1118389T1 (pt)
DK (1) DK2513147T3 (pt)
EA (1) EA201290525A1 (pt)
ES (1) ES2596254T3 (pt)
HK (1) HK1216537A1 (pt)
HR (1) HRP20161298T1 (pt)
HU (1) HUE029824T2 (pt)
IL (1) IL220447A0 (pt)
LT (1) LT2513147T (pt)
MA (1) MA33930B1 (pt)
MX (2) MX347613B (pt)
PL (1) PL2513147T3 (pt)
PT (1) PT2513147T (pt)
SG (2) SG10201405259PA (pt)
SI (1) SI2513147T1 (pt)
TW (1) TW201132759A (pt)
UY (1) UY33115A (pt)
WO (1) WO2011073954A2 (pt)
ZA (1) ZA201204421B (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9139825B2 (en) 2009-10-30 2015-09-22 Novartis Ag Universal fibronectin type III bottom-side binding domain libraries
EA201290525A1 (ru) * 2009-12-18 2013-01-30 Санофи Новые антитела-антагонисты, их fab-фрагменты против gpvi и способы их применения
WO2012042026A1 (en) 2010-09-30 2012-04-05 Ablynx Nv Biological materials related to c-met
US11644471B2 (en) 2010-09-30 2023-05-09 Ablynx N.V. Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
ES2865068T3 (es) 2011-01-14 2021-10-14 Univ California Anticuerpos terapéuticos contra la proteína ROR-1 y métodos para usarlos
RS55775B2 (sr) * 2011-06-23 2022-10-31 Ablynx Nv Tehnike za predviđanje, otkrivanje i smanjenje nespecifične proteinske interferencije u testovima koji uključuju pojedinačne varijabilne domene imunoglobulina
PL2723771T3 (pl) 2011-06-23 2020-04-30 Ablynx Nv Białka wiążące albuminy surowicy
KR20220114104A (ko) * 2011-06-23 2022-08-17 아블린쓰 엔.브이. 면역글로불린 단일 가변 도메인을 수반하는 어세이에서 비특이적 단백질 간섭을 예측하고 검출하고 감소시키는 기법
CA2845029A1 (en) * 2011-08-17 2013-02-21 Glaxo Group Limited Modified proteins and peptides
US9346884B2 (en) 2011-09-30 2016-05-24 Ablynx N.V. Biological materials related to c-Met
US9328174B2 (en) 2012-05-09 2016-05-03 Novartis Ag Chemokine receptor binding polypeptides
EP2895510A2 (en) * 2012-09-13 2015-07-22 Novartis AG Single domain antibody with c-terminal modification
CN103396492A (zh) * 2013-08-06 2013-11-20 安徽新标志科技有限公司 抗人血小板胶原蛋白受体的人源性单克隆抗体片段及其应用
MX2018001465A (es) 2015-08-05 2019-01-31 Acticor Biotech Nuevos anticuerpos anti-gpvi humana y sus usos.
EP3538552B1 (en) 2016-11-14 2023-09-13 MorphoSys AG Fab molecules with a rodent hinge region and a non-rodent ch1 region
KR102633644B1 (ko) * 2017-02-03 2024-02-05 액티코어 바이오테크 항-인간 gpvi 항체를 이용한 혈소판 응집의 억제
CN112118869A (zh) * 2018-05-16 2020-12-22 莫佛塞斯公司 靶向糖蛋白vi的抗体
GB202020602D0 (en) * 2020-12-24 2021-02-10 Univ Birmingham Nanobody
WO2022257106A1 (zh) * 2021-06-11 2022-12-15 江苏丰华生物制药有限公司 一种人源化抗人GPVI单克隆抗体Fab片段及其应用
WO2023133470A2 (en) * 2022-01-07 2023-07-13 BioLegend, Inc. Tmprss2 binding antibodies and antigen binding fragments thereof

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6498237B2 (en) 1989-08-07 2002-12-24 Peptech Limited Tumor necrosis factor antibodies
US5919452A (en) * 1991-03-18 1999-07-06 New York University Methods of treating TNFα-mediated disease using chimeric anti-TNF antibodies
GB9109478D0 (en) * 1991-05-02 1991-06-26 Therapeutic Antibodies Inc Antivenoms
US7062219B2 (en) * 1997-01-31 2006-06-13 Odyssey Thera Inc. Protein fragment complementation assays for high-throughput and high-content screening
US7291714B1 (en) * 1999-06-30 2007-11-06 Millennium Pharmaceuticals, Inc. Glycoprotein VI and uses thereof
US20040001826A1 (en) * 1999-06-30 2004-01-01 Millennium Pharmaceuticals, Inc. Glycoprotein VI and uses thereof
WO2001016321A1 (en) * 1999-09-01 2001-03-08 Otsuka Pharmaceutical Co., Ltd. Platelet membrane glycoprotein vi (gpvi) dna and protein sequences, and uses thereof
AU1446801A (en) * 1999-10-29 2001-05-14 Rutgers, The State University Of New Jersey Renilla reniformis green fluorescent protein
AU2002211835A1 (en) * 2000-09-29 2002-04-08 Clinomics Laboratories, Inc. Oncology tissue microarrays
EP1224942A1 (en) * 2001-01-23 2002-07-24 Bernhard Dr. Nieswandt Use of JAQ1 (monoclonal antibody anti GPVI) as a medicament for the protection against thrombotic diseases
GB0130543D0 (en) * 2001-12-20 2002-02-06 Univ Cambridge Tech Human antibodies and their use
EP1538165A1 (en) * 2003-12-03 2005-06-08 Procorde GmbH Inhibitors of glycoprotein VI based on monoclonal antibody hgp 5c4
EP1369128A1 (en) * 2002-06-07 2003-12-10 Procorde GmbH Inhibitors of glycoprotein VI and their therapeutic use
GB0511590D0 (en) 2005-06-07 2005-07-13 Procorde Gmbh Anti-thrombotic agents
WO2005007800A2 (ja) * 2003-07-18 2005-01-27 Mochida Pharm Co Ltd 抗血小板膜糖蛋白質ⅵモノクローナル抗体
EP2332990A1 (en) * 2004-03-19 2011-06-15 Imclone LLC Human anti-epidermal growth factor receptor antibody
WO2005111083A2 (en) * 2004-04-29 2005-11-24 Otsuka Pharmaceutical Co., Ltd. Antibodies specific for glycoprotein vi and methods of producing these antibodies
EP1824979A2 (en) * 2004-12-10 2007-08-29 Trigen GmbH Methods, products and uses involving platelets and/or the vasculature
GB0502358D0 (en) * 2005-02-04 2005-03-16 Novartis Ag Organic compounds
US20090041783A1 (en) 2005-04-28 2009-02-12 Mochida Pharmaceutical Co., Ltd. Anti-platelet membrane glycoprotein vi monoclonal antibody
CA2606450A1 (en) * 2005-04-28 2006-11-09 Mochida Pharmaceutical Co., Ltd. Anti-platelet membrane glycoprotein vi monoclonal antibody
JP5224707B2 (ja) * 2005-04-28 2013-07-03 持田製薬株式会社 抗血小板膜糖蛋白質ｖｉモノクローナル抗体
WO2007091719A1 (ja) * 2006-02-07 2007-08-16 Mochida Pharmaceutical Co., Ltd. 抗gpvi抗体の併用療法及び新規医薬用途
CA2646807A1 (en) * 2006-03-31 2007-10-18 Mochida Pharmaceutical Co., Ltd. Novel platelet activation marker and method for determination thereof
EP1916259A1 (en) * 2006-10-26 2008-04-30 Institut National De La Sante Et De La Recherche Medicale (Inserm) Anti-glycoprotein VI SCFV fragment for treatment of thrombosis
WO2009032661A1 (en) 2007-08-29 2009-03-12 Sanofi-Aventis Humanized anti-cxcr5 antibodies, derivatives thereof and their uses
US20100297116A1 (en) * 2007-10-31 2010-11-25 Yongge Liu Uses of a glycoprotein vi (gpvi) inhibitor
EP2362783A2 (en) * 2008-10-31 2011-09-07 Biogen Idec MA Inc. Light targeting molecules and uses thereof
EA201290525A1 (ru) * 2009-12-18 2013-01-30 Санофи Новые антитела-антагонисты, их fab-фрагменты против gpvi и способы их применения

Also Published As

Publication number Publication date
EP2513147A2 (en) 2012-10-24
SG10201405259PA (en) 2014-10-30
ES2596254T3 (es) 2017-01-05
TW201132759A (en) 2011-10-01
WO2011073954A3 (en) 2012-03-08
EP2933269A1 (en) 2015-10-21
ZA201204421B (en) 2013-09-25
MA33930B1 (fr) 2013-01-02
UY33115A (es) 2011-07-29
LT2513147T (lt) 2016-10-25
SI2513147T1 (sl) 2016-11-30
AU2010331807A1 (en) 2012-07-12
EA201290525A1 (ru) 2013-01-30
PL2513147T3 (pl) 2017-08-31
JP2013514077A (ja) 2013-04-25
CA2784498A1 (en) 2011-06-23
CN102725309B (zh) 2016-01-06
IL220447A0 (en) 2012-08-30
PT2513147T (pt) 2016-10-11
KR20120102125A (ko) 2012-09-17
US9441040B2 (en) 2016-09-13
MX347613B (es) 2017-05-04
US20150098939A1 (en) 2015-04-09
HRP20161298T1 (hr) 2016-11-18
AR079645A1 (es) 2012-02-08
SG181707A1 (en) 2012-07-30
EP2513147B1 (en) 2016-07-20
JP5843783B2 (ja) 2016-01-13
US20120244152A1 (en) 2012-09-27
AU2010331807B2 (en) 2016-08-04
CN102725309A (zh) 2012-10-10
HUE029824T2 (en) 2017-04-28
US8852593B2 (en) 2014-10-07
HK1216537A1 (zh) 2016-11-18
DK2513147T3 (en) 2016-10-24
MX2012007153A (es) 2012-07-03
CY1118389T1 (el) 2017-06-28
CL2012001650A1 (es) 2012-12-14
WO2011073954A2 (en) 2011-06-23

Similar Documents

Publication Publication Date Title
BR112012014975A2 (pt) novos anticorpos antagonistas e seus fragmentos fab contra gpvi e seus usos
BR112016022819A2 (pt) uso de um método, método para a produção de um anticorpo com reatividade cruzada para humano e cinomolgo e anticorpo com reatividade cruzada para humano e cinomolgo
CO2019006657A2 (es) Anticuerpos anti-cd73 y usos de los mismos
BR112019021991A2 (pt) Proteínas de ligação ao antígeno trem2 e seus usos
EA201391761A1 (ru) Анти-альфа-синуклеинсвязывающие молекулы
BR112017010094A2 (pt) anticorpos compreendendo regiões constantes de cadeias pesadas modificadas
BR112016022910A2 (pt) anticorpos contra her2 biespecíficos
PE20200152A1 (es) Receptores de union a antigeno mejorados
BRPI1008145B8 (pt) Proteína de ligação de antígeno biespecífica, método para preparar uma proteína de ligação de antígeno biespecífica, micro-organismo transgênico, composição farmacêutica e uso da proteína de ligação de antígeno biespecífica
CR20140542A (es) Anticuerpos biespecíficos anti-vegf7anti-ang-2 y su utilización en el tratamiento de enfermedades vasculares oculares
BR112015014751A8 (pt) anti-corpos anti-tau humanos e fragmento de ligação a tau dos mesmo, seu uso na preparação de um medicamento, bem como polipeptídeos codificando os mesmos.
PE20081478A1 (es) Anticuerpos cd44
CL2021002637A1 (es) Anticuerpos y fragmentos de los mismos que se unen al receptor cannabinoide 1 (cb1) humano y métodos para antagonizar cb1 (divisional de la solicitud no. 201602433)
UA109633C2 (uk) Антитіло людини проти тканинного фактора
UA113623C2 (uk) Моноклональне антитіло проти інгібітору шляху тканинного фактора (tfpi)
CO6460768A2 (es) Anticuerpos específicos para dkk-1 y sus usos
AR071304A1 (es) Anticuerpos anti cd151 (proteina de membrana de la flia. de las tetraspaninas) utiles para el tratamiento de cancer
PE20130040A1 (es) Proteinas de union a antigeno
BR112017027702A2 (pt) anticorpos antirreceptor do fator de crescimento endotelial vascular 2 (vegfr2)
BR112021019107A2 (pt) Anticorpos contra amiloide-beta piroglutamato e usos dos mesmos
PH12020551012A1 (en) Monoclonal antibodies and methods for using same
PH12021551535A1 (en) Monoclonal antibodies that bind specifically to human trbv9
BR112018015090A2 (pt) anticorpo anti-trombina, fragmento de ligação ao antígeno e uso farmacêutico dos mesmos
BR112016022508A2 (pt) anticorpos contra hpa-1a
WO2020139175A3 (ru) Моноклональные антитела против участка бета-цепи trbv9 человека

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.