PL100316B1 - Sposob wytwarzania nowych pochodnych indolopirydonaftyrydyny - Google Patents
Sposob wytwarzania nowych pochodnych indolopirydonaftyrydyny Download PDFInfo
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- PL100316B1 PL100316B1 PL1975183606A PL18360675A PL100316B1 PL 100316 B1 PL100316 B1 PL 100316B1 PL 1975183606 A PL1975183606 A PL 1975183606A PL 18360675 A PL18360675 A PL 18360675A PL 100316 B1 PL100316 B1 PL 100316B1
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- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 239000012433 hydrogen halide Substances 0.000 description 1
- 229910000039 hydrogen halide Inorganic materials 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 125000005929 isobutyloxycarbonyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])OC(*)=O 0.000 description 1
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical group CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 125000002950 monocyclic group Chemical group 0.000 description 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- KJCVRFUGPWSIIH-UHFFFAOYSA-M naphthalen-1-olate Chemical compound C1=CC=C2C([O-])=CC=CC2=C1 KJCVRFUGPWSIIH-UHFFFAOYSA-M 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- MUMZUERVLWJKNR-UHFFFAOYSA-N oxoplatinum Chemical group [Pt]=O MUMZUERVLWJKNR-UHFFFAOYSA-N 0.000 description 1
- 230000020477 pH reduction Effects 0.000 description 1
- 238000009304 pastoral farming Methods 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 229910003446 platinum oxide Inorganic materials 0.000 description 1
- 229920001515 polyalkylene glycol Polymers 0.000 description 1
- 125000003367 polycyclic group Chemical group 0.000 description 1
- 239000010970 precious metal Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000007790 scraping Methods 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- VKTOXAGUZWAECL-UHFFFAOYSA-N trans-eburnamenine Natural products C1=CC=C2C(CCN3CCC4)=C5C3C4(CC)C=CN5C2=C1 VKTOXAGUZWAECL-UHFFFAOYSA-N 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
- 230000000304 vasodilatating effect Effects 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 229960002726 vincamine Drugs 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU74RI00000547A HU171163B (hu) | 1974-09-27 | 1974-09-27 | Sposob poluchenija proizvodnykh trans eburnamenina |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL100316B1 true PL100316B1 (pl) | 1978-09-30 |
Family
ID=11000958
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL1975183606A PL100316B1 (pl) | 1974-09-27 | 1975-09-26 | Sposob wytwarzania nowych pochodnych indolopirydonaftyrydyny |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4057550A (en, 2012) |
| JP (1) | JPS6028838B2 (en, 2012) |
| AT (1) | AT348690B (en, 2012) |
| BE (1) | BE833674A (en, 2012) |
| BG (1) | BG30776A3 (en, 2012) |
| CA (1) | CA1066706A (en, 2012) |
| CH (1) | CH618700A5 (en, 2012) |
| CS (1) | CS190495B2 (en, 2012) |
| DD (1) | DD122821A5 (en, 2012) |
| DE (1) | DE2539867C2 (en, 2012) |
| DK (1) | DK139682B (en, 2012) |
| FR (1) | FR2285882A1 (en, 2012) |
| GB (1) | GB1519646A (en, 2012) |
| HU (1) | HU171163B (en, 2012) |
| IL (1) | IL48030A (en, 2012) |
| NL (1) | NL7511341A (en, 2012) |
| PL (1) | PL100316B1 (en, 2012) |
| SE (1) | SE425784B (en, 2012) |
| SU (1) | SU554816A3 (en, 2012) |
| YU (1) | YU39202B (en, 2012) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1550496A (en) * | 1976-12-31 | 1979-08-15 | Logeais Labor Jacques | 1,2,3,3a4,5-hexahydro-canthine derivatives a process for their preparation and their therapeutic applications |
| US4316028A (en) * | 1978-11-20 | 1982-02-16 | Sumitomo Chemical Company, Limited | Process for producing eburnane derivatives |
| AU532001B2 (en) * | 1978-11-20 | 1983-09-15 | Sumitomo Chemical Company, Limited | Polycyclic indole derivatives |
| HU198207B (en) * | 1985-04-19 | 1989-08-28 | Richter Gedeon Vegyeszet | Process for production of derivatives of eburnamenin and medical compositions containing them |
| ATE65815T1 (de) * | 1986-04-09 | 1991-08-15 | Humberto Urriola | Zellenfoermiges gefuege. |
| FR2869034B1 (fr) * | 2004-04-14 | 2008-04-04 | Biocortech Soc Par Actions Sim | Derive du 14,15-dihydro 20,21-dinoreburnamenin 14-ol et leur utilisation pour le traitement des depressions |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3454583A (en) * | 1965-07-19 | 1969-07-08 | Us Health Education & Welfare | Synthesis of vincamine |
| FR2211004A5 (en, 2012) * | 1972-12-15 | 1974-07-12 | Synthelabo | |
| FR2228479B1 (en, 2012) * | 1973-05-07 | 1976-05-14 | Synthelabo | |
| FR2259612B1 (en, 2012) * | 1974-01-31 | 1977-09-09 | Synthelabo | |
| FR2262035B1 (en, 2012) * | 1974-02-22 | 1977-01-21 | Synthelabo |
-
1974
- 1974-09-27 HU HU74RI00000547A patent/HU171163B/hu not_active IP Right Cessation
-
1975
- 1975-09-02 IL IL48030A patent/IL48030A/xx unknown
- 1975-09-08 DE DE2539867A patent/DE2539867C2/de not_active Expired
- 1975-09-08 CH CH1176475A patent/CH618700A5/de not_active IP Right Cessation
- 1975-09-10 AT AT696575A patent/AT348690B/de not_active IP Right Cessation
- 1975-09-17 US US05/614,239 patent/US4057550A/en not_active Expired - Lifetime
- 1975-09-22 YU YU02377/75A patent/YU39202B/xx unknown
- 1975-09-22 BE BE160251A patent/BE833674A/xx not_active IP Right Cessation
- 1975-09-23 FR FR7529075A patent/FR2285882A1/fr active Granted
- 1975-09-25 SE SE7510787A patent/SE425784B/xx not_active IP Right Cessation
- 1975-09-25 CA CA236,326A patent/CA1066706A/en not_active Expired
- 1975-09-25 DD DD188551A patent/DD122821A5/xx unknown
- 1975-09-25 BG BG031070A patent/BG30776A3/xx unknown
- 1975-09-26 GB GB39505/75A patent/GB1519646A/en not_active Expired
- 1975-09-26 CS CS756524A patent/CS190495B2/cs unknown
- 1975-09-26 DK DK433075AA patent/DK139682B/da unknown
- 1975-09-26 NL NL7511341A patent/NL7511341A/xx not_active Application Discontinuation
- 1975-09-26 JP JP50117087A patent/JPS6028838B2/ja not_active Expired
- 1975-09-26 SU SU2175262A patent/SU554816A3/ru active
- 1975-09-26 PL PL1975183606A patent/PL100316B1/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SE7510787L (sv) | 1976-03-29 |
| CS190495B2 (en) | 1979-05-31 |
| DK433075A (en, 2012) | 1976-03-28 |
| DD122821A5 (en, 2012) | 1976-11-05 |
| DK139682C (en, 2012) | 1979-10-01 |
| DK139682B (da) | 1979-03-26 |
| DE2539867A1 (de) | 1976-04-08 |
| FR2285882A1 (fr) | 1976-04-23 |
| CH618700A5 (en, 2012) | 1980-08-15 |
| ATA696575A (de) | 1978-07-15 |
| BG30776A3 (en) | 1981-08-14 |
| HU171163B (hu) | 1977-11-28 |
| GB1519646A (en) | 1978-08-02 |
| AT348690B (de) | 1979-02-26 |
| YU237775A (en) | 1982-06-30 |
| DE2539867C2 (de) | 1982-05-19 |
| IL48030A0 (en) | 1975-11-25 |
| NL7511341A (nl) | 1976-03-30 |
| SU554816A3 (ru) | 1977-04-15 |
| BE833674A (fr) | 1976-01-16 |
| US4057550A (en) | 1977-11-08 |
| JPS5159900A (en, 2012) | 1976-05-25 |
| JPS6028838B2 (ja) | 1985-07-06 |
| YU39202B (en) | 1984-08-31 |
| FR2285882B1 (en, 2012) | 1978-11-17 |
| CA1066706A (en) | 1979-11-20 |
| SE425784B (sv) | 1982-11-08 |
| IL48030A (en) | 1980-09-16 |
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