DE68920900D1 - Prourokinasederivate mit niedrigem Molekulargewicht und sie enthaltende pharmazeutische Zusammensetzungen. - Google Patents

Prourokinasederivate mit niedrigem Molekulargewicht und sie enthaltende pharmazeutische Zusammensetzungen.

Info

Publication number
DE68920900D1
DE68920900D1 DE68920900T DE68920900T DE68920900D1 DE 68920900 D1 DE68920900 D1 DE 68920900D1 DE 68920900 T DE68920900 T DE 68920900T DE 68920900 T DE68920900 T DE 68920900T DE 68920900 D1 DE68920900 D1 DE 68920900D1
Authority
DE
Germany
Prior art keywords
molecular weight
low molecular
derivatives
prourokinase
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE68920900T
Other languages
English (en)
Inventor
Anna Brandazza
Jacqueline Lansen
Guy Mazue
Paolo Sarmientos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Carlo Erba SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL, Carlo Erba SpA filed Critical Farmitalia Carlo Erba SRL
Application granted granted Critical
Publication of DE68920900D1 publication Critical patent/DE68920900D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE68920900T 1988-04-18 1989-04-13 Prourokinasederivate mit niedrigem Molekulargewicht und sie enthaltende pharmazeutische Zusammensetzungen. Expired - Lifetime DE68920900D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888809093A GB8809093D0 (en) 1988-04-18 1988-04-18 Low molecular weight derivatives of prourokinase

Publications (1)

Publication Number Publication Date
DE68920900D1 true DE68920900D1 (de) 1995-03-16

Family

ID=10635366

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68920900T Expired - Lifetime DE68920900D1 (de) 1988-04-18 1989-04-13 Prourokinasederivate mit niedrigem Molekulargewicht und sie enthaltende pharmazeutische Zusammensetzungen.

Country Status (18)

Country Link
EP (1) EP0338409B1 (de)
JP (1) JPH03500125A (de)
KR (1) KR900700598A (de)
CN (1) CN1037360A (de)
AT (1) ATE118033T1 (de)
AU (1) AU617459B2 (de)
DE (1) DE68920900D1 (de)
FI (1) FI896003A0 (de)
GB (1) GB8809093D0 (de)
HU (1) HUT52558A (de)
IL (1) IL90011A (de)
MY (1) MY105110A (de)
NZ (1) NZ228791A (de)
PH (1) PH27586A (de)
PT (1) PT90298B (de)
WO (1) WO1989010402A1 (de)
YU (1) YU79189A (de)
ZA (1) ZA892829B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4101736A1 (de) * 1991-01-22 1992-07-23 Gruenenthal Gmbh Neue als plasminogenaktivatoren einsetzbare polypeptide, dafuer codierende plasmide und verfahren zu deren herstellung und deren verwendung
DE4440892A1 (de) * 1994-11-17 1996-05-23 Gruenenthal Gmbh Proteine mit fibrinolytischen und gerinnungshemmenden Eigenschaften
EP1060255A2 (de) * 1998-03-06 2000-12-20 Abbott Laboratories Hochkristalline urokinase
CN100420485C (zh) * 2004-08-06 2008-09-24 上海天士力药业有限公司 含活性尿激酶原的组合物、其冻干方法及冻干制剂
CN110339349A (zh) * 2018-04-04 2019-10-18 天士力生物医药股份有限公司 一种重组人尿激酶原组合物及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8601240A (nl) * 1986-05-15 1987-12-01 Leuven Res & Dev Vzw Plasminogeenactivator en trombolytisch geneesmiddel.
JPH0761266B2 (ja) * 1986-07-03 1995-07-05 株式会社ミドリ十字 変異ヒトプロウロキナ−ゼ
JPH02438A (ja) * 1987-10-09 1990-01-05 Collaborative Res Inc 修飾した低分子量プラスミノーゲン活性化因子およびその製造方法

Also Published As

Publication number Publication date
WO1989010402A1 (en) 1989-11-02
PT90298A (pt) 1989-11-10
PT90298B (pt) 1994-09-30
AU617459B2 (en) 1991-11-28
ATE118033T1 (de) 1995-02-15
EP0338409A1 (de) 1989-10-25
KR900700598A (ko) 1990-08-16
FI896003A0 (fi) 1989-12-15
JPH03500125A (ja) 1991-01-17
CN1037360A (zh) 1989-11-22
IL90011A (en) 1994-10-21
EP0338409B1 (de) 1995-02-01
MY105110A (en) 1994-08-30
AU3414989A (en) 1989-11-24
IL90011A0 (en) 1989-12-15
HU892527D0 (en) 1990-05-28
PH27586A (en) 1993-08-18
GB8809093D0 (en) 1988-05-18
HUT52558A (en) 1990-07-28
NZ228791A (en) 1991-04-26
ZA892829B (en) 1990-01-31
YU79189A (sh) 1992-07-20

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: PHARMACIA S.P.A., MILANO, MAILAND, IT

8332 No legal effect for de