PL1767642T3 - Konstrukcja onkolitycznego rekombinanta adenowirusa swoiście eksprymującego czynnik immunomodulujący GM-CSF w komórkach nowotworowych i jego zastosowania - Google Patents

Konstrukcja onkolitycznego rekombinanta adenowirusa swoiście eksprymującego czynnik immunomodulujący GM-CSF w komórkach nowotworowych i jego zastosowania

Info

Publication number
PL1767642T3
PL1767642T3 PL04797352T PL04797352T PL1767642T3 PL 1767642 T3 PL1767642 T3 PL 1767642T3 PL 04797352 T PL04797352 T PL 04797352T PL 04797352 T PL04797352 T PL 04797352T PL 1767642 T3 PL1767642 T3 PL 1767642T3
Authority
PL
Poland
Prior art keywords
csf
construction
tumor cells
oncolytic adenovirus
immune modulatory
Prior art date
Application number
PL04797352T
Other languages
English (en)
Inventor
Zunhong Ke
Original Assignee
Chengdu Kanghong Biotechnologies Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chengdu Kanghong Biotechnologies Co Ltd filed Critical Chengdu Kanghong Biotechnologies Co Ltd
Publication of PL1767642T3 publication Critical patent/PL1767642T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10332—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
    • C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
    • C12N2810/6009—Vectors comprising as targeting moiety peptide derived from defined protein from viruses dsDNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/36—Vector systems having a special element relevant for transcription being a transcription termination element
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL04797352T 2004-06-07 2004-11-19 Konstrukcja onkolitycznego rekombinanta adenowirusa swoiście eksprymującego czynnik immunomodulujący GM-CSF w komórkach nowotworowych i jego zastosowania PL1767642T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNB200410046237XA CN100361710C (zh) 2004-06-07 2004-06-07 肿瘤细胞专一表达免疫调节因子gm-csf的溶瘤性腺病毒重组体的构建及其应用
EP04797352.4A EP1767642B1 (en) 2004-06-07 2004-11-19 Construction of oncolytic adenovirus recombinant specifically expressing immune modulatory factor gm-csf in tumor cells and uses thereof
PCT/CN2004/001321 WO2005121343A1 (fr) 2004-06-07 2004-11-19 Construction d'une recombinaison d'adenovirus oncolytique exprimant de facon specifique un facteur immunomodulateur gm-csf dans des cellules tumorales et utilisations correspondantes

Publications (1)

Publication Number Publication Date
PL1767642T3 true PL1767642T3 (pl) 2014-08-29

Family

ID=35503069

Family Applications (1)

Application Number Title Priority Date Filing Date
PL04797352T PL1767642T3 (pl) 2004-06-07 2004-11-19 Konstrukcja onkolitycznego rekombinanta adenowirusa swoiście eksprymującego czynnik immunomodulujący GM-CSF w komórkach nowotworowych i jego zastosowania

Country Status (12)

Country Link
US (1) US7951585B2 (pl)
EP (1) EP1767642B1 (pl)
JP (1) JP4874247B2 (pl)
CN (1) CN100361710C (pl)
BR (1) BRPI0418805B8 (pl)
CA (1) CA2568995C (pl)
DK (1) DK1767642T3 (pl)
ES (1) ES2466415T3 (pl)
PL (1) PL1767642T3 (pl)
PT (1) PT1767642E (pl)
RU (1) RU2361611C2 (pl)
WO (1) WO2005121343A1 (pl)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008527981A (ja) * 2005-01-25 2008-07-31 アポロ ライフ サイエンシズ リミテッド 治療目的および診断目的のためにパラメーターにより選択されたｇｍ−ｃｓｆ、ｉｌ−３、ｉｌ−４、ｉｌ−５、ならびにそのキメラ
CA2995971A1 (en) 2005-03-25 2006-10-05 Regeneron Pharmaceuticals, Inc. Vegf antagonist formulations
JP5216002B2 (ja) 2006-06-16 2013-06-19 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 硝子体内投与に適したｖｅｇｆアンタゴニスト製剤
JP2008048621A (ja) * 2006-08-22 2008-03-06 Chiba Prefecture キメラ型アデノウイルスとその作製方法並びにそれを用いた医薬
CN101391104B (zh) * 2007-09-21 2010-10-06 成都康弘生物科技有限公司 肿瘤细胞专一表达免疫调节因子gm-csf的溶瘤性腺病毒重组体的新用途
CN103221423B (zh) 2010-09-24 2015-09-30 昂克斯治疗有限公司 溶瘤腺病毒载体及与其相关的方法和用途
WO2012088446A1 (en) 2010-12-22 2012-06-28 Board Of Trustees Of The Leland Stanford Junior University Superagonists and antagonists of interleukin-2
EP3763379A1 (en) 2011-01-13 2021-01-13 Regeneron Pharmaceuticals, Inc. Use of a vegf antagonist to treat angiogenic eye disorders
CN102174479B (zh) * 2011-03-02 2013-04-03 北京锤特生物科技有限公司 靶向性治疗人肿瘤的溶肿瘤腺病毒及其应用
JP5971599B2 (ja) * 2011-08-23 2016-08-17 国立研究開発法人医薬基盤・健康・栄養研究所 制限増殖型アデノウイルス
US9624476B2 (en) 2011-08-23 2017-04-18 National Institute Of Biomedical Innovation Conditionally replicating adenovirus
FI123955B (en) 2011-11-25 2014-01-15 Oncos Therapeutics Ltd Oncolytic adenovirus
CA2865642C (en) * 2012-03-14 2021-10-26 Salk Institute For Biological Studies Adenoviral tumor diagnostics
US9017672B2 (en) 2012-05-11 2015-04-28 Immunicum Aktiebolag Hexon Tat-PTD modified adenovirus and uses thereof
EP2971008B1 (en) 2013-03-14 2018-07-25 Salk Institute for Biological Studies Oncolytic adenovirus compositions
KR20160002848A (ko) * 2013-03-24 2016-01-08 오이신 바이오테크놀로지스 표적 세포 내에서 치료적 단백질의 표적화된 생산을 위한 시스템 및 방법
WO2014171526A1 (ja) * 2013-04-17 2014-10-23 国立大学法人九州大学 遺伝子改変コクサッキーウイルス
LT3021859T (lt) 2013-10-25 2018-06-11 Psioxus Therapeutics Limited Onkolitiniai adenovirusai su heterologiniais genais
RU2682762C2 (ru) * 2013-11-27 2019-03-21 Общество С Ограниченной Ответственностью "Панацела Лабс" Улучшенный вектор, экспрессирующий toll-подобный рецептор и агонист, и применение в терапии рака
EP3391892A1 (en) 2015-04-30 2018-10-24 Psioxus Therapeutics Limited Oncolytic adenovirus encoding a b7 protein
JP7064437B2 (ja) 2015-12-17 2022-05-10 サイオクサス セラピューティクス リミテッド 抗ｔｃｒ複合体抗体又は断片をコードするｂ群アデノウイルス
KR102471633B1 (ko) 2016-02-23 2022-11-25 솔크 인스티튜트 포 바이올로지칼 스터디즈 바이러스 동역학에 미치는 영향 최소화를 위한 치료용 아데노바이러스의 외인성 유전자 발현
WO2017147265A1 (en) 2016-02-23 2017-08-31 Salk Institute For Biological Studies High throughput assay for measuring adenovirus replication kinetics
CN110062630A (zh) 2016-12-12 2019-07-26 萨克生物研究学院 肿瘤靶向合成腺病毒及其用途
CA3047140A1 (en) 2017-01-09 2018-07-12 Oisin Biotechnologies Constructs for expression of therapeutic proteins in target cells
CA3067909A1 (en) * 2017-06-19 2018-12-27 Medicenna Therapeutics Inc. Uses and methods for il-2 superagonists, agonists, and fusions thereof
SG11202005509YA (en) * 2017-12-13 2020-07-29 Genemedicine Co Ltd Recombinant adenoviruses and stem cells comprising same
JP2021526505A (ja) 2018-04-18 2021-10-07 オイシン バイオテクノロジーズ，インク． 治療用タンパク質の標的細胞に特異的な産生のための、および、標的細胞に関連する疾患、疾病、または障害の処置のための、融合性脂質ナノ粒子、および、融合性脂質ナノ粒子の製造方法と使用方法
KR20210093303A (ko) 2018-11-21 2021-07-27 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 아데노바이러스 및 아데노바이러스의 사용 방법
WO2020166727A1 (ja) * 2019-02-12 2020-08-20 国立大学法人大阪大学 ヒト３５型アデノウイルスを基板とした腫瘍溶解性ウイルス
JP7381604B2 (ja) 2019-04-29 2023-11-15 メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ 癌を治療するための多価ｐｄ－ｌ１結合化合物
JP2023519926A (ja) * 2020-03-23 2023-05-15 キュリジン カンパニー，リミテッド 二重特異性核酸分子を含む抗癌ウイルスの構造
RU2753742C1 (ru) * 2020-10-16 2021-08-24 Федеральное государственное автономное образовательное учреждение высшего образования "Новосибирский национальный исследовательский государственный университет" (Новосибирский государственный университет, НГУ) Рекомбинантный штамм Ad6-hTERT-GMCSF, содержащий встройку промотора теломеразы человека hTERT, а также гена гранулоцитарно-макрофагального колониестимулирующего фактора человека, обладающий избирательной цитолитической активностью против теломераза-положительных опухолевых клеток и экспрессирующий активный человеческий гранулоцитарно-макрофагальный колониестимулирующий фактор
CN115029325A (zh) * 2021-03-08 2022-09-09 南京惟亚德生物医药有限公司 一种重组溶瘤腺病毒及其应用
CN113444730A (zh) * 2021-03-17 2021-09-28 昆明市延安医院 一种原发性肝细胞klotho基因转导干细胞筛选构建方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7592317B1 (en) * 1994-08-11 2009-09-22 The University Of Chicago Constitutive gene expression in conjuction with ionizing radiation
AU3551195A (en) 1994-09-23 1996-04-09 Somatix Therapy Corporation Chimeric adenovirus for gene delivery
US6020191A (en) 1997-04-14 2000-02-01 Genzyme Corporation Adenoviral vectors capable of facilitating increased persistence of transgene expression
US5891432A (en) * 1997-07-29 1999-04-06 The Immune Response Corporation Membrane-bound cytokine compositions comprising GM=CSF and methods of modulating an immune response using same
US6348450B1 (en) 1997-08-13 2002-02-19 The Uab Research Foundation Noninvasive genetic immunization, expression products therefrom and uses thereof
AU762493B2 (en) 1998-03-11 2003-06-26 Board Of Regents, The University Of Texas System Induction of apoptic or cytotoxic gene expression by adenoviral mediated gene codelivery
CN1298451A (zh) * 1998-04-24 2001-06-06 昂尼克斯药物公司 用于治疗疾病的腺病毒载体
US6627190B2 (en) 1999-07-12 2003-09-30 Saint Louis University Recombinant adenovirus vectors that are replication-competent in tert-expressing cells
GB9916851D0 (en) * 1999-07-20 1999-09-22 Univ Wales Bangor Manipulation of particles in liquid media
DK1230378T3 (da) 1999-11-15 2007-10-08 Onyx Pharma Inc Et onkolytisk adenovirus
DE60116513T2 (de) * 2000-08-10 2006-09-21 Crucell Holland B.V. Adenovirenvektoren zur transduktion der chondrozyten
US6713055B2 (en) 2000-11-27 2004-03-30 Geron Corporation Glycosyltransferase vectors for treating cancer
IL152420A0 (en) * 2001-02-23 2003-05-29 Novartis Ag Novel oncolytic adenoviral vectors
CN1177053C (zh) 2001-04-13 2004-11-24 上海华康生物技术有限公司 靶向性、高表达人粒细胞巨噬细胞集落刺激因子的重组腺病毒及其制法和用途
US6905678B2 (en) * 2001-07-07 2005-06-14 Crucell Holland B.V. Gene delivery vectors with cell type specificity for mesenchymal stem cells
CN1195056C (zh) * 2001-07-12 2005-03-30 钱其军 一种在肿瘤细胞中特异性增殖及高效表达抗癌基因的重组病毒及其构建方法
US20030099616A1 (en) * 2001-07-25 2003-05-29 Irving John M. Dual specificity tumor killing vectors driven by the telomerase promoter
US20030082722A1 (en) 2001-08-08 2003-05-01 Bingliang Fang Method for amplifying expression from a cell specific promoter
JP3867968B2 (ja) * 2002-07-08 2007-01-17 関西ティー・エル・オー株式会社 腫瘍細胞において選択的に増殖する腫瘍融解ウイルス
CN1259106C (zh) * 2002-12-23 2006-06-14 中国科学院上海生命科学研究院 一种抗癌靶向基因病毒药物的制备方法
ES2292271B1 (es) 2004-05-20 2009-02-16 Proyecto De Biomedicina Cima, S.L. Un vector hibrido adenovirus-alfavirus para la administracion eficaz y expresion de genes terapeuticos en celulas tumorales.

Also Published As

Publication number Publication date
BRPI0418805B1 (pt) 2021-01-26
US7951585B2 (en) 2011-05-31
RU2361611C2 (ru) 2009-07-20
JP4874247B2 (ja) 2012-02-15
BRPI0418805B8 (pt) 2021-05-25
EP1767642A1 (en) 2007-03-28
PT1767642E (pt) 2014-06-03
WO2005121343A1 (fr) 2005-12-22
EP1767642B1 (en) 2014-04-23
JP2008501349A (ja) 2008-01-24
CN100361710C (zh) 2008-01-16
CN1706955A (zh) 2005-12-14
CA2568995E (en) 2005-12-22
DK1767642T3 (da) 2014-05-26
ES2466415T3 (es) 2014-06-10
RU2006146665A (ru) 2008-07-20
EP1767642A4 (en) 2008-06-25
CA2568995C (en) 2012-02-21
US20100047208A1 (en) 2010-02-25
BRPI0418805A (pt) 2007-10-16
CA2568995A1 (en) 2005-12-22

Similar Documents

Publication Publication Date Title
PT1767642E (pt) Construção de um adenovírus oncolítico recombinante que expressa de um modo específico um fator imunomodulador gmcsf em células tumorais e suas utilizações
PL1727833T3 (pl) Rekombinowane polipeptydy członków rodziny ligandów TNF i ich zastosowanie
HK1107228A1 (en) Preparation of canola protein isolate and use in aquaculture
LT1749027T (lt) Geno produktai, diferencijuotai išreikšti navikuose, ir jų naudojimas
EP1934605A4 (en) IN HEFEMUTANTEN PRODUCED GLYCOSYLATED POLYPEPTIDES AND USE METHOD THEREFOR
LT2999791T (lt) Modifikuotos kapsidės, raav3 vektoriaus kompozicijos ir panaudojimo būdai žmogaus kepenų vėžio genų terapijoje
EP1802214B8 (en) Compact having slidable in and out structure of content case
EP1758617A4 (en) STABLE LIQUID AND LYOPHILIZED PROTEIN FORMULATIONS
IL183035A0 (en) Selection of host cells expressing protein at high levels
EP2029165A4 (en) VACCINE BASED ON LYMPHOCYTE B CHARGED WITH LIGMPHYTE T NK LIGAND AND ANTIGEN
PT2029149T (pt) Células progenitoras imunopriviligiadas e moduladoras
EP1809603A4 (en) NITROBENZINDOLES AND THEIR USE IN CANCER THERAPY
EP1531848A4 (en) DIFFERENTIAL EXPRESSED GENE IN BREAST AND BLADDER CANCER AND CODED POLYPEPTIDE
PL2055718T3 (pl) Ukierunkowywanie i śledzenie antygenów w żywych komórkach
EP1802740A4 (en) TRANSGENIC STRAINS OF TRICHODERMA AND THEIR USE IN BIOLOGICAL CONTROL
HK1148026A1 (en) Novel rubella e1 envelope protein variants and their use in the detection of antirubella antibodies e1
HK1104317A1 (en) Culture and use of cells that secrete liver secretory factors
ZA200609002B (en) Culture and use of cells that secrete liver secretory factors
IL164467A0 (en) binding agents and their use in targeting tumor cells
EP1813671A4 (en) SOLUBLE PROTEIN AND USE THEREOF
DE602006021315D1 (de) Gen und polypeptid in zusammenhang mit brustkrebs
AU2003259761A8 (en) Enhancement of adenoviral oncolytic activity in prostate cells by modification of the e1a gene product
HK1081854A1 (en) Canine distemper virus isolated in korea and recombinant vaccine using the same
EP1980615A4 (en) POLYPEPTIDE WITH AFFINITY FOR A CURVED VIRUS COMPONENT AND USE THEREOF IN THE TRANSFER OF A SUBSTANCE INTO A CELL
AU2002311146A1 (en) Virus high effectively expressing the tumor interferon and specifically reproduction in tumor cells and the use thereof