PL1926712T3 - 6-PODSTAWIONE 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINY JAKO AGONIŚCI RECEPTORA 5-HT2c - Google Patents
6-PODSTAWIONE 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINY JAKO AGONIŚCI RECEPTORA 5-HT2cInfo
- Publication number
- PL1926712T3 PL1926712T3 PL06802904T PL06802904T PL1926712T3 PL 1926712 T3 PL1926712 T3 PL 1926712T3 PL 06802904 T PL06802904 T PL 06802904T PL 06802904 T PL06802904 T PL 06802904T PL 1926712 T3 PL1926712 T3 PL 1926712T3
- Authority
- PL
- Poland
- Prior art keywords
- sup
- sub
- substituted
- azepines
- benzo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71358405P | 2005-09-01 | 2005-09-01 | |
| PCT/US2006/034430 WO2007028131A1 (fr) | 2005-09-01 | 2006-09-01 | 2,3,4,5-TÉTRAHYDRO-1H-BENZO[d]AZÉPINES SUBSTITUÉS EN POSITION 6 EN TANT QU’AGONISTES DU RÉCEPTEUR DE 5-HT2C |
| EP06802904A EP1926712B1 (fr) | 2005-09-01 | 2006-09-01 | 2,3,4,5-tétrahydro-1h-benzo[d]azépines substitués en position 6 en tant qu agonistes du récepteur de 5-ht2c |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1926712T3 true PL1926712T3 (pl) | 2009-12-31 |
Family
ID=37499390
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL06802904T PL1926712T3 (pl) | 2005-09-01 | 2006-09-01 | 6-PODSTAWIONE 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINY JAKO AGONIŚCI RECEPTORA 5-HT2c |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8420631B2 (fr) |
| EP (1) | EP1926712B1 (fr) |
| JP (1) | JP5237810B2 (fr) |
| CN (1) | CN101253153A (fr) |
| AT (1) | ATE437859T1 (fr) |
| AU (1) | AU2006287160B2 (fr) |
| BR (1) | BRPI0615033A2 (fr) |
| CA (1) | CA2619287C (fr) |
| CY (1) | CY1110486T1 (fr) |
| DE (1) | DE602006008155D1 (fr) |
| DK (1) | DK1926712T3 (fr) |
| ES (1) | ES2328408T3 (fr) |
| MX (1) | MX2008002180A (fr) |
| PL (1) | PL1926712T3 (fr) |
| PT (1) | PT1926712E (fr) |
| SI (1) | SI1926712T1 (fr) |
| WO (1) | WO2007028131A1 (fr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2619450C (fr) * | 2005-09-01 | 2013-10-22 | Eli Lilly And Company | 2,3,4,5-tetrahydro-1h-benzo[d]azepines substituees par un heterocycle a liaison 6-n en tant qu'agonistes de recepteur 5-ht2c |
| DK1924560T3 (da) * | 2005-09-01 | 2009-10-19 | Lilly Co Eli | 6-substituerede-2,3,4,5-tetrahydro-1H-benzo[d]azepiner som 5-HT2C-receptoragonister |
| ES2397400T3 (es) * | 2005-09-01 | 2013-03-06 | Eli Lilly & Company | 6-arilalquilamino-2,3,4,5-tetrahidro-1H-benzo[D]azepinas como agonistas del receptor 5-HT2C |
| US8158617B2 (en) | 2006-05-16 | 2012-04-17 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compound and use thereof |
| US7897595B2 (en) | 2006-05-26 | 2011-03-01 | Forest Laboratories Holdings Limited | Pyridoazepine derivatives |
| WO2009063992A1 (fr) | 2007-11-15 | 2009-05-22 | Takeda Pharmaceutical Company Limited | Dérivé de pyridine condensé et son utilisation |
| CN101684096A (zh) * | 2008-09-23 | 2010-03-31 | 中国科学院上海药物研究所 | 一类新型苯并氮杂卓类化合物及其制备方法和用途 |
| KR101768234B1 (ko) | 2009-06-15 | 2017-08-14 | 다케다 야쿠힌 고교 가부시키가이샤 | 피라지노옥사제핀 유도체 |
| CA2808904A1 (fr) * | 2010-09-01 | 2012-03-08 | Arena Pharmaceuticals, Inc. | Sels non hygroscopiques d'agonistes de 5-ht2c |
| KR20130138768A (ko) * | 2010-09-01 | 2013-12-19 | 아레나 파마슈티칼스, 인크. | 5-ｈｔ2ｃ 아고니스트의 신속-용해성 투여 형태 |
| CA2808909A1 (fr) * | 2010-09-01 | 2012-03-08 | Arena Pharmaceuticals, Inc. | Sels de lorcaserine dotes d'acides optiquement actifs |
| US20130267500A1 (en) | 2010-09-01 | 2013-10-10 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists in the treatment of disorders ameliorated by reduction of norepinephrine level |
| JP6440625B2 (ja) | 2012-11-14 | 2018-12-19 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 精神分裂病を処置するための方法および組成物 |
| WO2015066344A1 (fr) | 2013-11-01 | 2015-05-07 | Arena Pharmaceuticals, Inc. | Agonistes du récepteur 5-ht2c et compositions et procédés d'utilisation |
| EP3733204A4 (fr) | 2017-12-27 | 2021-09-15 | Takeda Pharmaceutical Company Limited | Agent thérapeutique pour incontinence urinaire de stress et incontinence fécale |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4265890A (en) | 1978-07-07 | 1981-05-05 | Smithkline Corporation | 6-Phenyl thio- and 6-cyclohexyl thio-2,3,4,5-tetrahydro-1H-3-benzazepines |
| EP0285287A3 (fr) | 1987-03-23 | 1990-08-16 | Smithkline Beecham Corporation | Emploi de 3-benzazépines pour le traitement des troubles de la mobilité gastro-intestinale |
| US4985352A (en) | 1988-02-29 | 1991-01-15 | The Trustees Of Columbia University In The City Of New York | DNA encoding serotonin 1C (5HT1c) receptor, isolated 5HT1c receptor, mammalian cells expressing same and uses thereof |
| GB9116824D0 (en) | 1991-08-05 | 1991-09-18 | Smithkline Beecham Corp | Chemical compounds |
| US5639748A (en) | 1991-08-05 | 1997-06-17 | Smithkline Beecham Corporation | 6,9-disubstituted benzazepines having α-adrenoceptor blocking activity |
| EP0562118B1 (fr) | 1991-09-11 | 1998-03-04 | Canon Kabushiki Kaisha | Element de nettoyage ameliore pour tete de jet d'encre et dispositif a jet d'encre equipe d'un tel element de nettoyage |
| GB9119467D0 (en) * | 1991-09-12 | 1991-10-23 | Smithkline Beecham Corp | Chemical compounds |
| US5698766A (en) | 1995-04-05 | 1997-12-16 | The Regents Of The University Of California | Transgenic animal model for testing drugs for treating eating disorders and epilepsy |
| JP2002371059A (ja) * | 2000-05-16 | 2002-12-26 | Takeda Chem Ind Ltd | メラニン凝集ホルモン拮抗剤 |
| EP1213017A3 (fr) | 2000-12-05 | 2003-11-12 | Akzo Nobel N.V. | Utilisation d'un agoniste du récepteur 5-HT2C pour traiter les bouffées de chaleur |
| WO2002074746A1 (fr) * | 2001-03-16 | 2002-09-26 | Yamanouchi Pharmaceutical Co., Ltd. | Derives de benzazepine |
| DE60206762T2 (de) | 2001-07-13 | 2006-07-13 | Pharmacia & Upjohn Co. Llc, Kalamazoo | Hexahydroazepino(4,5-g)indole und -indoline als 5-ht rezeptor-liganden |
| MXPA04005151A (es) | 2001-11-28 | 2004-08-11 | Upjohn Co | Compuestos terapeuticos. |
| US6953787B2 (en) * | 2002-04-12 | 2005-10-11 | Arena Pharmaceuticals, Inc. | 5HT2C receptor modulators |
| EP2332921B1 (fr) | 2003-06-17 | 2016-03-02 | Arena Pharmaceuticals, Inc. | 8-Chloro-1 -methyl-2,3,4,5-tetrahydro-1 H-3benzazapine Hydrochloride |
| EP1633720A1 (fr) * | 2003-06-17 | 2006-03-15 | Arena Pharmaceuticals, Inc. | Derives de benzazepine et methodes de prophylaxie ou de traitement de maladies associees au recepteur 5ht2c |
| TW200510324A (en) * | 2003-08-11 | 2005-03-16 | Lilly Co Eli | 6-(2,2,2-trifluoroethylamino)-7-chiloro-2, 3, 4, 5-tetrahydro-1h-benzo[d]azepine as a 5-ht2c receptor agonist |
| WO2005042490A1 (fr) | 2003-10-22 | 2005-05-12 | Arena Pharmaceuticals, Inc. | Derives de benzazepine et methodes de prophylaxie ou de traitement de maladies associees au recepteur 5-ht2c |
| WO2005042491A1 (fr) * | 2003-10-22 | 2005-05-12 | Arena Pharmaceuticals, Inc. | Derives de benzazepine et methodes de prophylaxie ou traitement de maladies associees au recepteur 5ht2c |
| CN102311387A (zh) | 2004-02-25 | 2012-01-11 | 伊莱利利公司 | 作为5-HT2C受体激动剂的6-取代的2,3,4,5-四氢-1H-苯并[d]氮杂䓬 |
| KR101281919B1 (ko) | 2004-12-21 | 2013-07-03 | 아레나 파마슈티칼스, 인크. | (ｒ)-8-클로로-1-메틸-2,3,4,5-테트라히드로-1ｈ-3-벤즈아제핀 히드로클로라이드의 결정질 형태 |
| JP4886700B2 (ja) | 2004-12-23 | 2012-02-29 | アリーナ ファーマシューティカルズ， インコーポレイテッド | ５ｈｔ２ｃレセプターモジュレーターの組成物およびその使用方法 |
| ES2397400T3 (es) * | 2005-09-01 | 2013-03-06 | Eli Lilly & Company | 6-arilalquilamino-2,3,4,5-tetrahidro-1H-benzo[D]azepinas como agonistas del receptor 5-HT2C |
| DK1924560T3 (da) * | 2005-09-01 | 2009-10-19 | Lilly Co Eli | 6-substituerede-2,3,4,5-tetrahydro-1H-benzo[d]azepiner som 5-HT2C-receptoragonister |
| CA2619450C (fr) * | 2005-09-01 | 2013-10-22 | Eli Lilly And Company | 2,3,4,5-tetrahydro-1h-benzo[d]azepines substituees par un heterocycle a liaison 6-n en tant qu'agonistes de recepteur 5-ht2c |
-
2006
- 2006-09-01 JP JP2008529360A patent/JP5237810B2/ja not_active Expired - Fee Related
- 2006-09-01 DE DE602006008155T patent/DE602006008155D1/de active Active
- 2006-09-01 PT PT06802904T patent/PT1926712E/pt unknown
- 2006-09-01 MX MX2008002180A patent/MX2008002180A/es active IP Right Grant
- 2006-09-01 PL PL06802904T patent/PL1926712T3/pl unknown
- 2006-09-01 CA CA2619287A patent/CA2619287C/fr not_active Expired - Fee Related
- 2006-09-01 AT AT06802904T patent/ATE437859T1/de active
- 2006-09-01 ES ES06802904T patent/ES2328408T3/es active Active
- 2006-09-01 CN CNA2006800318925A patent/CN101253153A/zh active Pending
- 2006-09-01 BR BRPI0615033-0A patent/BRPI0615033A2/pt not_active IP Right Cessation
- 2006-09-01 AU AU2006287160A patent/AU2006287160B2/en not_active Ceased
- 2006-09-01 EP EP06802904A patent/EP1926712B1/fr not_active Not-in-force
- 2006-09-01 SI SI200630454T patent/SI1926712T1/sl unknown
- 2006-09-01 US US11/995,344 patent/US8420631B2/en not_active Expired - Fee Related
- 2006-09-01 WO PCT/US2006/034430 patent/WO2007028131A1/fr active Application Filing
- 2006-09-01 DK DK06802904T patent/DK1926712T3/da active
-
2009
- 2009-09-02 CY CY20091100923T patent/CY1110486T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CY1110486T1 (el) | 2015-04-29 |
| ES2328408T3 (es) | 2009-11-12 |
| ATE437859T1 (de) | 2009-08-15 |
| WO2007028131A1 (fr) | 2007-03-08 |
| JP2009507037A (ja) | 2009-02-19 |
| SI1926712T1 (sl) | 2010-01-29 |
| US8420631B2 (en) | 2013-04-16 |
| EP1926712A1 (fr) | 2008-06-04 |
| EP1926712B1 (fr) | 2009-07-29 |
| DE602006008155D1 (de) | 2009-09-10 |
| CN101253153A (zh) | 2008-08-27 |
| CA2619287C (fr) | 2013-10-22 |
| US20080207897A1 (en) | 2008-08-28 |
| DK1926712T3 (da) | 2009-11-09 |
| PT1926712E (pt) | 2009-10-06 |
| AU2006287160B2 (en) | 2012-04-05 |
| JP5237810B2 (ja) | 2013-07-17 |
| CA2619287A1 (fr) | 2007-03-08 |
| BRPI0615033A2 (pt) | 2011-04-26 |
| AU2006287160A1 (en) | 2007-03-08 |
| MX2008002180A (es) | 2008-04-22 |
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