PL206023B1 - Kompozycja do pielęgnacji jamy ustnej i jej zastosowanie - Google Patents
Kompozycja do pielęgnacji jamy ustnej i jej zastosowanieInfo
- Publication number
- PL206023B1 PL206023B1 PL355965A PL35596500A PL206023B1 PL 206023 B1 PL206023 B1 PL 206023B1 PL 355965 A PL355965 A PL 355965A PL 35596500 A PL35596500 A PL 35596500A PL 206023 B1 PL206023 B1 PL 206023B1
- Authority
- PL
- Poland
- Prior art keywords
- tin
- composition
- fluoride
- ions
- compositions
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 340
- IUTCEZPPWBHGIX-UHFFFAOYSA-N tin(2+) Chemical compound [Sn+2] IUTCEZPPWBHGIX-UHFFFAOYSA-N 0.000 claims abstract description 83
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims abstract description 39
- 238000000034 method Methods 0.000 claims abstract description 30
- 230000009467 reduction Effects 0.000 claims abstract description 19
- -1 tin (II) ions Chemical class 0.000 claims description 131
- DAOANAATJZWTSJ-UHFFFAOYSA-N N-Decanoylmorpholine Chemical compound CCCCCCCCCC(=O)N1CCOCC1 DAOANAATJZWTSJ-UHFFFAOYSA-N 0.000 claims description 71
- 229920000388 Polyphosphate Polymers 0.000 claims description 46
- 239000001205 polyphosphate Substances 0.000 claims description 46
- 235000011176 polyphosphates Nutrition 0.000 claims description 46
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 40
- 229910019142 PO4 Inorganic materials 0.000 claims description 21
- 239000010452 phosphate Substances 0.000 claims description 19
- 235000011180 diphosphates Nutrition 0.000 claims description 17
- 208000007565 gingivitis Diseases 0.000 claims description 16
- 230000000845 anti-microbial effect Effects 0.000 claims description 15
- 150000001875 compounds Chemical class 0.000 claims description 15
- 150000002500 ions Chemical class 0.000 claims description 14
- 239000004599 antimicrobial Substances 0.000 claims description 12
- 229910052783 alkali metal Inorganic materials 0.000 claims description 10
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical class OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 claims description 6
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims description 6
- VVYPIVJZLVJPGU-UHFFFAOYSA-L copper;2-aminoacetate Chemical compound [Cu+2].NCC([O-])=O.NCC([O-])=O VVYPIVJZLVJPGU-UHFFFAOYSA-L 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 229920001983 poloxamer Polymers 0.000 claims description 5
- GZNAASVAJNXPPW-UHFFFAOYSA-M tin(4+) chloride dihydrate Chemical compound O.O.[Cl-].[Sn+4] GZNAASVAJNXPPW-UHFFFAOYSA-M 0.000 claims description 5
- FWPIDFUJEMBDLS-UHFFFAOYSA-L tin(II) chloride dihydrate Substances O.O.Cl[Sn]Cl FWPIDFUJEMBDLS-UHFFFAOYSA-L 0.000 claims description 5
- CANRESZKMUPMAE-UHFFFAOYSA-L Zinc lactate Chemical compound [Zn+2].CC(O)C([O-])=O.CC(O)C([O-])=O CANRESZKMUPMAE-UHFFFAOYSA-L 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 3
- 229960000502 poloxamer Drugs 0.000 claims description 3
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 claims description 3
- 239000011746 zinc citrate Substances 0.000 claims description 3
- 235000006076 zinc citrate Nutrition 0.000 claims description 3
- 229940068475 zinc citrate Drugs 0.000 claims description 3
- 239000011576 zinc lactate Substances 0.000 claims description 3
- 235000000193 zinc lactate Nutrition 0.000 claims description 3
- 229940050168 zinc lactate Drugs 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 abstract description 57
- 239000000551 dentifrice Substances 0.000 abstract description 56
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract description 45
- 239000011707 mineral Substances 0.000 abstract description 45
- 230000000694 effects Effects 0.000 abstract description 35
- 208000006558 Dental Calculus Diseases 0.000 abstract description 26
- 235000019606 astringent taste Nutrition 0.000 abstract description 17
- 230000001225 therapeutic effect Effects 0.000 abstract description 12
- 150000003839 salts Chemical class 0.000 abstract description 8
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 abstract description 3
- 230000036344 tooth staining Effects 0.000 abstract description 3
- 229960002799 stannous fluoride Drugs 0.000 abstract 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 44
- 235000010755 mineral Nutrition 0.000 description 43
- 238000009472 formulation Methods 0.000 description 41
- 229940091249 fluoride supplement Drugs 0.000 description 36
- 208000004509 Tooth Discoloration Diseases 0.000 description 27
- 206010044032 Tooth discolouration Diseases 0.000 description 27
- 230000036367 tooth discoloration Effects 0.000 description 27
- 238000009739 binding Methods 0.000 description 26
- 238000002360 preparation method Methods 0.000 description 25
- 238000012360 testing method Methods 0.000 description 24
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 22
- 239000003795 chemical substances by application Substances 0.000 description 22
- 239000000377 silicon dioxide Substances 0.000 description 22
- 229920000642 polymer Polymers 0.000 description 21
- 239000000243 solution Substances 0.000 description 21
- 235000021317 phosphate Nutrition 0.000 description 20
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 18
- 239000000463 material Substances 0.000 description 16
- 238000002156 mixing Methods 0.000 description 16
- 238000002845 discoloration Methods 0.000 description 15
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 15
- 230000008901 benefit Effects 0.000 description 14
- 210000000214 mouth Anatomy 0.000 description 14
- 230000002829 reductive effect Effects 0.000 description 14
- 239000004615 ingredient Substances 0.000 description 13
- 239000000047 product Substances 0.000 description 13
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- 230000015572 biosynthetic process Effects 0.000 description 12
- 239000000796 flavoring agent Substances 0.000 description 12
- 235000019634 flavors Nutrition 0.000 description 12
- 239000003082 abrasive agent Substances 0.000 description 11
- 235000011187 glycerol Nutrition 0.000 description 11
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 11
- 238000010186 staining Methods 0.000 description 11
- 239000000126 substance Substances 0.000 description 11
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical group OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 description 10
- 230000001680 brushing effect Effects 0.000 description 10
- 238000005259 measurement Methods 0.000 description 10
- 239000006072 paste Substances 0.000 description 10
- 150000002978 peroxides Chemical class 0.000 description 10
- 239000000725 suspension Substances 0.000 description 10
- 239000000606 toothpaste Substances 0.000 description 10
- 239000006172 buffering agent Substances 0.000 description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
- 239000004408 titanium dioxide Substances 0.000 description 9
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 8
- 229920001577 copolymer Polymers 0.000 description 8
- 238000005498 polishing Methods 0.000 description 8
- 229920001223 polyethylene glycol Polymers 0.000 description 8
- 239000011734 sodium Substances 0.000 description 8
- 239000002562 thickening agent Substances 0.000 description 8
- 230000000052 comparative effect Effects 0.000 description 7
- 239000002537 cosmetic Substances 0.000 description 7
- 239000000499 gel Substances 0.000 description 7
- 210000003296 saliva Anatomy 0.000 description 7
- 229910052708 sodium Inorganic materials 0.000 description 7
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 7
- 229940034610 toothpaste Drugs 0.000 description 7
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 6
- 238000002835 absorbance Methods 0.000 description 6
- 229920006318 anionic polymer Polymers 0.000 description 6
- 239000011230 binding agent Substances 0.000 description 6
- 125000004432 carbon atom Chemical group C* 0.000 description 6
- 208000002925 dental caries Diseases 0.000 description 6
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 6
- 239000000080 wetting agent Substances 0.000 description 6
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 5
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 5
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 5
- 244000269722 Thea sinensis Species 0.000 description 5
- 239000002253 acid Substances 0.000 description 5
- 239000003945 anionic surfactant Substances 0.000 description 5
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 5
- 230000033558 biomineral tissue development Effects 0.000 description 5
- 238000004140 cleaning Methods 0.000 description 5
- 239000003086 colorant Substances 0.000 description 5
- 150000002222 fluorine compounds Chemical class 0.000 description 5
- 239000002736 nonionic surfactant Substances 0.000 description 5
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 5
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 5
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 5
- 239000011775 sodium fluoride Substances 0.000 description 5
- 235000013024 sodium fluoride Nutrition 0.000 description 5
- 239000000600 sorbitol Substances 0.000 description 5
- AEQDJSLRWYMAQI-UHFFFAOYSA-N 2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline Chemical compound C1CN2CC(C(=C(OC)C=C3)OC)=C3CC2C2=C1C=C(OC)C(OC)=C2 AEQDJSLRWYMAQI-UHFFFAOYSA-N 0.000 description 4
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 4
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical group C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 4
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 4
- 229910021626 Tin(II) chloride Inorganic materials 0.000 description 4
- 239000002280 amphoteric surfactant Substances 0.000 description 4
- 125000000129 anionic group Chemical group 0.000 description 4
- 239000008365 aqueous carrier Substances 0.000 description 4
- 239000001506 calcium phosphate Substances 0.000 description 4
- 239000001768 carboxy methyl cellulose Substances 0.000 description 4
- 230000003750 conditioning effect Effects 0.000 description 4
- XQRLCLUYWUNEEH-UHFFFAOYSA-N diphosphonic acid Chemical compound OP(=O)OP(O)=O XQRLCLUYWUNEEH-UHFFFAOYSA-N 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 4
- 239000011521 glass Substances 0.000 description 4
- 230000006872 improvement Effects 0.000 description 4
- 238000000338 in vitro Methods 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
- 235000019198 oils Nutrition 0.000 description 4
- 239000000176 sodium gluconate Substances 0.000 description 4
- 235000012207 sodium gluconate Nutrition 0.000 description 4
- 229940005574 sodium gluconate Drugs 0.000 description 4
- 235000011121 sodium hydroxide Nutrition 0.000 description 4
- 235000019832 sodium triphosphate Nutrition 0.000 description 4
- 230000000087 stabilizing effect Effects 0.000 description 4
- 235000011150 stannous chloride Nutrition 0.000 description 4
- 239000005720 sucrose Substances 0.000 description 4
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 4
- 229960003500 triclosan Drugs 0.000 description 4
- 229920001285 xanthan gum Polymers 0.000 description 4
- 239000000230 xanthan gum Substances 0.000 description 4
- 235000010493 xanthan gum Nutrition 0.000 description 4
- 229940082509 xanthan gum Drugs 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- PNEYBMLMFCGWSK-UHFFFAOYSA-N Alumina Chemical class [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 3
- 239000005711 Benzoic acid Substances 0.000 description 3
- 239000002028 Biomass Substances 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 3
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
- 229930006000 Sucrose Natural products 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 125000000217 alkyl group Chemical group 0.000 description 3
- 230000002882 anti-plaque Effects 0.000 description 3
- 238000003556 assay Methods 0.000 description 3
- 235000010233 benzoic acid Nutrition 0.000 description 3
- 230000002051 biphasic effect Effects 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
- 229910052791 calcium Inorganic materials 0.000 description 3
- 229910000389 calcium phosphate Inorganic materials 0.000 description 3
- 235000011010 calcium phosphates Nutrition 0.000 description 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 3
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 3
- 239000000969 carrier Substances 0.000 description 3
- 239000004359 castor oil Substances 0.000 description 3
- 235000019438 castor oil Nutrition 0.000 description 3
- 229940112822 chewing gum Drugs 0.000 description 3
- 235000015218 chewing gum Nutrition 0.000 description 3
- 229960004106 citric acid Drugs 0.000 description 3
- 210000003298 dental enamel Anatomy 0.000 description 3
- 229940023487 dental product Drugs 0.000 description 3
- 229940088598 enzyme Drugs 0.000 description 3
- 235000003599 food sweetener Nutrition 0.000 description 3
- 239000003205 fragrance Substances 0.000 description 3
- 229940050410 gluconate Drugs 0.000 description 3
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 3
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 3
- 238000011065 in-situ storage Methods 0.000 description 3
- 230000003993 interaction Effects 0.000 description 3
- 239000007937 lozenge Substances 0.000 description 3
- 230000004060 metabolic process Effects 0.000 description 3
- 239000000178 monomer Substances 0.000 description 3
- 239000002324 mouth wash Substances 0.000 description 3
- 239000013588 oral product Substances 0.000 description 3
- 239000007935 oral tablet Substances 0.000 description 3
- 150000007524 organic acids Chemical class 0.000 description 3
- 229920001523 phosphate polymer Polymers 0.000 description 3
- 230000007505 plaque formation Effects 0.000 description 3
- 229920001992 poloxamer 407 Polymers 0.000 description 3
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- 239000013641 positive control Substances 0.000 description 3
- 238000001556 precipitation Methods 0.000 description 3
- 230000009257 reactivity Effects 0.000 description 3
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 3
- 239000004299 sodium benzoate Substances 0.000 description 3
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- 239000003765 sweetening agent Substances 0.000 description 3
- 230000008719 thickening Effects 0.000 description 3
- OBBXFSIWZVFYJR-UHFFFAOYSA-L tin(2+);sulfate Chemical compound [Sn+2].[O-]S([O-])(=O)=O OBBXFSIWZVFYJR-UHFFFAOYSA-L 0.000 description 3
- 229910000375 tin(II) sulfate Inorganic materials 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 229940042129 topical gel Drugs 0.000 description 3
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
- 206010006326 Breath odour Diseases 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 239000004343 Calcium peroxide Substances 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- VUNOFAIHSALQQH-UHFFFAOYSA-N Ethyl menthane carboxamide Chemical compound CCNC(=O)C1CC(C)CCC1C(C)C VUNOFAIHSALQQH-UHFFFAOYSA-N 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 125000001931 aliphatic group Chemical group 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- LHJQIRIGXXHNLA-UHFFFAOYSA-N calcium peroxide Chemical compound [Ca+2].[O-][O-] LHJQIRIGXXHNLA-UHFFFAOYSA-N 0.000 description 2
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- 229940043256 calcium pyrophosphate Drugs 0.000 description 2
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- 125000002091 cationic group Chemical group 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 230000002925 chemical effect Effects 0.000 description 2
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- 238000006731 degradation reaction Methods 0.000 description 2
- 210000004268 dentin Anatomy 0.000 description 2
- 201000002170 dentin sensitivity Diseases 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- XQRLCLUYWUNEEH-UHFFFAOYSA-L diphosphonate(2-) Chemical group [O-]P(=O)OP([O-])=O XQRLCLUYWUNEEH-UHFFFAOYSA-L 0.000 description 2
- 206010013781 dry mouth Diseases 0.000 description 2
- 239000000975 dye Substances 0.000 description 2
- CBOQJANXLMLOSS-UHFFFAOYSA-N ethyl vanillin Chemical group CCOC1=CC(C=O)=CC=C1O CBOQJANXLMLOSS-UHFFFAOYSA-N 0.000 description 2
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
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- 230000034659 glycolysis Effects 0.000 description 2
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- 150000004679 hydroxides Chemical class 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 239000003446 ligand Substances 0.000 description 2
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 2
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 2
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 2
- 229940041678 oral spray Drugs 0.000 description 2
- 239000000668 oral spray Substances 0.000 description 2
- 208000028169 periodontal disease Diseases 0.000 description 2
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 description 2
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 2
- 229940068196 placebo Drugs 0.000 description 2
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Landscapes
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- Birds (AREA)
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- Emergency Medicine (AREA)
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- Engineering & Computer Science (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16535099P | 1999-11-12 | 1999-11-12 | |
| PCT/US2000/030809 WO2001034108A1 (en) | 1999-11-12 | 2000-11-10 | Improved stannous oral compositions |
Publications (2)
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|---|---|
| PL355965A1 PL355965A1 (en) | 2004-05-31 |
| PL206023B1 true PL206023B1 (pl) | 2010-06-30 |
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| Application Number | Title | Priority Date | Filing Date |
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| PL355965A PL206023B1 (pl) | 1999-11-12 | 2000-11-10 | Kompozycja do pielęgnacji jamy ustnej i jej zastosowanie |
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| Country | Link |
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| US (3) | US6555094B1 (https=) |
| EP (2) | EP2238965A1 (https=) |
| JP (1) | JP3860471B2 (https=) |
| CN (1) | CN1200685C (https=) |
| AT (1) | ATE476955T1 (https=) |
| AU (1) | AU1479301A (https=) |
| CA (1) | CA2389174C (https=) |
| DE (1) | DE60044819D1 (https=) |
| ES (1) | ES2350177T3 (https=) |
| HK (1) | HK1049611A1 (https=) |
| MX (1) | MXPA02004787A (https=) |
| PL (1) | PL206023B1 (https=) |
| RU (1) | RU2219902C1 (https=) |
| WO (1) | WO2001034108A1 (https=) |
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| US20030206874A1 (en) * | 1996-11-21 | 2003-11-06 | The Proctor & Gamble Company | Promoting whole body health |
| US20060171907A1 (en) * | 1996-11-21 | 2006-08-03 | The Procter & Gamble Company | Oral care compositions providing enhanced whitening and stain prevention |
| US6350436B1 (en) | 1996-11-21 | 2002-02-26 | The Procter & Gamble Company | Method of reducing staining of stannous in dentifrice compositions |
| US20040146466A1 (en) * | 1999-11-12 | 2004-07-29 | The Procter & Gamble Company | Method of protecting teeth against erosion |
| ES2350177T3 (es) * | 1999-11-12 | 2011-01-19 | THE PROCTER & GAMBLE COMPANY | Composiciones orales que contienen iones estannosos. |
| US6685920B2 (en) * | 1999-11-12 | 2004-02-03 | The Procter & Gamble Company | Method of protecting teeth against erosion |
| US7387774B2 (en) * | 1999-11-12 | 2008-06-17 | The Procter & Gamble Co. | Method of enhancing fluoridation and mineralization of teeth |
| US10470985B2 (en) | 1999-11-12 | 2019-11-12 | The Procter & Gamble Company | Method of protecting teeth against erosion |
| US20070025928A1 (en) * | 1999-11-12 | 2007-02-01 | The Procter & Gamble Company | Stannous oral care compositions |
| JP2003526649A (ja) * | 2000-03-14 | 2003-09-09 | ザ、プロクター、エンド、ギャンブル、カンパニー | ポリホスフェート、フッ化物及びスズ（ｉｉ）塩を含む安定な歯磨き組成物 |
| US8283135B2 (en) * | 2000-06-30 | 2012-10-09 | The Procter & Gamble Company | Oral care compositions containing combinations of anti-bacterial and host-response modulating agents |
| US6685921B2 (en) | 2000-10-25 | 2004-02-03 | The Procter & Gamble Company | Dental care compositions |
| US20040115247A1 (en) * | 2001-01-12 | 2004-06-17 | Melman Steven A. | Multi-functional dental composition |
| ES2346856T3 (es) | 2001-11-28 | 2010-10-21 | THE PROCTER & GAMBLE COMPANY | Composiciones de dentifrico. |
| US20040029842A1 (en) * | 2001-12-18 | 2004-02-12 | Gardner Wallace J. | Triglyceride lowering, common cold and pneumonia prevention composition comprising tetracycline, and methods of treating or preventing diseases using same |
| CN100534413C (zh) * | 2001-12-25 | 2009-09-02 | 花王株式会社 | 口腔用组合物 |
| US6890182B2 (en) * | 2002-07-25 | 2005-05-10 | The Procter & Gamble Company | Method and apparatus for the selection of oral care chemistry |
| AU2002950426A0 (en) * | 2002-07-29 | 2002-09-12 | Patrick John Shanahan | Anti microbial oro-dental system |
| US6692726B1 (en) * | 2003-02-11 | 2004-02-17 | Colgate Palmolive Company | Enzyme containing oral composition having enhanced stability |
| US20050079187A1 (en) * | 2003-10-14 | 2005-04-14 | Gardner Wallace J. | Composition, kit and method for reducing plaque formation, tooth decay and incidence of caries |
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| US5780015A (en) | 1997-05-14 | 1998-07-14 | Colgate Palmolive Company | Dentifrice for the treatment of dentinal hypersensitivity having limited astringency |
| US5948390A (en) | 1997-08-25 | 1999-09-07 | Pfizer Inc. | Stable zinc/citrate/CPC oral rinse formulations |
| US5814303A (en) | 1997-09-17 | 1998-09-29 | Chesebrough-Pond's Usa Co., Division Of Conocpo, Inc. | Dental product |
| US6120754A (en) * | 1998-03-11 | 2000-09-19 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Remineralization of teeth |
| AU761437B2 (en) | 1998-11-30 | 2003-06-05 | Procter & Gamble Company, The | Method of reducing staining of stannous in dentifrice compositions |
| US6207139B1 (en) * | 1999-04-16 | 2001-03-27 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Anti-tartar dental product and related method |
| CA2387956C (en) * | 1999-11-12 | 2007-02-06 | The Procter & Gamble Company | Improved dual phase stannous oral compositions |
| ES2350177T3 (es) * | 1999-11-12 | 2011-01-19 | THE PROCTER & GAMBLE COMPANY | Composiciones orales que contienen iones estannosos. |
-
2000
- 2000-11-10 ES ES00977110T patent/ES2350177T3/es not_active Expired - Lifetime
- 2000-11-10 EP EP10171585A patent/EP2238965A1/en not_active Withdrawn
- 2000-11-10 WO PCT/US2000/030809 patent/WO2001034108A1/en not_active Ceased
- 2000-11-10 HK HK03100347.7A patent/HK1049611A1/zh unknown
- 2000-11-10 DE DE60044819T patent/DE60044819D1/de not_active Expired - Lifetime
- 2000-11-10 CN CNB008182701A patent/CN1200685C/zh not_active Expired - Lifetime
- 2000-11-10 US US09/710,440 patent/US6555094B1/en not_active Expired - Lifetime
- 2000-11-10 RU RU2002115627/15A patent/RU2219902C1/ru active
- 2000-11-10 AT AT00977110T patent/ATE476955T1/de not_active IP Right Cessation
- 2000-11-10 JP JP2001536109A patent/JP3860471B2/ja not_active Expired - Lifetime
- 2000-11-10 PL PL355965A patent/PL206023B1/pl unknown
- 2000-11-10 AU AU14793/01A patent/AU1479301A/en not_active Abandoned
- 2000-11-10 EP EP00977110A patent/EP1227788B1/en not_active Revoked
- 2000-11-10 MX MXPA02004787A patent/MXPA02004787A/es active IP Right Grant
- 2000-11-10 CA CA002389174A patent/CA2389174C/en not_active Expired - Lifetime
-
2003
- 2003-01-24 US US10/351,205 patent/US6821507B2/en not_active Expired - Lifetime
-
2004
- 2004-10-28 US US10/975,963 patent/US20050112070A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN1200685C (zh) | 2005-05-11 |
| US6555094B1 (en) | 2003-04-29 |
| EP1227788A1 (en) | 2002-08-07 |
| US6821507B2 (en) | 2004-11-23 |
| JP3860471B2 (ja) | 2006-12-20 |
| US20050112070A1 (en) | 2005-05-26 |
| JP2003513899A (ja) | 2003-04-15 |
| EP2238965A1 (en) | 2010-10-13 |
| ATE476955T1 (de) | 2010-08-15 |
| RU2002115627A (ru) | 2004-01-27 |
| AU1479301A (en) | 2001-06-06 |
| ES2350177T3 (es) | 2011-01-19 |
| US20030152527A1 (en) | 2003-08-14 |
| WO2001034108A1 (en) | 2001-05-17 |
| CN1420757A (zh) | 2003-05-28 |
| RU2219902C1 (ru) | 2003-12-27 |
| CA2389174A1 (en) | 2001-05-17 |
| CA2389174C (en) | 2007-01-23 |
| DE60044819D1 (de) | 2010-09-23 |
| EP1227788B1 (en) | 2010-08-11 |
| HK1049611A1 (zh) | 2003-05-23 |
| MXPA02004787A (es) | 2002-08-30 |
| PL355965A1 (en) | 2004-05-31 |
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| Date | Code | Title | Description |
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| RECP | Rectifications of patent specification |