PL1888742T3 - Komórki progenitorowe wątroby - Google Patents

Komórki progenitorowe wątroby

Info

Publication number
PL1888742T3
PL1888742T3 PL06756297T PL06756297T PL1888742T3 PL 1888742 T3 PL1888742 T3 PL 1888742T3 PL 06756297 T PL06756297 T PL 06756297T PL 06756297 T PL06756297 T PL 06756297T PL 1888742 T3 PL1888742 T3 PL 1888742T3
Authority
PL
Poland
Prior art keywords
cell lines
cells
methods
markers
progenitor cells
Prior art date
Application number
PL06756297T
Other languages
English (en)
Inventor
Sanchez Maria Beatriz Herrera
Benedetta Bussolati
Giovanni Camussi
Stefano Buttiglieri
Original Assignee
Fresenius Medical Care Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fresenius Medical Care Deutschland Gmbh filed Critical Fresenius Medical Care Deutschland Gmbh
Publication of PL1888742T3 publication Critical patent/PL1888742T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
PL06756297T 2005-05-26 2006-05-24 Komórki progenitorowe wątroby PL1888742T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/IT2005/000303 WO2006126219A1 (en) 2005-05-26 2005-05-26 Liver progenitor cells
EP06756297A EP1888742B1 (en) 2005-05-26 2006-05-24 Liver progenitor cells
PCT/IT2006/000391 WO2006126236A1 (en) 2005-05-26 2006-05-24 Liver progenitor cells

Publications (1)

Publication Number Publication Date
PL1888742T3 true PL1888742T3 (pl) 2011-04-29

Family

ID=35462653

Family Applications (1)

Application Number Title Priority Date Filing Date
PL06756297T PL1888742T3 (pl) 2005-05-26 2006-05-24 Komórki progenitorowe wątroby

Country Status (12)

Country Link
US (1) US9334479B2 (pl)
EP (1) EP1888742B1 (pl)
JP (1) JP5144505B2 (pl)
CN (2) CN103396989A (pl)
AT (1) ATE486126T1 (pl)
BR (1) BRPI0613375B1 (pl)
CA (1) CA2609523C (pl)
DE (1) DE602006017833D1 (pl)
DK (1) DK1888742T3 (pl)
ES (1) ES2355327T3 (pl)
PL (1) PL1888742T3 (pl)
WO (2) WO2006126219A1 (pl)

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ATE498005T1 (de) † 2005-12-21 2011-02-15 Univ Catholique Louvain Isolierte leberstammzellen
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CN103800895B (zh) 2008-06-11 2016-12-28 弗雷森纽斯医疗护理德国有限责任公司 肝祖细胞的条件培养基
RU2011143730A (ru) * 2009-03-31 2013-05-10 Риджентс Оф Дзе Юниверсити Оф Миннесота Децеллюляризации и рецеллюляризация органов и тканей
EP2447385B1 (en) 2009-06-24 2013-12-04 Hitachi Metals, Ltd. Heat-resistant steel for engine valve having excellent high-temperature strength
EP2333047A1 (en) 2009-12-09 2011-06-15 Fresenius Medical Care Deutschland GmbH Adult stem cell derived conditioned medium and/or adult stem cells for use in the therapeutic treatment of a tumor disease
EP2363136A1 (en) 2010-03-02 2011-09-07 Fresenius Medical Care Deutschland GmbH Microvesicles (MVs) derived from adult stem cells for use in the therapeutic treatment of a tumor disease
US9719068B2 (en) 2010-05-06 2017-08-01 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
US8415149B2 (en) * 2010-05-06 2013-04-09 Gwo Xi Stem Cell Applied Technology Co., Ltd. Hepatic progenitor cells and uses thereof
ES2562707T3 (es) 2010-09-01 2016-03-07 Regents Of The University Of Minnesota Métodos de recelularización de un tejido u órgano para una mejor capacidad de trasplante
EP2667878B1 (en) 2011-01-25 2016-03-30 Université Catholique de Louvain Compositions and methods for cell transplantation
US9775890B2 (en) 2012-01-25 2017-10-03 Université Catholique de Louvain Factor Xa inhibitor used with liver-derived progenitor cells
US10073096B2 (en) * 2012-10-05 2018-09-11 Life Technologies Corporation Markers capable of distinguishing cell pluripotency and uses thereof
MX376437B (es) 2013-03-15 2025-03-04 Miromatrix Medical Inc Uso de hígado descelularizado por perfusión para recelularización de células de islote.
EP3016665B1 (en) 2013-07-05 2019-09-18 Université Catholique de Louvain Conditioned medium from human adult liver stem cells and its use in the treatment of liver disorders
BR112016013623B1 (pt) * 2013-12-16 2023-03-21 Fresenius Medical Care Deutschland Gmbh Método de preparação de uma estrutura de célula esferoide semelhante à ilhota pancreática cultivada artificialmente, e uso de uma estrutura de célula esferoide
SG10201801654RA (en) 2014-05-28 2018-04-27 Childrens Hospital Med Ct Methods and systems for converting precursor cells into gastric tissues through directed differentiation
WO2015190522A1 (ja) * 2014-06-12 2015-12-17 国立大学法人京都大学 内胚葉性幹細胞の製造方法
AU2015331848B2 (en) 2014-10-17 2022-03-03 Children's Hospital Medical Center, D/B/A Cincinnati Children's Hospital Medical Center In vivo model of human small intestine using pluripotent stem cells and methods of making and using same
JP7174408B2 (ja) 2016-02-10 2022-11-17 ウェイク・フォレスト・ユニヴァーシティ・ヘルス・サイエンシズ 肝線維症のモデル系ならびにその作製および使用方法
KR20180114073A (ko) 2016-03-02 2018-10-17 위니베르시트카솔리끄드루뱅 향상된 성체 간 전구 세포 제제
CN109415685B (zh) 2016-05-05 2023-07-04 儿童医院医疗中心 用于体外制造胃底组织的方法和与其相关的组合物
AU2017260660B2 (en) 2016-05-06 2023-12-21 Unicyte Ev Ag Pharmaceutical carriers containing miRNAs for use in the treatment of fibrotic diseases caused by hyperglycemia
EP3509651B1 (en) 2016-09-06 2022-12-28 Miromatrix Medical Inc. Use of resected liver serum for whole liver engineering
EP3534976A4 (en) 2016-11-04 2020-09-16 Children's Hospital Medical Center PATHOLOGICAL MODELS OF HEPATIC ORGANOIDS AND ASSOCIATED METHODS OF MANUFACTURE AND USE
CA3045145A1 (en) 2016-12-05 2018-06-14 Children's Hospital Medical Center Colonic organoids and methods of making and using same
WO2018191673A1 (en) 2017-04-14 2018-10-18 Children's Hospital Medical Center Multi donor stem cell compositions and methods of making same
JP2020536529A (ja) 2017-10-10 2020-12-17 チルドレンズ ホスピタル メディカル センター 食道組織および／または臓器組成物およびそれを作製する方法
EP3724334A1 (en) 2017-12-14 2020-10-21 Unicyte EV AG Pharmaceutical carriers containing mirnas for use in the treatment of renal cancer
WO2019126626A1 (en) 2017-12-21 2019-06-27 Children's Hospital Medical Center Digitalized human organoids and methods of using same
WO2019197442A1 (en) 2018-04-12 2019-10-17 Unicyte Ev Ag A combination of active ingredients for the treatment of tumor
WO2019241499A1 (en) 2018-06-13 2019-12-19 Miromatrix Medical Inc. Fistula filler and deployment system
EP3826652B1 (en) 2018-07-26 2026-02-25 Children's Hospital Medical Center Hepato-biliary-pancreatic tissues and methods of making same
US20210238552A1 (en) 2018-08-10 2021-08-05 Unicyte Ev Ag Extracellular vesicles loaded with an exogenous molecule
WO2020035480A1 (en) 2018-08-16 2020-02-20 Unicyte Islet Ag Viable pancreatic islet-like cell structures and a method of preparing thereof
EP3849568A4 (en) 2018-09-12 2022-06-15 Children's Hospital Medical Center Organoid compositions for the production of hematopoietic stem cells and derivatives thereof
EP3976066A4 (en) 2019-05-31 2023-06-28 Children's Hospital Medical Center Methods of generating and expanding hematopoietic stem cells
AU2020283048A1 (en) 2019-05-31 2021-12-23 Children's Hospital Medical Center Shaped organoid compositions and methods of making same
JP2022536145A (ja) 2019-06-10 2022-08-12 ユニシテ エーファウ アクチェンゲゼルシャフト 細胞老化を低下させるためのヒト肝臓幹細胞由来の細胞外小胞（ｈｌｓｃ－ｅｖ）
CN111394391B (zh) * 2019-07-11 2022-12-06 上海赛立维生物科技有限公司 肝祖细胞样细胞库的构建方法及其制备的细胞株与应用
EP3816276A1 (en) 2019-10-31 2021-05-05 Unicyte Islet AG Viable pancreatic islet-like cell structures and a method of preparing thereof
JP2023516484A (ja) 2020-03-11 2023-04-19 ビット バイオ リミテッド 肝細胞作製方法
CN113999876B (zh) * 2021-08-31 2023-09-05 四川大学华西医院 一种基于肝卵圆细胞恶性化的原发性小鼠肝癌模型及其建立方法和应用
EP4534649A1 (en) 2023-10-03 2025-04-09 Unicyte AG A method of qualifying as pharmaceutically active a batch of undifferentiated adult stem cells having the potential to differentiate along the hepatic lineage
EP4560009A1 (en) 2023-11-27 2025-05-28 Cellaïon SA Method for the preparation of isolated liver-derived cells

Family Cites Families (9)

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Publication number Priority date Publication date Assignee Title
US6129911A (en) 1998-07-10 2000-10-10 Rhode Island Hospital, A Lifespan Partner Liver stem cell
DK2048228T3 (en) 1999-01-19 2016-05-09 Univ North Carolina Human liver progenitors
US7456017B2 (en) * 1999-10-01 2008-11-25 University Of North Carolina At Chapel Hill Processes for clonal growth of hepatic progenitor cells
ATE410688T1 (de) 2001-05-16 2008-10-15 Kanagawa Kagaku Gijutsu Akad Verfahren zum nachweis und zur trennung undifferenzierter leberzellen mit dlk
WO2003033697A1 (en) 2001-10-18 2003-04-24 Ixion Biotechnology, Inc. Conversion of liver stem and progenitor cells to pancreatic functional cells
JP2003208195A (ja) * 2002-01-16 2003-07-25 Sharp Corp 連続音声認識装置および連続音声認識方法、連続音声認識プログラム、並びに、プログラム記録媒体
CA2479510C (en) * 2002-03-15 2019-10-29 University Of North Carolina At Chapel Hill Primitive and proximal hepatic stem cells
CA2444292A1 (en) * 2003-10-03 2005-04-03 Inserm Bipotential liver cell lines from wild-type mammalian liver tissue
CN101550406B (zh) * 2008-04-03 2016-02-10 北京大学 制备多潜能干细胞的方法,试剂盒及用途

Also Published As

Publication number Publication date
JP2008541717A (ja) 2008-11-27
CN101228266A (zh) 2008-07-23
CA2609523C (en) 2015-01-06
CN103396989A (zh) 2013-11-20
BRPI0613375B1 (pt) 2021-07-27
EP1888742A1 (en) 2008-02-20
DE602006017833D1 (de) 2010-12-09
WO2006126219A1 (en) 2006-11-30
CA2609523A1 (en) 2006-11-30
WO2006126219A8 (en) 2007-02-08
JP5144505B2 (ja) 2013-02-13
ES2355327T3 (es) 2011-03-24
BRPI0613375A2 (pt) 2011-01-11
EP1888742B1 (en) 2010-10-27
ATE486126T1 (de) 2010-11-15
US9334479B2 (en) 2016-05-10
WO2006126236A1 (en) 2006-11-30
US20100003752A1 (en) 2010-01-07
CN101228266B (zh) 2015-07-29
DK1888742T3 (da) 2011-01-24

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