PL1853619T3 - 3-beta-Hydroksy-17-(1H-benzimidazol-1-ilo)-androsta-5,16-dien do zastosowania do leczenia choroby prostaty - Google Patents

3-beta-Hydroksy-17-(1H-benzimidazol-1-ilo)-androsta-5,16-dien do zastosowania do leczenia choroby prostaty

Info

Publication number
PL1853619T3
PL1853619T3 PL06736460T PL06736460T PL1853619T3 PL 1853619 T3 PL1853619 T3 PL 1853619T3 PL 06736460 T PL06736460 T PL 06736460T PL 06736460 T PL06736460 T PL 06736460T PL 1853619 T3 PL1853619 T3 PL 1853619T3
Authority
PL
Poland
Prior art keywords
diene
treatment
methods
androsta
benzimidazol
Prior art date
Application number
PL06736460T
Other languages
English (en)
Polish (pl)
Inventor
Angela Brodie
Vincent Njar
Original Assignee
Univ Maryland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Maryland filed Critical Univ Maryland
Publication of PL1853619T3 publication Critical patent/PL1853619T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL06736460T 2005-03-02 2006-03-02 3-beta-Hydroksy-17-(1H-benzimidazol-1-ilo)-androsta-5,16-dien do zastosowania do leczenia choroby prostaty PL1853619T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US65739005P 2005-03-02 2005-03-02
PCT/US2006/007143 WO2006093993A1 (en) 2005-03-02 2006-03-02 Novel c-17-heteroaryl steroidal cyp17 inhibitors/antiandrogens: synthesis, in vitro biological activities, pharmacokinetics and antitumor activity
EP06736460A EP1853619B1 (en) 2005-03-02 2006-03-02 3-beta-hydroxy-17-(1h-benzimidazol-1-yl)androsta-5,16-diene for use in the treatment of a prostate disease

Publications (1)

Publication Number Publication Date
PL1853619T3 true PL1853619T3 (pl) 2011-03-31

Family

ID=36941503

Family Applications (2)

Application Number Title Priority Date Filing Date
PL06736460T PL1853619T3 (pl) 2005-03-02 2006-03-02 3-beta-Hydroksy-17-(1H-benzimidazol-1-ilo)-androsta-5,16-dien do zastosowania do leczenia choroby prostaty
PL10150763T PL2206719T3 (pl) 2005-03-02 2006-03-02 Kompozycja farmaceutyczna zawierająca 3-beta-hydroksy-17-(1-h-benzimidazol-1-il)androsta-5,16-dien

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL10150763T PL2206719T3 (pl) 2005-03-02 2006-03-02 Kompozycja farmaceutyczna zawierająca 3-beta-hydroksy-17-(1-h-benzimidazol-1-il)androsta-5,16-dien

Country Status (21)

Country Link
US (1) US7875599B2 (cg-RX-API-DMAC7.html)
EP (2) EP1853619B1 (cg-RX-API-DMAC7.html)
JP (2) JP5130453B2 (cg-RX-API-DMAC7.html)
KR (1) KR101380959B1 (cg-RX-API-DMAC7.html)
CN (2) CN101155823A (cg-RX-API-DMAC7.html)
AT (1) ATE482969T1 (cg-RX-API-DMAC7.html)
AU (1) AU2006218711B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0607523A2 (cg-RX-API-DMAC7.html)
CA (1) CA2599953C (cg-RX-API-DMAC7.html)
DE (1) DE602006017175D1 (cg-RX-API-DMAC7.html)
DK (2) DK1853619T3 (cg-RX-API-DMAC7.html)
EA (1) EA019560B1 (cg-RX-API-DMAC7.html)
ES (2) ES2528055T3 (cg-RX-API-DMAC7.html)
IL (3) IL185608A (cg-RX-API-DMAC7.html)
MX (1) MX2007010593A (cg-RX-API-DMAC7.html)
NZ (1) NZ561571A (cg-RX-API-DMAC7.html)
PL (2) PL1853619T3 (cg-RX-API-DMAC7.html)
PT (2) PT2206719E (cg-RX-API-DMAC7.html)
SI (2) SI2206719T1 (cg-RX-API-DMAC7.html)
WO (1) WO2006093993A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200708106B (cg-RX-API-DMAC7.html)

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US8569275B2 (en) 2002-08-28 2013-10-29 Harbor Therapeutics, Inc. Steroids having 7-oxgen and 17-heteroaryl substitution
PT2206719E (pt) * 2005-03-02 2015-02-05 Univ Maryland Composição farmacêutica compreendendo 3-beta-hidroxi-17- (1-h-benzimidazol-1-il)androsta-5,16-dieno
EP2359828A1 (en) 2007-06-06 2011-08-24 University of Maryland, Baltimore HDAC inhibitors and hormone targeted drugs for the treatment of cancer
US20110105445A1 (en) * 2008-03-12 2011-05-05 University Of Maryland, Baltimore Androgen receptor inactivation contributes to antitumor efficacy of cyp17 inhibitors in prostate cancer
US20100048914A1 (en) * 2008-03-14 2010-02-25 Angela Brodie Novel C-17-Heteroaryl Steroidal Cyp17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
US20110118219A1 (en) 2008-03-25 2011-05-19 University Of Maryland, Baltimore Novel prodrugs of c-17-heteroaryl steroidal cyp17 inhibitors/antiandrogens: synthesis, in vitro biological activities, pharmacokinetics and antitumor activity
US8785423B2 (en) * 2008-04-14 2014-07-22 University Of Maryland, Baltimore Compositions and methods of inducing endoplasmic reticulum stress response for the treatment of cell proliferative diseases
WO2010024930A2 (en) 2008-08-28 2010-03-04 President And Fellows Of Harvard College Cortistatin analogues and syntheses therof
BRPI0920681A2 (pt) * 2008-10-28 2015-12-29 Biomarin Pharm Inc inibidores de decahidro-1h-indenoquinolinona e decahidro-3h-ciclopentafenantridinona de cyp17
US8791095B2 (en) 2009-02-05 2014-07-29 Tokai Pharmaceuticals, Inc. Steroidal CYP17 inhibitors/antiandrogens
GB201114153D0 (en) * 2009-02-05 2011-10-05 Tokai Pharmaceuticals Inc Combination of a 17 alpha-hydroxylase/c17, 20-lyase inhibitor with an additional therapeutic agent
BRPI1008745A2 (pt) * 2009-02-05 2019-09-17 Tokai Pharmaceuticals Inc pró-fármacos de inibidores esteroidais de cyp17/antiandrogênios
KR101360725B1 (ko) 2009-06-26 2014-02-07 노파르티스 아게 Ｃｙｐ17의 억제제로서의 1,3-이치환된 이미다졸리딘-2-온 유도체
US8791094B2 (en) * 2009-08-07 2014-07-29 Tokai Pharmaceuticals, Inc. Treatment of prostate cancer
JP5956928B2 (ja) * 2009-11-13 2016-07-27 トーカイ ファーマシューティカルズ，インク． 哺乳類のステロイドの代謝物質
WO2011066582A1 (en) * 2009-11-30 2011-06-03 Harbor Biosciences, Inc. Anticancer compounds and screening method
EP2627648A1 (en) 2010-09-16 2013-08-21 Novartis AG 17aHYDROXYLASE/C17,20-LYASE INHIBITORS
RU2013132766A (ru) * 2010-12-16 2015-01-27 Байомарин Фармасьютикал Инк. Ингибиторы cyp11b, cyp17 и/или cyp21
JP6002210B2 (ja) 2011-04-28 2016-10-05 ノバルティス アーゲー １７α−ヒドロキシラーゼ／Ｃ１７，２０−リアーゼ阻害剤
BR112014001440A2 (pt) * 2011-07-18 2017-02-21 Tokai Pharmaceuticals Inc novas composições e métodos para o tratamento de câncer de próstata
AU2012358219A1 (en) * 2011-12-22 2014-07-10 Tokai Pharmaceuticals, Inc. Methods and compositions for combination therapy using P13K/mTOR inhibitors
SG11201507093WA (en) 2013-03-14 2015-10-29 Univ Maryland Baltimore Office Of Technology Transfer Androgen receptor down-regulating agents and uses thereof
WO2014165815A2 (en) 2013-04-04 2014-10-09 University Of Maryland, Baltimore Nonsteroidal and steroidal compounds with potent androgen receptor down-regulation and anti prostate cancer activity
CA2920317A1 (en) 2013-08-12 2015-02-19 Tokai Pharmaceuticals, Inc. Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies
KR20160101162A (ko) 2013-12-24 2016-08-24 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 코르티스타틴 유사체 및 그의 합성 및 용도
CN103694299A (zh) * 2014-01-13 2014-04-02 中国药科大学 甾体类雄激素受体抑制剂、其制备方法及其医药用途
CN105732759A (zh) * 2015-01-29 2016-07-06 苏州晶云药物科技有限公司 (3β)-17-(1H-苯并咪唑-1-基)雄甾-5，16-二烯-3-醇的盐及其制备方法
EP3294298A4 (en) 2015-05-08 2018-10-17 President and Fellows of Harvard College Cortistatin analogues, syntheses, and uses thereof
EP3316889A4 (en) 2015-07-01 2018-11-14 President and Fellows of Harvard College Cortistatin analogues and syntheses and uses thereof
US10682362B2 (en) 2015-10-14 2020-06-16 Wayne State University Treatments and diagnostics for cancers
IT201600121375A1 (it) * 2016-11-30 2018-05-30 Ind Chimica Srl PROCESSO PER LA PREPARAZIONE DI 3ß-IDROSSI-17-(1H-BENZIMIDAZOL-1-IL)ANDROSTA-5,16-DIENE
IT201600083406A1 (it) * 2016-08-08 2018-02-08 Ind Chimica Srl PROCESSO PER LA PREPARAZIONE DI 3β-IDROSSI-17-(1H-BENZIMIDAZOL-1-IL)ANDROSTA-5,16-DIENE
US11390645B2 (en) 2016-08-08 2022-07-19 Industriale Chimica S.R.L. Process for the preparation of 3β-hydroxy-17-(1H-benzimidazol-1-YL) androsta-5,16-diene
US20200369715A1 (en) * 2018-02-13 2020-11-26 Dana-Farber Cancer Institute, Inc. Cyclin-dependent kinase inhibitors and methods of use
CA3087286C (en) 2018-02-13 2023-06-27 Dana-Farber Cancer Institute, Inc. Cyclin-dependent kinase degraders and methods of use
US12410194B2 (en) 2019-11-26 2025-09-09 Dana-Farber Cancer Institute, Inc. Potent and selective azaindole inhibitors of CDK8 and CDK19

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CA27440A (en) 1887-08-16 James T. Walsh Art of making sheet metal cans, for packing meats, fruits, vegetables, etc.
CH621803A5 (cg-RX-API-DMAC7.html) * 1974-08-08 1981-02-27 Siphar Sa
US5604213A (en) 1992-03-31 1997-02-18 British Technology Group Limited 17-substituted steroids useful in cancer treatment
US5994335A (en) 1997-10-17 1999-11-30 The University Of Maryland, Baltimore 17-azolyl steroids useful as androgen synthesis inhibitors
DK1660115T3 (da) 2003-07-29 2011-10-10 Dompe Spa Farmaceutisk kombination af G-CSF og PLGF anvendelig til blodstamceller
PT2206719E (pt) 2005-03-02 2015-02-05 Univ Maryland Composição farmacêutica compreendendo 3-beta-hidroxi-17- (1-h-benzimidazol-1-il)androsta-5,16-dieno

Also Published As

Publication number Publication date
WO2006093993A1 (en) 2006-09-08
EA019560B1 (ru) 2014-04-30
PL2206719T3 (pl) 2015-03-31
PT2206719E (pt) 2015-02-05
BRPI0607523A2 (pt) 2009-09-08
EP1853619A1 (en) 2007-11-14
IL210478A0 (en) 2011-03-31
CA2599953A1 (en) 2006-09-08
EP1853619A4 (en) 2009-08-26
ES2528055T3 (es) 2015-02-03
ATE482969T1 (de) 2010-10-15
SI1853619T1 (sl) 2011-01-31
CA2599953C (en) 2013-08-13
IL210480A0 (en) 2011-03-31
AU2006218711A1 (en) 2006-09-08
AU2006218711B2 (en) 2010-11-11
MX2007010593A (es) 2008-02-20
DK1853619T3 (da) 2011-01-10
KR101380959B1 (ko) 2014-04-04
CN101155823A (zh) 2008-04-02
IL185608A0 (en) 2008-01-06
AU2006218711A2 (en) 2006-09-08
KR20070120119A (ko) 2007-12-21
EP2206719A2 (en) 2010-07-14
ES2353413T3 (es) 2011-03-01
DE602006017175D1 (de) 2010-11-11
NZ561571A (en) 2009-09-25
US7875599B2 (en) 2011-01-25
EP2206719B1 (en) 2014-10-22
EP1853619B1 (en) 2010-09-29
IL185608A (en) 2016-06-30
IL210480A (en) 2015-06-30
EP2206719A3 (en) 2011-01-05
SI2206719T1 (sl) 2015-03-31
JP2008536807A (ja) 2008-09-11
PT1853619E (pt) 2011-01-03
JP2012255026A (ja) 2012-12-27
CN103349664A (zh) 2013-10-16
US20080280864A1 (en) 2008-11-13
DK2206719T3 (en) 2015-01-26
JP5130453B2 (ja) 2013-01-30
HK1115387A1 (en) 2008-11-28
ZA200708106B (en) 2008-12-31
JP5613206B2 (ja) 2014-10-22
EA200701872A1 (ru) 2008-06-30

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