PL2173730T3 - Nowe związki 951: kwas bifenyloksypropanowy jako modulator CRTh2 i związki pośrednie - Google Patents

Nowe związki 951: kwas bifenyloksypropanowy jako modulator CRTh2 i związki pośrednie

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Publication number
PL2173730T3
PL2173730T3 PL08776164T PL08776164T PL2173730T3 PL 2173730 T3 PL2173730 T3 PL 2173730T3 PL 08776164 T PL08776164 T PL 08776164T PL 08776164 T PL08776164 T PL 08776164T PL 2173730 T3 PL2173730 T3 PL 2173730T3
Authority
PL
Poland
Prior art keywords
biphenyloxypropanoic
intermediates
acid
novel compounds
crth2
Prior art date
Application number
PL08776164T
Other languages
English (en)
Polish (pl)
Inventor
Roger Victor Bonnert
Timothy Jon Luker
Anil Patel
Aaron Rigby
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39942682&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2173730(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PL2173730T3 publication Critical patent/PL2173730T3/pl

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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
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  • Diabetes (AREA)
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PL08776164T 2007-07-05 2008-07-01 Nowe związki 951: kwas bifenyloksypropanowy jako modulator CRTh2 i związki pośrednie PL2173730T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94801207P 2007-07-05 2007-07-05
PCT/GB2008/050525 WO2009004379A1 (en) 2007-07-05 2008-07-01 Novel compounds 951: a biphenyloxypropanoic acid as crth2 modulator and intermediates
EP08776164.9A EP2173730B1 (en) 2007-07-05 2008-07-01 Novel compounds 951: a biphenyloxypropanoic acid as crth2 modulator and intermediates

Publications (1)

Publication Number Publication Date
PL2173730T3 true PL2173730T3 (pl) 2014-03-31

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Application Number Title Priority Date Filing Date
PL08776164T PL2173730T3 (pl) 2007-07-05 2008-07-01 Nowe związki 951: kwas bifenyloksypropanowy jako modulator CRTh2 i związki pośrednie

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US (1) US8507544B2 (cg-RX-API-DMAC7.html)
EP (1) EP2173730B1 (cg-RX-API-DMAC7.html)
JP (1) JP5368438B2 (cg-RX-API-DMAC7.html)
KR (1) KR20100039326A (cg-RX-API-DMAC7.html)
CN (1) CN101796042B (cg-RX-API-DMAC7.html)
AR (1) AR067461A1 (cg-RX-API-DMAC7.html)
AU (1) AU2008272690B2 (cg-RX-API-DMAC7.html)
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CA (1) CA2691615A1 (cg-RX-API-DMAC7.html)
CL (1) CL2008001982A1 (cg-RX-API-DMAC7.html)
CO (1) CO6270211A2 (cg-RX-API-DMAC7.html)
CY (1) CY1114804T1 (cg-RX-API-DMAC7.html)
DK (1) DK2173730T3 (cg-RX-API-DMAC7.html)
EC (1) ECSP109848A (cg-RX-API-DMAC7.html)
ES (1) ES2442523T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20140004T1 (cg-RX-API-DMAC7.html)
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NZ (1) NZ582192A (cg-RX-API-DMAC7.html)
PE (2) PE20090475A1 (cg-RX-API-DMAC7.html)
PL (1) PL2173730T3 (cg-RX-API-DMAC7.html)
PT (1) PT2173730E (cg-RX-API-DMAC7.html)
RS (1) RS53129B (cg-RX-API-DMAC7.html)
SA (1) SA08290406B1 (cg-RX-API-DMAC7.html)
SI (1) SI2173730T1 (cg-RX-API-DMAC7.html)
TW (1) TWI453017B (cg-RX-API-DMAC7.html)
UA (1) UA100983C2 (cg-RX-API-DMAC7.html)
UY (1) UY31208A1 (cg-RX-API-DMAC7.html)
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Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0301010D0 (sv) * 2003-04-07 2003-04-07 Astrazeneca Ab Novel compounds
SE0301009D0 (sv) * 2003-04-07 2003-04-07 Astrazeneca Ab Novel compounds
SA04250253B1 (ar) 2003-08-21 2009-11-10 استرازينيكا ايه بي احماض فينوكسي اسيتيك مستبدلة باعتبارها مركبات صيدلانية لعلاج الامراض التنفسية مثل الربو ومرض الانسداد الرئوي المزمن
GB0415320D0 (en) * 2004-07-08 2004-08-11 Astrazeneca Ab Novel compounds
GB0418830D0 (en) 2004-08-24 2004-09-22 Astrazeneca Ab Novel compounds
GB0422057D0 (en) * 2004-10-05 2004-11-03 Astrazeneca Ab Novel compounds
US8524715B2 (en) 2004-11-23 2013-09-03 Astrazeneca Ab Phenoxyacetic acid derivatives useful for treating respiratory diseases
WO2007039736A1 (en) 2005-10-06 2007-04-12 Astrazeneca Ab Novel compounds
TW200745003A (en) 2005-10-06 2007-12-16 Astrazeneca Ab Novel compounds
EP1948630A2 (en) * 2005-11-05 2008-07-30 AstraZeneca AB Novel compounds
US20080293775A1 (en) * 2005-12-15 2008-11-27 Astrazeneca Ab Substituted Diphenylethers, -Amines, -Sulfides and -Methanes for the Treatment of Respiratory Disease
UA100983C2 (ru) 2007-07-05 2013-02-25 Астразенека Аб Бифенилоксипропановая кислота как модулятор crth2 и интермедиаты
US8168678B2 (en) 2008-02-01 2012-05-01 Panmira Pharmaceuticals, Inc. N,N-disubstituted aminoalkylbiphenyl antagonists of prostaglandin D2 receptors
JP2011513242A (ja) 2008-02-25 2011-04-28 アミラ ファーマシューティカルズ，インク． プロスタグランジンｄ２受容体アンタゴニスト
GB2463788B (en) 2008-09-29 2010-12-15 Amira Pharmaceuticals Inc Heteroaryl antagonists of prostaglandin D2 receptors
WO2010039977A2 (en) 2008-10-01 2010-04-08 Amira Pharmaceuticals, Inc. Heteroaryl antagonists of prostaglandin d2 receptors
US8524748B2 (en) 2008-10-08 2013-09-03 Panmira Pharmaceuticals, Llc Heteroalkyl biphenyl antagonists of prostaglandin D2 receptors
GB2465062B (en) 2008-11-06 2011-04-13 Amira Pharmaceuticals Inc Cycloalkane(B)azaindole antagonists of prostaglandin D2 receptors
JP2013500978A (ja) 2009-07-31 2013-01-10 パンミラ ファーマシューティカルズ，エルエルシー． Ｄｐ２受容体アンタゴニストの眼の医薬組成物
MX2012001542A (es) 2009-08-05 2012-06-19 Panmira Pharmaceuticals Llc Antagonista dp2 y usos del mismo.
CA2805452C (en) 2010-07-05 2018-07-31 Actelion Pharmaceuticals Ltd 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin d2 receptor modulators
EP2457900A1 (en) 2010-11-25 2012-05-30 Almirall, S.A. New pyrazole derivatives having CRTh2 antagonistic behaviour
EP2526945A1 (en) 2011-05-25 2012-11-28 Almirall, S.A. New CRTH2 Antagonists
EP2548863A1 (en) 2011-07-18 2013-01-23 Almirall, S.A. New CRTh2 antagonists.
EP2548876A1 (en) 2011-07-18 2013-01-23 Almirall, S.A. New CRTh2 antagonists
ES2624379T3 (es) 2011-12-21 2017-07-14 Idorsia Pharmaceuticals Ltd Derivados de heterociclilo y su uso como moduladores del receptor de prostaglandina D2
JP6127135B2 (ja) 2012-07-05 2017-05-10 アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ １−フェニル置換ヘテロシクリル誘導体及びプロスタグランジンｄ２受容体調節剤としてのそれらの使用
KR101538846B1 (ko) 2013-07-30 2015-07-22 동아에스티 주식회사 신규한 바이페닐 유도체 및 그의 제조방법

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3278524A (en) 1962-03-13 1966-10-11 Beecham Group Ltd Penicillins and their production
CH432119A (de) 1963-02-22 1967-03-15 Geigy Ag J R Verwendung von Halogen-o-hydroxy-diphenyläthern als antimikrobielle Mittel
BE790679A (fr) 1971-11-03 1973-04-27 Ici Ltd Derives de l'indole
DD113545A5 (cg-RX-API-DMAC7.html) 1973-03-30 1975-06-12
JPS5239888B2 (cg-RX-API-DMAC7.html) 1973-05-28 1977-10-07
CH582476A5 (cg-RX-API-DMAC7.html) 1973-10-29 1976-12-15 Ciba Geigy Ag
GB1585963A (en) 1976-10-14 1981-03-11 Lilly Industries Ltd Aryl sulphur compounds
JPS5951943B2 (ja) 1978-08-21 1984-12-17 キツセイ薬品工業株式会社 新規なイミダゾ−ル誘導体
GB2041363B (en) 1979-01-19 1982-10-06 Pfizer Ltd N-benzyl-imidazoles
US4670566A (en) 1979-07-12 1987-06-02 A. H. Robins Company, Incorporated 3-methyl-hio-4-(5-, 6-, or 7-)phenylindolindolin-2-ones
US4486593A (en) 1983-01-19 1984-12-04 The Upjohn Company 2-,3-, or 4-Pyridinylmethylamino arylic acids as thromboxane A2 synthetase and 5-lipoxygenase inhibitors
US5006542A (en) 1988-10-31 1991-04-09 E. R. Squibb & Sons, Inc. Arylthioalkylphenyl carboxylic acids, derivatives thereof, compositions containing same and method of use
US5145790A (en) 1990-05-04 1992-09-08 Abbott Laboratories Reagents and method for detecting polychlorinated biphenyls
EP0540165A1 (en) 1991-10-03 1993-05-05 Zeneca Limited Alkanoic acid derivatives
WO1993012086A1 (fr) 1991-12-11 1993-06-24 Ss Pharmaceutical Co., Ltd. Derive d'arylamide
CA2090283A1 (en) 1992-02-28 1993-08-29 Nobuyuki Hamanaka Phenoxyacetic acid derivatives
CA2110095A1 (en) 1992-12-08 1994-06-09 Teruo Komoto Arylamide derivatives
JPH06313995A (ja) 1993-04-28 1994-11-08 Hodogaya Chem Co Ltd 静電荷像現像用トナー
JPH07140725A (ja) 1993-06-25 1995-06-02 Hodogaya Chem Co Ltd 負帯電性トナー用摩擦帯電付与部材
CA2227691A1 (en) 1995-08-28 1997-03-06 American Home Products Corporation Phenoxy acetic acids as aldose reductase inhibitors and antihyperglycemic agents
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
JP4471404B2 (ja) 1996-02-13 2010-06-02 アストラゼネカ ユーケイ リミテッド Ｖｅｇｆインヒビターとしてのキナゾリン誘導体
KR100489174B1 (ko) 1996-03-05 2005-09-30 제네카-파마 소시에떼아노님 4-아닐리노퀴나졸린유도체
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
EP0839808A1 (en) 1996-10-29 1998-05-06 Novartis AG Pyrazole derivatives, processes for their preparation, and their use as herbicides
FR2763588B1 (fr) 1997-05-23 1999-07-09 Cird Galderma Composes triaromatiques, compositions les contenant et utilisations
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
CO4960662A1 (es) 1997-08-28 2000-09-25 Novartis Ag Ciertos acidos 5-alquil-2-arilaminofenilaceticos y sus derivados
US5942532A (en) 1997-09-05 1999-08-24 Ortho Pharmaceutical Corporation 2-substituted phenyl-benzimidazole antibacterial agents
AU741755B2 (en) 1997-09-12 2001-12-06 Merck Frosst Canada Ltd. 2,3,5-trisubstituted pyridines as inhibitors of cyclooxygenase-2
CN1103332C (zh) 1997-10-14 2003-03-19 旭化成株式会社 联苯基－5－链烷羧酸衍生物和其应用
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
GB9900752D0 (en) 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
WO2001014882A1 (fr) 1999-08-23 2001-03-01 Bml, Inc. Identification des proprietes d'une substance pour les recepteurs de prostaglandine d
CA2382966A1 (en) 1999-08-27 2001-03-08 Eli Lilly And Company Biaryl-oxa(thia)zole derivatives and their use as ppars modulators
CA2400021A1 (en) 2000-02-18 2001-08-23 Merck & Co., Inc. Aryloxyacetic acids for diabetes and lipid disorders
AU2001254555A1 (en) 2000-04-24 2001-11-07 Merck Frosst Canada & Co Method of treatment using phenyl and biaryl derivatives as prostaglandin E inhibitors and compounds useful therefore
AU2001258628A1 (en) 2000-05-31 2001-12-11 Astrazeneca Ab Indole derivatives with vascular damaging activity
KR20030017569A (ko) 2000-06-28 2003-03-03 테바 파마슈티컬 인더스트리즈 리미티드 카르베딜올
JP2004504391A (ja) 2000-07-07 2004-02-12 アンギオジェン・ファーマシューティカルズ・リミテッド 血管新生阻害剤としてのコルキノール誘導体
US6878522B2 (en) 2000-07-07 2005-04-12 Baiyong Li Methods for the identification of compounds useful for the treatment of disease states mediated by prostaglandin D2
NZ522861A (en) 2000-07-07 2004-07-30 Angiogene Pharm Ltd Colchinol derivatives as vascular damaging agents
US20040097555A1 (en) 2000-12-26 2004-05-20 Shinegori Ohkawa Concomitant drugs
WO2002100399A1 (en) 2001-06-12 2002-12-19 Elan Pharmaceuticals, Inc. Macrocycles useful in the treatment of alzheimer's disease
KR100656037B1 (ko) 2002-02-01 2006-12-11 에프. 호프만-라 로슈 아게 알파-1 작용제인 치환된 인돌
SE0200411D0 (sv) 2002-02-05 2002-02-05 Astrazeneca Ab Novel use
AU2003211427A1 (en) 2002-02-18 2003-09-04 Ishihara Sangyo Kaisha, Ltd. Pyridine derivatives or salts thereof and cytokine production inhibitors containing the same
NZ535603A (en) 2002-03-20 2007-10-26 Metabolex Inc Substituted phenylacetic acids
SE0201635D0 (sv) 2002-05-30 2002-05-30 Astrazeneca Ab Novel compounds
SE0202241D0 (sv) 2002-07-17 2002-07-17 Astrazeneca Ab Novel Compounds
PE20040844A1 (es) 2002-11-26 2004-12-30 Novartis Ag Acidos fenilaceticos y derivados como inhibidores de la cox-2
EP1585511B1 (en) 2002-12-20 2013-01-23 Amgen Inc. Asthma and allergic inflammation modulators
CA2518180A1 (en) 2003-03-28 2004-11-04 Eli Lilly And Company Isoquinoline-5-sulfonic acid amides as inhibitors of akt (protein kinase b)
SE0301009D0 (sv) 2003-04-07 2003-04-07 Astrazeneca Ab Novel compounds
SE0301010D0 (sv) 2003-04-07 2003-04-07 Astrazeneca Ab Novel compounds
DE60303238T2 (de) 2003-04-25 2006-09-14 Actimis Pharmaceuticals, Inc., La Jolla Pyrimidin-Essigsäure Derivate geeignet zur Behandlung von CRTH2-bedingten Krankheiten
SA04250253B1 (ar) 2003-08-21 2009-11-10 استرازينيكا ايه بي احماض فينوكسي اسيتيك مستبدلة باعتبارها مركبات صيدلانية لعلاج الامراض التنفسية مثل الربو ومرض الانسداد الرئوي المزمن
GB0324763D0 (en) 2003-10-23 2003-11-26 Oxagen Ltd Use of compounds in therapy
US7166738B2 (en) 2004-04-23 2007-01-23 Roche Palo Alto Llc Non-nucleoside reverse transcriptase inhibitors
GB0409921D0 (en) 2004-05-04 2004-06-09 Novartis Ag Organic compounds
NZ551810A (en) 2004-05-29 2010-09-30 7Tm Pharma As CRTH2 receptor ligands for medicinal uses
GB0415320D0 (en) 2004-07-08 2004-08-11 Astrazeneca Ab Novel compounds
GB0418830D0 (en) 2004-08-24 2004-09-22 Astrazeneca Ab Novel compounds
GB0422057D0 (en) 2004-10-05 2004-11-03 Astrazeneca Ab Novel compounds
US8524715B2 (en) 2004-11-23 2013-09-03 Astrazeneca Ab Phenoxyacetic acid derivatives useful for treating respiratory diseases
GB0510584D0 (en) 2005-05-24 2005-06-29 Novartis Ag Organic compounds
WO2007039736A1 (en) 2005-10-06 2007-04-12 Astrazeneca Ab Novel compounds
TW200745003A (en) * 2005-10-06 2007-12-16 Astrazeneca Ab Novel compounds
EP1948630A2 (en) 2005-11-05 2008-07-30 AstraZeneca AB Novel compounds
US20080293775A1 (en) 2005-12-15 2008-11-27 Astrazeneca Ab Substituted Diphenylethers, -Amines, -Sulfides and -Methanes for the Treatment of Respiratory Disease
UA100983C2 (ru) 2007-07-05 2013-02-25 Астразенека Аб Бифенилоксипропановая кислота как модулятор crth2 и интермедиаты

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AU2008272690A1 (en) 2009-01-08
CO6270211A2 (es) 2011-04-20
HK1143140A1 (en) 2010-12-24
RU2010101278A (ru) 2011-08-10
ZA200909226B (en) 2011-05-25
PE20121515A1 (es) 2012-12-16
BRPI0813992A2 (pt) 2017-05-09
DK2173730T3 (da) 2014-01-20
SA08290406B1 (ar) 2013-04-02
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UY31208A1 (es) 2009-03-02
US8507544B2 (en) 2013-08-13
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KR20100039326A (ko) 2010-04-15
NZ582192A (en) 2012-01-12
AR067461A1 (es) 2009-10-14
UA100983C2 (ru) 2013-02-25
TWI453017B (zh) 2014-09-21
JP2010532340A (ja) 2010-10-07
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ECSP109848A (es) 2010-02-26
WO2009004379A1 (en) 2009-01-08
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