PH30152A - Apoptosis regulating composition - Google Patents

Apoptosis regulating composition

Info

Publication number
PH30152A
PH30152A PH46711A PH46711A PH30152A PH 30152 A PH30152 A PH 30152A PH 46711 A PH46711 A PH 46711A PH 46711 A PH46711 A PH 46711A PH 30152 A PH30152 A PH 30152A
Authority
PH
Philippines
Prior art keywords
regulating composition
apoptosis regulating
apoptosis
composition
regulating
Prior art date
Application number
PH46711A
Other languages
English (en)
Inventor
Satoru Nakai
Koutoku Aihara
Hideo Tanaka
Kazuyoshi Kawai
Hiroyuki Ichikawa
Deiji Akamatsu
Michiaki Tominaga
Hitomi Iba
Fumio Saitoh
Masakazu Adachi
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of PH30152A publication Critical patent/PH30152A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PH46711A 1992-08-19 1993-08-18 Apoptosis regulating composition PH30152A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP22037392 1992-08-19

Publications (1)

Publication Number Publication Date
PH30152A true PH30152A (en) 1997-01-21

Family

ID=16750110

Family Applications (1)

Application Number Title Priority Date Filing Date
PH46711A PH30152A (en) 1992-08-19 1993-08-18 Apoptosis regulating composition

Country Status (8)

Country Link
US (2) US5464833A (es)
EP (1) EP0623598A4 (es)
AU (1) AU666577B2 (es)
CA (1) CA2121148A1 (es)
MX (1) MX9305056A (es)
PH (1) PH30152A (es)
TW (1) TW240168B (es)
WO (1) WO1994004504A1 (es)

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AU672288B2 (en) * 1993-03-02 1996-09-26 Akira Matsumori Rejection inhibitor for transplants and IL-1 production inhibitor
US5497913A (en) * 1993-12-15 1996-03-12 Denny D. Baker Mixing bag arrangement and method
WO1995033070A1 (en) * 1994-05-26 1995-12-07 New York Medical College Detection of halogenated precursors incorporated into dna
US5504093A (en) * 1994-08-01 1996-04-02 Otsuka Pharmaceutical Co., Ltd. Method for inhibiting nucleoside and nucleobase transport in mammalian cells, and method for inhibition of DNA virus replication
CA2158822C (en) * 1994-09-27 2008-12-23 Kusuki Nishioka Therapeutic agent for rheumatic disease
US5620888A (en) * 1994-12-29 1997-04-15 Lxr Biotechnology, Inc. Cell strains for use in identifying potentially therapeutically effective agents
US5571523A (en) * 1995-03-09 1996-11-05 President And Fellows Of Harvard College Antioxidant-induced apoptosis in vascular smooth muscle cells
WO1998046229A1 (fr) * 1995-06-21 1998-10-22 Otsuka Pharmaceutical Co., Ltd. Inhibiteurs de la production d'il-8 et du mcaf
US5912126A (en) * 1995-08-30 1999-06-15 Darzynkiewicz; Zbigniew Methods for labeling DNA ends with halogenated nucleotides and detecting same with antibodies
US5846758A (en) * 1995-11-30 1998-12-08 His Excellency Ghassan I. Shaker Method for diagnosing autoimmune diseases
US5780480A (en) * 1996-02-28 1998-07-14 Merck & Co., Inc. Fibrinogen receptor antagonists
JP2000505471A (ja) * 1996-02-28 2000-05-09 メルク エンド カンパニー インコーポレーテッド フィブリノーゲン受容体拮抗物質
US5912168A (en) * 1996-08-30 1999-06-15 Genesis Research & Development Corporation Limited CD95 regulatory gene sequences
US20020151063A1 (en) * 1996-08-30 2002-10-17 Annette Lasham Methods for modulating apoptotic cell death
US6180402B1 (en) 1996-11-20 2001-01-30 Qlt Inc. Method for inhibiting apoptosis induced by photodynamic therapy using a cysteine or serine protease inhibitor
WO1998048807A1 (fr) * 1997-04-25 1998-11-05 Otsuka Pharmaceutical Co., Ltd. Inhibiteurs de la synthese de l'hyaluronate
TWI244484B (en) * 1998-06-09 2005-12-01 Takara Bio Inc Pharmaceutical composition containing oxy-containing hexacyclic compound
ES2233065T3 (es) 1998-07-13 2005-06-01 Board Of Regents, The University Of Texas System Utilizacion de anticuerpos anti-aminofosfolipidos para el tratamiento del cancer.
SI1107795T1 (en) 1998-09-04 2003-06-30 The Regents Of The University Of Michigan Thiomolybdate associated with at least one carbohydrate, and its use for preventing or treating diseases characterized by aberrant vascularization, such as cancer, wet type macular degeneration, rheumatoid arthritis
AU5877500A (en) * 1999-06-15 2001-01-02 Neurogen Corporation Piperidinyl and piperazinyl substituted benzofused lactams
US6254888B1 (en) 2000-01-28 2001-07-03 Boehringer Ingelheim Pharmaceuticals, Inc. Method for coating pharmaceutical dosage forms
US20050165053A1 (en) * 2001-06-04 2005-07-28 Cytovia, Inc. Substituted4-aryl-3-(3-aryl-1-oxo-2-propenyl)-2(1h)-quinolinones and analogs as activators of caspases and inducers of apoptosis and the use thereof
GB0124848D0 (en) 2001-10-16 2001-12-05 Celltech R&D Ltd Chemical compounds
WO2003038060A2 (en) * 2001-11-01 2003-05-08 The Regents Of The University Of Michigan Small molecule inhibitors targeted at bcl-2
US20040014744A1 (en) * 2002-04-05 2004-01-22 Fortuna Haviv Substituted pyridines having antiangiogenic activity
BR0312692A (pt) 2002-07-15 2007-06-26 Univ Texas anticorpos selecionados e peptìdeos de duramicina que se ligam a fosfolipìdios aniÈnicos e aminofosfolipìdios e seus usos no tratamento de infecções virais e cáncer
US8431396B2 (en) 2003-03-21 2013-04-30 The Cleveland Clinic Foundation Anti-angiogenic peptides
JP5247031B2 (ja) 2004-01-22 2013-07-24 ユニバーシティー・オブ・マイアミ 局所用コエンザイムｑ１０製剤
EP2219672B1 (en) 2007-11-09 2016-02-17 Peregrine Pharmaceuticals, Inc. Anti-vegf antibody compositions and methods
GB2532990A (en) 2014-12-05 2016-06-08 Schlumberger Holdings Corrosion inhibition
GB2543498A (en) 2015-10-19 2017-04-26 Schlumberger Holdings Corrosion inhibition
CN107174584B (zh) * 2016-03-12 2020-09-01 福建金乐医药科技有限公司 含哌嗪结构化合物在制备lsd1抑制剂中的应用

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DE2931741A1 (de) * 1979-08-04 1981-02-26 Thomae Gmbh Dr K Arzneimittel zur vermeidung von tumormetastierung
JPS6038384B2 (ja) * 1978-03-24 1985-08-31 大塚製薬株式会社 チオセミカルバゾン誘導体
JPS5742673A (en) * 1980-08-29 1982-03-10 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS5777676A (en) * 1980-10-31 1982-05-15 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS5883677A (ja) * 1981-11-11 1983-05-19 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
JPS5929667A (ja) * 1982-08-13 1984-02-16 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体および強心剤
JPS59104378A (ja) * 1982-12-03 1984-06-16 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
US4677112A (en) * 1984-02-02 1987-06-30 Warner-Lambert Company 1,2,3,4-tetrahydro-2-oxo-8-quinolineacetic and -propanoic acids and derivatives as cognition activators
US4582909A (en) * 1984-02-02 1986-04-15 Warner-Lambert Company Benzobicyclic lactam acids and derivatives as cognition activators
JPH07100696B2 (ja) * 1984-12-18 1995-11-01 大塚製薬株式会社 カルボスチリル誘導体
US4760064A (en) * 1984-12-18 1988-07-26 Otsuka Pharmaceutical Co., Ltd. Carbostyril compounds, compositions containing same and processes for preparing same
DE3526044A1 (de) * 1985-07-20 1987-01-22 Hoechst Ag Dihydrochinolinon-derivate, verfahren zu ihrer herstellung, sie enthaltende arzneimittel und deren verwendung, sowie zwischenprodukte zu ihrer herstellung
JPS62135423A (ja) * 1985-12-09 1987-06-18 Otsuka Pharmaceut Co Ltd 低酸素症改善剤
DK588486A (da) * 1985-12-09 1987-06-10 Otsuka Pharma Co Ltd Anvendelse af en forbindelse til behandling af hypoxi
JPS63225357A (ja) * 1987-03-12 1988-09-20 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
US5185346A (en) * 1988-11-29 1993-02-09 Hanssen Pharmaceutica (1H-azol-1-ylmethyl)substituted quinoline derivatives
TW201305B (es) * 1991-04-03 1993-03-01 Otsuka Pharma Co Ltd
AU648690B2 (en) * 1991-07-03 1994-04-28 Otsuka Pharmaceutical Co., Ltd. Apoptosis regulator
JPH05320133A (ja) * 1991-07-18 1993-12-03 Japan Tobacco Inc ３，４−ジヒドロ−２（１ｈ）−キノリノン誘導体
WO1993011769A1 (en) * 1991-12-10 1993-06-24 Otsuka Pharmaceutical Co., Ltd Carcinostatic
JPH0612248A (ja) * 1992-04-02 1994-01-21 Hitachi Ltd プログラムの自動生成方式

Also Published As

Publication number Publication date
AU4761593A (en) 1994-03-15
CA2121148A1 (en) 1994-03-03
EP0623598A1 (en) 1994-11-09
US5464833A (en) 1995-11-07
US5691341A (en) 1997-11-25
TW240168B (es) 1995-02-11
MX9305056A (es) 1994-04-29
EP0623598A4 (en) 1997-05-02
AU666577B2 (en) 1996-02-15
WO1994004504A1 (en) 1994-03-03

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