PL1707562T3 - Forma krystaliczna gamma chlorowodorku iwabradyny, sposób jej wytwarzania oraz kompozycje farmaceutyczne, które ją zawierają - Google Patents
Forma krystaliczna gamma chlorowodorku iwabradyny, sposób jej wytwarzania oraz kompozycje farmaceutyczne, które ją zawierająInfo
- Publication number
- PL1707562T3 PL1707562T3 PL06290328T PL06290328T PL1707562T3 PL 1707562 T3 PL1707562 T3 PL 1707562T3 PL 06290328 T PL06290328 T PL 06290328T PL 06290328 T PL06290328 T PL 06290328T PL 1707562 T3 PL1707562 T3 PL 1707562T3
- Authority
- PL
- Poland
- Prior art keywords
- pharamcetuical
- ivabradine
- chlorhydrate
- preparation
- composition containing
- Prior art date
Links
- ACRHBAYQBXXRTO-OAQYLSRUSA-N ivabradine Chemical compound C1CC2=CC(OC)=C(OC)C=C2CC(=O)N1CCCN(C)C[C@H]1CC2=C1C=C(OC)C(OC)=C2 ACRHBAYQBXXRTO-OAQYLSRUSA-N 0.000 title 1
- 229960003825 ivabradine Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- G—PHYSICS
- G04—HOROLOGY
- G04F—TIME-INTERVAL MEASURING
- G04F1/00—Apparatus which can be set and started to measure-off predetermined or adjustably-fixed time intervals without driving mechanisms, e.g. egg timers
- G04F1/04—Apparatus which can be set and started to measure-off predetermined or adjustably-fixed time intervals without driving mechanisms, e.g. egg timers by movement or acceleration due to gravity
- G04F1/06—Apparatus which can be set and started to measure-off predetermined or adjustably-fixed time intervals without driving mechanisms, e.g. egg timers by movement or acceleration due to gravity by flowing-away of a prefixed quantity of fine-granular or liquid materials, e.g. sand-glass, water-clock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04L—TRANSMISSION OF DIGITAL INFORMATION, e.g. TELEGRAPHIC COMMUNICATION
- H04L51/00—User-to-user messaging in packet-switching networks, transmitted according to store-and-forward or real-time protocols, e.g. e-mail
- H04L51/21—Monitoring or handling of messages
- H04L51/214—Monitoring or handling of messages using selective forwarding
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04L—TRANSMISSION OF DIGITAL INFORMATION, e.g. TELEGRAPHIC COMMUNICATION
- H04L51/00—User-to-user messaging in packet-switching networks, transmitted according to store-and-forward or real-time protocols, e.g. e-mail
- H04L51/21—Monitoring or handling of messages
- H04L51/212—Monitoring or handling of messages using filtering or selective blocking
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Signal Processing (AREA)
- Computer Networks & Wireless Communication (AREA)
- Vascular Medicine (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0501989A FR2882555B1 (fr) | 2005-02-28 | 2005-02-28 | Forme cristalline gamma du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
| EP06290328A EP1707562B1 (fr) | 2005-02-28 | 2006-02-28 | Forme cristalline gamma du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutique qui la contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1707562T3 true PL1707562T3 (pl) | 2008-08-29 |
Family
ID=34954955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL06290328T PL1707562T3 (pl) | 2005-02-28 | 2006-02-28 | Forma krystaliczna gamma chlorowodorku iwabradyny, sposób jej wytwarzania oraz kompozycje farmaceutyczne, które ją zawierają |
Country Status (41)
| Country | Link |
|---|---|
| US (3) | US7361650B2 (pl) |
| EP (1) | EP1707562B1 (pl) |
| JP (1) | JP4628974B2 (pl) |
| KR (1) | KR100835447B1 (pl) |
| CN (1) | CN100402502C (pl) |
| AP (1) | AP1956A (pl) |
| AR (1) | AR052926A1 (pl) |
| AT (1) | ATE396974T1 (pl) |
| BR (1) | BRPI0600796B8 (pl) |
| CA (1) | CA2537400C (pl) |
| CO (1) | CO5770097A1 (pl) |
| CR (1) | CR8249A (pl) |
| CU (1) | CU23616B7 (pl) |
| CY (1) | CY1109010T1 (pl) |
| DE (1) | DE602006001312D1 (pl) |
| DK (1) | DK1707562T3 (pl) |
| EA (1) | EA008465B1 (pl) |
| ES (1) | ES2308689T3 (pl) |
| FR (1) | FR2882555B1 (pl) |
| GE (1) | GEP20084467B (pl) |
| GT (1) | GT200600088A (pl) |
| HR (1) | HRP20080406T5 (pl) |
| IL (1) | IL173959A0 (pl) |
| JO (1) | JO2515B1 (pl) |
| MA (1) | MA28134A1 (pl) |
| ME (1) | ME02747B (pl) |
| MY (1) | MY158129A (pl) |
| NO (1) | NO338481B1 (pl) |
| NZ (1) | NZ545578A (pl) |
| PE (1) | PE20061142A1 (pl) |
| PL (1) | PL1707562T3 (pl) |
| PT (1) | PT1707562E (pl) |
| RS (1) | RS50598B (pl) |
| SA (1) | SA06270040B1 (pl) |
| SG (1) | SG125229A1 (pl) |
| SI (1) | SI1707562T1 (pl) |
| TW (1) | TWI314143B (pl) |
| UA (1) | UA86595C2 (pl) |
| UY (1) | UY29406A1 (pl) |
| WO (1) | WO2006092492A1 (pl) |
| ZA (1) | ZA200601764B (pl) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2868777B1 (fr) * | 2004-04-13 | 2006-05-26 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| FR2882553B1 (fr) * | 2005-02-28 | 2007-05-04 | Servier Lab | Forme cristalline beta du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
| FR2882556B1 (fr) * | 2005-02-28 | 2007-05-04 | Servier Lab | Forme cristalline gamma d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
| FR2882554B1 (fr) * | 2005-02-28 | 2007-05-04 | Servier Lab | Forme critalline beta d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
| FR2891827B1 (fr) * | 2005-10-11 | 2007-12-28 | Servier Lab | Forme cristalline deltad du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
| FR2891826B1 (fr) * | 2005-10-11 | 2007-12-28 | Servier Lab | Forme cristalline 6 du chlorhydrate de l'ivabradine, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
| FR2894825B1 (fr) * | 2005-12-21 | 2010-12-03 | Servier Lab | Nouvelle association d'un inhibiteur du courant if sinusal et d'un inhibiteur de l'enzyme de conversion et les compositions pharmaceutiques qui la contiennent |
| EP2097383B1 (en) | 2006-11-30 | 2012-02-08 | Cadila Healthcare Limited | Process for preparation of ivabradine hydrochloride |
| CN101353325B (zh) * | 2007-07-27 | 2011-11-09 | 上海优拓医药科技有限公司 | 稳定型盐酸伊伐布雷定结晶及其制备方法 |
| PT2471780E (pt) | 2007-05-30 | 2015-02-24 | Ind Swift Lab Ltd | Sais oxalato de ivabradina cristalinos e seus polimorfos |
| WO2010072409A1 (en) | 2008-12-22 | 2010-07-01 | Krka, D. D., Novo Mesto | Process for preparation of ivabradine |
| CN101774969B (zh) | 2009-01-13 | 2012-07-04 | 江苏恒瑞医药股份有限公司 | 硫酸伊伐布雷定及其i型结晶的制备方法 |
| WO2010128525A2 (en) | 2009-05-04 | 2010-11-11 | Dinesh Shantilal Patel | A formulation of ivabradine for treating the cardiovascular disease |
| PL2902384T3 (pl) | 2010-02-12 | 2018-04-30 | Krka, D.D., Novo Mesto | Postać chlorowodorku iwabradyny |
| HUP1000245A2 (en) | 2010-05-07 | 2011-11-28 | Richter Gedeon Nyrt | Industrial process for the production ivabradin salts |
| TWI499587B (zh) * | 2010-06-03 | 2015-09-11 | Jiangsu Hengrui Medicine Co | 硫酸伊伐佈雷定及其ｉ型結晶的製備方法 |
| WO2012025940A1 (en) | 2010-08-25 | 2012-03-01 | Cadila Healthcare Limited | Polymorphic form of ivabradine hydrochloride and process for preparation thereof |
| EP2726462B1 (en) | 2011-08-02 | 2017-03-22 | Sandoz AG | Acetone solvate of ivabradine hydrochloride |
| EP2589594A1 (en) | 2011-11-04 | 2013-05-08 | Urquima S.A. | Ivabradine hydrochloride Form IV |
| EP2773621B1 (en) | 2011-11-04 | 2015-12-30 | Synthon BV | A process for making crystalline delta-form of ivabradine hydrochloride |
| WO2013102919A1 (en) | 2011-11-14 | 2013-07-11 | Cadila Healthcare Limited | Polymorphic forms of ivabradine hydrochloride |
| CN103183639B (zh) * | 2011-12-30 | 2015-06-17 | 浙江京新药业股份有限公司 | 一种稳定的盐酸伊伐布雷定ii晶型及其制备方法 |
| WO2014114341A1 (en) | 2013-01-24 | 2014-07-31 | Synthon Bv | Process for making ivabradine |
| HUE047705T2 (hu) * | 2013-03-19 | 2020-05-28 | Chemo Res S L | Ivabradin-hidroklorid új polimorfja és eljárás elõállítására |
| ITMI20130416A1 (it) * | 2013-03-19 | 2014-09-20 | Chemo Res S L | Nuovo polimorfo del cloridrato di ivabradina e metodo per la sua preparazione |
| CZ2013767A3 (cs) | 2013-10-02 | 2015-04-29 | Zentiva, K.S. | Pevná forma Ivabradin hydrochloridu a (S)-mandlové kyseliny a její farmaceutická kompozice |
| MX363389B (es) | 2013-12-12 | 2019-03-20 | Synthon Bv | Composicion farmaceutica que comprende ivabradina amorfa. |
| PT2774606T (pt) | 2014-02-14 | 2019-05-06 | Synthon Bv | Composição farmacêutica compreendendo polimorfo de cloridrato de ivabradina iv |
| CZ2014478A3 (cs) | 2014-07-10 | 2015-09-16 | Zentiva, K.S. | Pevná forma Ivabradin hydrochloridu a (R)-mandlové kyseliny a její farmaceutická kompozice |
| WO2017173458A1 (en) * | 2016-04-01 | 2017-10-05 | Swiderski Cyprianna | Compositions and methods targeting hcn channels for breathing therapeutics |
| EP3366282B1 (en) | 2017-02-28 | 2025-10-01 | Sanovel Ilac Sanayi ve Ticaret A.S. | Solid oral pharmaceutical compositions of ivabradine |
| TR201703066A2 (tr) | 2017-02-28 | 2018-09-21 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | İvabradi̇ni̇n kati oral farmasöti̇k kompozi̇syonlari |
| WO2020092288A1 (en) | 2018-10-30 | 2020-05-07 | Amgen Inc. | Process of making ivabradine hydrochloride drug product |
| AU2020408323A1 (en) | 2019-12-16 | 2022-08-11 | Tenax Therapeutics, Inc. | Levosimendan for treating pulmonary hypertension with heart failure with preserved ejection fraction (PH-HF-pEF) |
| IT202000025312A1 (it) | 2020-10-26 | 2022-04-26 | Cambrex Profarmaco Milano S R L | Processi per la preparazione di polimorfi di ivabradina hcl |
| US20250064799A1 (en) | 2021-12-31 | 2025-02-27 | Tenax Therapeutics, Inc. | Oral formulations of levosimendan for treating pulmonary hypertension with heart failure with preserved ejection fraction |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3119874A1 (de) * | 1981-05-19 | 1982-12-09 | Dr. Karl Thomae Gmbh, 7950 Biberach | "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel" |
| US4490369A (en) * | 1981-05-19 | 1984-12-25 | Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung | Benzazepine derivatives, their pharmaceutical compositions and method of use |
| FR2681862B1 (fr) * | 1991-09-27 | 1993-11-12 | Adir Cie | Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent. |
| FR2868777B1 (fr) * | 2004-04-13 | 2006-05-26 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| FR2882556B1 (fr) * | 2005-02-28 | 2007-05-04 | Servier Lab | Forme cristalline gamma d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
| FR2882554B1 (fr) * | 2005-02-28 | 2007-05-04 | Servier Lab | Forme critalline beta d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
| FR2882553B1 (fr) * | 2005-02-28 | 2007-05-04 | Servier Lab | Forme cristalline beta du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
| FR2891827B1 (fr) * | 2005-10-11 | 2007-12-28 | Servier Lab | Forme cristalline deltad du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
| FR2891826B1 (fr) * | 2005-10-11 | 2007-12-28 | Servier Lab | Forme cristalline 6 du chlorhydrate de l'ivabradine, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
-
2005
- 2005-02-28 FR FR0501989A patent/FR2882555B1/fr not_active Expired - Fee Related
-
2006
- 2006-02-13 MA MA28795A patent/MA28134A1/fr unknown
- 2006-02-14 JO JO200648A patent/JO2515B1/en active
- 2006-02-14 PE PE2006000171A patent/PE20061142A1/es not_active Application Discontinuation
- 2006-02-21 SG SG200601141A patent/SG125229A1/en unknown
- 2006-02-21 CR CR8249A patent/CR8249A/es unknown
- 2006-02-22 TW TW095105986A patent/TWI314143B/zh active
- 2006-02-22 GT GT200600088A patent/GT200600088A/es unknown
- 2006-02-22 CU CU20060037A patent/CU23616B7/es active IP Right Grant
- 2006-02-22 US US11/358,955 patent/US7361650B2/en active Active
- 2006-02-22 AP AP2006003521A patent/AP1956A/xx active
- 2006-02-24 CA CA002537400A patent/CA2537400C/fr active Active
- 2006-02-24 BR BRPI0600796A patent/BRPI0600796B8/pt active IP Right Grant
- 2006-02-24 UY UY29406A patent/UY29406A1/es not_active Application Discontinuation
- 2006-02-27 IL IL173959A patent/IL173959A0/en active IP Right Grant
- 2006-02-27 SA SA06270040A patent/SA06270040B1/ar unknown
- 2006-02-27 UA UAA200602126A patent/UA86595C2/ru unknown
- 2006-02-27 MY MYPI20060821A patent/MY158129A/en unknown
- 2006-02-27 NO NO20060948A patent/NO338481B1/no unknown
- 2006-02-27 GE GEAP20069265A patent/GEP20084467B/en unknown
- 2006-02-27 EA EA200600320A patent/EA008465B1/ru unknown
- 2006-02-27 NZ NZ545578A patent/NZ545578A/en unknown
- 2006-02-27 KR KR1020060018718A patent/KR100835447B1/ko active Active
- 2006-02-28 RS RSP-2008/0365A patent/RS50598B/sr unknown
- 2006-02-28 ZA ZA200601764A patent/ZA200601764B/en unknown
- 2006-02-28 AT AT06290328T patent/ATE396974T1/de active
- 2006-02-28 ME MEP-2008-925A patent/ME02747B/me unknown
- 2006-02-28 WO PCT/FR2006/000443 patent/WO2006092492A1/fr not_active Ceased
- 2006-02-28 ES ES06290328T patent/ES2308689T3/es active Active
- 2006-02-28 SI SI200630042T patent/SI1707562T1/sl unknown
- 2006-02-28 PL PL06290328T patent/PL1707562T3/pl unknown
- 2006-02-28 CO CO06019930A patent/CO5770097A1/es not_active Application Discontinuation
- 2006-02-28 AR ARP060100730A patent/AR052926A1/es not_active Application Discontinuation
- 2006-02-28 DK DK06290328T patent/DK1707562T3/da active
- 2006-02-28 PT PT06290328T patent/PT1707562E/pt unknown
- 2006-02-28 CN CNB2006100580784A patent/CN100402502C/zh active Active
- 2006-02-28 DE DE602006001312T patent/DE602006001312D1/de active Active
- 2006-02-28 EP EP06290328A patent/EP1707562B1/fr active Active
- 2006-02-28 JP JP2006051649A patent/JP4628974B2/ja active Active
-
2008
- 2008-02-28 US US12/072,793 patent/US20080153803A1/en not_active Abandoned
- 2008-07-10 CY CY20081100726T patent/CY1109010T1/el unknown
- 2008-08-21 HR HR20080406T patent/HRP20080406T5/xx unknown
-
2009
- 2009-08-27 US US12/583,885 patent/US7867996B2/en active Active
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