MX347613B - Nuevos anticuerpos antagonistas y sus fragmentos fab contra gpvi y sus usos. - Google Patents

Nuevos anticuerpos antagonistas y sus fragmentos fab contra gpvi y sus usos.

Info

Publication number
MX347613B
MX347613B MX2014005133A MX2014005133A MX347613B MX 347613 B MX347613 B MX 347613B MX 2014005133 A MX2014005133 A MX 2014005133A MX 2014005133 A MX2014005133 A MX 2014005133A MX 347613 B MX347613 B MX 347613B
Authority
MX
Mexico
Prior art keywords
antibodies
fab
gpvi
fragments
fab fragments
Prior art date
Application number
MX2014005133A
Other languages
English (en)
Inventor
Corvey Carsten
Lange Christian
Mikol Vincent
Rao Ercole
Baurin Nicolas
Langer Thomas
Blanche Francis
Cameron Béatrice
Dabdoubi Tarik
Engel Christian
Florian Peter
Focken Ingo
Kroll Katja
Kruip Jochen
Wonerow Peter
Lorenz Martin
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP09306283A external-priority patent/EP2336188A1/en
Priority claimed from EP10305660A external-priority patent/EP2397495A1/en
Priority claimed from EP10305721A external-priority patent/EP2402371A1/en
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of MX347613B publication Critical patent/MX347613B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Vascular Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención se refiere a nuevos anticuerpos que se unen específicamente a la proteína de las membranas plaquetarias humanas Glicoproteína VI (GPVI) y sus fragmentos monovalentes o derivados. Los anticuerpos de la invención son anticuerpos de clon 390 de hibridoma y sus fragmentos de anticuerpo capaces de inducir un fenotipo de reducción de GPVI. Estos anticuerpos y fragmentos Fab pueden bloquear la unión de colágeno y evitar así la activación plaquetaria por colágeno. La invención también se refiere a clones de hibridoma y plásmidos de expresión para la producción de anticuerpos y fragmentos Fab descritos. La presente invención se refiere además a los usos de fragmentos de anticuerpos monovalentes para fabricar agentes de investigación, de diagnóstico e inmunoterapéuticos para el tratamiento de trombosis y otras vasculares. La invención también se refiere a Fab que soporta una molécula en el extremo C-terminal, así como método para evitar el reconocimiento de Fab por anticuerpos usando tal Fab modificado. La invención se refiere a un método para evitar la activación plaquetaria cuando se usa un Fab de anti-GPVI.
MX2014005133A 2009-12-18 2010-12-17 Nuevos anticuerpos antagonistas y sus fragmentos fab contra gpvi y sus usos. MX347613B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP09306283A EP2336188A1 (en) 2009-12-18 2009-12-18 Novel antagonist antibodies and their Fab fragments against GPVI and uses thereof
EP10305660A EP2397495A1 (en) 2010-06-21 2010-06-21 Novel antagonist antibodies and their Fab fragments against GPVI and uses thereof
EP10305721A EP2402371A1 (en) 2010-07-01 2010-07-01 Novel antagonist antibodies and their Fab fragments against GPVI and uses thereof
PCT/IB2010/055917 WO2011073954A2 (en) 2009-12-18 2010-12-17 Novel antagonist antibodies and their fab fragments against gpvi and uses thereof

Publications (1)

Publication Number Publication Date
MX347613B true MX347613B (es) 2017-05-04

Family

ID=44060924

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2014005133A MX347613B (es) 2009-12-18 2010-12-17 Nuevos anticuerpos antagonistas y sus fragmentos fab contra gpvi y sus usos.
MX2012007153A MX2012007153A (es) 2009-12-18 2010-12-17 Nuevos anticuerpos antagonistas y sus fragmentos fab contra gpvi y sus usos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2012007153A MX2012007153A (es) 2009-12-18 2010-12-17 Nuevos anticuerpos antagonistas y sus fragmentos fab contra gpvi y sus usos.

Country Status (29)

Country Link
US (2) US8852593B2 (es)
EP (2) EP2513147B1 (es)
JP (1) JP5843783B2 (es)
KR (1) KR20120102125A (es)
CN (1) CN102725309B (es)
AR (1) AR079645A1 (es)
AU (1) AU2010331807B2 (es)
BR (1) BR112012014975A2 (es)
CA (1) CA2784498A1 (es)
CL (1) CL2012001650A1 (es)
CY (1) CY1118389T1 (es)
DK (1) DK2513147T3 (es)
EA (1) EA201290525A1 (es)
ES (1) ES2596254T3 (es)
HK (1) HK1216537A1 (es)
HR (1) HRP20161298T1 (es)
HU (1) HUE029824T2 (es)
IL (1) IL220447A0 (es)
LT (1) LT2513147T (es)
MA (1) MA33930B1 (es)
MX (2) MX347613B (es)
PL (1) PL2513147T3 (es)
PT (1) PT2513147T (es)
SG (2) SG10201405259PA (es)
SI (1) SI2513147T1 (es)
TW (1) TW201132759A (es)
UY (1) UY33115A (es)
WO (1) WO2011073954A2 (es)
ZA (1) ZA201204421B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9139825B2 (en) 2009-10-30 2015-09-22 Novartis Ag Universal fibronectin type III bottom-side binding domain libraries
EA201290525A1 (ru) * 2009-12-18 2013-01-30 Санофи Новые антитела-антагонисты, их fab-фрагменты против gpvi и способы их применения
WO2012042026A1 (en) 2010-09-30 2012-04-05 Ablynx Nv Biological materials related to c-met
US11644471B2 (en) 2010-09-30 2023-05-09 Ablynx N.V. Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
ES2865068T3 (es) 2011-01-14 2021-10-14 Univ California Anticuerpos terapéuticos contra la proteína ROR-1 y métodos para usarlos
RS55775B2 (sr) * 2011-06-23 2022-10-31 Ablynx Nv Tehnike za predviđanje, otkrivanje i smanjenje nespecifične proteinske interferencije u testovima koji uključuju pojedinačne varijabilne domene imunoglobulina
PL2723771T3 (pl) 2011-06-23 2020-04-30 Ablynx Nv Białka wiążące albuminy surowicy
KR20220114104A (ko) * 2011-06-23 2022-08-17 아블린쓰 엔.브이. 면역글로불린 단일 가변 도메인을 수반하는 어세이에서 비특이적 단백질 간섭을 예측하고 검출하고 감소시키는 기법
CA2845029A1 (en) * 2011-08-17 2013-02-21 Glaxo Group Limited Modified proteins and peptides
US9346884B2 (en) 2011-09-30 2016-05-24 Ablynx N.V. Biological materials related to c-Met
US9328174B2 (en) 2012-05-09 2016-05-03 Novartis Ag Chemokine receptor binding polypeptides
EP2895510A2 (en) * 2012-09-13 2015-07-22 Novartis AG Single domain antibody with c-terminal modification
CN103396492A (zh) * 2013-08-06 2013-11-20 安徽新标志科技有限公司 抗人血小板胶原蛋白受体的人源性单克隆抗体片段及其应用
MX2018001465A (es) 2015-08-05 2019-01-31 Acticor Biotech Nuevos anticuerpos anti-gpvi humana y sus usos.
EP3538552B1 (en) 2016-11-14 2023-09-13 MorphoSys AG Fab molecules with a rodent hinge region and a non-rodent ch1 region
KR102633644B1 (ko) * 2017-02-03 2024-02-05 액티코어 바이오테크 항-인간 gpvi 항체를 이용한 혈소판 응집의 억제
CN112118869A (zh) * 2018-05-16 2020-12-22 莫佛塞斯公司 靶向糖蛋白vi的抗体
GB202020602D0 (en) * 2020-12-24 2021-02-10 Univ Birmingham Nanobody
WO2022257106A1 (zh) * 2021-06-11 2022-12-15 江苏丰华生物制药有限公司 一种人源化抗人GPVI单克隆抗体Fab片段及其应用
WO2023133470A2 (en) * 2022-01-07 2023-07-13 BioLegend, Inc. Tmprss2 binding antibodies and antigen binding fragments thereof

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6498237B2 (en) 1989-08-07 2002-12-24 Peptech Limited Tumor necrosis factor antibodies
US5919452A (en) * 1991-03-18 1999-07-06 New York University Methods of treating TNFα-mediated disease using chimeric anti-TNF antibodies
GB9109478D0 (en) * 1991-05-02 1991-06-26 Therapeutic Antibodies Inc Antivenoms
US7062219B2 (en) * 1997-01-31 2006-06-13 Odyssey Thera Inc. Protein fragment complementation assays for high-throughput and high-content screening
US7291714B1 (en) * 1999-06-30 2007-11-06 Millennium Pharmaceuticals, Inc. Glycoprotein VI and uses thereof
US20040001826A1 (en) * 1999-06-30 2004-01-01 Millennium Pharmaceuticals, Inc. Glycoprotein VI and uses thereof
WO2001016321A1 (en) * 1999-09-01 2001-03-08 Otsuka Pharmaceutical Co., Ltd. Platelet membrane glycoprotein vi (gpvi) dna and protein sequences, and uses thereof
AU1446801A (en) * 1999-10-29 2001-05-14 Rutgers, The State University Of New Jersey Renilla reniformis green fluorescent protein
AU2002211835A1 (en) * 2000-09-29 2002-04-08 Clinomics Laboratories, Inc. Oncology tissue microarrays
EP1224942A1 (en) * 2001-01-23 2002-07-24 Bernhard Dr. Nieswandt Use of JAQ1 (monoclonal antibody anti GPVI) as a medicament for the protection against thrombotic diseases
GB0130543D0 (en) * 2001-12-20 2002-02-06 Univ Cambridge Tech Human antibodies and their use
EP1538165A1 (en) * 2003-12-03 2005-06-08 Procorde GmbH Inhibitors of glycoprotein VI based on monoclonal antibody hgp 5c4
EP1369128A1 (en) * 2002-06-07 2003-12-10 Procorde GmbH Inhibitors of glycoprotein VI and their therapeutic use
GB0511590D0 (en) 2005-06-07 2005-07-13 Procorde Gmbh Anti-thrombotic agents
WO2005007800A2 (ja) * 2003-07-18 2005-01-27 Mochida Pharm Co Ltd 抗血小板膜糖蛋白質ⅵモノクローナル抗体
EP2332990A1 (en) * 2004-03-19 2011-06-15 Imclone LLC Human anti-epidermal growth factor receptor antibody
WO2005111083A2 (en) * 2004-04-29 2005-11-24 Otsuka Pharmaceutical Co., Ltd. Antibodies specific for glycoprotein vi and methods of producing these antibodies
EP1824979A2 (en) * 2004-12-10 2007-08-29 Trigen GmbH Methods, products and uses involving platelets and/or the vasculature
GB0502358D0 (en) * 2005-02-04 2005-03-16 Novartis Ag Organic compounds
US20090041783A1 (en) 2005-04-28 2009-02-12 Mochida Pharmaceutical Co., Ltd. Anti-platelet membrane glycoprotein vi monoclonal antibody
CA2606450A1 (en) * 2005-04-28 2006-11-09 Mochida Pharmaceutical Co., Ltd. Anti-platelet membrane glycoprotein vi monoclonal antibody
JP5224707B2 (ja) * 2005-04-28 2013-07-03 持田製薬株式会社 抗血小板膜糖蛋白質ｖｉモノクローナル抗体
WO2007091719A1 (ja) * 2006-02-07 2007-08-16 Mochida Pharmaceutical Co., Ltd. 抗gpvi抗体の併用療法及び新規医薬用途
CA2646807A1 (en) * 2006-03-31 2007-10-18 Mochida Pharmaceutical Co., Ltd. Novel platelet activation marker and method for determination thereof
EP1916259A1 (en) * 2006-10-26 2008-04-30 Institut National De La Sante Et De La Recherche Medicale (Inserm) Anti-glycoprotein VI SCFV fragment for treatment of thrombosis
WO2009032661A1 (en) 2007-08-29 2009-03-12 Sanofi-Aventis Humanized anti-cxcr5 antibodies, derivatives thereof and their uses
US20100297116A1 (en) * 2007-10-31 2010-11-25 Yongge Liu Uses of a glycoprotein vi (gpvi) inhibitor
EP2362783A2 (en) * 2008-10-31 2011-09-07 Biogen Idec MA Inc. Light targeting molecules and uses thereof
EA201290525A1 (ru) * 2009-12-18 2013-01-30 Санофи Новые антитела-антагонисты, их fab-фрагменты против gpvi и способы их применения

Also Published As

Publication number Publication date
EP2513147A2 (en) 2012-10-24
SG10201405259PA (en) 2014-10-30
ES2596254T3 (es) 2017-01-05
TW201132759A (en) 2011-10-01
WO2011073954A3 (en) 2012-03-08
EP2933269A1 (en) 2015-10-21
ZA201204421B (en) 2013-09-25
MA33930B1 (fr) 2013-01-02
UY33115A (es) 2011-07-29
LT2513147T (lt) 2016-10-25
SI2513147T1 (sl) 2016-11-30
AU2010331807A1 (en) 2012-07-12
EA201290525A1 (ru) 2013-01-30
PL2513147T3 (pl) 2017-08-31
JP2013514077A (ja) 2013-04-25
CA2784498A1 (en) 2011-06-23
CN102725309B (zh) 2016-01-06
BR112012014975A2 (pt) 2019-09-24
IL220447A0 (en) 2012-08-30
PT2513147T (pt) 2016-10-11
KR20120102125A (ko) 2012-09-17
US9441040B2 (en) 2016-09-13
US20150098939A1 (en) 2015-04-09
HRP20161298T1 (hr) 2016-11-18
AR079645A1 (es) 2012-02-08
SG181707A1 (en) 2012-07-30
EP2513147B1 (en) 2016-07-20
JP5843783B2 (ja) 2016-01-13
US20120244152A1 (en) 2012-09-27
AU2010331807B2 (en) 2016-08-04
CN102725309A (zh) 2012-10-10
HUE029824T2 (en) 2017-04-28
US8852593B2 (en) 2014-10-07
HK1216537A1 (zh) 2016-11-18
DK2513147T3 (en) 2016-10-24
MX2012007153A (es) 2012-07-03
CY1118389T1 (el) 2017-06-28
CL2012001650A1 (es) 2012-12-14
WO2011073954A2 (en) 2011-06-23

Similar Documents

Publication Publication Date Title
MX2012007153A (es) Nuevos anticuerpos antagonistas y sus fragmentos fab contra gpvi y sus usos.
EA201991099A1 (ru) Антитела против cd73 и их применение
PH12019502561A1 (en) Novel monoclonal antibodies to cytotoxic t-lymphocyte-associated protein 4 (ctla-4)
TN2011000528A1 (en) Compositions and methods for antibodies targeting complement protein c3b
MY187263A (en) Il-17 reception a antigen binding proteins
UA102867C2 (uk) Антитіла до cxcr4 та їх застосування у лікуванні раку
TN2012000434A1 (en) Biparatopic abeta binding polypeptides
EP2582722A4 (en) ANTIBODIES AGAINST GD2
MY151191A (en) Novel antibodies
MX2018010331A (es) Agentes de ligacion al factor de crecimiento endotelial vascular/ligando 4 similar a delta (vegf/dll4) y usos de los mismos.
TW200738748A (en) Human monoclonal antibody human CD134 (OX40) and methods of making and using same
MX2007011064A (es) Anticuerpos contra cd38 para tratamiento de mieloma multiple.
WO2011119979A3 (en) Antibodies to muc16 and methods of use thereof
UA94452C2 (ru) Гуманизированные моноклональные антитела к фактору роста гепатоцитов
MX2009005743A (es) Nuevos anticuerpos monoclonales de globulomero anti-ab selectivos del conformero ab.
TN2012000466A1 (en) Humanized anti cxcr4 antibodies for the treatment of cancer
MX2009006969A (es) Purificacion de romidepsina.
UA113623C2 (uk) Моноклональне антитіло проти інгібітору шляху тканинного фактора (tfpi)
WO2008027739A3 (en) Antibodies to ntb-a
WO2009051957A3 (en) Antibodies to irem-1
MY170404A (en) Antigen binding proteins
MX2019009498A (es) Anticuerpos mimeticos de fgf21 y usos de los mismos.
PH12020551012A1 (en) Monoclonal antibodies and methods for using same
WO2012075342A3 (en) Anti-bradykinin b2 receptor (bkb2r) monoclonal antibody
JOP20210168A1 (ar) أجسام مضادة أحادية النسيلة ترتبط نوعيًا مع trbv9 بشري