AU2006287160B2 - 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines as 5-HT2C receptor agonists - Google Patents

6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines as 5-HT2C receptor agonists Download PDF

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Publication number
AU2006287160B2
AU2006287160B2 AU2006287160A AU2006287160A AU2006287160B2 AU 2006287160 B2 AU2006287160 B2 AU 2006287160B2 AU 2006287160 A AU2006287160 A AU 2006287160A AU 2006287160 A AU2006287160 A AU 2006287160A AU 2006287160 B2 AU2006287160 B2 AU 2006287160B2
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alkyl
substituents
optionally substituted
fluoro
moiety
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Ceased
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AU2006287160A
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AU2006287160A1 (en
Inventor
John Gordon Allen
Karin Briner
Anne Marie Camp
Manuel Javier Cases-Thomas
Richard Charles Hoying
Maria Angeles Martinez-Grau
Michael Philip Mazanetz
Natalia Pokrovskaia
Richard Edmund Rathmell
Roger Ryan Rothhaar
Selma Sapmaz
Andrew Caerwyn Williams
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Eli Lilly and Co
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Eli Lilly and Co
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Ceased legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
AU2006287160A 2005-09-01 2006-09-01 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines as 5-HT2C receptor agonists Ceased AU2006287160B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71358405P 2005-09-01 2005-09-01
US60/713,584 2005-09-01
PCT/US2006/034430 WO2007028131A1 (fr) 2005-09-01 2006-09-01 2,3,4,5-TÉTRAHYDRO-1H-BENZO[d]AZÉPINES SUBSTITUÉS EN POSITION 6 EN TANT QU’AGONISTES DU RÉCEPTEUR DE 5-HT2C

Publications (2)

Publication Number Publication Date
AU2006287160A1 AU2006287160A1 (en) 2007-03-08
AU2006287160B2 true AU2006287160B2 (en) 2012-04-05

Family

ID=37499390

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2006287160A Ceased AU2006287160B2 (en) 2005-09-01 2006-09-01 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines as 5-HT2C receptor agonists

Country Status (17)

Country Link
US (1) US8420631B2 (fr)
EP (1) EP1926712B1 (fr)
JP (1) JP5237810B2 (fr)
CN (1) CN101253153A (fr)
AT (1) ATE437859T1 (fr)
AU (1) AU2006287160B2 (fr)
BR (1) BRPI0615033A2 (fr)
CA (1) CA2619287C (fr)
CY (1) CY1110486T1 (fr)
DE (1) DE602006008155D1 (fr)
DK (1) DK1926712T3 (fr)
ES (1) ES2328408T3 (fr)
MX (1) MX2008002180A (fr)
PL (1) PL1926712T3 (fr)
PT (1) PT1926712E (fr)
SI (1) SI1926712T1 (fr)
WO (1) WO2007028131A1 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007028083A2 (fr) * 2005-09-01 2007-03-08 Eli Lilly And Company Utilisation de 6-arylalkylamino- 2,3,4,5-tetrahydro-1h-benzo[d]azepines comme agonistes des recepteurs 5-ht2c
DE602006008323D1 (de) * 2005-09-01 2009-09-17 Lilly Co Eli 6-substituierte- 2,3,4,5-tetrahydro-1h-benzoädüazepine als 5-ht2c-rezeptoragonisten
CA2619450C (fr) * 2005-09-01 2013-10-22 Eli Lilly And Company 2,3,4,5-tetrahydro-1h-benzo[d]azepines substituees par un heterocycle a liaison 6-n en tant qu'agonistes de recepteur 5-ht2c
JP5528699B2 (ja) 2006-05-16 2014-06-25 武田薬品工業株式会社 縮合複素環化合物およびその用途
WO2007140213A1 (fr) 2006-05-26 2007-12-06 Forest Laboratories Holdings Limited Dérivés de pyridoazépines
EP2789338A3 (fr) 2007-11-15 2015-01-14 Takeda Pharmaceutical Company Limited Dérivé de pyridine condensé et son utilisation
CN101684096A (zh) * 2008-09-23 2010-03-31 中国科学院上海药物研究所 一类新型苯并氮杂卓类化合物及其制备方法和用途
KR101768234B1 (ko) 2009-06-15 2017-08-14 다케다 야쿠힌 고교 가부시키가이샤 피라지노옥사제핀 유도체
CN103189358A (zh) * 2010-09-01 2013-07-03 艾尼纳制药公司 5-ht2c激动剂的快速溶解剂型
US20130267500A1 (en) 2010-09-01 2013-10-10 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists in the treatment of disorders ameliorated by reduction of norepinephrine level
CN103189359A (zh) * 2010-09-01 2013-07-03 艾尼纳制药公司 5-ht2c激动剂的光学活性酸盐
KR20130101524A (ko) * 2010-09-01 2013-09-13 아레나 파마슈티칼스, 인크. 5-ｈｔ2ｃ 아고니스트의 비-흡습성 염
EP3610890A1 (fr) 2012-11-14 2020-02-19 The Johns Hopkins University Procédés et compositions de traitement de la schizophrénie
WO2015066344A1 (fr) 2013-11-01 2015-05-07 Arena Pharmaceuticals, Inc. Agonistes du récepteur 5-ht2c et compositions et procédés d'utilisation
JPWO2019131902A1 (ja) 2017-12-27 2020-12-10 武田薬品工業株式会社 腹圧性尿失禁および便失禁の治療薬

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639748A (en) * 1991-08-05 1997-06-17 Smithkline Beecham Corporation 6,9-disubstituted benzazepines having α-adrenoceptor blocking activity
WO2005019180A1 (fr) * 2003-08-11 2005-03-03 Eli Lilly And Company 6-(2,2,2-trifluoroethylamino)-7-chloro-2,3,4,5-tetrahydro-1h-benzo[d]azepine utilisee comme agoniste du recepteur 5-ht2c
WO2005042491A1 (fr) * 2003-10-22 2005-05-12 Arena Pharmaceuticals, Inc. Derives de benzazepine et methodes de prophylaxie ou traitement de maladies associees au recepteur 5ht2c
WO2005082859A1 (fr) * 2004-02-25 2005-09-09 Eli Lilly And Company 2,3,4,5-tetrahydro-1h-benzo[d]azepines substitues en position 6 en tant qu'agonistes de recepteur 5-ht2c

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US4265890A (en) 1978-07-07 1981-05-05 Smithkline Corporation 6-Phenyl thio- and 6-cyclohexyl thio-2,3,4,5-tetrahydro-1H-3-benzazepines
EP0285287A3 (fr) 1987-03-23 1990-08-16 Smithkline Beecham Corporation Emploi de 3-benzazépines pour le traitement des troubles de la mobilité gastro-intestinale
US4985352A (en) 1988-02-29 1991-01-15 The Trustees Of Columbia University In The City Of New York DNA encoding serotonin 1C (5HT1c) receptor, isolated 5HT1c receptor, mammalian cells expressing same and uses thereof
GB9116824D0 (en) 1991-08-05 1991-09-18 Smithkline Beecham Corp Chemical compounds
EP0562118B1 (fr) 1991-09-11 1998-03-04 Canon Kabushiki Kaisha Element de nettoyage ameliore pour tete de jet d'encre et dispositif a jet d'encre equipe d'un tel element de nettoyage
GB9119467D0 (en) * 1991-09-12 1991-10-23 Smithkline Beecham Corp Chemical compounds
US5698766A (en) 1995-04-05 1997-12-16 The Regents Of The University Of California Transgenic animal model for testing drugs for treating eating disorders and epilepsy
JP2002371059A (ja) * 2000-05-16 2002-12-26 Takeda Chem Ind Ltd メラニン凝集ホルモン拮抗剤
EP1213017A3 (fr) 2000-12-05 2003-11-12 Akzo Nobel N.V. Utilisation d'un agoniste du récepteur 5-HT2C pour traiter les bouffées de chaleur
JPWO2002074746A1 (ja) 2001-03-16 2004-07-08 山之内製薬株式会社 ベンゾアゼピン誘導体
ES2250667T3 (es) 2001-07-13 2006-04-16 PHARMACIA & UPJOHN COMPANY LLC Hexahidroazepino(4,5-g)indoles e indolinas como ligandos del receptor 5-ht.
WO2003045940A2 (fr) * 2001-11-28 2003-06-05 Pharmacia & Upjohn Company Composes therapeutiques
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
NZ578503A (en) * 2003-06-17 2011-02-25 Arena Pharm Inc Benzazepine derivatives useful for the treatment of 5HT2C receptor associated diseases
EP2189448B1 (fr) 2003-06-17 2014-01-29 Arena Pharmaceuticals, Inc. Procédés de séparation de racemates de 3-Benzazepines
US20070275949A1 (en) 2003-10-22 2007-11-29 Arena Pharmaceuticals, Inc. Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2C Receptor Associated Diseases
EP1838677B1 (fr) 2004-12-21 2009-09-09 Arena Pharmaceuticals, Inc. Formes cristallines d'hydrochlorure de (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine
CA2588941A1 (fr) 2004-12-23 2006-07-06 Arena Pharmaceuticals, Inc. Compositions renfermant un modulateur des recepteurs 5ht2c et procedes d'utilisation correspondants
DE602006008323D1 (de) * 2005-09-01 2009-09-17 Lilly Co Eli 6-substituierte- 2,3,4,5-tetrahydro-1h-benzoädüazepine als 5-ht2c-rezeptoragonisten
WO2007028083A2 (fr) * 2005-09-01 2007-03-08 Eli Lilly And Company Utilisation de 6-arylalkylamino- 2,3,4,5-tetrahydro-1h-benzo[d]azepines comme agonistes des recepteurs 5-ht2c
CA2619450C (fr) * 2005-09-01 2013-10-22 Eli Lilly And Company 2,3,4,5-tetrahydro-1h-benzo[d]azepines substituees par un heterocycle a liaison 6-n en tant qu'agonistes de recepteur 5-ht2c

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639748A (en) * 1991-08-05 1997-06-17 Smithkline Beecham Corporation 6,9-disubstituted benzazepines having α-adrenoceptor blocking activity
WO2005019180A1 (fr) * 2003-08-11 2005-03-03 Eli Lilly And Company 6-(2,2,2-trifluoroethylamino)-7-chloro-2,3,4,5-tetrahydro-1h-benzo[d]azepine utilisee comme agoniste du recepteur 5-ht2c
WO2005042491A1 (fr) * 2003-10-22 2005-05-12 Arena Pharmaceuticals, Inc. Derives de benzazepine et methodes de prophylaxie ou traitement de maladies associees au recepteur 5ht2c
WO2005082859A1 (fr) * 2004-02-25 2005-09-09 Eli Lilly And Company 2,3,4,5-tetrahydro-1h-benzo[d]azepines substitues en position 6 en tant qu'agonistes de recepteur 5-ht2c

Also Published As

Publication number Publication date
US20080207897A1 (en) 2008-08-28
US8420631B2 (en) 2013-04-16
MX2008002180A (es) 2008-04-22
DE602006008155D1 (de) 2009-09-10
BRPI0615033A2 (pt) 2011-04-26
PL1926712T3 (pl) 2009-12-31
EP1926712B1 (fr) 2009-07-29
ES2328408T3 (es) 2009-11-12
WO2007028131A1 (fr) 2007-03-08
EP1926712A1 (fr) 2008-06-04
JP2009507037A (ja) 2009-02-19
CN101253153A (zh) 2008-08-27
CA2619287A1 (fr) 2007-03-08
CA2619287C (fr) 2013-10-22
SI1926712T1 (sl) 2010-01-29
CY1110486T1 (el) 2015-04-29
ATE437859T1 (de) 2009-08-15
JP5237810B2 (ja) 2013-07-17
DK1926712T3 (da) 2009-11-09
PT1926712E (pt) 2009-10-06
AU2006287160A1 (en) 2007-03-08

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CA2619450C (fr) 2,3,4,5-tetrahydro-1h-benzo[d]azepines substituees par un heterocycle a liaison 6-n en tant qu'agonistes de recepteur 5-ht2c
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MK14 Patent ceased section 143(a) (annual fees not paid) or expired