PH27586A - Low molecular weight derivatives of proukokinase pharmaceutical composition containing the same and method of use thereof - Google Patents

Low molecular weight derivatives of proukokinase pharmaceutical composition containing the same and method of use thereof

Info

Publication number
PH27586A
PH27586A PH38528A PH38528A PH27586A PH 27586 A PH27586 A PH 27586A PH 38528 A PH38528 A PH 38528A PH 38528 A PH38528 A PH 38528A PH 27586 A PH27586 A PH 27586A
Authority
PH
Philippines
Prior art keywords
molecular weight
low molecular
proukokinase
pharmaceutical composition
composition containing
Prior art date
Application number
PH38528A
Other languages
English (en)
Inventor
Anna Brandazza
Jacqueline Lansen
Guy Mazue
Paolo Sarmientos
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Publication of PH27586A publication Critical patent/PH27586A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PH38528A 1988-04-18 1989-04-18 Low molecular weight derivatives of proukokinase pharmaceutical composition containing the same and method of use thereof PH27586A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888809093A GB8809093D0 (en) 1988-04-18 1988-04-18 Low molecular weight derivatives of prourokinase

Publications (1)

Publication Number Publication Date
PH27586A true PH27586A (en) 1993-08-18

Family

ID=10635366

Family Applications (1)

Application Number Title Priority Date Filing Date
PH38528A PH27586A (en) 1988-04-18 1989-04-18 Low molecular weight derivatives of proukokinase pharmaceutical composition containing the same and method of use thereof

Country Status (18)

Country Link
EP (1) EP0338409B1 (ja)
JP (1) JPH03500125A (ja)
KR (1) KR900700598A (ja)
CN (1) CN1037360A (ja)
AT (1) ATE118033T1 (ja)
AU (1) AU617459B2 (ja)
DE (1) DE68920900D1 (ja)
FI (1) FI896003A0 (ja)
GB (1) GB8809093D0 (ja)
HU (1) HUT52558A (ja)
IL (1) IL90011A (ja)
MY (1) MY105110A (ja)
NZ (1) NZ228791A (ja)
PH (1) PH27586A (ja)
PT (1) PT90298B (ja)
WO (1) WO1989010402A1 (ja)
YU (1) YU79189A (ja)
ZA (1) ZA892829B (ja)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4101736A1 (de) * 1991-01-22 1992-07-23 Gruenenthal Gmbh Neue als plasminogenaktivatoren einsetzbare polypeptide, dafuer codierende plasmide und verfahren zu deren herstellung und deren verwendung
DE4440892A1 (de) * 1994-11-17 1996-05-23 Gruenenthal Gmbh Proteine mit fibrinolytischen und gerinnungshemmenden Eigenschaften
EP1060255A2 (en) * 1998-03-06 2000-12-20 Abbott Laboratories Highly crystalline urokinase
CN100420485C (zh) * 2004-08-06 2008-09-24 上海天士力药业有限公司 含活性尿激酶原的组合物、其冻干方法及冻干制剂
CN110339349A (zh) * 2018-04-04 2019-10-18 天士力生物医药股份有限公司 一种重组人尿激酶原组合物及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8601240A (nl) * 1986-05-15 1987-12-01 Leuven Res & Dev Vzw Plasminogeenactivator en trombolytisch geneesmiddel.
JPH0761266B2 (ja) * 1986-07-03 1995-07-05 株式会社ミドリ十字 変異ヒトプロウロキナ−ゼ
JPH02438A (ja) * 1987-10-09 1990-01-05 Collaborative Res Inc 修飾した低分子量プラスミノーゲン活性化因子およびその製造方法

Also Published As

Publication number Publication date
AU617459B2 (en) 1991-11-28
WO1989010402A1 (en) 1989-11-02
FI896003A0 (fi) 1989-12-15
EP0338409A1 (en) 1989-10-25
KR900700598A (ko) 1990-08-16
AU3414989A (en) 1989-11-24
GB8809093D0 (en) 1988-05-18
IL90011A0 (en) 1989-12-15
NZ228791A (en) 1991-04-26
MY105110A (en) 1994-08-30
HU892527D0 (en) 1990-05-28
DE68920900D1 (de) 1995-03-16
ZA892829B (en) 1990-01-31
PT90298A (pt) 1989-11-10
PT90298B (pt) 1994-09-30
EP0338409B1 (en) 1995-02-01
IL90011A (en) 1994-10-21
CN1037360A (zh) 1989-11-22
JPH03500125A (ja) 1991-01-17
HUT52558A (en) 1990-07-28
YU79189A (sh) 1992-07-20
ATE118033T1 (de) 1995-02-15

Similar Documents

Publication Publication Date Title
IL86693A0 (en) Novel proteins with factor viii activity,process for their preparation using genetically engineered cells and pharmaceutical compositions containing them
WO1998017319A3 (en) Platelet substitutes and conjugation methods suitable for their preparation
IL90550A0 (en) Amino acid derivatives,their manufacture and pharmaceutical compositions containing them
IL89427A0 (en) Amino acid derivatives,their manufacture and pharmaceutical compositions containing them
GB2200115B (en) Novel peptide derivatives, their production and use
EP0232849A3 (en) Pyrrolidineamide derivative of acylamino acid, pharmaceutical composition and use
NZ225117A (en) Trans -2,2-dimethylchroman-3-ol derivatives and pharmaceutical compositions
EP0437610A4 (en) Novel physiologically active polypeptide, recombinant plasmid, recombinant microbial cells, medicinal composition, and process for recovering purified polypeptide
EP0280736A4 (en) AROMATIC POLYAMIDES AND AGENTS FOR GIVING GAS PROTECTIVE LAYERS.
IL87949A0 (en) Dideoxycytidine derivatives,their preparation and pharmaceutical compositions containing them
HUT66309A (en) Bpc peptides, their preparation and therapeutic use
IL89663A0 (en) Substituted isonicotinic acid amides and hydrazides,their preparation and their use for protecting plants against diseases
IL87871A0 (en) Amino acid derivatives,their manufacture and pharmaceutical compositions containing them
ES8608313A1 (es) Procedimiento para preparar microcapsulas con liberacion controlada de la substancias activa, que contienen peptidos,reguladores y un material de soporte biologicamente degradable.
HU895788D0 (en) Process for producing peptides and medical products containing them
PH24239A (en) New 4-pyridone derivatives,their pharmaceutical compositions and use
HUT41784A (en) Process for producing 1,8-naphtiridine derivatives and pharmaceutical compositions containing them as active agents
PH27586A (en) Low molecular weight derivatives of proukokinase pharmaceutical composition containing the same and method of use thereof
IL85189A (en) Beta-alkyl substituted melatonins,their preparation and pharmaceutical compositions containing them
GB8925896D0 (en) Indole derivatives,their preparation and use as medicament
NZ223682A (en) Pyridazine-substituted benzimidazoles, and pharmaceutical compositions containing them
EP0208785A4 (en) FIBRINOPHILER UROKINASE COMPLEX AND THEIR PRODUCTION.
EP0190860A3 (en) 6-chloro-3-methyl-1h-2,3,4,5-tetrahydro-3-benzazepine-n-oxide and medical compositions using it
IL85651A0 (en) Optically active oxo-isoindolinyl derivatives,their preparation and pharmaceutical compositions containing them
NZ219403A (en) 1,3,4,9-tetrahydropyrano(3,4-b indole-1-acetic acid derivatives and pharmaceutical compositions