PL2134360T3 - Oczyszczanie cząstek wirusopodobnych - Google Patents
Oczyszczanie cząstek wirusopodobnychInfo
- Publication number
- PL2134360T3 PL2134360T3 PL08782762T PL08782762T PL2134360T3 PL 2134360 T3 PL2134360 T3 PL 2134360T3 PL 08782762 T PL08782762 T PL 08782762T PL 08782762 T PL08782762 T PL 08782762T PL 2134360 T3 PL2134360 T3 PL 2134360T3
- Authority
- PL
- Poland
- Prior art keywords
- virus
- particle purification
- purification
- particle
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title 1
- 239000002245 particle Substances 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/02—Recovery or purification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/16011—Caliciviridae
- C12N2770/16023—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/16011—Caliciviridae
- C12N2770/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/16011—Caliciviridae
- C12N2770/16051—Methods of production or purification of viral material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Virology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Analytical Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90682107P | 2007-03-14 | 2007-03-14 | |
| PCT/US2008/057072 WO2008113011A2 (en) | 2007-03-14 | 2008-03-14 | Virus like particle purification |
| EP08782762.2A EP2134360B1 (en) | 2007-03-14 | 2008-03-14 | Virus like particle purification |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2134360T3 true PL2134360T3 (pl) | 2016-05-31 |
Family
ID=39760420
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL08782762T PL2134360T3 (pl) | 2007-03-14 | 2008-03-14 | Oczyszczanie cząstek wirusopodobnych |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US8481693B2 (OSRAM) |
| EP (1) | EP2134360B1 (OSRAM) |
| JP (4) | JP5284290B2 (OSRAM) |
| KR (3) | KR20150098681A (OSRAM) |
| AU (1) | AU2008224877B2 (OSRAM) |
| CA (1) | CA2683977C (OSRAM) |
| DK (1) | DK2134360T3 (OSRAM) |
| ES (1) | ES2559421T3 (OSRAM) |
| HU (1) | HUE028605T2 (OSRAM) |
| PL (1) | PL2134360T3 (OSRAM) |
| SG (2) | SG179488A1 (OSRAM) |
| WO (1) | WO2008113011A2 (OSRAM) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007303608B2 (en) | 2006-09-29 | 2013-05-02 | Takeda Vaccines, Inc. | Norovirus vaccine formulations |
| HUE028605T2 (en) | 2007-03-14 | 2016-12-28 | Takeda Vaccines Inc | Cleaning virus-like particles |
| CN101918028B (zh) | 2007-09-18 | 2015-01-07 | 莱戈赛特医药股份有限公司 | 赋予针对诺如病毒的保护性免疫应答的疫苗 |
| US20100266636A1 (en) | 2007-09-18 | 2010-10-21 | Ligocyte Pharmaceuticals, Inc. | Method of conferring a protective immune response to norovirus |
| HUE054940T2 (hu) | 2009-06-16 | 2021-10-28 | Genzyme Corp | Javított eljárások rekombináns AAV-vektorok tisztítására |
| AU2010268694A1 (en) * | 2009-07-03 | 2012-02-09 | The University Of Queensland | A method of preparation of a biological particulate structure |
| US20110142863A1 (en) * | 2009-12-16 | 2011-06-16 | Millipore Corporation | Flow through purification processes for large biomolecules |
| JP5773454B2 (ja) | 2010-01-15 | 2015-09-02 | バイオ−ラッド ラボラトリーズ インコーポレーティッド | アパタイトの表面中和方法 |
| WO2011130119A2 (en) * | 2010-04-14 | 2011-10-20 | Millipore Corporation | Methods of producing high titer, high purity virus stocks and methods of use thereof |
| DE102010046817A1 (de) * | 2010-09-28 | 2012-03-29 | Sartorius Stedim Biotech Gmbh | Verfahren zur Abtrennung von Viren aus einem Kontaminanten enthaltenden flüssigen Medium |
| FI122520B (fi) * | 2010-10-15 | 2012-03-15 | Vesna Blazevic | Noroviruksen kapsidi ja rotaviruksen VP6-proteiini käytettäväksi yhdistelmärokotteena |
| US9592540B2 (en) | 2011-02-02 | 2017-03-14 | Bio-Rad Laboratories, Inc. | Apatite surface neutralization with alkali solutions |
| DK3299030T3 (da) | 2011-07-11 | 2022-09-05 | Takeda Vaccines Inc | Parenterale norovirus-vaccineformuleringer |
| EP2554664A1 (de) * | 2011-08-02 | 2013-02-06 | Life Science Inkubator | Verfahren zur Aufreinigung von Virus-ähnlichen Partikeln (VLP) |
| ES2748039T3 (es) * | 2011-12-30 | 2020-03-12 | Deutsches Krebsforsch | Partículas similares a virus (VLP) de segunda generación a partir de virus de Epstein-Barr para fines de vacunación |
| EP2855501B1 (en) * | 2012-05-30 | 2018-04-25 | Bio-Rad Laboratories, Inc. | In situ restoration of apatite-based chromatography resins |
| JOP20130186B1 (ar) * | 2012-06-22 | 2021-08-17 | Takeda Vaccines Montana Inc | تنقية الجزيئات الشبيهة بالفيروسات |
| EP2958995A4 (en) | 2013-02-22 | 2016-11-23 | Agency Science Tech & Res | CHROMATOGRAPHIC CLEANING OF VIRUS PREPARATIONS WITH NEGATIVELY LOADED PARTICLES |
| JP2015015931A (ja) * | 2013-07-12 | 2015-01-29 | 株式会社Umnファーマ | ウイルス様粒子を含む培養物の製造方法 |
| JP6479305B2 (ja) * | 2013-07-12 | 2019-03-06 | 株式会社Umnファーマ | ウイルス様粒子の精製方法 |
| JP2015017065A (ja) * | 2013-07-12 | 2015-01-29 | 株式会社Umnファーマ | ノロウイルスのウイルス様粒子を含む医薬組成物 |
| AU2014329403B2 (en) | 2013-10-03 | 2020-10-08 | Takeda Vaccines, Inc. | Methods of detection and removal of rhabdoviruses from cell lines |
| EP3157689B1 (en) | 2014-06-23 | 2021-04-28 | Bio-Rad Laboratories, Inc. | Apatite pretreatment |
| WO2015200278A1 (en) | 2014-06-23 | 2015-12-30 | Bio-Rad Laboratories, Inc. | Apatite in-situ restoration |
| CN107603959A (zh) * | 2017-08-30 | 2018-01-19 | 四川大学 | 提高缓冲液盐离子浓度纯化病毒的方法 |
| CN111602050B (zh) * | 2017-12-07 | 2024-04-26 | Emp生物技术股份有限公司 | 应用径向技术色谱的系统和方法 |
| JP6704074B2 (ja) * | 2019-02-04 | 2020-06-03 | 株式会社Umnファーマ | ウイルス様粒子の精製方法 |
| WO2021002257A1 (ja) * | 2019-07-04 | 2021-01-07 | 株式会社カネカ | ウイルスまたはウイルス様粒子の精製方法 |
| WO2022044727A1 (ja) * | 2020-08-28 | 2022-03-03 | 株式会社カネカ | 有用物質の精製方法 |
| CN116348598A (zh) * | 2020-10-05 | 2023-06-27 | 赛多利斯比亚分离有限责任公司 | 通过疏水相互作用色谱法改善dna质粒制剂中rna和污染物的去除 |
| KR20230143161A (ko) * | 2021-02-02 | 2023-10-11 | 니치모 가부시키가이샤 | 태양광 발전 시스템 및 태양광 발전 시스템용 반사체 |
| US20240238401A1 (en) | 2021-05-21 | 2024-07-18 | Takeda Vaccines, Inc. | Solid composition, freeze-drying method and glass vial |
| WO2025077800A1 (en) * | 2023-10-12 | 2025-04-17 | Chengdu Kanghua Biological Products Co., Ltd. | Purification of norovirus virus-like particles (vlps) |
| WO2025077807A1 (en) * | 2023-10-12 | 2025-04-17 | Chengdu Kanghua Biological Products Co., Ltd. | Methods for obtaining high-purity norovirus virus-like particles (vlps) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2833106B2 (ja) | 1990-02-21 | 1998-12-09 | 株式会社島津製作所 | 液体クロマトグラフ |
| WO1994026087A2 (en) | 1993-05-14 | 1994-11-24 | Connor Kim C O | Recombinant protein production and insect cell culture and process |
| SI0757717T1 (sl) * | 1994-05-16 | 2006-08-31 | Merck & Co Inc | Cepivo proti papilomavirusu |
| AR004464A1 (es) | 1994-11-14 | 1998-12-16 | Merck Sharp & Dohme | Un metodo para producir una proteina de capside de papilomavirus |
| JP3316325B2 (ja) | 1994-12-20 | 2002-08-19 | 富士シリシア化学株式会社 | ビール安定化処理用シリカゲル及びその製造方法並びにビールの安定化処理方法 |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| EP0941337B1 (en) | 1996-11-08 | 2009-02-18 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Synthesis and purification of hepatitis c virus-like particles |
| EP1700911B1 (en) * | 1997-09-05 | 2016-04-06 | Medimmune, Inc. | In vitro method for disassembly/reassembly of papillomavirus virus-like particles (VLPs) |
| DE19823814A1 (de) * | 1998-05-27 | 1999-12-02 | Octapharma Ag Ziegelbruecke | Verfahren zur Trennung und/oder Isolierung von Plasmaproteinen mit annularer Chromatographie |
| DE69931053T2 (de) * | 1998-08-14 | 2006-11-23 | Merck & Co., Inc. | Verfahren zur reinigung von menschlichen, dem papillomavirus ähnlichen partikeln. |
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| JP2003066021A (ja) | 2001-08-28 | 2003-03-05 | Hiroshi Shionoya | 連続分取液体クロマトグラフィー装置とそれを用いる方法 |
| AU2003219760A1 (en) * | 2002-02-14 | 2003-09-04 | Novavax, Inc. | Optimization of gene sequences of virus-like particles for expression in insect cells |
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| WO2004020971A2 (en) | 2002-08-28 | 2004-03-11 | Introgen Therapeutics Inc. | Chromatographic methods for adenovirus purification |
| US7879338B2 (en) * | 2003-07-21 | 2011-02-01 | Boyce Thompson Institute For Plant Research | Vectors and methods for immunization against norovirus using transgenic plants |
| US7481997B1 (en) * | 2004-02-12 | 2009-01-27 | Montana State University | Snow mountain virus genome sequence, virus-like particles and methods of use |
| WO2006138514A2 (en) * | 2005-06-16 | 2006-12-28 | Children's Hospital Medical Center | Novel norovirus particle for use as an antiviral or vaccine |
| EP1736538A1 (en) * | 2005-06-21 | 2006-12-27 | Cytos Biotechnology AG | Process for the preparative purification of virus-like-particles (VLPs) |
| US7527801B2 (en) * | 2005-11-22 | 2009-05-05 | Novartis Vaccines And Diagnostics, Inc. | Norovirus and Sapovirus antigens |
| CN102698263B (zh) | 2005-12-29 | 2016-07-06 | 贝林格尔.英格海姆维特梅迪卡有限公司 | 多价pcv2免疫原性组合物和制备此类组合物的方法 |
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| EP2235165A1 (en) | 2007-12-21 | 2010-10-06 | Cytos Biotechnology AG | Process for clarifying cell homogenates |
| JP5852883B2 (ja) * | 2008-08-08 | 2016-02-03 | タケダ ワクチン,インコーポレイテッド | 交差反応性の増強のための複合カプシドアミノ酸配列を含むウイルス様粒子 |
| JP5683476B2 (ja) | 2008-11-03 | 2015-03-11 | タケダ ヴァクシーンズ, インコーポレイテッド | 感染因子を含まないエンベロープウイルスベースvlpを単離するための改良法 |
| US8945895B2 (en) | 2009-07-31 | 2015-02-03 | Baxter International Inc. | Methods of purifying recombinant ADAMTS13 and other proteins and compositions thereof |
| EP2525816A4 (en) * | 2010-01-21 | 2013-10-02 | Ligocyte Pharmaceuticals Inc | PRESENTATION OF TARGETED HETEROLOGOUS ANTIGENS ON CALICIVIRUS VIRAL PSEUDO PARTICLES |
| US9193760B2 (en) | 2010-09-20 | 2015-11-24 | Bio-Rad Laboratories, Inc. | Dissociation of product-complexed contaminants in chromatography |
| FI122520B (fi) | 2010-10-15 | 2012-03-15 | Vesna Blazevic | Noroviruksen kapsidi ja rotaviruksen VP6-proteiini käytettäväksi yhdistelmärokotteena |
| CN102260651A (zh) | 2011-06-24 | 2011-11-30 | 华中科技大学同济医学院附属协和医院 | 一种纯化病毒样颗粒蛋白的方法及其应用 |
| JOP20130186B1 (ar) | 2012-06-22 | 2021-08-17 | Takeda Vaccines Montana Inc | تنقية الجزيئات الشبيهة بالفيروسات |
| JP2015015931A (ja) | 2013-07-12 | 2015-01-29 | 株式会社Umnファーマ | ウイルス様粒子を含む培養物の製造方法 |
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2008
- 2008-03-14 HU HUE08782762A patent/HUE028605T2/en unknown
- 2008-03-14 US US12/531,248 patent/US8481693B2/en active Active
- 2008-03-14 PL PL08782762T patent/PL2134360T3/pl unknown
- 2008-03-14 SG SG2012018131A patent/SG179488A1/en unknown
- 2008-03-14 EP EP08782762.2A patent/EP2134360B1/en active Active
- 2008-03-14 KR KR1020157020558A patent/KR20150098681A/ko not_active Ceased
- 2008-03-14 AU AU2008224877A patent/AU2008224877B2/en active Active
- 2008-03-14 ES ES08782762.2T patent/ES2559421T3/es active Active
- 2008-03-14 KR KR1020167036031A patent/KR20170001720A/ko not_active Ceased
- 2008-03-14 KR KR1020097021421A patent/KR101576219B1/ko active Active
- 2008-03-14 SG SG10201701988TA patent/SG10201701988TA/en unknown
- 2008-03-14 DK DK08782762.2T patent/DK2134360T3/en active
- 2008-03-14 JP JP2009553820A patent/JP5284290B2/ja active Active
- 2008-03-14 CA CA2683977A patent/CA2683977C/en active Active
- 2008-03-14 WO PCT/US2008/057072 patent/WO2008113011A2/en not_active Ceased
-
2013
- 2013-05-29 JP JP2013112580A patent/JP2013176392A/ja active Pending
- 2013-06-10 US US13/914,331 patent/US9359410B2/en active Active
-
2016
- 2016-05-02 US US15/144,265 patent/US10172930B2/en active Active
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2017
- 2017-02-23 JP JP2017032171A patent/JP2017086090A/ja active Pending
-
2018
- 2018-12-07 US US16/213,297 patent/US10792353B2/en active Active
-
2019
- 2019-01-07 JP JP2019000688A patent/JP2019068846A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR20170001720A (ko) | 2017-01-04 |
| AU2008224877B2 (en) | 2013-07-11 |
| KR20100015562A (ko) | 2010-02-12 |
| JP2010530734A (ja) | 2010-09-16 |
| US20160317645A1 (en) | 2016-11-03 |
| EP2134360B1 (en) | 2015-11-18 |
| EP2134360A2 (en) | 2009-12-23 |
| SG10201701988TA (en) | 2017-04-27 |
| WO2008113011A3 (en) | 2008-12-24 |
| JP2017086090A (ja) | 2017-05-25 |
| JP5284290B2 (ja) | 2013-09-11 |
| CA2683977A1 (en) | 2008-09-18 |
| EP2134360A4 (en) | 2011-08-24 |
| HK1138795A1 (zh) | 2010-09-03 |
| US8481693B2 (en) | 2013-07-09 |
| US9359410B2 (en) | 2016-06-07 |
| WO2008113011A2 (en) | 2008-09-18 |
| SG179488A1 (en) | 2012-04-27 |
| ES2559421T3 (es) | 2016-02-12 |
| KR101576219B1 (ko) | 2015-12-10 |
| US10792353B2 (en) | 2020-10-06 |
| JP2013176392A (ja) | 2013-09-09 |
| KR20150098681A (ko) | 2015-08-28 |
| US20190282686A1 (en) | 2019-09-19 |
| DK2134360T3 (en) | 2016-02-22 |
| US10172930B2 (en) | 2019-01-08 |
| AU2008224877A1 (en) | 2008-09-18 |
| US20130344107A1 (en) | 2013-12-26 |
| JP2019068846A (ja) | 2019-05-09 |
| CA2683977C (en) | 2017-04-25 |
| US20100150961A1 (en) | 2010-06-17 |
| HUE028605T2 (en) | 2016-12-28 |
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