PL2167523T3 - Synteza i zastosowanie anty-odwrotnych tiofosforanowych analogów kapu matrycowego RNA - Google Patents

Synteza i zastosowanie anty-odwrotnych tiofosforanowych analogów kapu matrycowego RNA

Info

Publication number
PL2167523T3
PL2167523T3 PL08771474T PL08771474T PL2167523T3 PL 2167523 T3 PL2167523 T3 PL 2167523T3 PL 08771474 T PL08771474 T PL 08771474T PL 08771474 T PL08771474 T PL 08771474T PL 2167523 T3 PL2167523 T3 PL 2167523T3
Authority
PL
Poland
Prior art keywords
synthesis
messenger rna
rna cap
phosphorothioate analogs
reverse
Prior art date
Application number
PL08771474T
Other languages
English (en)
Inventor
Jacek Jemielity
Ewa M Grudzien-Nogalska
Joanna Kowalska
Edward Darzynkiewicz
Robert E Rhoads
Original Assignee
Univ Louisiana State
Univ Warszawski
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Louisiana State, Univ Warszawski filed Critical Univ Louisiana State
Publication of PL2167523T3 publication Critical patent/PL2167523T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
PL08771474T 2007-06-19 2008-06-19 Synteza i zastosowanie anty-odwrotnych tiofosforanowych analogów kapu matrycowego RNA PL2167523T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94484207P 2007-06-19 2007-06-19
EP08771474.7A EP2167523B1 (en) 2007-06-19 2008-06-19 Synthesis and use of anti-reverse phosphorothioate analogs of the messenger rna cap
PCT/US2008/067494 WO2008157688A2 (en) 2007-06-19 2008-06-19 Synthesis and use of anti-reverse phosphorothioate analogs of the messenger rna cap

Publications (1)

Publication Number Publication Date
PL2167523T3 true PL2167523T3 (pl) 2014-12-31

Family

ID=40156965

Family Applications (1)

Application Number Title Priority Date Filing Date
PL08771474T PL2167523T3 (pl) 2007-06-19 2008-06-19 Synteza i zastosowanie anty-odwrotnych tiofosforanowych analogów kapu matrycowego RNA

Country Status (15)

Country Link
US (1) US8153773B2 (pl)
EP (1) EP2167523B1 (pl)
CN (3) CN101855231B (pl)
AU (1) AU2008265683B2 (pl)
CA (1) CA2692906C (pl)
CY (1) CY1115525T1 (pl)
DK (1) DK2167523T3 (pl)
EA (1) EA017740B1 (pl)
ES (1) ES2500515T3 (pl)
HK (1) HK1200461A1 (pl)
HR (1) HRP20140771T1 (pl)
PL (1) PL2167523T3 (pl)
PT (1) PT2167523E (pl)
SI (1) SI2167523T1 (pl)
WO (1) WO2008157688A2 (pl)

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CA2692906A1 (en) 2008-12-24
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PT2167523E (pt) 2014-09-22
EP2167523A2 (en) 2010-03-31
DK2167523T3 (da) 2014-09-08
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US20100233757A1 (en) 2010-09-16
CN101855231B (zh) 2014-06-11
EA017740B1 (ru) 2013-02-28
HRP20140771T1 (hr) 2014-11-07
HK1200461A1 (en) 2015-08-07
CN104072561B (zh) 2017-12-22
EP2167523A4 (en) 2011-06-15
WO2008157688A2 (en) 2008-12-24
EA201070030A1 (ru) 2010-06-30
ES2500515T3 (es) 2014-09-30
SI2167523T1 (sl) 2014-09-30
CN104072561A (zh) 2014-10-01
CN107501370A (zh) 2017-12-22
CN101855231A (zh) 2010-10-06
CN107501370B (zh) 2021-06-18
US8153773B2 (en) 2012-04-10
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AU2008265683B2 (en) 2013-08-29
AU2008265683A1 (en) 2008-12-24

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